公开(公告)号：WO2003039382A2

公开(公告)日：2003-05-15

申请号：PCT/IL2002/000880

申请日：2002-11-05

Applicant: MEDGENICS, INC. ,  PEARLMAN, Andrew, L. ,  BELLOMO, Stephen, F. ,  GARFINKEL, Leonard, I. ,  PIVA, Guillermo, A. ,  SHAVITT, Menachem, D. ,  ROSENBERG, Lior ,  LIPPIN, Itzhak ,  BUKHMAN, Mordechay ,  ALMON, Einat ,  SHER, Niv

Inventor： PEARLMAN, Andrew, L. ,  BELLOMO, Stephen, F. ,  GARFINKEL, Leonard, I. ,  PIVA, Guillermo, A. ,  SHAVITT, Menachem, D. ,  ROSENBERG, Lior ,  LIPPIN, Itzhak ,  BUKHMAN, Mordechay ,  ALMON, Einat ,  SHER, Niv

IPC: A61B17/322

CPC classification number: C12M21/08 ,  A61B17/322 ,  A61B2017/3225 ,  A61K35/36 ,  A61K38/1816 ,  A61K38/212 ,  A61K47/6901 ,  C12M35/08 ,  C12M45/02 ,  A61K2300/00

Abstract: A micro-organ processing system, comprising: a plurality of operational modules, each said module performing all or part of a process of producing said micro-organ from a tissue sample; and means for transferring the tissue sample or micro-organ from one module to a next module in the process, via ports in the modules, without removal of the tissue sample from the modules.

Abstract translation: 一种微器官处理系统，包括：多个操作模块，每个所述模块执行从组织样本产生所述微器官的过程的全部或部分; 以及用于通过模块中的端口将组织样本或微器官从一个模块转移到该过程中的下一个模块的装置，而不从模块中移除组织样本。

公开(公告)号：WO02058774A3

公开(公告)日：2002-11-28

申请号：PCT/IL0200073

申请日：2002-01-24

Applicant: LRR & D LTD ,  ROSENBERG LIOR

Inventor： ROSENBERG LIOR

IPC: A61B17/34 ,  A61M25/02 ,  A61M5/158

CPC classification number: A61M25/02 ,  A61B17/3401

Abstract: Method of holding in place a transcutaneous implant by applying an adhesive in liquid form to the implant and the area of the patient's skin about the needle and allowing the adhesive to set. The implant is constituted by an infusion needle, a catheter or any transcutaneous implant. Whenever the adhesive is in liquid form, it has such a surface tension that it will flow along the implant and the skin to reach a terminal point, which is the point at which the implant is inserted. The adhesive is applied in liquid form and flows along the implant and the skin to reach the point at which the implant is inserted, and then allowed to set, to hold the implant in place.

Abstract translation: 通过将液体形式的粘合剂施加到植入物和围绕针的患者皮肤区域并允许粘合剂固定来保持经皮植入物的方法。 植入物由输注针，导管或任何经皮植入物构成。 每当粘合剂是液体形式时，它具有这样的表面张力，它将沿着植入物和皮肤流动到达终点，这是植入物被插入的点。 粘合剂以液体形式施加并沿植入物和皮肤流动到达植入物插入点，然后允许固定，以将植入物保持在适当位置。

公开(公告)号：WO2010038231A1

公开(公告)日：2010-04-08

申请号：PCT/IL2009/000946

申请日：2009-10-01

Applicant: L.R.R.& D. LTD. ,  ROSENBERG, Lior

Inventor： ROSENBERG, Lior

IPC: A61F13/00 ,  A61F15/00

CPC classification number: A61F13/00008 ,  A61F13/00063 ,  A61F13/00991 ,  A61F2013/00157 ,  A61F2013/00165 ,  A61F2013/00255 ,  A61F2013/00285 ,  A61F2013/00323 ,  A61F2013/00519 ,  A61F2013/0054 ,  A61F2013/00634 ,  A61F2013/0074 ,  A61F2013/00748 ,  A61F2013/0091 ,  A61F2013/00927 ,  A61F2013/00931 ,  A61L15/28 ,  A61L15/425 ,  A61L15/60

Abstract: The invention relates to a wound dressing and methods of preparation and use thereof for promoting healing of a wound bed. In particular, the wound dressing is advantageous for application to a debrided wound bed. The wound dressing comprises an open conduit polymeric foam matrix, and a hydrophilic polymer which is disposed in dry form on the inner surfaces of the conduits within the matrix.

Abstract translation: 本发明涉及一种伤口敷料及其制备和使用方法，用于促进伤口床的愈合。 特别地，伤口敷料对于应用于清创伤口床是有利的。 伤口敷料包括开放导管聚合物泡沫基质和亲水性聚合物，其以干燥形式设置在基质内导管的内表面上。

公开(公告)号：WO03040686A2

公开(公告)日：2003-05-15

申请号：PCT/IL0200877

申请日：2002-11-05

Applicant: MEDGENICS INC ,  PEARLMAN ANDREW L ,  BELLOMO STEPHEN F ,  LIPPIN ITZHAK ,  ALMON EINAT ,  PIVA GUILLERMO A ,  GARFINKEL LEONARD I ,  ROSENBERG LIOR ,  SHAVITT MENACHEM D

Inventor： PEARLMAN ANDREW L ,  BELLOMO STEPHEN F ,  LIPPIN ITZHAK ,  ALMON EINAT ,  PIVA GUILLERMO A ,  GARFINKEL LEONARD I ,  ROSENBERG LIOR ,  SHAVITT MENACHEM D

IPC: A61B17/322 ,  A61K9/00 ,  A61K38/21 ,  A61K47/48 ,  A61K48/00 ,  A61P37/00 ,  C12N5/02 ,  G01N

CPC classification number: C12M21/08 ,  A61B17/322 ,  A61B2017/3225 ,  A61K35/36 ,  A61K38/1816 ,  A61K38/212 ,  A61K47/6901 ,  C12M35/08 ,  C12M45/02 ,  A61K2300/00

Abstract: A method of determining the amount of a therapeutic micro-organ to be implanted in a patient, the method comprising: determining a secretion level of a therapeutic agent by a quantity of the micro-organ in vitro; estimating a relationship between in vitro secretions and in vivo serum levels of the therapeutic agent; and determining an amount of therapeutic micro-organ to be implanted, based on the determined secretion level and the estimated relationship.

Abstract translation: 一种确定要植入患者的治疗性微器官的量的方法，所述方法包括：通过体外测定微量器官的量的治疗剂的分泌水平; 估计体内分泌物与治疗剂的体内血清水平之间的关系; 并根据确定的分泌水平和所估计的关系确定待植入的治疗性微器官的量。

公开(公告)号：WO2003008033A1

公开(公告)日：2003-01-30

申请号：PCT/IL2002/000591

申请日：2002-07-18

Applicant: L.R. R & D LTD. ,  ROSENBERG, Lior

Inventor： ROSENBERG, Lior

IPC: A61M35/00

CPC classification number: B05C17/002 ,  A61B90/80 ,  A61B2017/320008 ,  A61M35/003

Abstract: Device for treating pathological conditions of skin surfaces, which comprises a main component that includes a body and a contact layer superimposed to one another, wherein the body is porous to provide storage capacity for liquid medicament fed to it and permeable for transmitting the medicament to the contact layer by compression or capillarity or both. The contact layer is also porous for transmitting the medicament received from the body to the skin surface being treated and has a mildly or strongly abrasive outer surface for removing damaged surface skin tissue. The device also comprises a delivery apparatus for feeding liquid medicament to the body of the main component and, an optional storage container for the liquid medicament.

Abstract translation: 用于治疗皮肤表面的病理状况的装置，其包括主要成分，所述主要成分包括主体和彼此重叠的接触层，其中所述主体是多孔的，以提供供给其的液体药物的储存能力，并且可渗透以将药物传输至 接触层通过压缩或毛细作用或两者兼而有之。 接触层也是多孔的，用于将从身体接收的药物传送到被治疗的皮肤表面，并且具有轻微或强烈磨蚀的外表面，用于去除损伤的表面皮肤组织。 该装置还包括用于将液体药物输送到主要部件的主体的输送装置和用于液体药物的任选的储存容器。

公开(公告)号：WO9720509A3

公开(公告)日：1997-08-28

申请号：PCT/IL9600174

申请日：1996-12-06

Applicant: L R SURGICAL INSTR LTD ,  ROSENBERG LIOR

Inventor： ROSENBERG LIOR

IPC: A61B17/00 ,  A61B17/322 ,  A61B17/326 ,  A61B19/00 ,  A61B19/02

CPC classification number: A61B17/322 ,  A61B50/30 ,  A61B2017/00477 ,  A61B2017/3225 ,  A61B2090/0813 ,  Y10T83/9408

Abstract: The present invention generally relates to a skin graft preparation device, hereinafter called a mesher. This device is designed to incise and 'mesh' a piece of skin usually prior to grafting in order to allow it to expand and cover a larger area than its donor site area. More specifically, the said invention relates to an adjustable mesher device wherein the mesher has an adjustable meshing drum (roller) or drums useful for the meshing of the entire range of meshing ratios thus eliminating the need to keep various meshing devices. Another embodiment of the mesher has two consecutive meshing drums. A further embodiment of the mesher has a rotatable common holder allowing selection from a number of meshing drums. These meshers can mesh skin in both powered and manual modes of operation and may be used with most existing skin graft carriers or may be used without any carrier. The present invention further relates to a system for using the mesher.

公开(公告)号：WO1997020509A2

公开(公告)日：1997-06-12

申请号：PCT/IL1996000174

申请日：1996-12-06

Applicant: L.R. SURGICAL INSTRUMENTS LTD. ,  ROSENBERG, Lior

Inventor： L.R. SURGICAL INSTRUMENTS LTD.

IPC: A61B17/322

CPC classification number: A61B17/322 ,  A61B50/30 ,  A61B2017/00477 ,  A61B2017/3225 ,  A61B2090/0813 ,  Y10T83/9408

Abstract: The present invention generally relates to a skin graft preparation device, hereinafter called a mesher. This device is designed to incise and "mesh" a piece of skin usually prior to grafting in order to allow it to expand and cover a larger area than its donor site area. More specifically, the said invention relates to an adjustable mesher device wherein the mesher has an adjustable meshing drum (roller) or drums useful for the meshing of the entire range of meshing ratios thus eliminating the need to keep various meshing devices. Another embodiment of the mesher has two consecutive meshing drums. A further embodiment of the mesher has a rotatable common holder allowing selection from a number of meshing drums. These meshers can mesh skin in both powered and manual modes of operation and may be used with most existing skin graft carriers or may be used without any carrier. The present invention further relates to a system for using the mesher.

Abstract translation: 皮肤移植物制备装置技术领域本发明总体上涉及一种皮肤移植物制备装置，以下称为网状织物。 该装置旨在通常在移植之前切割和“啮合”一块皮肤，以使其能够扩大并覆盖比其供体部位区域更大的面积。 更具体地说，本发明涉及一种可调节筛网装置，其中筛网具有可用于啮合啮合比的整个啮合比的啮合滚筒（滚筒）或滚筒，从而无需保持各种啮合装置。 筛网的另一个实施例具有两个连续的啮合鼓。 网格器的另一实施例具有可旋转的公共支架，允许从多个啮合滚筒进行选择。 这些网眼机可以在动力和手动操作模式下啮合皮肤，并且可以与大多数现有的皮肤移植物载体一起使用，或者可以在没有任何载体的情况下使用。 本发明还涉及一种使用该筛网的系统。