公开(公告)号：WO2010093627A2

公开(公告)日：2010-08-19

申请号：PCT/US2010/023625

申请日：2010-02-09

Applicant: CENTOCOR ORTHO BIOTECH INC. ,  JACOBS, Steven ,  O'NEIL, Karyn

Inventor： JACOBS, Steven ,  O'NEIL, Karyn

IPC: A61K9/00 ,  C07K14/78 ,  C40B50/00 ,  C07H21/00 ,  C12N15/74 ,  C40B40/10 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  A61K38/14 ,  A61P35/00 ,  A61P9/10 ,  A61P25/00 ,  A61P11/00

CPC classification number: C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C40B40/08 ,  C40B50/06

Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG bassed on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.

Abstract translation: 基于来自人纤连蛋白的第十纤维连接蛋白III型（FN3）重复共有序列的蛋白质支架，包括编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备和使用的方法具有诊断和/ 或治疗组合物，方法和装置。 特别地，已经鉴定了结合到共有序列上的IgG结合的蛋白质支架分子对于诊断和/或治疗应用是有用的。

公开(公告)号：WO2010051274A2

公开(公告)日：2010-05-06

申请号：PCT/US2009/062200

申请日：2009-10-27

Applicant: CENTOCOR ORTHO BIOTECH INC. ,  JACOBS, Steven ,  O'NEIL, Karyn

Inventor： JACOBS, Steven ,  O'NEIL, Karyn

IPC: C40B30/04 ,  C07K7/06 ,  C07K14/00 ,  C07H21/04

CPC classification number: C07K14/78 ,  C40B40/08 ,  C40B50/06

Abstract: A protein scaffold based on a consensus sequence of fϊbronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fϊbronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.

Abstract translation: 基于fβ型支链淀粉III型（FN3）蛋白的共有序列的蛋白质支架，例如来自人f？bronectin（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞， 其制备和使用方法具有在诊断和/或治疗组合物，方法和装置中的应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。

公开(公告)号：WO2009086116A3

公开(公告)日：2009-10-08

申请号：PCT/US2008087696

申请日：2008-12-19

Applicant: CENTOCOR INC ,  JACOBS STEVEN

Inventor： JACOBS STEVEN

IPC: C12N15/00

CPC classification number: C40B40/02 ,  C12N15/1037 ,  C12N15/1044

Abstract: The invention relates to compositions and methods for generating and using plX phage display libraries for producing non-antibody scaffold protein fusions using plX of M13 phage.

Abstract translation: 本发明涉及用于产生和使用plX噬菌体展示文库用于使用M13噬菌体的plX产生非抗体支架蛋白融合物的组合物和方法。

公开(公告)号：WO2009086116A2

公开(公告)日：2009-07-09

申请号：PCT/US2008/087696

申请日：2008-12-19

Applicant: CENTOCOR, INC. ,  JACOBS, Steven

Inventor： JACOBS, Steven

IPC: C40B40/02

CPC classification number: C40B40/02 ,  C12N15/1037 ,  C12N15/1044

Abstract: The invention relates to compositions and methods for generating and using plX phage display libraries for producing non-antibody scaffold protein fusions using plX of M13 phage.

Abstract translation: 本发明涉及用于产生和使用用于使用M13噬菌体的pIX产生非抗体支架蛋白融合物的pIX噬菌体展示文库的组合物和方法。

公开(公告)号：WO2009009136A3

公开(公告)日：2009-03-05

申请号：PCT/US2008008546

申请日：2008-07-11

Applicant: LEEDS MARSHALL T ,  JACOBS STEVEN C ,  CAMACHO SUSAN M

Inventor： LEEDS MARSHALL T ,  JACOBS STEVEN C ,  CAMACHO SUSAN M

IPC: G08B23/00 ,  G08B7/00

CPC classification number: G11B33/06 ,  A63H3/28 ,  A63H2200/00

Abstract: A method and apparatus allow for remotely playing back recorded personalized and non-personalized audio messages to a listener. A first recorded message, which has been personalized for an intended listener, is stored in a first memory of an audio player. A second recorded message, which has not been personalized for an intended listener, is stored in a second memory of the audio player. Responsive to receiving a control command from a remote control device, the audio player plays the messages according to a predetermined arrangement, such as in a predetermined order or at predetermined intervals (e.g., the personalized message may be played a number of times before the non-personalized message is played). In one embodiment, the personalized message contains audio intended to be a calming and/or instructional influence on a small child. In another embodiment, the non- personalized message may include information associated with a sponsoring business.

Abstract translation: 一种方法和装置允许向收听者远程回放记录的个性化和非个性化音频消息。 已经为预期的收听者个性化的第一录制的消息被存储在音频播放器的第一存储器中。 没有针对预期听众进行个性化的第二录制消息被存储在音频播放器的第二存储器中。 响应于从遥控设备接收到控制命令，音频播放器根据预定布置播放消息，诸如以预定顺序或以预定间隔播放消息（例如，个性化消息可在非消息之前播放多次 - 个性化的消息被播放）。 在一个实施例中，个性化消息包含意图成为对小孩的平静和/或教学影响的音频。 在另一个实施例中，非个性化消息可以包括与赞助商相关联的信息。

公开(公告)号：WO2009009136A2

公开(公告)日：2009-01-15

申请号：PCT/US2008/008546

申请日：2008-07-11

Applicant: LEEDS, Marshall, T. ,  JACOBS, Steven, C. ,  CAMACHO, Susan, M.

Inventor： LEEDS, Marshall, T. ,  JACOBS, Steven, C. ,  CAMACHO, Susan, M.

IPC: G08B23/00 ,  G08B7/00

CPC classification number: G11B33/06 ,  A63H3/28 ,  A63H2200/00

Abstract: A method and apparatus allow for remotely playing back recorded personalized and non-personalized audio messages to a listener. A first recorded message, which has been personalized for an intended listener, is stored in a first memory of an audio player. A second recorded message, which has not been personalized for an intended listener, is stored in a second memory of the audio player. Responsive to receiving a control command from a remote control device, the audio player plays the messages according to a predetermined arrangement, such as in a predetermined order or at predetermined intervals (e.g., the personalized message may be played a number of times before the non-personalized message is played). In one embodiment, the personalized message contains audio intended to be a calming and/or instructional influence on a small child. In another embodiment, the non- personalized message may include information associated with a sponsoring business.

Abstract translation: 一种方法和装置允许将记录的个性化和非个性化音频消息远程回放到收听者。 已经为预期收听者个性化的第一记录消息被存储在音频播放器的第一存储器中。 尚未为预期收听者个性化的第二记录消息被存储在音频播放器的第二存储器中。 响应于从遥控设备接收控制命令，音频播放器按照预定的布置（例如以预定的顺序或以预定的间隔播放消息）（例如，个性化消息可以在非 - 个人化消息播放）。 在一个实施例中，个性化消息包含旨在对小孩子进行平静和/或教学影响的音频。 在另一个实施例中，非个性化消息可以包括与赞助业务相关联的信息。

公开(公告)号：WO2011137319A3

公开(公告)日：2012-01-19

申请号：PCT/US2011034512

申请日：2011-04-29

Applicant: CENTOCOR ORTHO BIOTECH INC ,  JACOBS STEVEN

Inventor： JACOBS STEVEN

IPC: A61K49/00 ,  A61K38/16 ,  A61K38/22 ,  A61P1/00 ,  A61P7/00 ,  A61P9/00 ,  A61P11/00 ,  A61P11/02 ,  A61P25/00 ,  A61P27/02 ,  A61P27/16 ,  A61P31/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07H21/00 ,  C07K14/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/63 ,  C40B30/04 ,  C40B40/02 ,  C40B40/08 ,  C40B50/00

CPC classification number: C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C07K16/18 ,  C07K2318/20

Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof. The protein scaffold molecules of the present invention exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract translation: 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并使用它们。 本发明的蛋白质支架分子表现出增强的热和化学稳定性，同时呈现六个可修饰的环结构域，其可被工程化以形成能够与诊断和/或治疗组合物，方法和装置中的应用结合的靶标的结合配偶体。

公开(公告)号：WO2009094331A1

公开(公告)日：2009-07-30

申请号：PCT/US2009/031433

申请日：2009-01-20

Applicant: CENTOCOR_ORTHO BIOTECH INC. ,  O'NEIL, Karen ,  JACOBS, Steven ,  WU, Sheng-Jiun ,  BETHEA, Deirdra ,  FEND, Yiqing

Inventor： O'NEIL, Karen ,  JACOBS, Steven ,  WU, Sheng-Jiun ,  BETHEA, Deirdra ,  FEND, Yiqing

IPC: G01N33/537

CPC classification number: G01N33/6854 ,  B01D15/3809

Abstract: The invention provides methods for testing and ranking therapeutic antibody candidates for biophysical properties related to solubility and the susceptibility of the antibody to aggregate in aqueous solutions. The methods are useful for selecting among antibody libraries or variants for candidates which can be formulated at high concentrations.

Abstract translation: 本发明提供了用于测试和评估与溶解度相关的生物物理性质的治疗性抗体候选物和抗体在水溶液中聚集的易感性的方法。 该方法可用于在可以以高浓度配制的候选物之间选择抗体文库或变体。

公开(公告)号：WO2006096455A1

公开(公告)日：2006-09-14

申请号：PCT/US2006/007437

申请日：2006-03-02

Applicant: OMNIGUIDE, INC. ,  GOELL, James ,  JACOBS, Steven A. ,  WANG, Tairan ,  SOLJACIC, Marin ,  ULU, Gokhan ,  TEMELKURAN, Burak ,  JOHNSON, Steven G.

Inventor： GOELL, James ,  JACOBS, Steven A. ,  WANG, Tairan ,  SOLJACIC, Marin ,  ULU, Gokhan ,  TEMELKURAN, Burak ,  JOHNSON, Steven G.

IPC: G02B6/02 ,  G02B6/036

CPC classification number: G02B6/02304 ,  A61B1/018 ,  A61B18/201 ,  A61B18/22 ,  A61B2018/2272 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00821 ,  A61F9/00825 ,  A61F2009/00863 ,  A61F2009/00891 ,  C03B2201/86 ,  C03B2203/12 ,  C03B2203/14 ,  C03B2203/16 ,  C03B2203/18 ,  C03B2203/42 ,  G02B6/023 ,  G02B6/02385 ,  G02B6/03622 ,  G02B6/03638 ,  G02B6/03694 ,  Y02P40/57

Abstract: In general, in a first aspect, the invention features photonic crystal fibers that include a core (120) extending along a waveguide axis, a confinement region (110) extending along the waveguide axis (199) surrounding the core, and a cladding (160) extending along the waveguide axis surrounding the confinement region, wherein the cladding has an asymmetric cross-section.

Abstract translation: 通常，在第一方面，本发明的特征在于光子晶体光纤，其包括沿着波导轴延伸的芯（120），沿着围绕芯的波导轴线（199）延伸的约束区域（110）和包层（160） ）沿着围绕限制区域的波导轴延伸，其中包层具有不对称的横截面。

公开(公告)号：WO2005096783A3

公开(公告)日：2005-12-15

申请号：PCT/US2005012047

申请日：2005-04-08

Applicant: OMNIGUIDE INC ,  TEMELKURAN BURAK ,  ANASTASSIOU CHARALAMBOS ,  TORRES DAVID ,  SHAPIRA GIL ,  SHURGALIN MAX ,  DELLEMANN GREGOR ,  WEISBERG ORI ,  JACOBS STEVEN A ,  WANG TAIRAN ,  KOLODNY URI ,  RUSK JESSE ,  PAYNE ROBERT ,  FINK YOEL ,  ULU GOKHAN

Inventor： TEMELKURAN BURAK ,  ANASTASSIOU CHARALAMBOS ,  TORRES DAVID ,  SHAPIRA GIL ,  SHURGALIN MAX ,  DELLEMANN GREGOR ,  WEISBERG ORI ,  JACOBS STEVEN A ,  WANG TAIRAN ,  KOLODNY URI ,  RUSK JESSE ,  PAYNE ROBERT ,  FINK YOEL ,  ULU GOKHAN

IPC: A61B1/018 ,  A61B18/22 ,  G02B6/02 ,  G02B6/06

CPC classification number: A61B1/018 ,  A61B18/201 ,  A61B2018/2272 ,  G02B6/02304 ,  G02B6/02385

Abstract: In general, in one aspect, the invention features systems, including a photonic crystal fiber (120) including a core (210) extending along a waveguide axis and a dielectric confinement region (220) surrounding the core, the dielectric confinement region (220) being configured to guide radiation along the waveguide axis from an input end to an output end of the photonic crystal fiber (120). The systems also includes a handpiece (680) attached to the photonic crystal fiber (120), wherein the handpiece allows an operator to control the orientation of the output end to direct the radiation to a target location of a patient.

Abstract translation: 通常，在一个方面，本发明的特征在于系统，包括光子晶体光纤（120），包括沿着波导轴延伸的芯（210）和围绕芯的电介质约束区（220），电介质约束区（220） 被配置为沿着波导轴从光子晶体光纤（120）的输入端引导到输出端。 所述系统还包括附接到光子晶体光纤（120）的手持件（680），其中所述手持件允许操作者控制所述输出端的取向以将所述辐射引导到患者的目标位置。