公开(公告)号：WO2011022709A1

公开(公告)日：2011-02-24

申请号：PCT/US2010/046247

申请日：2010-08-20

Applicant: ARRESTO BIOSCIENCES, INC ,  MARSHALL, Derek ,  SMITH, Victoria

Inventor： MARSHALL, Derek ,  SMITH, Victoria

IPC: G01N33/00

CPC classification number: G01N33/5064 ,  G01N33/5026 ,  G01N2333/906

Abstract: Disclosed herein are methods for identifying inhibitors of the catalytic activity of LOXL2 using in vitro assays. In certain embodiments, inhibitors identified by these in vitro assays are effective in inhibiting tumor desmoplasia and fibrosis.

Abstract translation: 本文公开了使用体外测定来鉴定LOXL2的催化活性的抑制剂的方法。 在某些实施方案中，通过这些体外测定法鉴定的抑制剂有效抑制肿瘤发育不全和纤维化。

公开(公告)号：WO2010132890A1

公开(公告)日：2010-11-18

申请号：PCT/US2010/035152

申请日：2010-05-17

Applicant: SRU BIOSYSTEMS, INC ,  SHAMAH, Steven ,  LAING, Lance, G. ,  YUZHAKOV, Alexander ,  WAGNER, Rick ,  ABODEELY, Marla ,  ROCKNEY, Bennet ,  SCHULZ, Stephen, C. ,  PADALIA, Zinkal ,  GETMAN, Michael ,  SANDBERG, Eric

Inventor： SHAMAH, Steven ,  LAING, Lance, G. ,  YUZHAKOV, Alexander ,  WAGNER, Rick ,  ABODEELY, Marla ,  ROCKNEY, Bennet ,  SCHULZ, Stephen, C. ,  PADALIA, Zinkal ,  GETMAN, Michael ,  SANDBERG, Eric

IPC: G01N33/543 ,  G01N33/566 ,  G01N33/50

CPC classification number: G01N33/54373 ,  G01N21/7743 ,  G01N33/5044 ,  G01N33/5064 ,  G01N33/5073

Abstract: The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.

Abstract translation: 本发明提供了无标记检测细胞群体和混合细胞群体变化的方法。

公开(公告)号：WO2010105285A1

公开(公告)日：2010-09-23

申请号：PCT/AU2010/000251

申请日：2010-03-08

Applicant: THE HEART RESEARCH INSTITUTE ,  TSO, Colin

Inventor： TSO, Colin

IPC: C12N5/0786 ,  C12N5/071

CPC classification number: C12N5/069 ,  C12N2502/28 ,  C12N2506/11 ,  G01N33/5008 ,  G01N33/5064 ,  G01N2800/323 ,  G01N2800/50 ,  G01N2800/52

Abstract: The present invention provides a method of producing non-haematopoietic cells, in particular cells having one or more properties of endothelial cells, from monocytes. A range of diagnostic and prognostic assay methods for determining whether or not a subject has atherosclerosis or vascular complication associated therewith, or a predisposition for developing atherosclerosis or complication associated therewith employing this method are provided. A range of screens to identify and isolate compositions of matter that modulate the ability of monocytes to differentiate into such non-haematopoietic cells and/or that modulate the ability of such non-haematopoietic cells to become incorporated into endothelium e.g., vascular endothelium, are also provided.

Abstract translation: 本发明提供从单核细胞产生非造血细胞，特别是具有一种或多种内皮细胞特性的细胞的方法。 提供了一系列用于确定受试者是否具有动脉粥样硬化或与其相关的血管并发症的诊断和预后测定方法，或者用于发展动脉粥样硬化或伴随其使用该并发症的并发症的倾向。 用于鉴定和分离调节单核细胞分化成这种非造血细胞的能力和/或调节这种非造血细胞变得并入内皮例如血管内皮的能力的物质组合的范围也是 提供。

公开(公告)号：WO2010079230A1

公开(公告)日：2010-07-15

申请号：PCT/EP2010/050233

申请日：2010-01-11

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  CENTRE LEON BERARD ,  ENS - ECOLE NORMALE SUPERIEURE DE LYON ,  MEHLEN, Patrick, Etienne, Roger ,  BERNET, Agnès, Christine ,  DELLOYE, Céline, Jacqueline, Andrée ,  CASTETS-MESTRALLET, Marie, Anne-Sophie, Emmanuelle

Inventor： MEHLEN, Patrick, Etienne, Roger ,  BERNET, Agnès, Christine ,  DELLOYE, Céline, Jacqueline, Andrée ,  CASTETS-MESTRALLET, Marie, Anne-Sophie, Emmanuelle

IPC: C07K14/475 ,  G01N33/50

CPC classification number: C07K14/475 ,  G01N33/5017 ,  G01N33/5064 ,  G01N2333/4703 ,  G01N2500/10

Abstract: The present invention relates to an in vitro method for selecting a compound capable to induce the death of endothelial cells, preferably endothelial cells from vessels or neovessels. The invention further comprises the use of netrin-1 function inhibitors as compounds capable to induce the death of endothelial cells, preferably endothelial cells from vessels or neovessels of tumor expressing netrin-1. Finally, the invention relates to a kit for the selection of a compound capable to induce the death of endothelial cells.

Abstract translation: 本发明涉及用于选择能够诱导内皮细胞（优选来自血管或新血管内皮细胞）死亡的化合物的体外方法。 本发明还包括使用netrin-1功能抑制剂作为能够诱导内皮细胞死亡的化合物，优选来自表达netrin-1的肿瘤的血管或新血管的内皮细胞。 最后，本发明涉及用于选择能够诱导内皮细胞死亡的化合物的试剂盒。

公开(公告)号：WO2009155669A1

公开(公告)日：2009-12-30

申请号：PCT/AU2009/000840

申请日：2009-06-29

Applicant: THE HEART RESEARCH INSTITUTE LTD ,  NG, Martin Kean Chong ,  DUNN, Louise Lorraine ,  BUCKLE, Andrew

Inventor： NG, Martin Kean Chong ,  DUNN, Louise Lorraine ,  BUCKLE, Andrew

IPC: C12Q1/26 ,  A61P3/10 ,  A61P9/00 ,  A61K39/00 ,  A61K38/00 ,  A61K48/00 ,  G01N33/53

CPC classification number: C12N15/113 ,  A61K31/7088 ,  A61K35/44 ,  A61K38/00 ,  A61K39/3955 ,  C12N2310/14 ,  C12N2320/30 ,  G01N33/5064 ,  G01N33/6893 ,  G01N2800/042 ,  G01N2800/32

Abstract: The present invention provides methods for the prevention or treatment of one or more vascular complication(s) in a subject at risk of developing diabetes mellitus, impaired glucose tolerance and/or hyperglycemia or a subject suffering from diabetes mellitus, impaired glucose tolerance and/or hyperglycemia, wherein an amount of a composition effective to inhibit, repress, delay or otherwise reduce expression and/or activity and/or level of TXNIP and/or an amount of a composition effective to induce, enhance or otherwise increase expression and/or activity and/or level of TRX is/are administered to a subject in need thereof. The present invention also provides methods for identifying and isolating modulators of TXNIP expression and/or activity and/or level and/or TRX expression and/or activity and/or level for use in such therapeutic and prophylactic methods.

Abstract translation: 本发明提供了用于预防或治疗患有糖尿病，葡萄糖耐量异常和/或高血糖风险的患者中的一种或多种血管并发症的方法或患有糖尿病，葡萄糖耐量异常和/或 高血糖症，其中有效抑制，抑制，延迟或以其他方式降低TXNIP的表达和/或活性和/或水平的组合物的量和/或有效诱导，增强或以其它方式增加表达和/或活性的组合物的量 和/或TRX的水平被施用给有需要的受试者。 本发明还提供了用于鉴定和分离用于这种治疗和预防方法的TXNIP表达和/或活性和/或水平和/或TRX表达和/或活性和/或水平的调节剂的方法。

公开(公告)号：WO2009085209A3

公开(公告)日：2009-12-17

申请号：PCT/US2008013899

申请日：2008-12-19

Applicant: VASGENE THERAPEUTICS INC ,  GILL PARKASH ,  LIU REN ,  KRASNOPEROV VALERY

Inventor： GILL PARKASH ,  LIU REN ,  KRASNOPEROV VALERY

IPC: A61K39/395 ,  A61P35/00 ,  C07K16/22

CPC classification number: C07K16/22 ,  A61K38/177 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/30 ,  G01N33/5011 ,  G01N33/5064 ,  A61K2300/00

Abstract: In certain embodiments, this present invention provides methods of identifying and using agonists and antagonists of Delta-like 4 (Dll4) signaling.

Abstract translation: 在某些实施方案中，本发明提供了鉴定和使用Delta样4（Dll4）信号传导的激动剂和拮抗剂的方法。

公开(公告)号：WO2009051410A3

公开(公告)日：2009-07-09

申请号：PCT/KR2008006089

申请日：2008-10-15

Applicant: SEOUL NAT UNIV IND FOUNDATION ,  MOOK-JUNG INHEE ,  SON SUNGMIN

Inventor： MOOK-JUNG INHEE ,  SON SUNGMIN

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N33/502 ,  G01N33/5064 ,  G01N2500/00 ,  G01N2800/2821

Abstract: Provided are a system and a method of screening for RAGE- amyloid beta peptide interaction inhibiting materials using a Transwell plate and a RAGE-expressing cell line.

Abstract translation: 提供了使用Transwell板和RAGE表达细胞系筛选RAGE-淀粉状蛋白β肽相互作用抑制材料的系统和方法。

公开(公告)号：WO2006078814A3

公开(公告)日：2009-04-09

申请号：PCT/US2006001893

申请日：2006-01-19

Applicant: UNIV CALIFORNIA ,  FLAIM CHRISTOPHER ,  EDDINGTON DAVID ,  BHATIA SANGEETA N

Inventor： FLAIM CHRISTOPHER ,  EDDINGTON DAVID ,  BHATIA SANGEETA N

IPC: G01N33/558 ,  C12M1/34 ,  C12M3/00 ,  C23C14/30

CPC classification number: G01N33/5023 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00367 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00432 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00691 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01J2219/00743 ,  B01L3/5027 ,  B01L3/5085 ,  B01L2300/0636 ,  B01L2300/0829 ,  B82Y30/00 ,  C12M25/14 ,  C12M41/46 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5032 ,  G01N33/5064 ,  G01N33/5067 ,  G01N33/507

Abstract: Provided is a microarray platform for the culture of cells atop combinatorial matrix mixtures; enabling the study of differentiation in response to a multitude of microenvironments in parallel.

Abstract translation: 提供了用于组合基质混合物上的细胞培养的微阵列平台; 使得能够并行地响应多种微环境的分化研究。

公开(公告)号：WO2008085518A2

公开(公告)日：2008-07-17

申请号：PCT/US2007060290

申请日：2007-01-09

Applicant: PHYLONIX PHARMACEUTICALS INC ,  SENG WEN LIN ,  SERBEDZIJA GEORGE ,  MCGRATH PATRICIA

Inventor： SENG WEN LIN ,  SERBEDZIJA GEORGE ,  MCGRATH PATRICIA

IPC: A01K67/027 ,  G01N33/53

CPC classification number: G01N33/5082 ,  A01K67/027 ,  A01K2227/40 ,  A01K2267/00 ,  C07K16/18 ,  G01N33/5064 ,  G01N33/6854 ,  G01N2500/00 ,  G01N2800/32

Abstract: Disclosed are methods for producing organ-, tissue-, or cell-specific antibodies, antibodies against developmentally regulated antigens, antibodies against disease-associated antigens, and antibodies against antigens that are modulated during a physiological response to an agent (e.g., in response to a drug). Also disclosed are methods for screening an agent for activity in modulating angiogenesis, as well as antibodies specific for angiogenic vessels.

Abstract translation: 公开了用于产生器官，组织或细胞特异性抗体的方法，抗发育调节抗原的抗体，抗疾病相关抗原的抗体和针对在对试剂的生理反应期间调节的抗原的抗体（例如响应于 一种药物）。 还公开了用于筛选在调节血管生成中的活性的药剂以及对血管生成血管特异性的抗体的方法。

公开(公告)号：WO2008047370A3

公开(公告)日：2008-06-19

申请号：PCT/IL2007001256

申请日：2007-10-18

Applicant: UNIV RAMOT ,  HARDY BRITTA ,  BATTLER ALEXANDER ,  RAITER ANNAT ,  WEISS CHANA

Inventor： HARDY BRITTA ,  BATTLER ALEXANDER ,  RAITER ANNAT ,  WEISS CHANA

IPC: C07K7/06 ,  C07K7/08 ,  G01N33/68

CPC classification number: C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/47 ,  G01N33/5064 ,  G01N2333/96486

Abstract: An isolated peptide comprising an amino acid sequence HWRR as set forth by SEQ ID NO:5, the peptide consists of 4 or 5 amino acids, is provided. Also provided are methods of treating angiogenesis-related pathologies using the peptide of the invention or pharmaceutical compositions comprising same.

Abstract translation: 包含由SEQ ID NO：5所示的氨基酸序列HWRR的分离肽，肽由4或5个氨基酸组成。 还提供了使用本发明的肽或包含其的药物组合物治疗血管生成相关病理学的方法。