公开(公告)号：WO2005115343A2

公开(公告)日：2005-12-08

申请号：PCT/EP2005005806

申请日：2005-05-30

Applicant: ABBOTT GMBH & CO KG ,  FASTNACHT KATJA ,  DEGENHARDT MATTHIAS ,  BERNDL GUNTHER ,  ROSENBERG JOERG ,  BREITENBACH JOERG

Inventor： FASTNACHT KATJA ,  DEGENHARDT MATTHIAS ,  BERNDL GUNTHER ,  ROSENBERG JOERG ,  BREITENBACH JOERG

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/20

CPC classification number: A61K9/143 ,  A61K9/146 ,  A61K9/2095

Abstract: Disclosed is a solid formulation with a matrix having at least one active ingredients homogeneously dispersed in the matrix, which is obtained by melting a powder mixture, wherein the powder mixture contains at least one thermoplastic binding agent and a combination of highly dispersed silicic acid and an inorganic pigment. The combined use of highly dispersed silicic acid and inorganic pigment provides a better flow performance of the powder mixture, causes a more rapid release of active ingredients from the formulation thus obtained and gives these formulations an optically attractive appearance. Disclosed is also a method for the production of the inventive formulation.

Abstract translation: 描述了一种固体剂型，其包含含有至少一种均匀地分散在活性化合物，它是通过熔融的粉末混合物而得到的矩阵的矩阵，所述含有至少一种热塑性粘合剂和细碎二氧化硅的组合和至少一种无机颜料的粉末混合物。 伴随使用的高度分散的硅酸和无机颜料的导致粉末混合物的更好的流动特性，从而引起活性成分从所得剂型更快速的释放，并给出了剂型的光学吸引人的外观。 描述的是也可用于制备所述剂型的方法。

公开(公告)号：WO0224184A3

公开(公告)日：2002-07-18

申请号：PCT/EP0110830

申请日：2001-09-19

Applicant: KNOLL GMBH ,  ROSENBERG JOERG ,  BREITENBACH JOERG

Inventor： ROSENBERG JOERG ,  BREITENBACH JOERG

IPC: A23L33/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K31/122

CPC classification number: A61K31/122 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/2013 ,  A61K9/2027 ,  A23V2250/314 ,  A23V2250/712 ,  A23V2250/188

Abstract: The invention relates to stable solid dosage forms for peroral administration containing, in addition to an ubiquinone, at least one thermoplastically processible matrix-forming auxiliary agent.

Abstract translation: 使用涉及稳定的固体剂型用于经口给药，包括，除了一个泛醌的至少一种热塑性加工的基质形成的佐剂。

公开(公告)号：WO0123362A3

公开(公告)日：2001-12-06

申请号：PCT/EP0009149

申请日：2000-09-19

Applicant: KNOLL AG ,  HANTKE THOMAS ,  REHBOCK BETTINA ,  ROSENBERG JOERG ,  BREITENBACH JOERG

Inventor： HANTKE THOMAS ,  REHBOCK BETTINA ,  ROSENBERG JOERG ,  BREITENBACH JOERG

IPC: C07D251/48 ,  A61K9/16 ,  A61K31/496 ,  A61K31/505 ,  A61K31/53 ,  A61K47/12 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61P31/12 ,  A61P35/00 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D251/18 ,  C07D403/12 ,  C07D405/14 ,  C07D521/00 ,  A61K9/14

CPC classification number: C07D239/48 ,  A61K9/1635 ,  A61K31/496 ,  A61K31/505 ,  A61K31/53 ,  C07D231/12 ,  C07D233/56 ,  C07D239/50 ,  C07D249/08 ,  C07D251/18 ,  C07D403/12 ,  C07D405/14

Abstract: Rate-controlled particles, comprising compounds of formula (I) as a solid dispersion.

Abstract translation: 速率受控的颗粒，包含作为固体分散体的式（I）的化合物。

公开(公告)号：WO0101956A2

公开(公告)日：2001-01-11

申请号：PCT/EP0005848

申请日：2000-06-23

Applicant: KNOLL AG ,  ROSENBERG JOERG ,  BREITENBACH JOERG ,  LIEPOLD BERND

Inventor： ROSENBERG JOERG ,  BREITENBACH JOERG ,  LIEPOLD BERND

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/26 ,  A61K31/4525 ,  A61P25/24 ,  A61K9/00

CPC classification number: A61K31/4525 ,  A61K9/1635 ,  A61K9/2027 ,  A61K9/2054

Abstract: The invention relates to solid or semi-solid preparations of paroxetine or one of the physiologically acceptable salts thereof in the form of a molecular-disperse distribution of paroxetine in a pharmaceutically acceptable matrix material.

Abstract translation: 本发明涉及帕罗西汀或其生理学可接受的盐之一的固体或半固体制剂，其形式为帕罗西汀在可药用基质材料中的分子分散分布。

公开(公告)号：WO1998010752A2

公开(公告)日：1998-03-19

申请号：PCT/EP1997004984

申请日：1997-09-11

Applicant: BASF AKTIENGESELLSCHAFT ,  BREITENBACH, Jörg ,  KLEINKE, Andreas ,  KOTHRADE, Stephan ,  ROSENBERG, Joerg

Inventor： BASF AKTIENGESELLSCHAFT

IPC: A61K09/20

CPC classification number: A61K9/2095 ,  A61K9/2027 ,  A61K9/2086

Abstract: The present invention relates to a process for producing solid dosage forms by mixing at least one polymer binder, possibly at least one active substance and possibly the usual additives, as well as products derived from this mixture, of which at least one component is added in liquid state.

Abstract translation: 本发明涉及一种用于生产通过混合至少一种聚合物粘合剂的固体剂型的方法，任选的至少一种活性成分和任选的常规添加剂，并将该混合物的整形，被使用，以液体形式的组分中的至少一种。

公开(公告)号：WO2008067164A3

公开(公告)日：2008-12-18

申请号：PCT/US2007084617

申请日：2007-11-14

Applicant: ABBOTT LAB ,  BERNDL GUNTHER ,  ROSENBERG JOERG ,  FASTNACHT KATJA ,  LIEPOLD BERND ,  BREITENBACH JOERG ,  JUNG TINA ,  ROTH WOLFGANG ,  MORRIS JOHN ,  KLEIN CHERI E ,  CAI YAN ,  ALANI LAMAN ,  GHOSH SOUMOJEET

Inventor： BERNDL GUNTHER ,  ROSENBERG JOERG ,  FASTNACHT KATJA ,  LIEPOLD BERND ,  BREITENBACH JOERG ,  JUNG TINA ,  ROTH WOLFGANG ,  MORRIS JOHN ,  KLEIN CHERI E ,  CAI YAN ,  ALANI LAMAN ,  GHOSH SOUMOJEET

IPC: A61K9/28 ,  A01N43/54 ,  A01N43/78

CPC classification number: A61K31/427 ,  A61K9/146 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2077 ,  A61K9/2095

Abstract: The present invention features solid pharmaceutical dosage formulations comprising ritonavir. As a non-limiting example, a dosage form of the present invention comprises a solid dispersion or solid solution of ritonavir in a matrix, where the matrix comprises at least one water-soluble polymer, such as copovidone, and at least one surfactant, such as polyoxyl 40 hydrogenated castor oil or macrogolglycerol hydroxystearate. Preferably, the solid dispersion or solution does not include, or includes only an insignificant amount of, PEG.

Abstract translation: 本发明的特征在于包含利托那韦的固体药物剂量制剂。 作为非限制性实例，本发明的剂型包含利托那韦在基质中的固体分散体或固体溶液，其中基质包含至少一种水溶性聚合物如共聚维酮和至少一种表面活性剂，例如 作为聚乙二醇40氢化蓖麻油或聚乙二醇甘油羟基硬脂酸酯。 优选地，固体分散体或溶液不包括或仅包含不显着量的PEG。

公开(公告)号：WO0041481A2

公开(公告)日：2000-07-20

申请号：PCT/EP0000053

申请日：2000-01-07

Applicant: KNOLL AG ,  ROSENBERG JOERG ,  NEUMANN JOERG ,  VOLLGRAF CHRISTIANE ,  REINHOLD ULRICH

Inventor： ROSENBERG JOERG ,  NEUMANN JOERG ,  VOLLGRAF CHRISTIANE ,  REINHOLD ULRICH

IPC: A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61K9/28 ,  A61K31/138 ,  A61K47/32 ,  A61P9/12

CPC classification number: A61K31/138 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095 ,  A61K9/2866

Abstract: The invention relates to a medicament form containing an active substance with a water-solubility, according to USP, ranging from 23 to 30 in a matrix that is based on acrylate polymers, whereby the medicament form can be obtained by melt extrusion.

Abstract translation: 含有根据USP 23在水中的溶解度的活性成分的剂型最多30在基于丙烯酸酯聚合物的基体，其中所述剂型是通过熔融挤出而获得。

公开(公告)号：WO9810752A3

公开(公告)日：1998-06-18

申请号：PCT/EP9704984

申请日：1997-09-11

Applicant: BASF AG ,  BREITENBACH JOERG ,  KLEINKE ANDREAS ,  KOTHRADE STEPHAN ,  ROSENBERG JOERG

Inventor： BREITENBACH JOERG ,  KLEINKE ANDREAS ,  KOTHRADE STEPHAN ,  ROSENBERG JOERG

IPC: A61J3/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22

CPC classification number: A61K9/2095 ,  A61K9/2027 ,  A61K9/2086

Abstract: The present invention relates to a process for producing solid dosage forms by mixing at least one polymer binder, possibly at least one active substance and possibly the usual additives, as well as products derived from this mixture, of which at least one component is added in liquid state. 00000

Abstract translation: 00000

公开(公告)号：WO1998023721A1

公开(公告)日：1998-06-04

申请号：PCT/EP1997006430

申请日：1997-11-18

Applicant: KNOLL AKTIENGESELLSCHAFT ,  GRÜNHAGEN, Hans-Heinrich ,  BREITENBACH, Jörg ,  ROSENBERG, Joerg

Inventor： KNOLL AKTIENGESELLSCHAFT

IPC: C11D11/00

CPC classification number: C11D17/0086 ,  C11D11/0082 ,  C11D17/06

Abstract: Method for the production of high density detergent formulations that decompose quickly in the washing bath, characterized in that the feed material mixture is subjected to a kneading and mixing process, followed by forming by calendering.

Abstract translation: 一种用于洗涤剂配方，在洗涤液体中的高密度和快速崩解的制备方法，其特征在于，所述起始材料的混合物进行捏合和混合处理，然后通过成型，然后通过压延。

公开(公告)号：WO9715293A3

公开(公告)日：1997-08-14

申请号：PCT/EP9604601

申请日：1996-10-23

Applicant: BASF AG ,  BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

Inventor： BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

CPC classification number: A61J3/10 ,  A61J2200/20 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/2893 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/616 ,  B30B11/14 ,  B30B11/16 ,  B30B11/18 ,  B30B11/34 ,  B30B15/308 ,  A61K31/19 ,  A61K2300/00

Abstract: The invention concerns a method of producing multi-layer medicaments in solid form for oral or rectal administration. At least two substances, which each comprise a thermoplastic, pharmacologically acceptable polymer binder which is soluble or can swell in a physiological environment, at least one of the substances comprising a pharmaceutical active substance, are coextruded and the coextruded multi-layer material is shaped to form the desired medicament.