公开(公告)号：WO2020165345A1

公开(公告)日：2020-08-20

申请号：PCT/EP2020/053761

申请日：2020-02-13

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITÉ DE STRASBOURG

Inventor： BORNERT, Fabien ,  HUCK, Olivier ,  OFFNER, Damien ,  IDOUX-GILLET, Ysia ,  CLAUSS, François ,  BENKIRANE-JESSEL, Nadia

IPC: A61L27/12 ,  A61L27/34 ,  A61L27/46 ,  A61L27/54 ,  A61L27/38

Abstract: The present invention concerns a biomaterial comprising a scaffold containing a mineral component, wherein said mineral component comprises at least one calcium phosphate compound, and wherein said scaffold has a surface coated with an interrupted coating made of multilayered droplets, said multilayered droplets being droplets composed of at least one layer pair consisting of a layer of polyanions and a layer of polycations.

公开(公告)号：WO2020148402A1

公开(公告)日：2020-07-23

申请号：PCT/EP2020/051055

申请日：2020-01-16

Applicant: TROPHY ,  CARESTREAM DENTAL LLC ,  UNIVERSITE DE TOURS ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS

Inventor： CAPRI, Arnaud ,  ROUDERGUES, David ,  INGLÈSE, Jean-Marc ,  JOSSO, Hervé ,  SHELLARD, Edward ,  CHEVALLIOT, Stéphanie ,  GRÉGOIRE, Jean-Marc ,  OSSANT, Frédéric ,  BANQUART, Aline

IPC: A61B8/08 ,  A61B8/12 ,  A61C9/00 ,  A61B8/00

Abstract: At least one embodiment of an ultrasonic periodontal probe, the ultrasonic periodontal probe comprising a grip portion having a longitudinal axis, a support member comprising a part having a longitudinal axis different from the longitudinal axis of the grip portion, and an ultrasonic device fastened to the grip portion via the support member, wherein the ultrasonic device is configured for emitting ultrasound signals within at least two emitting cones and for receiving corresponding echoed ultrasound signals, the at least two emitting cones extending in opposite directions with regard to a plane comprising the longitudinal axis of the grip portion.

公开(公告)号：WO2020144366A1

公开(公告)日：2020-07-16

申请号：PCT/EP2020/050602

申请日：2020-01-10

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE DE PARIS ,  CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  UNIVERSITE DE NANTES

Inventor： ANGLICHEAU, Dany ,  CHARREAU, Béatrice

IPC: G01N33/564 ,  G01N33/68 ,  G01N33/50

Abstract: The present invention relates to the field of organ transplant and the issues associated with transplant rejection. Antibody-mediated rejection (AMR) is associated with a poor transplant outcome. Pathogenic alloantibodies are usually directed against human leucocyte antigens (HLAs). However, evidence of AMR in the absence of anti-HLA antibodies suggests the presence of non-anti-HLA antibodies, identified as anti-endothelial cell antibodies (AECAs). The inventors have demonstrated that kidney recipients who experienced acute rejection with microvascular inflammation within the first 3 months after transplantation in the absence of anti-HLA donor-specific antibodies, carried, before transplantation, unknown AECAs in their sera that specifically targeted the glomerular microvascular endothelium. Thus, the present invention relates to in vitro methods and kits for determining the likelihood of occurrence of an acute microvascular rejection (AMVR) against a renal allograft in an individual.

公开(公告)号：WO2020120910A1

公开(公告)日：2020-06-18

申请号：PCT/FR2019/053036

申请日：2019-12-12

Applicant: UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE LAVAL ,  TRANSGENE ,  ECOLE NORMALE SUPERIEURE DE LYON

Inventor： ROSA-CALATRAVA, Manuel ,  BOIVIN, Guy ,  DUBOIS, Julia ,  PIZZORNO, Mario Andres ,  TERRIER, Olivier ,  TRAVERSIER, Aurélien

IPC: A61K39/12 ,  A61P31/14 ,  C12N7/04

Abstract: La présente invention concerne l'utilisation de la lignée cellulaire immortalisée ECACC 09070703, déposée le 7 juillet 2009 auprès de l'European Collection of Cell Cultures (ECACC, Salisbury, Royaume Uni) sous le numéro 09070703, pour la production d'un vaccin viral constitué parune souche atténuée dérivée d'un metapneumovirus humain. Figure pour l'abrégé : NON

公开(公告)号：WO2020025891A1

公开(公告)日：2020-02-06

申请号：PCT/FR2019/051867

申请日：2019-07-29

Applicant: ETABLISSEMENT FRANCAIS DU SANG ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE DE STRASBOURG

Inventor： MAITRE, Blandine ,  ANGENIEUX, Catherine ,  DE LA SALLE, Henri ,  GACHET, Christian

IPC: G01N15/14 ,  G01N21/64 ,  G01N15/10 ,  G01N33/50 ,  G01N33/86 ,  G01N21/47

Abstract: La présente invention est relative à un procédé pour analyser les plaquettes présentes dans un échantillon sanguin, ledit procédé comprend les étapes de (a) ajouter audit échantillon un ligand qui se lie au CMH I couplé à un fluorochrome, (b) mesurer l'intensité de fluorescence moyenne des plaquettes (MFI piaquettes ) avec un cytomètre en flux et c) mesurer le paramètre « Forward Scatter » moyen (FSC) avec ledit cytomètre en flux et déterminer le ratio MFI piaquettes / FSC. L'invention concerne également un procédé de diagnostic in vitro d'une thrombopénie périphérique ou centrale chez un sujet.

公开(公告)号：WO2020016192A1

公开(公告)日：2020-01-23

申请号：PCT/EP2019/069042

申请日：2019-07-15

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITÉ CLAUDE BERNARD LYON 1 ,  CENTRE LÉON-BÉRARD

Inventor： SUN, Zhishen ,  CATHELINE, Stefan

IPC: A61B8/08 ,  A61B5/00 ,  A61B5/05 ,  A61B5/053 ,  A61B5/055 ,  G01R33/563

Abstract: The present invention relates to the field of acoustic imaging of soft materials, such as shear wave elastography. A method for generating shear waves in a soft material includes placing at least one patch including a metallic material along and in contact with an external boundary of a soft material, and applying a variable magnetic field on the patch using an electromagnet, in order to generate eddy currents circulating inside each metal strip and a Lorentz force imparting an oscillation movement of the patch.

公开(公告)号：WO2019243272A1

公开(公告)日：2019-12-26

申请号：PCT/EP2019/065911

申请日：2019-06-17

Applicant: COLLEGE DE FRANCE ,  ECOLE NORMALE SUPERIEURE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  SORBONNE UNIVERSITE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Inventor： MALLET, Jean-Maurice ,  LAVIELLE, Solange ,  MARQUANT, Rodrigue ,  PROCHIANTZ, Alain ,  DI NARDO, Ariel ,  TESTA, Damien

IPC: C07K7/08 ,  C07K14/00 ,  C07K14/47 ,  A61K38/04

Abstract: The invention relates to new compounds that mimic Glycosaminoglycans and are able to control interaction between Glycosaminoglycans with their effector molecules. The compounds of the invention are peptides and are able to prevent or reduce the binding of at least one effector molecule with at least one glycosaminoglycan. The compounds according to the invention can be used as drug, in particular for the stimulation of the neurogenesis and more generally to treat nervous system related pathologies.

公开(公告)号：WO2019175415A1

公开(公告)日：2019-09-19

申请号：PCT/EP2019/056605

申请日：2019-03-15

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  ECOLE NORMALE SUPERIEURE DE LYON ,  UNIVERSITÉ CLAUDE BERNARD LYON 1 ,  UNIVERSITE PARIS DESCARTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： MARGOTTIN-GOGUET, Florence ,  CHOUGUI, Line Ghina ,  ETIENNE, Lucie ,  MUNIR-MATLOOB, Soundasse

IPC: C07K14/155 ,  A61K38/00 ,  C12N15/86

Abstract: The present invention relates to the treatment of latent virus infections and improvement of transgene expression. Using Virus-like Particles (VLPs) containing Vpx in an in vitro HIV-1 latent model, the Inventors evidenced an unexpected capacity of Vpx to reactivate latent proviruses through TASOR binding and subsequent degradation, in a way that is independent from SAMHD1. Besides, the Vpx protein strikingly enhanced viral expression following transduction of a transgene placed under the control of a cytomegalovirus (CMV) promoter in a HIV-1- derived vector or a SIVmac-derived vector. The present invention thus relates to a Vpx protein and/or nucleic acid encoding thereof for use as a medicament, particularly for reactivating a latent virus and/or improving expression of a transgene, for example in the context of gene therapy. The Vpx protein is preferably provided in the form of VLPs. The present invention also relates to the use of a Vpx protein as a transgene activator.

公开(公告)号：WO2019134975A1

公开(公告)日：2019-07-11

申请号：PCT/EP2019/050175

申请日：2019-01-04

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE DE NICE SOPHIA ANTIPOLIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  CENTRE HOSPITALIER UNIVERSITAIRE DE NICE

Inventor： PASSERON, Thierry ,  BENHIDA, Rachid ,  DAO, Pascal ,  DE DONATIS, Gian Marco ,  MARTIN, Anthony

IPC: C07D215/44 ,  A61K31/4706 ,  A61P35/00

CPC classification number: C07D215/44

Abstract: The present invention relates to a compound of general formula (I), wherein R 1 is OCH 2 CH 2 OCH 3 or OCH 3 , R' 1 is H or OH, R 2 is Cl, F, Br or I, with the proviso that when: R 1 is OCH 2 CH 2 OCH 3 then R' 1 is H, R 1 is OCH 3 then R' 1 is OH, its pharmaceutically acceptable salts and/or optical isomers, tautomers, solvates or isotopic variations thereof. The invention also relates to said compounds for use in the treatment of cancer, namely solid tumor cancer, and preferably those selected from melanoma, colon, lung, pancreas, kidney, Merkel carcinoma, squamous cell carcinoma, prostate, breast and bladder. The invention also relates to a pharmaceutical composition comprising said compounds.

公开(公告)号：WO2019122357A1

公开(公告)日：2019-06-27

申请号：PCT/EP2018/086648

申请日：2018-12-21

Applicant: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  UNIVERSITE PARIS-SUD

Inventor： CHENEGROS, Guillaume ,  LIBERT, Nicolas ,  CORDURIE, Gilles ,  BENOSMAN, Ryad ,  DURANTEAU, Jacques ,  HARROIS, Anatole ,  VICAUT, Eric

IPC: A61B5/021 ,  A61B5/029 ,  A61M5/142

CPC classification number: A61B5/029 ,  A61B5/02028 ,  A61B5/021 ,  A61B5/0245 ,  A61B5/0295 ,  A61B5/14542 ,  A61B5/4833 ,  A61B5/4839 ,  A61B5/4848 ,  A61M5/1407 ,  A61M5/142 ,  A61M5/16827 ,  A61M5/16877 ,  A61M5/1723 ,  A61M2005/14292 ,  A61M2230/30

Abstract: L'invention concerne un dispositif (5) de détermination des quantités de liquide de remplissage et de vasopresseur destinés à être administrés à un patient au moyen respectivement d'un premier distributeur (3) et d'un second distributeur (4), caractérisé en ce que le dispositif (5) est configuré pour, à partir d'une pression artérielle préalablement mesurée sur un patient, déterminer une quantité de liquide de remplissage et une quantité de vasopresseur telles que lesdites quantités sont fonctions du ratio entre des quantités de liquide de remplissage et de vasopresseur déjà administrées sur une période donnée.