-
91.发明申请METHOD AND APPARATUS FOR PROVIDING TRANSCRANIAL MAGNETIC STIMULATION (TMS) TO AN INDIVIDUAL 审中-公开用于向个体提供经颅磁刺激（TMS）的方法和设备
公开(公告)号：WO2017193078A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/031413
申请日：2017-05-05
IPC分类号： A61N2/06 , A61N2/12 , A61B5/0476 , A61B5/05
CPC分类号： A61N2/006 , A61B5/0476 , A61B5/05 , A61B5/4836 , A61N2/06 , A61N2/12
摘要： An apparatus for applying Transcranial Magnetic Stimulation (TMS) to the brain of an individual comprising: a head mount; a plurality of magnet assemblies for releasable mounting on the head mount; each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, to provide a rapidly changing magnetic field; and a computerized controller for operating at least one of the movement mechanism and the magnetic shield shutter mechanism of at least one of the magnet assemblies to apply a rapidly changing magnetic field to the brain of the individual, wherein the computerized controller is configured to provide one of intermittent oscillatory stimulation and continuous oscillatory stimulation, to induce weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual.
摘要翻译： 一种用于将经颅磁刺激（TMS）应用于个体的大脑的装置，包括：头部支架; 多个磁体组件，用于可释放地安装在头架上; 每个磁体组件包括永磁体以及（i）用于移动永磁体的运动机构和/或（ii）磁屏蔽快门机构中的至少一个，以提供快速变化的磁场; 以及计算机化的控制器，用于操作所述磁体组件中的至少一个的所述移动机构和所述磁屏蔽快门机构中的至少一个，以将快速变化的磁场施加到所述个体的大脑，其中所述计算机化控制器被配置为提供一个 间歇振荡刺激和持续振荡刺激，以诱导个体大脑中的弱电流，从而改变个体大脑的自然电活动。
-
92.发明申请PRE-TRANSPLANT TCR CLONALITY ASSESSMENT TO PREDICT POST-LIVER TRANSPLANT SURVIVAL 审中-公开移植前TCR克隆评估预测肝移植后存活率
公开(公告)号：WO2017165614A1
公开(公告)日：2017-09-28
申请号：PCT/US2017/023756
申请日：2017-03-23
摘要： Disclosed herein are methods for scoring a patient on a liver transplant list, methods of performing a liver transplant, methods of determining expected post-transplant mortality in a subject, and methods of determining expected sepsis. The disclosed methods can be used to avoid futile transplantation, avoid wasting organs, and promote efficient management of organ placement. These methods involve assaying a sample from the subject for T cell receptor (TCR) repertoire.
摘要翻译： 本文公开了用于对肝脏移植名单上的患者进行评分的方法，进行肝脏移植的方法，确定受试者的预期移植后死亡率的方法以及确定预期败血症的方法。 所公开的方法可用于避免无效移植，避免器官浪费，并促进器官放置的有效管理。 这些方法涉及测定受试者的样品中的T细胞受体（TCR）库。
-
93.发明申请SYSTEM AND METHOD USING CARDIAC-ESOPHAGEAL IMPEDANCE MAPPING TO PREDICT AND DETECT ESOPHAGEAL INJURY DURING CARDIAC ABLATION PROCEDURES 审中-公开使用心脏 - 食管阻抗映射预测和检测心脏消融过程中的食管损伤的系统和方法
公开(公告)号：WO2017151576A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/019877
申请日：2017-02-28
IPC分类号： A61B5/0205 , A61B5/042 , A61B5/0215 , A61B5/04 , A61B18/04 , A61N1/05
摘要： Exemplified methods and apparatus use assess electrical coupling between an ablative catheter and the esophagus using measurements of electrical impedance to beneficially predict esophageal damage prior to ablation and to detect on-going esophageal damage during ablation. The technology facilitates the determination of regional variations of electrical coupling between the esophagus and the ablation catheter to infer the risk of the esophagus and its nearby structures.
摘要翻译： 示例性的方法和设备使用使用电阻抗的测量来评估消融导管和食管之间的电耦合，以有利地预测消融之前的食管损伤并且检测消融期间的正在进行的食管损伤。 该技术有助于确定食管和消融导管之间电耦合的区域变化，从而推断食管及其附近结构的风险。
-
公开(公告)号：WO2017146819A9
公开(公告)日：2017-08-31
申请号：PCT/US2017/000017
申请日：2017-02-22
摘要： Disclosed are biocompatible, biodegradable, implantable devices for the controlled release of bioactive molecules. In particular embodiments, nanotechnology-based tunable implants are disclosed for 1) localized delivery of analgesics to treat postoperative pain; 2) sustained delivery of growth factors to promote vascularization; and 3) directing tissue regeneration, including the self-direction of autologous stem cells for organ remodeling.
-
公开(公告)号：WO2017070196A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/057679
申请日：2016-10-19
CPC分类号： A61K31/704
摘要： Disclosed are compositions and methods for electroporation that provide for high payload of a therapeutic agent into a cell. Electroporation buffer solutions comprising a plurality of buffering agents, at least one salt, a carbon polyol, and optionally an acid, wherein the plurality of buffering agents and acid are in an amount such that the pH of the electroporation buffer solution is from about 4.5 to about 5 are disclosed. Kits comprising the electroporation buffer solutions, and optionally a therapeutic agent, are also disclosed. Methods of introducing doxorubicin into immune cells to form a cellular vector, using the electroporation buffer solutions, and compositions produced therefrom are also described. The compositions comprising the cellular vectors can be used to treat a cancerous tissue in a subject, such as the lungs.
摘要翻译： 公开了用于将治疗剂的高有效载荷提供到细胞中的用于电穿孔的组合物和方法。 包含多种缓冲剂，至少一种盐，碳多元醇和任选的酸的电穿孔缓冲溶液，其中所述多种缓冲剂和酸的量使得电穿孔缓冲溶液的pH为约4.5至 约披露了5个。 还公开了包含电穿孔缓冲溶液和任选的治疗剂的试剂盒。 还描述了使用电穿孔缓冲溶液将多柔比星引入免疫细胞以形成细胞载体的方法，以及由其产生的组合物。 包含细胞载体的组合物可以用于治疗受试者（例如肺）中的癌性组织。
-
96.发明申请MULTIPLEXED VOLUMETRIC BAR CHART CHIP FOR POINT OF CARE BIOMARKER AND/OR ANALYTE QUANTITATION, INCLUDING COMPETITIVE CONTROL 审中-公开用于保护生物标记点和/或分析数量的多重体积条形图形芯片，包括竞争控制
公开(公告)号：WO2016154113A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/023416
申请日：2016-03-21
发明人： QIN, Lidong , LI, Ying , WANG, Ping , WU, Xifeng
CPC分类号： G01N33/54366 , B01L3/502715 , B01L3/502738 , B01L2200/0621 , B01L2200/0642 , B01L2200/0694 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0883 , B01L2400/0406 , B01L2400/0622 , B01L2400/065 , B81B1/00 , B81B7/04 , B81C1/00
摘要： Apparatus for determining the quantity of a target analyte present in a sample, the apparatus comprising: a first plate comprising a plurality of recesses arranged to form a plurality of rows extending parallel to one another, and a plurality of channels extending perpendicularly to the plurality of rows of the first plate; and a second plate comprising a plurality of recesses arranged to form a plurality of rows extending parallel to one another, and a plurality of channels extending perpendicularly to the plurality of rows of the second plate; wherein the first plate and the second plate are assembled together so that the first plate is positioned against the second plate and the recesses of the first plate communicate with the recesses of the second plate so as to form a plurality of sample rows, a plurality of control rows, and an ink row disposed between the plurality of sample rows and the plurality of control rows.
摘要翻译： 用于确定样品中存在的目标分析物的量的装置，所述装置包括：第一板，包括多个凹槽，所述多个凹槽被布置成形成彼此平行延伸的多个行，以及垂直于所述多个 第一板的行; 以及第二板，其包括布置成形成彼此平行延伸的多个行的多个凹槽和垂直于所述第二板的多排延伸的多个通道; 其中所述第一板和所述第二板被组装在一起，使得所述第一板抵靠所述第二板定位，并且所述第一板的凹部与所述第二板的凹部连通，以形成多个样品行， 控制行和布置在多个样本行和多个控制行之间的墨水行。
-
公开(公告)号：WO2016138348A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/019713
申请日：2016-02-26
CPC分类号： A61B5/0476 , A61B5/0006 , A61B5/04012 , A61B5/16 , A61B5/165 , A61B5/7405 , A61B5/746 , A61B17/34 , A61B34/20 , A61B90/37 , A61B2034/2057 , A61B2034/2065 , G06F19/3481 , G16H40/20
摘要： Systems and methods for monitoring medical procedures. Particular embodiment's relate to monitoring medical procedures performed in operating room environments through the use of various types of sensors, including for example, wireless electroencephalography (EEG) monitoring systems. Presented are systems and methods directed to a monitor medical procedures, including in particular the mental state of medical personnel associated with such procedures. Exemplary embodiment's of the present disclosure relate to systems and methods for monitoring medical procedures. Particular embodiment's relate to monitoring medical procedures performed in operating room environments through the use of various types of sensors, including for example, wireless electroencephalography (EEG) monitoring systems.
摘要翻译： 用于监测医疗程序的系统和方法。 具体实施例涉及通过使用各种类型的传感器（例如无线脑电图（EEG）监视系统）来监视在手术室环境中执行的医疗程序。 提出了针对监视医疗程序的系统和方法，特别包括与这种程序相关联的医务人员的精神状态。 本公开的示例性实施例涉及用于监测医疗程序的系统和方法。 具体实施例涉及通过使用各种类型的传感器（例如无线脑电图（EEG）监视系统）来监视在手术室环境中执行的医疗程序。
-
公开(公告)号：WO2016015015A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/042118
申请日：2015-07-24
申请人： BAYLOR COLLEGE OF MEDICINE , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , THE METHODIST HOSPITAL
发明人： CURLEY, Steven , CORR, Stuart , SERDA, Rita , RAOOF, Mustafa
CPC分类号： A61K41/0052 , A61B5/015 , A61B5/055 , A61B5/4839 , A61B5/4848 , A61B18/18 , A61B2018/1807 , A61K31/337 , A61K31/7068 , A61K47/643 , A61M37/00 , A61M2037/0007 , A61N1/406
摘要： Embodiments of the disclosure concern methods and compositions for treating a subject with cancer, including overcoming resistance to a cancer drug using non-invasive radiotherapy frequency in combination with cancer drugs. In particular embodiments, radiofrequency therapy and cancer drugs in combination provide a synergistic benefit for cancer therapy. Use of radiofrequency therapy is an effective means to facilitate transport and perfusion of the cancer drugs in the subject.
摘要翻译： 本公开的实施方案涉及用于治疗患有癌症的受试者的方法和组合物，包括使用非侵入性放射治疗频率与癌症药物结合来克服对癌症药物的抗性。 在具体实施方案中，组合的射频治疗和癌症药物为癌症治疗提供协同效益。 使用射频治疗是促进受试者中癌症药物的运输和灌注的有效手段。
-
99.发明申请SINGLE-CELL PIPETTE ASSEMBLY COMPRISING SINGLE-CELL PIPETTE HANDLE AND SINGLE-CELL PIPETTE TIP 审中-公开单细胞管组件包含单细胞管子手柄和单细胞管子提示
公开(公告)号：WO2015116714A1
公开(公告)日：2015-08-06
申请号：PCT/US2015/013343
申请日：2015-01-28
发明人： QIN, Lidong , ZHANG, Kai
IPC分类号： B01L3/02
CPC分类号： B01L3/0275 , B01L2200/0657 , B01L2200/0668 , B01L2300/0832 , B01L2400/086
摘要： Apparatus for isolating an individual cell from a group of cells and transferring that isolated cell to a desired location, the apparatus comprising: a single-cell pipette tip, the single-cell pipette tip comprising: a structure having a distal end; a Y-shaped microchannel formed in the structure, the Y-shaped microchannel comprising a base microchannel, a first branch microchannel and a second branch microchannel, wherein the base microchannel extends to the distal end of the structure, the first branch microchannel is connectable to a first pressure channel, the second branch microchannel is connectable to a second pressure channel, and a single-cell trap is disposed in the base microchannel, distal to the convergence of the base microchannel with the first branch microchannel and the second branch microchannel.
摘要翻译： 用于从一组细胞分离单个细胞并将该分离的细胞转移到所需位置的装置，所述装置包括：单细胞移液管尖端，所述单细胞移液管末端包括：具有远端的结构; 在所述结构中形成的Y形微通道，所述Y形微通道包括基底微通道，第一分支微通道和第二分支微通道，其中所述基底微通道延伸到所述结构的远端，所述第一支路微通道可连接到 第一压力通道，第二分支微通道可连接到第二压力通道，并且单个电池阱设置在基极微通道中，远离基极微通道与第一分支微通道和第二分支微通道的会聚。
-
100.发明申请
公开(公告)号：WO2015023980A3
公开(公告)日：2015-02-19
申请号：PCT/US2014/051340
申请日：2014-08-15
摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to an individual, wherein the apparatus comprises: a head mount for disposition on the head of an individual; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each individual, whereby to provide individual-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.
-
-
-
-
-
-
-
-
-
搜索结果
138 条记录 (耗时 0.025 秒)
