公开(公告)号：WO2005041264A2

公开(公告)日：2005-05-06

申请号：PCT/US2004/034899

申请日：2004-10-20

Applicant: STAR CRYOELECTRONICS, LLC ,  CANTOR, Robin, Harold ,  HALL, John, Addison

Inventor： CANTOR, Robin, Harold ,  HALL, John, Addison

IPC: H01L

CPC classification number: H01L39/223 ,  G01R33/0052 ,  G01R33/035 ,  H01L39/2493 ,  Y10S428/93 ,  Y10S505/701

Abstract: A Superconducting Quantum Interference Device (SQUID) is disclosed comprising a pair of resistively shunted Josephson junctions connected in parallel within a superconducting loop and biased by an external direct current (dc) source. The SQUID comprises a semiconductor substrate and at least one superconducting layer. The metal layer(s) are separated by or covered with a semiconductor material layer having the properties of a conductor at room temperature and the properties of an insulator at operating temperatures (generally less than 100 Kelvins). The properties of the semiconductor material layer greatly reduces the risk of electrostatic discharge that can damage the device during normal handling of the device at room temperature, while still providing the insulating properties desired to allow normal functioning of the device at its operating temperature. A method of manufacturing the SQUID device is also disclosed.

Abstract translation: 公开了一种超导量子干涉装置（SQUID），其包括在超导环路内并联连接并被外部直流（dc）源偏置的一对电阻分流的约瑟夫逊结。 SQUID包括半导体衬底和至少一个超导层。 金属层由在室温下具有导体性质的半导体材料层和在工作温度（通常小于100Kelvins）下的绝缘体的性质分开或覆盖。 半导体材料层的性质大大降低了静电放电的风险，其可能在室温正常处理器件期间损坏器件，同时仍然提供期望的绝缘性能以允许器件在其工作温度下正常工作。 还公开了一种制造SQUID器件的方法。

公开(公告)号：WO2004105640A2

公开(公告)日：2004-12-09

申请号：PCT/US2004/017183

申请日：2004-05-28

Applicant: THE CLEVELAND CLINIC FOUNDATION ,  REZAI, Ali, R. ,  BAKER, Kenneth, B. ,  HALL, John, D. ,  SHELLOCK, Frank, G.

Inventor： REZAI, Ali, R. ,  BAKER, Kenneth, B. ,  HALL, John, D. ,  SHELLOCK, Frank, G.

IPC: A61F

CPC classification number: A61N1/0529 ,  A61B2090/103 ,  A61N1/0539

Abstract: A device and method for retaining an excess portion of a lead implanted within or on a surface of a brain of a patient is disclosed. The device comprises a burr hole ring configured to be secured to a skull of the patient and a lead retainer extending from the burr hole ring. The lead retainer is configured to store at least a section of the excess portion of the lead.

Abstract translation: 公开了一种用于保持植入在患者的脑内或表面上的铅的多余部分的装置和方法。 该装置包括构造成固定到患者颅骨的毛刺孔环和从毛刺孔环延伸的引线保持器。 引线保持器构造成存储引线的多余部分的至少一部分。

公开(公告)号：WO2004024551A3

公开(公告)日：2004-03-25

申请号：PCT/GB2003/003981

申请日：2003-09-12

Applicant: SEALINE INTERNATIONAL LIMITED ,  HAYES, Kevin ,  HALL, John, William

Inventor： HAYES, Kevin ,  HALL, John, William

IPC: B63B29/04

Abstract: A display device (8) such as a flat screen television may be stowed away out of sight within a cabin by partly recessing into a moulded coaming (3) forming part of the boat's superstructure (1) in addition to being partially received in a special housing (7). In this way, the fact that a display device (8) is hidden out of view is made less obvious because the housing (7) does not conform to the shape of the display device (8).

公开(公告)号：WO2002010357A3

公开(公告)日：2002-02-07

申请号：PCT/US2001/023539

申请日：2001-07-25

Applicant: CHIRON CORPORATION ,  HARRISON, Stephen, D. ,  HALL, John, A. ,  CALDERON-CACIA, Maria ,  ZHONG, Ziyang ,  FANG, Eric, Y. ,  COIT, Doris, G. ,  NGUYEN, Steven, H. ,  MEDINA-SELBY, Angelica

Inventor： HARRISON, Stephen, D. ,  HALL, John, A. ,  CALDERON-CACIA, Maria ,  ZHONG, Ziyang ,  FANG, Eric, Y. ,  COIT, Doris, G. ,  NGUYEN, Steven, H. ,  MEDINA-SELBY, Angelica

IPC: C12N9/12

Abstract: The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, inlcuding Alzheimer's disease, type 2 diabetes, and inflammation.

公开(公告)号：WO0015119A9

公开(公告)日：2000-08-24

申请号：PCT/US9920305

申请日：1999-09-03

Applicant: MEDTRONIC INC ,  BORST CORNELIUS ,  MANSVELT BECK HENDRICUS J ,  BOONE ERIC ,  GOODMAN JACK ,  HALL JOHN D ,  NEILL WILLIAM G O ,  TESTA VINCENT J ,  VROEGOP ERIC

Inventor： BORST CORNELIUS ,  MANSVELT-BECK HENDRICUS J ,  BOONE ERIC ,  GOODMAN JACK ,  HALL JOHN D ,  O'NEILL WILLIAM G ,  TESTA VINCENT J ,  VROEGOP ERIC

IPC: A61B19/00 ,  A61B17/00 ,  A61B17/02 ,  A61B17/28 ,  A61B17/30

CPC classification number: A61B17/02 ,  A61B17/0218 ,  A61B2017/00314 ,  A61B2017/0243 ,  A61B2017/2904 ,  A61B2017/2905 ,  A61B2017/306

Abstract: The invention is a method and apparatus for performing beating heart surgery, in which a single articulating arm supports multiple suction pods. Once the suction pods are applied to the heart surface, tightening a cable fixes the arm in place. Then, the suction pods may be spread apart from each other to tighten the surface of the cardiac tissue lying between the suction pods. In one embodiment, fixation of the arm as well as the spreading apart of the suction pods may occur concurrently or almost concurrently through the tensioning of a single cable. Additional embodiments of the method, system and its components are shown.

Abstract translation: 本发明是一种用于进行心跳手术的方法和装置，其中单个关节臂支撑多个抽吸荚。 一旦吸入荚被施加到心脏表面上，紧固电缆将臂固定到位。 然后，抽吸荚可以彼此分开，以紧固位于抽吸荚之间的心脏组织的表面。 在一个实施例中，臂的固定以及吸入舱的扩展分开可以通过单个电缆的张紧同时或几乎同时地发生。 示出了该方法，系统及其部件的附加实施例。

公开(公告)号：WO1992001905A1

公开(公告)日：1992-02-06

申请号：PCT/GB1990001106

申请日：1990-07-19

Applicant: THE SECRETARY OF STATE FOR DEFENCE IN HER ... ,  HALL, John, Richard

Inventor： THE SECRETARY OF STATE FOR DEFENCE IN HER ...

IPC: G01C23/00

CPC classification number: G01C23/00

Abstract: An aircraft instrumentation system providing a head-up display which displays modified indications of flight path and other parameters, very substantial modifications being made to achieve a display which is useful in all manoeuvres even in an agile fast-jet aircraft. The modifications reduce the transient movements of the display indicia which are due to the increased incidence needed to instigate flight path changes. One modification provides an aircraft symbol constrained to stay on a vertical centreline of the display unit, with a displacement depending on bank angle to preserve horizon correlation as far as possible. A comparatively small symbol (vv diamond) with unlimited motion indicates the flight path direction and a pitch ladder indicates modified climb-dive angle when read against the aircraft symbol. The positions of the aircraft symbol, vv diamond, and pitch ladder are all modified by Q functions derived from pitch attitude or body pitch rate to offset the effect of transient variations of pitch in flight path manoeuvres. The Q functions are calculated by algorithms involving a variable time constant tau which is approximately matched to the time constant of the heave mode response of the aircraft, which is a function of mass, airspeed, wing area, and lift-curve slope coefficient. A linear approximation is used, with an experimental optimisation, to derive an appropriate expression for tau . Peripheral scales showing attitude and optional other parameters are positioned in a fixed relationship to the variable position of the aircraft symbol.

Abstract translation: 一种提供平视显示器的飞行器仪表系统，其显示飞行路径和其他参数的修改指示，进行非常实质的修改以实现即使在敏捷快速喷气式飞行器中在所有操纵中也是有用的显示器。 这些修改减少了显示标记的瞬时移动，这是由于引起飞行路径改变所需的增加的发生。 一个修改提供了被限制留在显示单元的垂直中心线上的飞行器符号，具有取决于岸角的位移，以尽可能地保持水平相关。 具有无限运动的相对较小的符号（vv diamond）表示飞行路线方向，俯仰梯表示当对飞机符号进行读取时修改的爬升角度。 飞行器符号，vv钻石和俯仰梯的位置都是通过从俯仰姿态或身体俯仰速率导出的Q函数进行修改，以抵消飞行路径演习中俯仰的瞬态变化的影响。 Q函数通过涉及可变时间常数τ的算法来计算，该时间常数τ与飞机起伏模式响应的时间常数近似匹配，这是质量，空速，机翼面积和升力曲线斜率系数的函数。 使用线性近似，通过实验优化，得出tau的适当表达式。 显示姿态和可选的其他参数的外围尺度与飞机符号的可变位置定位成固定的关系。

公开(公告)号：WO2020006541A1

公开(公告)日：2020-01-02

申请号：PCT/US2019/040026

申请日：2019-06-29

Applicant: HALL, John Peter

Inventor： HALL, John Peter

IPC: G02B27/22

Abstract: This is a structure for assembly of two videos or cameras, etc., that work as do human eyes. Our human eyes, when wishing to see something that is closure in distance, the eyes swerve more to the center, left eye turning right, and right eye turning left. In this analogy, we shall manifest two human eyes being six and a half centimeters apart from left pupil to right pupil. In order to target at a point from two angles, the eyes must give less attention to the wider area. All around the area, the two human eyes see a misty, vague shadow, and also double, since the two eyes look from different locations. This Video/Camera works in the same way as do our human eyes, with the two human lenses placed six and a half centimeters apart from the center of the left lens to the center of the right lens.

公开(公告)号：WO2019191776A1

公开(公告)日：2019-10-03

申请号：PCT/US2019/025234

申请日：2019-04-01

Applicant: HALL, John, L. ,  BELJANSKI, Sylvie, P.

Inventor： HALL, John, L. ,  BELJANSKI, Sylvie, P.

IPC: A61K31/475 ,  A61P29/00 ,  A61P35/00

Abstract: De-ethylflavopereirine, a pharmaceutically acceptable salt thereof, a solvate or a hydrate thereof, or a pharmaceutically acceptable salt of a solvate or a hydrate thereof may be used as cancer therapy (i.e., prevention and/or treatment) in a subject in need thereof, including a pathological condition such as inflammation, especially chronic, or cancer (e.g., a carcinoma, a sarcoma, a melanoma, a leukemia, a lymphoma), especially a solid tumor and/or a metastasis thereof. In particular, systemic administration of such improved anti-cancer agents in effective amounts may selectively destroy cancer cells (including cancer stem cells) in a solid tumor and/or at a site of metastasis. They are well-tolerated by the subject, even at large systemic doses and their resulting high concentrations in the circulation, and provide safe and effective anti-cancer agents.

公开(公告)号：WO2011053361A2

公开(公告)日：2011-05-05

申请号：PCT/US2010/002884

申请日：2010-11-02

Applicant: MEGASTIR TECHNOLOGIES, LLC ,  PETERSON, Jeremy ,  HALL, John ,  STEEL, Russell, J. ,  BABB, Jonathan ,  COLLIER, Matt ,  PACKER, Scott, M.

Inventor： PETERSON, Jeremy ,  HALL, John ,  STEEL, Russell, J. ,  BABB, Jonathan ,  COLLIER, Matt ,  PACKER, Scott, M.

IPC: B23K20/12 ,  B23K37/04 ,  B23K37/00

CPC classification number: B23K20/1255 ,  B23K20/126 ,  B23K37/0533 ,  B23K2201/06

Abstract: A system and method for friction stir welding of small diameter tubing, wherein the small diameter tubing is held in a correct position with a grasp sufficient to perform FSW when the tubing is comprised of high melting temperature materials, wherein the small diameter tubing can be rotated by the positioning and holding system while a FSW tool is held stationary, or vice versa, wherein internal mandrels are also described which can fit inside the smaller dimensions of the small diameter tubing and expand to provide a counter force to prevent deformation of the tubing when forces are applied by the FSW tool, wherein new FSW tool geometries are also described which enable the FSW tool to direct more heat on a tool/workpiece interface to counteract a lack of contact between the FSW shoulder and the workpiece because of tube curvature, and wherein the FSW tool is positioned on a small diameter tube by trailing the joint to provide desirable heating at the joint /workpiece interface and surface finishing.

Abstract translation: 一种用于小直径管道的摩擦搅拌焊接的系统和方法，其中当管道由高熔点材料组成时，小直径管道被保持在具有足以执行FSW的抓握的正确位置，其中小直径管道可以旋转 通过定位和固定系统，而FSW工具保持静止，反之亦然，其中还描述了内部心轴，其可以装配在小直径管的较小尺寸内并且膨胀以提供反作用力以防止管道变形 FSW工具施加了力，其中还描述了新的FSW工具几何形状，其使得FSW工具能够在工具/工件界面上引导更多的热量，以抵消由于管弯曲而在FSW肩部和工件之间的接触不足，以及 其中FSW工具通过拖尾来定位在小直径管上，以在接头/工件接口和su处提供所需的加热 表面处理

公开(公告)号：WO2009120283A3

公开(公告)日：2009-11-26

申请号：PCT/US2009001710

申请日：2009-03-18

Applicant: TYCO ELECTRONICS CORP ,  MYER JOHN MARK ,  HALL JOHN WESLEY ,  MOLL HURLEY CHESTER

Inventor： MYER JOHN MARK ,  HALL JOHN WESLEY ,  MOLL HURLEY CHESTER

IPC: H01R13/422

CPC classification number: H01R13/4223 ,  H01R13/4365

Abstract: A connector assembly (100) includes a housing having a cavity (108) defined by at least one wall (170). The cavity extends between a mating end and a loading end. The housing has a terminal latch (190) associated with the cavity, and the at least one wall has a projection (180) extending into the cavity. A terminal (104) is loaded into the cavity (108) through the loading end and is held within the cavity by the terminal latch (190). The terminal (104) includes body having an opening (158), wherein the projection (180) extends at least partially into the opening (158) to secure the terminal (104) within the cavity (108).

Abstract translation: 连接器组件（100）包括具有由至少一个壁（170）限定的空腔（108）的壳体。 该空腔在配合端和装载端之间延伸。 壳体具有与空腔相关联的端子闩锁（190），并且所述至少一个壁具有延伸到空腔中的突起（180）。 端子（104）通过装载端装入空腔（108）中并通过端子闩锁（190）保持在空腔内。 端子（104）包括具有开口（158）的主体，其中突起（180）至少部分地延伸到开口（158）中以将端子（104）固定在腔体（108）内。