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    APPARATUS FOR GUIDING SAMPLE AND REAGENT MANIPULATIONS AND RECEPTACLES FOR HOLDING SAME
    3.
    发明申请
    APPARATUS FOR GUIDING SAMPLE AND REAGENT MANIPULATIONS AND RECEPTACLES FOR HOLDING SAME 审中-公开
    用于指导样品和试剂操作的装置和用于控制样品的插入物

    公开(公告)号：WO2007121324A1

    公开(公告)日：2007-10-25

    申请号：PCT/US2007/066569

    申请日：2007-04-12

    Applicant: SAGE SCIENCE, INC. ,  MAGNANT, Gary ,  FINNEY, Michael, J. ,  BARBERA, Todd, J. ,  COREY, George ,  BOLES, Chris

    Inventor： MAGNANT, Gary ,  FINNEY, Michael, J. ,  BARBERA, Todd, J. ,  COREY, George ,  BOLES, Chris

    IPC: G01N35/00 ,  B01L11/00

    CPC classification number: G01N35/00584 ,  B01L3/0227 ,  B01L3/50855 ,  B01L9/50 ,  B01L2200/143 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/0829

    Abstract: A system has utility is guiding and tracking the execution of manual procedures. The system includes a support that holds multiple sample receptacles, computational circuitry to execute a protocol script that delivers instructions for executing various steps of the procedure, and a protocol progress sensor that advances the execution of the protocol script. The computer may be comparable in size to a support for holding the receptacles The receptacles be arranged in a frame, may be sealed with peelable or puncturable films and may include identifiers that are read by the system. The receptacles may be filled with a high heat capacity material to maintain a given temperature range. A variety of companion devices may interact with the system using the protocol script. An instrumented pipettor can communicate with the system for semi-automated execution of protocols.

    Abstract translation: 系统的实用程序是指导和跟踪手动过程的执行。 该系统包括一个支持多个样本插座的支持，执行一个协议脚本的计算电路，该协议脚本提供用于执行该过程的各个步骤的指令，以及协议进程传感器，其执行协议脚本的执行。 计算机的尺寸可以与用于保持插座的支撑件相当。插座布置在框架中，可以用可剥离的或可穿刺的膜密封，并且可以包括由系统读取的标识符。 容器可以填充高热容材料以保持给定的温度范围。 各种伴侣设备可以使用协议脚本与系统进行交互。 仪器化移液器可与系统进行通信，以实现协议的半自动执行。

    SEMI-AUTOMATED RESEARCH INSTRUMENT SYSTEM
    4.
    发明申请
    SEMI-AUTOMATED RESEARCH INSTRUMENT SYSTEM 审中-公开

    公开(公告)号：WO2019136301A1

    公开(公告)日：2019-07-11

    申请号：PCT/US2019/012416

    申请日：2019-01-04

    Applicant: SAGE SCIENCE, INC.

    Inventor： ABRAMS, Ezra S. ,  BARBERA, Todd J. ,  BOLES, T. Christian

    IPC: G01N27/447 ,  C12N15/10 ,  G01N27/453

    Abstract: A cassette for retaining molecules during electrophoresis has a housing with a lane configured therein. The lane has a first elongate edge and a second elongate edge, and an elution module is configured to be received in the late to divide the lane into a first chamber and a second chamber. A first buffer reservoir is positioned adjacent the first elongate edge, and a second buffer reservoir is positioned adjacent the second elongate edge. The first side of the elution module facing the first chamber comprises a porous sterile filtration membrane. The second side of the elution module facing the second chamber comprises an ultrafiltration membrane that has a pore size to retain molecules during electrophoresis.

    WORKFLOWS FOR ENZYMATIC NUCLEIC ACID MODIFICATION
    5.
    发明申请
    WORKFLOWS FOR ENZYMATIC NUCLEIC ACID MODIFICATION 审中-公开
    用于酶促核酸修饰的工作流程

    公开(公告)号：WO2017139669A1

    公开(公告)日：2017-08-17

    申请号：PCT/US2017/017508

    申请日：2017-02-10

    Applicant: SAGE SCIENCE, INC. ,  ABRAMS, Ezra ,  YUN, Danny ,  BOLES, T. Christian

    Inventor： ABRAMS, Ezra ,  YUN, Danny ,  BOLES, T. Christian

    IPC: C12Q1/68 ,  C12N9/00 ,  C12Q1/37 ,  C12N9/76 ,  C12N9/99

    CPC classification number: C12N9/00 ,  C12N9/99 ,  C12Q1/37 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q2521/501 ,  C12Q2527/127

    Abstract: A nucleic acid sample may be provided, and the sample may be treated by applying a first enzymatic nucleic acid modifying reagent to produce a first nucleic acid solution. A first protease reagent may be applied to the first nucleic acid solution to produce a second nucleic acid solution. The application of the first protease reagent may completely or substantially inactivate the first enzymatic nucleic acid modifying reagent. A first inhibitor reagent may be applied in order to produce a third nucleic acid solution, and the first inhibitor reagent may completely or substantially inactivate the first protease reagent.

    Abstract translation: 可以提供核酸样品，并且可以通过应用第一酶促核酸修饰试剂来处理样品以产生第一核酸溶液。 可以将第一蛋白酶试剂施加至第一核酸溶液以产生第二核酸溶液。 第一种蛋白酶试剂的应用可以完全或基本上使第一种酶促核酸修饰试剂失活。 可以施用第一抑制剂以产生第三核酸溶液，并且第一抑制剂可以完全或基本上使第一蛋白酶试剂失活。

    LABORATORY TEMPERATURE CONTROL WITH ULTRA-SMOOTH HEAT TRANSFER SURFACES
    6.
    发明申请
    LABORATORY TEMPERATURE CONTROL WITH ULTRA-SMOOTH HEAT TRANSFER SURFACES 审中-公开
    超声波传热表面的实验温度控制

    公开(公告)号：WO2007106823A2

    公开(公告)日：2007-09-20

    申请号：PCT/US2007/063904

    申请日：2007-03-13

    Applicant: SAGE SCIENCE, INC. ,  MAGNANT, Gary

    Inventor： MAGNANT, Gary

    IPC: F25D17/02 ,  F28F13/18 ,  G01N1/28

    CPC classification number: F28F13/18 ,  B01L7/00 ,  B01L2200/147 ,  B01L2300/0829 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/185 ,  F25B39/02 ,  F25B40/00 ,  F25D23/00 ,  G01N27/44704

    Abstract: A temperature regulation system has a polished surface sufficiently smooth so as to reduce the emissivity of the surface. A conduit is in thermal proximity to the polished surface and is in communication with a source of coolant. The coolant is circulated through the conduit so as to transfer heat from the surface to the coolant. System may include a sprayed-on resistive heater. An a temperature controlled vessel has a heat transfer wall that is of an electrically conductive material that is coated with a durable thermally conductive and electrically nonconductive coating. The coating may be a sprayed on coating and the vessel may hold a buffer for performing electrophoresis.

    Abstract translation: 温度调节系统具有足够平滑的抛光表面，以便降低表面的发射率。 导管处于与抛光表面接近热并与冷却剂源连通的位置。 冷却剂通过管道循环，以便将热量从表面传递到冷却剂。 系统可以包括喷涂电阻加热器。 温度控制容器具有导电材料的传热壁，其被涂覆有耐用的导热和非导电涂层。 涂层可以喷涂在涂层上，并且容器可以保持用于进行电泳的缓冲液。

    SYSTEMS AND METHODS FOR DETECTION OF GENETIC STRUCTURAL VARIATION USING INTEGRATED ELECTROPHORETIC DNA PURIFICATION
    7.
    发明申请
    SYSTEMS AND METHODS FOR DETECTION OF GENETIC STRUCTURAL VARIATION USING INTEGRATED ELECTROPHORETIC DNA PURIFICATION 审中-公开

    公开(公告)号：WO2018187779A1

    公开(公告)日：2018-10-11

    申请号：PCT/US2018/026603

    申请日：2018-04-06

    Applicant: SAGE SCIENCE, INC.

    Inventor： BOLES, T. Christian

    IPC: G01N27/26 ,  G01N27/28

    Abstract: An electrophoresis cassette may include sample well(s), gel column(s) containing a separation gel, and elution modules arranged adjacent the gel column(s). A sample may be provided to the electrophoresis cassette and high-molecular weight DNA may be isolated from the sample. Single-copy DNA sequences may be cleaved on both sides of a repeat region of the DNA sequences to produce a cleaved sample, which then may be fractionated using gel electrophoresis. DNA fractions may be isolated from consecutive sections of the separation gel and subjected to PCR assays to detect single-copy sequences within the DNA fraction, said single-copy sequence containing repeat expansion sequences. The subjected DNA fractions may be electroeluted into the plurality of elution modules. A size of DNA fractions having the repeat expansion sequences may be determined. It is also determined if that size is above a normal repeat size range.

    SYSTEMS AND METHODS FOR PROCESSING FLUIDS
    8.
    发明申请
    SYSTEMS AND METHODS FOR PROCESSING FLUIDS 审中-公开
    用于处理流体的系统和方法

    公开(公告)号：WO2013020089A2

    公开(公告)日：2013-02-07

    申请号：PCT/US2012/049603

    申请日：2012-08-03

    Applicant: SAGE SCIENCE, INC. ,  BOLES, T., Christian

    Inventor： BOLES, T., Christian

    IPC: B01L3/00

    CPC classification number: C12N15/1003 ,  B01L3/502715 ,  B01L3/502753 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0652 ,  B01L2300/0819 ,  B01L2400/086 ,  C12M45/09 ,  C12N15/102 ,  C12P19/34 ,  C40B50/06

    Abstract: Systems and methods for processing fluid samples are disclosed. Fluid sample processing is accomplished using a series of microfluidic bump arrays include an automated and integrated system for sorting particles from a biological sample, lysing those particles to expose total RNA or DNA, purifying the RNA or DNA, processing the RNA or DNA by chemical or enzymatic modification, to select RNA or DNA molecules by size, or to generate, optionally, a sequencing library. The sequencing library is suitable for use in next generation sequencing ("NGS").

    Abstract translation: 公开了用于处理流体样品的系统和方法。 使用一系列微流体凸块阵列实现流体样品处理，其包括用于从生物样品分选颗粒的自动化和集成系统，裂解那些颗粒以暴露总RNA或DNA，纯化RNA或DNA，通过化学或处理RNA或DNA 酶修饰，按大小选择RNA或DNA分子，或产生任选的测序文库。 测序文库适用于下一代测序（“NGS”）。

    APPARATUSES, METHODS AND SYSTEMS FOR AUTOMATED PROCESSING OF NUCLEIC ACIDS AND ELECTROPHORETIC SAMPLE PREPARATION
    10.
    发明申请
    APPARATUSES, METHODS AND SYSTEMS FOR AUTOMATED PROCESSING OF NUCLEIC ACIDS AND ELECTROPHORETIC SAMPLE PREPARATION 审中-公开
    自动处理核酸和电泳样品制备的装置，方法和系统

    公开(公告)号：WO2018067736A1

    公开(公告)日：2018-04-12

    申请号：PCT/US2017/055193

    申请日：2017-10-04

    Applicant: SAGE SCIENCE, INC. ,  ABRAMS, Ezra Solomon ,  BARBERA, Todd J.

    Inventor： ABRAMS, Ezra Solomon ,  BARBERA, Todd J.

    IPC: G01N27/447 ,  B01J19/00 ,  B01L3/00

    Abstract: Various implementations disclosed herein relate to automated processing of nucleic acids and electrophoretic sample preparation. An exemplary disposable cassette for automated molecular processing may include a base housing, a central channel arranged in the housing, and an elution module configured to be received in central channel and to divide the central channel into a first chamber and a second chamber. The elution module comprises a housing having a proximal side, a distal side and an elution module channel passing from the proximal side to the distal side. The elution module also comprises a first membrane attached to a proximal side of the elution module, a second membrane attached to a distal side of the elution module, and a porthole in fluid communication with the elution module channel and configured for receiving a sample.

    Abstract translation: 本文公开的各种实施方式涉及核酸的自动化处理和电泳样品制备。 用于自动化分子处理的示例性一次性盒可以包括基座壳体，布置在壳体中的中央通道以及构造成接收在中央通道中并将中央通道分成第一腔室和第二腔室的洗脱模块。 洗脱模块包括壳体，该壳体具有近侧，远侧和从近侧到远侧通过的洗脱模块通道。 洗脱模块还包括连接到洗脱模块的近侧的第一膜，连接到洗脱模块的远侧的第二膜和与洗脱模块通道流体连通并构造成用于接收样品的孔口。 / p>

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