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    MEDICAL DEVICE
    12.
    发明申请
    MEDICAL DEVICE 审中-公开
    医疗装置

    公开(公告)号：WO2012051278A1

    公开(公告)日：2012-04-19

    申请号：PCT/US2011/055937

    申请日：2011-10-12

    Applicant: TANIS, Kevin J. ,  ZHANG, Jin ,  ARRINGTON, Debra Ann ,  MEYERS, Kelly Ann

    Inventor： TANIS, Kevin J. ,  ZHANG, Jin ,  ARRINGTON, Debra Ann ,  MEYERS, Kelly Ann

    IPC: A61B19/00 ,  A61N7/00

    CPC classification number: A61N7/00 ,  A61B5/1172 ,  A61B34/25 ,  A61B90/90 ,  A61B2034/258 ,  A61B2090/0803 ,  A61M2205/6009 ,  A61N2007/0013 ,  A61N2007/0078 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/63

    Abstract: A medical device includes a treatment module configured to apply a treatment to a patient. The medical device includes an interface configured to operatively connect to a removable storage device storing authorization data that identifies a level of treatment authorization. The medical device includes a processing device configured to perform operations in response to receiving user input indicating a treatment should be initiated. The operations include determining whether the removable storage device is valid for use with the medical device. If the removable storage device is determined to be valid, the authorization data is accessed. The processing device determines whether the treatment is authorized based on the accessed authorization data. If the treatment is determined to be authorized, the treatment module is controlled to apply the treatment. If the treatment is determined to not be authorized, the treatment module is controlled such that the treatment is not applied.

    Abstract translation: 医疗装置包括被配置为向患者施加治疗的治疗模块。 医疗设备包括被配置为可操作地连接到存储授权数据的可移除存储设备的接口，其识别治疗授权级别。 该医疗装置包括处理装置，该处理装置被配置为响应于接收到指示应该开始治疗的用户输入而执行操作。 操作包括确定可移动存储设备是否有效用于医疗设备。 如果可移动存储设备被确定为有效，则访问授权数据。 处理装置基于所访问的授权数据确定处理是否被授权。 如果治疗被确定为授权，则治疗组件被控制以应用治疗。 如果治疗确定为不被授权，则治疗模块被控制以使得不应用治疗。

    EMISSION RATIOMETRIC INDICATORS OF PHOSPHORYLATION BY C-KINASE
    14.
    发明申请
    EMISSION RATIOMETRIC INDICATORS OF PHOSPHORYLATION BY C-KINASE 审中-公开
    通过C-激酶发射磷酸化的发射比率指标

    公开(公告)号：WO2005116267A2

    公开(公告)日：2005-12-08

    申请号：PCT/US2005/018662

    申请日：2005-05-26

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  VIOLIN, Jonathan, D. ,  NEWTON, Alexandra, C. ,  TSIEN, Roger, Y. ,  ZHANG, Jin

    Inventor： VIOLIN, Jonathan, D. ,  NEWTON, Alexandra, C. ,  TSIEN, Roger, Y. ,  ZHANG, Jin

    IPC: C12Q1/68

    CPC classification number: C12N9/1205 ,  C07K14/43595 ,  C07K2319/00 ,  C07K2319/60 ,  C12Q1/37 ,  C12Q1/42 ,  C12Q1/485 ,  G01N33/542 ,  G01N2333/43595

    Abstract: A chimeric phosphorylation indicator (CPI) as provided herein can contain a donor molecule, a phosphorylatabe domain, a phosphoaminoacid binding domain (PAABD), and an acceptor molecule. Where the phosphorylatable domain is phosphorylatable by protein kinase C (PKC), the CPI is a c-kinase activity reporter (CKAR). Donor and acceptor molecules may be, independently, fluorescent proteins such as non-oligomerizing fluorescent proteins. A CPI can contain a phosphorylatable polypeptide and a fluorescent protein; the phosphorylatable polypeptide may be contained within the sequence of the fluorescent protein, or the fluorescent protein may be contained within the sequence of the phosphorylatable polypeptide. The spatiotemporal properties of the PKC signal pathway may be tested with CKAR, calcium-sensing fluorophores and FRET-based translocation assays. Polynucleotides encoding such CPIs, and kits containing the indicators and/or the polynucleotides, are provided. A method of using the chimeric phosphorylation indicators to detect a kinase or phosphatase in a sample is provided.

    Abstract translation: 本文提供的嵌合磷酸化指示剂（CPI）可以含有供体分子，磷酰胺结构域，磷酸氨基酸结合结构域（PAABD）和受体分子。 当可磷酸化结构域由蛋白激酶C（PKC）磷酸化时，CPI是c-激酶活性报告物（CKAR）。 供体和受体分子可以独立地是荧光蛋白，例如非低聚荧光蛋白。 CPI可以含有可磷酸化的多肽和荧光蛋白; 可磷酸化多肽可以包含在荧光蛋白的序列内，或者荧光蛋白可以包含在可磷酸化多肽的序列内。 可以用CKAR，钙感应荧光团和基于FRET的易位测定来测试PKC信号通路的时空性质。 提供了编码这种CPI的多核苷酸，以及含有指示剂和/或多核苷酸的试剂盒。 提供了使用嵌合磷酸化指示剂来检测样品中的激酶或磷酸酶的方法。

    HANDLING OF DELIVERY REPORTS FOR MESSAGES HAVING A ONE-TO-MANY OR MANY-TO-ONE RELATIONSHIP
    15.
    发明申请
    HANDLING OF DELIVERY REPORTS FOR MESSAGES HAVING A ONE-TO-MANY OR MANY-TO-ONE RELATIONSHIP 审中-公开
    处理一个或多个或多个关系的信息的递送报告

    公开(公告)号：WO2010075890A1

    公开(公告)日：2010-07-08

    申请号：PCT/EP2008/068360

    申请日：2008-12-30

    Applicant: NOKIA SIEMENS NETWORKS OY ,  ZHANG, Jin ,  KAMPHUIS, Robert

    Inventor： ZHANG, Jin ,  KAMPHUIS, Robert

    IPC: H04W4/14 ,  H04L12/58 ,  H04W88/18

    CPC classification number: H04L51/30 ,  H04L51/38 ,  H04W4/14 ,  H04W88/184

    Abstract: A method for receiving a message for which a result record is generated. One or more linked result records are generated, where a linked result record comprises a link to or from the result record of the received message. Information is updated from delivery reports relating to the delivery of linked messages generated on the basis of the received message and transmitted to one or more destination nodes to the result record of the received message and to its linked result records. The method provides a simple and conservative implementation for one-to-many and many-to-one relationship between individually addressed mobile originated and mobile terminated messages and their associated reports.

    Abstract translation: 一种用于接收生成结果记录的消息的方法。 生成一个或多个链接的结果记录，其中链接的结果记录包括到达或从所接收的消息的结果记录的链接。 信息从与所接收的消息的基础上生成的链接消息的递送有关的传送报告中更新，并且被发送到一个或多个目的地节点到接收到的消息的结果记录和其链接的结果记录。 该方法为单独寻址的移动发起和移动终止的消息与其相关联的报告之间的一对多和多对一关系提供了简单和保守的实现。

    METHOD FOR IMPROVING THE IMMUNITY OF A COMPANION ANIMAL
    20.
    发明申请
    METHOD FOR IMPROVING THE IMMUNITY OF A COMPANION ANIMAL 审中-公开
    改善公民动物免疫力的方法

    公开(公告)号：WO2012061446A1

    公开(公告)日：2012-05-10

    申请号：PCT/US2011/058861

    申请日：2011-11-02

    Applicant: THE IAMS COMPANY ,  MASSIMINO, Stefan, Patrick ,  DAVENPORT, Gary, Mitchell ,  ZHANG, Jin

    Inventor： MASSIMINO, Stefan, Patrick ,  DAVENPORT, Gary, Mitchell ,  ZHANG, Jin

    IPC: A23K1/16 ,  A23K1/18

    CPC classification number: A23K50/42 ,  A23K20/163 ,  A23K50/40

    Abstract: A method of improving the immunity of a companion animal. The method can include administering to the companion animal a glucose anti-metabolite. The glucose anti-metabolite can be 2-deoxy-D-glucose; 5-thio-D-glucose; 3-O-methylglucose; 1,5-anhydro-D-glucitol; 2,5-anhydro-D-glucitol; 2,5-anhydro-D-mannitol; mannoheptulose; and mixtures and combinations thereof. The companion animal can be a dog or a cat. Improving the immunity can include altering the proliferative ability of T and B immune cells, and altering the relative distribution of immune cell phenotypes, for example.

    Abstract translation: 一种提高伴侣动物免疫力的方法。 该方法可以包括向伴侣动物施用葡萄糖抗代谢物。 葡萄糖抗代谢物可以是2-脱氧-D-葡萄糖; 5-硫代-D-葡萄糖; 3-O-甲基葡萄糖; 1,5-脱水-D-山梨醇; 2,5-脱水-D-葡萄糖醇; 2,5-脱水-D-甘露糖醇; 甘露庚酮糖; 及其混合物和组合。 伴侣动物可以是一只狗或一只猫。 提高免疫力可以包括改变T和B免疫细胞的增殖能力，并改变免疫细胞表型的相对分布。

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