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11.发明申请
公开(公告)号：WO2017005586A1
公开(公告)日：2017-01-12
申请号：PCT/EP2016/065249
申请日：2016-06-30
Applicant: ROBERT BOSCH GMBH
Inventor： MARUNIAK, Autumn , AHMAD, Habib , RAGHUNATHAN, Ashwin , JOHNSON, Christopher , KAVUSI, Sam , FOMINA, Nadezda , LANG, Christoph
IPC: G05D21/02 , G01N27/416 , G01N27/30
CPC classification number: G01N27/4167 , C12Q1/001 , G01N27/302 , G01N27/34 , G01N27/36 , G05D21/02
Abstract: Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.
Abstract translation: 用于生物传感器的装置和方法，包括测试点的多位阵列，所述装置和方法可用于通过调节（生物分子）探针或检测剂与所分析物之间的结合相互作用，通过调节附近的pH或离子梯度 这种生物传感器中的电极。 适用于改变生物缓冲液pH值的生物缓冲液中的电化学活性剂。 使用电化学活性剂改变生物缓冲液的pH的方法。 调节生物传感器中提供的结合相互作用的方法，用于更准确地控制和测量这些生物传感器中电极附近的pH或离子梯度的分析方法，以及用于更精确地测量生物样品中感兴趣分析物的分析方法。
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公开(公告)号：WO2015121206A1
公开(公告)日：2015-08-20
申请号：PCT/EP2015/052661
申请日：2015-02-09
Applicant: ROBERT BOSCH GMBH
Inventor： FUNK, Tobias , KAVUSI, Sam
IPC: G01N27/22
CPC classification number: G01N27/3274 , G01N27/226 , G01N27/228 , G01N27/3271 , G01N27/3272 , G01N27/3276
Abstract: A system and a method for detecting bubbles in an aqueous solution involve placing the solution onto a measurement area of a glass slide used for performing a life science experiment, the measurement area containing a plurality of electrodes. The slide includes a control unit that measures capacitance values associated with individual ones of the electrodes and/or pairs of the electrodes. A data processing unit receives and analyzes the measured capacitances to identify a presence and a location of a bubble in the solution. The system and the slide can optionally be used to adjust the pH level of the solution using at least some of the electrodes.
Abstract translation: 用于检测水溶液中的气泡的系统和方法包括将溶液放置在用于进行生命科学实验的玻璃载片的测量区域上，测量区域包含多个电极。 滑块包括控制单元，其测量与单独的电极和/或电极对相关联的电容值。 数据处理单元接收并分析测量的电容以识别解决方案中气泡的存在和位置。 系统和载玻片可以任选地用于使用至少一些电极来调节溶液的pH值。
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13.发明申请DEVICE AND METHOD FOR INDIRECT ELECTRONIC CONDITION CONTROL IN BIOMOLECULE DETECTION PLATFORMS 审中-公开生物分子检测平台中间接电子条件控制的装置和方法
公开(公告)号：WO2013106790A1
公开(公告)日：2013-07-18
申请号：PCT/US2013/021333
申请日：2013-01-12
Applicant: ROBERT BOSCH GMBH , CHEN, Michael , CHEN, Vincent , KAVUSI, Sam , LANG, Christoph
Inventor： CHEN, Michael , CHEN, Vincent , KAVUSI, Sam , LANG, Christoph
IPC: G01N33/543
CPC classification number: G01N33/54306 , G01N33/54366 , G01N33/54393
Abstract: A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a hydrogel composition loaded with a chemical factor at the test site, providing an actuator configured to activate the hydrogel composition to release a chemical factor at the test site, controlling the actuator to activate the hydrogel composition to release a chemical factor at the test site, and modifying the local chemical environment at the test site with the chemical factor.
Abstract translation: 在一个实施方案中间接改变测试部位的环境条件的系统和方法包括在基底上提供测试部位，在测试部位提供装载有化学因子的水凝胶组合物，提供构造成将水凝胶组合物活化的致动器 在试验现场释放化学因子，控制致动器激活水凝胶组合物以释放在试验部位的化学因子，并用化学因子改变试验部位的局部化学环境。
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公开(公告)号：WO2011143188A1
公开(公告)日：2011-11-17
申请号：PCT/US2011/035882
申请日：2011-05-10
Applicant: ROBERT BOSCH GMBH , KAVUSI, Sam , CHEN, Yi, Wei , CHEN, Michael , LANG, Christoph
Inventor： KAVUSI, Sam , CHEN, Yi, Wei , CHEN, Michael , LANG, Christoph
IPC: G01N33/543
CPC classification number: G01N33/54306 , G01N33/54366 , G01N33/54393 , Y10T436/25
Abstract: A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a first activatable stimulant at the test site, providing an actuator configured to activate the first activatable stimulant at the test site, controlling the actuator to activate the first activatable stimulant, and modifying the local chemical environment at the test site with the first activated stimulant.
Abstract translation: 在一个实施方案中间接改变测试部位环境条件的系统和方法包括在基底上提供测试部位，在测试部位提供第一可激活的刺激剂，提供构造成在测试部位激活第一可活化刺激物的致动器 控制致动器来激活第一可激活的兴奋剂，以及用第一个激活的兴奋剂改变测试部位的局部化学环境。
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公开(公告)号：WO2019032792A8
公开(公告)日：2019-02-14
申请号：PCT/US2018/045948
申请日：2018-08-09
Applicant: ROBERT BOSCH GMBH , PETKOV, Vladimir , KAVUSI, Sam , LAJEVARDI, Pedram , LANG, Christoph , NAIKAL, Nikhil
Inventor： PETKOV, Vladimir , KAVUSI, Sam , LAJEVARDI, Pedram , LANG, Christoph , NAIKAL, Nikhil
Abstract: An imaging system for low-power and low data-rate applications is provided. The imaging system comprises a pixel array having a plurality of photosensitive elements (pixels) divided into a plurality of groups of photosensitive elements (super pixels). An image processor is operably connected to the pixel array and configured to selectively operate each group of photosensitive elements in either (i) a high resolution mode in which the pixel array outputs readout voltages corresponding to all of the photosensitive elements in the respective group of photosensitive elements or (ii) a low resolution mode in which the pixel array outputs readout voltages corresponding to only a subset of the photosensitive elements in the respective group of photosensitive elements. Groups of photosensitive elements corresponding to detected motion in each image frame are operated in the high resolution mode, while the remaining groups of photosensitive elements are operated in the low resolution mode.
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Patent Agency Ranking
公开(公告)号：WO2019032792A1
公开(公告)日：2019-02-14
申请号：PCT/US2018/045948
申请日：2018-08-09
Applicant: ROBERT BOSCH GMBH , PETKOV, Vladimir , KAVUSI, Sam , LAJEVARDI, Pedram , LANG, Christoph , NAIKAL, Nikhil
Inventor： PETKOV, Vladimir , KAVUSI, Sam , LAJEVARDI, Pedram , LANG, Christoph , NAIKAL, Nikhil
Abstract: An imaging system for low-power and low data-rate applications is provided. The imaging system comprises a pixel array having a plurality of photosensitive elements (pixels) divided into a plurality of groups of photosensitive elements (super pixels). An image processor is operably connected to the pixel array and configured to selectively operate each group of photosensitive elements in either (i) a high resolution mode in which the pixel array outputs readout voltages corresponding to all of the photosensitive elements in the respective group of photosensitive elements or (ii) a low resolution mode in which the pixel array outputs readout voltages corresponding to only a subset of the photosensitive elements in the respective group of photosensitive elements. Groups of photosensitive elements corresponding to detected motion in each image frame are operated in the high resolution mode, while the remaining groups of photosensitive elements are operated in the low resolution mode.
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17.发明申请
公开(公告)号：WO2017207298A1
公开(公告)日：2017-12-07
申请号：PCT/EP2017/062083
申请日：2017-05-19
Applicant: ROBERT BOSCH GMBH
Inventor： MARUNIAK, Autumn , AHMAD, Habib , JOHNSON, Christopher , KAVUSI, Sam , FOMINA, Nadezda
IPC: C12N11/00 , C08L1/00 , C08L3/00 , C08L5/00 , C08L23/00 , C08L33/12 , C08L33/26 , C08L71/02 , C08L77/04 , C08L79/02
Abstract: A bifunctional polymer is functionalized at one end with an azlactone end group to conjugate biomolecules of interest, and is functionalized at another end with an azide anchor group to attach the polymer to a substrate. Methods of making the bifunctional polymer are also provided. A coated substrate includes the bifunctionalized polymers on the surface of a substrate. Methods of making the coated substrate are also provided. A microarray includes a plurality of discrete regions, each region including the coated substrate.
Abstract translation: 双功能聚合物在一端用吖内酯端基官能化以缀合感兴趣的生物分子，并且在另一端用叠氮基锚定基团官能化以将聚合物附着到基底上。 还提供了制备双官能聚合物的方法。 涂覆的基材包括在基材表面上的双官能化聚合物。 还提供了制造涂覆基材的方法。 微阵列包括多个分立的区域，每个区域包括涂覆的基底。
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18.发明申请
公开(公告)号：WO2017005587A1
公开(公告)日：2017-01-12
申请号：PCT/EP2016/065252
申请日：2016-06-30
Applicant: ROBERT BOSCH GMBH
Inventor： MARUNIAK, Autumn , AHMAD, Habib , RAGHUNATHAN, Ashwin , JOHNSON, Christopher , KAVUSI, Sam , FOMINA, Nadezda , LANG, Christoph
IPC: C12Q1/00 , G01N33/543 , C07C37/00
CPC classification number: C07C49/84 , C07C37/00 , C07C37/07 , C07C39/10 , C07C39/11 , C07C41/01 , C07C41/24 , C07C41/30 , C07C43/1783 , C07C43/2055 , C07C43/225 , C07C43/23 , C07C45/42 , C07C46/06 , C07C49/82 , C12Q1/001 , C12Q1/004 , G01N27/302 , G01N27/327 , G01N27/3275 , G01N27/4163 , G01N27/4167 , G01N33/5438
Abstract: Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent comprising quinone derivatives that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.
Abstract translation: 用于生物传感器的装置和方法，包括测试点的多位阵列，所述装置和方法可用于通过调节（生物分子）探针或检测剂与所分析物之间的结合相互作用，通过调节附近的pH或离子梯度 这种生物传感器中的电极。 包含适于用于改变生物缓冲液的pH的生物缓冲液中的醌衍生物的电化学活性剂。 使用电化学活性剂改变生物缓冲液的pH的方法。 调节生物传感器中提供的结合相互作用的方法，用于更准确地控制和测量这些生物传感器中电极附近的pH或离子梯度的分析方法，以及用于更精确地测量生物样品中感兴趣分析物的分析方法。
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公开(公告)号：WO2014134001A1
公开(公告)日：2014-09-04
申请号：PCT/US2014/018200
申请日：2014-02-25
Applicant: ROBERT BOSCH GMBH , LANG, Christoph , HASSIBI, Arjang , KAVUSI, Sam
Inventor： LANG, Christoph , HASSIBI, Arjang , KAVUSI, Sam
IPC: H01L21/68 , H01L23/544
CPC classification number: H01L22/12 , H01L21/68 , H01L23/544 , H01L2223/54426 , H01L2223/5448 , H01L2924/0002 , H01L2924/00
Abstract: A method of aligning a semiconductor chip includes forming a semiconductor chip with a light-activated circuit including at least one photosite, positioning the semiconductor chip relative to a device, and illuminating the positioned semiconductor chip. The method further includes generating an RF signal with an RF circuit based upon illumination of the at least one photosite, and determining the position of the photosite with respect to the device based upon the generated RF signal.
Abstract translation: 对准半导体芯片的方法包括用包括至少一个光泽的光激活电路形成半导体芯片，将半导体芯片相对于器件定位，以及照射所定位的半导体芯片。 该方法还包括基于至少一个光斑的照射产生具有RF电路的RF信号，以及基于所生成的RF信号来确定相对于器件的光电子的位置。
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20.发明申请
公开(公告)号：WO2014066353A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/066123
申请日：2013-10-22
Applicant: ROBERT BOSCH GMBH , KAVUSI, Sam , KOTZ, Frederik
Inventor： KAVUSI, Sam , KOTZ, Frederik
IPC: G01N33/50
CPC classification number: G01N33/561 , G01N33/54366
Abstract: Lateral flow immunoassay devices for determining the concentration of an analyte in a sample and methods for measuring analyte concentration in sample using such lateral flow immunoassay devices.
Abstract translation: 用于确定样品中分析物浓度的侧流免疫测定装置和使用这种侧流免疫测定装置测量样品中分析物浓度的方法。
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