公开(公告)号：WO2008021927A3

公开(公告)日：2008-05-29

申请号：PCT/US2007075544

申请日：2007-08-09

Applicant: SQUIBB BRISTOL MYERS CO ,  BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  WANG GAN ,  HAMANN LAWRENCE G

Inventor： BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  WANG GAN ,  HAMANN LAWRENCE G

IPC: C07D401/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61P31/12 ,  C07D403/14

CPC classification number: C07D233/64 ,  A61K31/4178 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present disclosure relates to a compound of Formula (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）的化合物，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2006133326A1

公开(公告)日：2006-12-14

申请号：PCT/US2006/022197

申请日：2006-06-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  SERRANO-WU, Michael ,  BELEMA, Makonen ,  SNYDER, Lawrence, B. ,  MEANWELL, Nicholas ,  ST. LAURENT, Denis ,  KAKARIA, Ramesh ,  NGUYEN, Van, N. ,  QIU, Yuping ,  YANG, Xuejie ,  LEET, John, E. ,  GAO, Min ,  O'BOYLE, Donald, R., II ,  LEMM, Julie, A. ,  YANG, Fukang

Inventor： SERRANO-WU, Michael ,  BELEMA, Makonen ,  SNYDER, Lawrence, B. ,  MEANWELL, Nicholas ,  ST. LAURENT, Denis ,  KAKARIA, Ramesh ,  NGUYEN, Van, N. ,  QIU, Yuping ,  YANG, Xuejie ,  LEET, John, E. ,  GAO, Min ,  O'BOYLE, Donald, R., II ,  LEMM, Julie, A. ,  YANG, Fukang

IPC: C07D207/22 ,  C07D409/06 ,  C07D407/06 ,  C07D207/24 ,  C07D209/42 ,  A61K31/401 ,  C07D211/60 ,  C07D413/06 ,  A61K31/44 ,  C07D217/26 ,  C07D403/06 ,  A61K31/47 ,  C07D263/04 ,  C07D417/06 ,  A61K31/4015

CPC classification number: C07D207/16 ,  C07D207/22 ,  C07D207/277 ,  C07D209/42 ,  C07D211/60 ,  C07D263/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.

Abstract translation: 描述具有式I结构的化合物。 该化合物可以抑制丙型肝炎病毒（HCV）复制，特别是可以抑制HCV NS5A蛋白的功能。

公开(公告)号：WO2011075439A1

公开(公告)日：2011-06-23

申请号：PCT/US2010/060077

申请日：2010-12-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BELEMA, Makonen ,  ROMINE, Jeffrey, Lee ,  NGUYEN, Van, N. ,  WANG, Gan ,  LOPEZ, Omar, D. ,  ST. LAURENT, Denis, R. ,  CHEN, Qi ,  BENDER, John, A. ,  YANG, Zhong ,  HEWAWASAM, Piyasena ,  XU, Ningning ,  MEANWELL, Nicholas, A. ,  EASTER, John, A. ,  SU, Bao-Ning ,  SMITH, Michael, J.

Inventor： BELEMA, Makonen ,  ROMINE, Jeffrey, Lee ,  NGUYEN, Van, N. ,  WANG, Gan ,  LOPEZ, Omar, D. ,  ST. LAURENT, Denis, R. ,  CHEN, Qi ,  BENDER, John, A. ,  YANG, Zhong ,  HEWAWASAM, Piyasena ,  XU, Ningning ,  MEANWELL, Nicholas, A. ,  EASTER, John, A. ,  SU, Bao-Ning ,  SMITH, Michael, J.

IPC: C07D403/14 ,  C07D405/14

CPC classification number: C07D403/14 ,  C07D405/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2008021936A3

公开(公告)日：2008-04-17

申请号：PCT/US2007075553

申请日：2007-08-09

Applicant: SQUIBB BRISTOL MYERS CO ,  BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

Inventor： BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

IPC: A61K31/501 ,  A61K31/497 ,  A61K31/506 ,  A61P31/12

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07F7/10

Abstract: The present disclosure relates to compounds of formula (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）的化合物，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2008021928A3

公开(公告)日：2008-03-27

申请号：PCT/US2007075545

申请日：2007-08-09

Applicant: SQUIBB BRISTOL MYERS CO ,  BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

Inventor： BACHAND CAROL ,  BELEMA MAKONEN ,  DEON DANIEL H ,  GOOD ANDREW C ,  GOODRICH JASON ,  JAMES CLINT A ,  LAVOIE RICO ,  LOPEZ OMAR D ,  MARTEL ALAIN ,  MEANWELL NICHOLAS A ,  NGUYEN VAN N ,  ROMINE JEFFREY LEE ,  RUEDIGER EDWARD H ,  SNYDER LAWRENCE B ,  ST LAURENT DENIS R ,  YANG FUKANG ,  LANGLEY DAVID R ,  HAMANN LAWRENCE G

IPC: A61K31/506 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61P31/12 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D401/14 ,  C07D403/14

Abstract: The present disclosure relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein A and B are selected from phenyl and a six-membered heteroaromatic ring containing one, two or three nitrogen atoms; provided that at least one of A and B is other than phenyl, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）化合物或其药学上可接受的盐，其中A和B选自苯基和含有一个，两个或三个氮原子的六元杂芳环; 条件是A和B中的至少一个不是苯基，用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2012154777A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/037012

申请日：2012-05-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  CHEN, Qi ,  LOPEZ, Omar D. ,  BENDER, John A. ,  WANG, Gan ,  NGUYEN, Van N. ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  BELEMA, Makonen

Inventor： CHEN, Qi ,  LOPEZ, Omar D. ,  BENDER, John A. ,  WANG, Gan ,  NGUYEN, Van N. ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  BELEMA, Makonen

IPC: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/4178 ,  A61P31/12

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/5377 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection of following Fomula (I). Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗以下Fomula（I）的丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2010117635A1

公开(公告)日：2010-10-14

申请号：PCT/US2010/028456

申请日：2010-03-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BENDER, John A. ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  LOPEZ, Omar D. ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  WANG, Gan ,  XU, Ningning ,  BELEMA, Makonen

Inventor： BENDER, John A. ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  LOPEZ, Omar D. ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  WANG, Gan ,  XU, Ningning ,  BELEMA, Makonen

IPC: C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  A61K31/4178 ,  A61P31/14

CPC classification number: C07D403/04 ,  C07D403/14 ,  C07D405/14

Abstract: This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

Abstract translation: 本公开涉及如说明书中定义的式（I）新化合物和包含这些新化合物的组合物。 这些化合物是有用的抗病毒剂，特别是抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能。 因此，本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物治疗HCV相关疾病或病症的方法。

公开(公告)号：WO2008144380A1

公开(公告)日：2008-11-27

申请号：PCT/US2008/063689

申请日：2008-05-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  HAMANN, Lawrence, G. ,  JAMES, Clint, A. ,  LANGLEY, David, R. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  WANG, Gan

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel, H. ,  GOOD, Andrew, C. ,  GOODRICH, Jason ,  HAMANN, Lawrence, G. ,  JAMES, Clint, A. ,  LANGLEY, David, R. ,  LAVOIE, Rico ,  LOPEZ, Omar, D. ,  MARTEL, Alain ,  MEANWELL, Nicholas, A. ,  NGUYEN, Van, N. ,  ROMINE, Jeffrey, Lee ,  RUEDIGER, Edward, H. ,  SNYDER, Lawrence, B. ,  ST. LAURENT, Denis, R. ,  YANG, Fukang ,  WANG, Gan

IPC: C07D413/14 ,  C07D403/04 ,  C07D403/14 ,  A61K31/40 ,  A61P31/12

CPC classification number: C07D413/14 ,  C07D403/04 ,  C07D403/14

Abstract: The present disclosure relates to compounds of the following formula (I) or a pharmaceutically acceptable salt thereof, wherein A and B are each phenyl; D and E are each five-membered aromatic rings containing one, two, or three i hcteroatoms independently selected from nitrogen, oxygen, and sulfur; provided that ', at least one of D and E is other than imidazole; compositions and methods for the treatment of Hepatitis C virus (HCV) inf ection. Also disclosed are pharmaceutical compositions containing such compounds and methods f or using these compounds in the treatment of HCV inf ection.

Abstract translation: 本公开涉及下式（I）的化合物或其药学上可接受的盐，其中A和B各自为苯基; D和E分别是含有独立地选自氮，氧和硫的一个，两个或三个独立原子的五元芳环; 条件是'，D和E中的至少一个不是咪唑; 用于治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和f或使用这些化合物治疗HCV感染的方法。