Abstract:
Embodiments of the present disclosure are directed to methods, systems and devices, for analyzing the molecules. For example, in some embodiments, a system is provided which includes a first volume of conducting fluid, a second volume of conducting fluid, an orifice in communication with said first and second volumes of fluid, and means for applying an electric potential difference between said first and second volumes of fluid. In some such embodiments, a conjugate product is provided which comprises charged polymers each having attached thereto at least one first molecule for analysis, where the product carries a predetermined charge greater than the charge on the first molecule, and upon dissolving a product in the first volume of fluid, the product is directed into the orifice.
Abstract:
[0076] Some embodiments of the present disclosure provide methods, devices, and systems for sequencing nucleic acid polymers that utilize palladium (Pd), for example, at least in part, as an electrode material that is (i) functionalized with one or more adaptor molecules and (ii) capable for use to sense one or more chemical compositions.
Abstract:
Embodiments of the present disclosure relate to amino acid, modified amino acid, peptide and protein identification and sequencing, by means of, for example, electronic detection of individual amino acids or small peptides.
Abstract:
Embodiments of the present disclosure include methods and systems of operating an HVAC system for an enclosed environment. In such embodiments, the HVAC system may be configured to at least one of heat and cool air and include an air circulation system configured to circulate air at least within the enclosed environment. The air within the enclosed environment may comprise at least the indoor air. The system may further include an outdoor air inlet for introducing at least a portion of outdoor air into the enclosed environment, where the outdoor air comprises air from outside the enclosed environment. The system may further include a scrubbing system having an adsorbent material to reduce presence of at least one gas contaminate in the indoor air. A controller system may be included for controlling the operation of at least one of the circulation system and the scrubbing system.
Abstract:
Systems and methods for stimulating a neuronal cell in the head of a patient in need of such stimulation are disclosed. The method includes positioning a light source proximal to the neuronal cell to be stimulated and pulsing the light from the light source to stimulate the neuronal cell for a predetermined period of time to achieve the desired effect.
Abstract:
A spinous process device and method are disclosed. The device includes a first plate (12020a) having a first part slidably coupled to a second part, a second plate (1202b) having a third part slidably coupled to a fourth part, and first and second connector devices (1220) configured to be placed through openings created in spinous processes and rotatably couple respective first and second parts to third and fourth parts of the first and second plates together allowing angular displacement of the second plate with respect to the first plate and secure the spinous processes between the first and second plates.
Abstract:
Novel uses of Platelet Rich Plasma (PRP) for infection prevention, bone repair and transmyocardial vascularization is disclosed. The present disclosure is directed to methods for preparing concentrated mesenchymal or haematopoietic stem cells, and autologous platelet- rich plasma (PRP) from the blood utilizing the Magallen® System. The stem cells and/or PRP may be combined with secondary biological agents such as antibiotics, fibrinogen and thrombin, and appropriately used in variety of medical conditions, such as, cardiovascular, thoracic, transplantation, head and neck, oral, gastrointestinal, orthopedic, neurosurgical, and plastic surgery.
Abstract:
The subject disclosure presents, in some embodiments, is systems, devices and methods for multi-sample analyte analysis. In some such embodiments, a method is presented which includes labeling at least one target analyte in each of a plurality of individual samples with at least one unique label probe. The method further includes combining the plurality of individual samples into a mixture, and flowing the mixture within at least one fluidic channel/1 ane having arranged thereon or in fluid communication with at least one set of a plurality of spatially distinct capture zones. Embodiments of the present disclosure additionally relate to, among other things, systems, devices, and related methods for operating the same, to analyze and rapidly identify and quantify microbial pathogens in environmental, food, and clinical settings. Specifically, a rapid one-step FISH method where fixation, permeabilization and addition of fluorescent labeled probe all occur in one step on a ferrofluidic system.
Abstract:
Embodiments of the present disclosure present methods, systems, and devices for extrachromosomal DNA extraction, and in some embodiments, isolation of DNA therefrom, and/or analysis of the extracted and/or isolated DNA, including, in some embodiments, ecDNA.
Abstract:
Accordingly, in some embodiments of the disclosure, a multi-chambered assay device is provided, which is configured for arrangement on a disc, as well as configured to process an individual sample. A plurality of such assay devices can be arranged along a periphery of the disc at a distance/radius from the center, such that a plurality of individual samples can be processed, e.g., one per assay device. In addition, in an arrangement that a plurality of assay devices are used, they can be spaced apart such that they balance the disc during rotation (which can be with samples contained in one or more of the assay devices, a plurality, a majority, or all of the assay devices).