公开(公告)号：WO2016028756A1

公开(公告)日：2016-02-25

申请号：PCT/US2015/045657

申请日：2015-08-18

Applicant: GARMOR, INC.

Inventor： CHRISTIANSEN, Sean ,  RESTREPO, David ,  STOLTZ, Richard ,  BULLINGTON, Jeff

IPC: C01B31/04 ,  C04B22/02

CPC classification number: C04B14/026 ,  C01B31/043 ,  C01B31/0469 ,  C01B32/192 ,  C01B32/198 ,  C01B32/20 ,  C04B14/06 ,  C04B26/26 ,  C04B28/04 ,  C04B14/00 ,  C04B40/0021

Abstract: A method of producing dispersed of high quality graphene/graphite oxides in a powder matrix to then be reacted to form a composite. Where the powders have similar hydrophobicity and the graphene/graphite oxides has minimal surface oxidation or minimal epoxy group and where the powders are sonically mixed.

Abstract translation: 一种在粉末基质中分散制备高质量石墨烯/石墨氧化物然后反应以形成复合材料的方法。 当粉末具有相似的疏水性，并且石墨烯/石墨氧化物具有最小的表面氧化或最小环氧基团，并且其中粉末被声波混合。

公开(公告)号：WO2015175387A1

公开(公告)日：2015-11-19

申请号：PCT/US2015/030108

申请日：2015-05-11

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： CHEN, Chau-Chyun ,  ISLAM, Md, Rashedul

IPC: G06F19/00

CPC classification number: G06F19/701 ,  G06F17/16 ,  G06F19/704

Abstract: An apparatus and computerized method optimizes or generates a sigma profile for a molecule by receiving a sigma profile for the molecule, calculating an activity coefficient for the molecule using the sigma profile for the molecule, calculating a solubility for the molecule using the activity coefficient for the molecule, optimizing or adjusting the sigma profile for the molecule by adjusting the sigma profile using an objective function and one or more constraints, providing the sigma profile to an output device communicably coupled to a processor.

Abstract translation: 装置和计算机化方法通过接收分子的σ分布优化或产生分子的σ分布，使用分子的σ分布计算分子的活度系数，使用分子的活度系数计算分子的溶解度 分子，通过使用目标函数和一个或多个约束调整σ分布来优化或调整分子的σ分布，将σ分布提供给可通信地耦合到处理器的输出设备。

公开(公告)号：WO2015127146A1

公开(公告)日：2015-08-27

申请号：PCT/US2015/016717

申请日：2015-02-19

Applicant: EVERGAZE, INC.

Inventor： ANTAKI, Patrick, R. ,  DUNN, Ronnie ,  LEMBURG, Russell

IPC: G06T5/50 ,  H04N5/225 ,  G06F3/01

CPC classification number: G02C11/10 ,  A61H5/00 ,  G02B27/0093 ,  G02B27/0172 ,  G02B2027/0138 ,  G02B2027/014 ,  G02B2027/0178 ,  G06F3/005 ,  G06F3/012 ,  G06F3/013 ,  G06F2203/0381 ,  G06F2203/04806 ,  G09B21/008 ,  H04N5/2251 ,  H04N5/2258 ,  H04N5/2351 ,  H04N5/247

Abstract: The present invention provides various apparatus and methods for improving, augmenting or enhancing a vision of a person that include a first camera, one or more sensors, a microdisplay, and one or more processors communicably coupled to the first camera, the one or more sensors and the microdisplay. The first camera is configured to acquire a first image of a scene facing away from an eye of the person. The microdisplay is configured to display a modified first image to the eye. In one operational mode, the one or more processors are configured to acquire the first image of the scene using the first camera, modify the first image based on one or more vision improvement parameters, and display the modified first image on the microdisplay to improve, augment or enhance the vision of the person.

Abstract translation: 本发明提供了用于改善，增强或增强人的视觉的各种装置和方法，其包括第一相机，一个或多个传感器，微显示器以及可通信地耦合到第一相机​​的一个或多个处理器，所述一个或多个传感器 和微显示器。 第一相机被配置为获取面向远离人的眼睛的场景的第一图像。 微显示器被配置为向眼睛显示修改的第一图像。 在一个操作模式中，一个或多个处理器被配置为使用第一相机获取场景的第一图像，基于一个或多个视觉改善参数来修改第一图像，并且在微显示器上显示经修改的第一图像， 增强或增强人的视野。

公开(公告)号：WO2015120094A2

公开(公告)日：2015-08-13

申请号：PCT/US2015/014518

申请日：2015-02-04

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ,  TRANSLATIONAL GENOMICS RESEARCH INSTITUTE

Inventor： GRAHAM, Rondell, P. ,  BORAD, Mitesh, J. ,  KIPP, Benjamin, R. ,  FRITCHER, Emily, G. Barr ,  CARPTEN, John ,  CRAIG, David

IPC: C12N15/82

CPC classification number: C12Q1/6886 ,  C07K14/71 ,  C12Q1/6841 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The present invention provides a method of characterizing a cancer by obtaining a sample from a subject suspected of having cancer; and determining whether a fibroblast growth factor receptor (FGFR) fusion is present in the sample, wherein the FGFR fusion comprises a FGFR locus, thereby characterizing the cancer based on the presence or absence of the FGFR fusion.

Abstract translation: 本发明提供了通过从怀疑患有癌症的受试者获得样品来表征癌症的方法; 并确定样品中是否存在成纤维细胞生长因子受体（FGFR）融合物，其中所述FGFR融合物包含FGFR基因座，由此基于FGFR融合物的存在或不存在来表征所述癌症。 / p>

公开(公告)号：WO2015077640A1

公开(公告)日：2015-05-28

申请号：PCT/US2014/066944

申请日：2014-11-21

Applicant: SIGNPATH PHARMA, INC.

Inventor： HELSON, Lawrence

IPC: A61K9/127 ,  A61K31/12 ,  A61P25/16 ,  A61P25/00

CPC classification number: A61K9/127 ,  A61K9/0019 ,  A61K31/12 ,  A61K45/06 ,  A61K47/34 ,  A61K47/593 ,  A61K2300/00

Abstract: Compositions and methods for the treatment of proliferative disorders including proliferative such as breast, uterine cervical, ophthalmic, and pancreatic cancer by the administration of intravenous synthetic curcumin (S-curcumin) are disclosed herein.

Abstract translation: 本文公开了通过给予静脉内合成姜黄素（S-姜黄素）治疗增殖性疾病（包括增殖性乳腺癌，子宫颈癌，眼科和胰腺癌）的组合物和方法。

公开(公告)号：WO2015054606A1

公开(公告)日：2015-04-16

申请号：PCT/US2014/060088

申请日：2014-10-10

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： FILLEUR, Stephanie ,  NELIUS, Nelius ,  MARTINEZ-MARIN, Dalia

IPC: C12N5/0786 ,  C12N15/15 ,  A61P35/00 ,  G01N33/53 ,  A61K38/55

CPC classification number: C12N5/0645 ,  A61K35/15 ,  A61K38/1709 ,  C12N2501/998 ,  G01N33/5011

Abstract: The present invention includes a modified macrophage comprising a monocyte, a primary macrophage, or macrophage cell line transformed to overexpress pigment epithelium-derived factor, a method of a modified macrophage comprising: isolating a monocyte, a primary macrophage, or a macrophage cell line; and transforming the monocyte, primary macrophage, or macrophage cell line with a vector that overexpress pigment epithelium-derived factor and uses thereof, wherein the modified macrophages or monocytes are used to treat kill cancer cells, including metastatic cancer cells.

Abstract translation: 本发明包括修饰的巨噬细胞，其包含转化为过表达色素上皮衍生因子的单核细胞，原代巨噬细胞或巨噬细胞细胞系，改良的巨噬细胞的方法，包括：分离单核细胞，原代巨噬细胞或巨噬细胞细胞系; 以及用过表达色素上皮衍生因子及其用途的载体转化单核细胞，原代巨噬细胞或巨噬细胞细胞系，其中所述修饰的巨噬细胞或单核细胞用于治疗包括转移性癌细胞在内的杀死癌细胞。

公开(公告)号：WO2015009553A1

公开(公告)日：2015-01-22

申请号：PCT/US2014/046266

申请日：2014-07-11

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： MADDALA, Jeevan ,  RENGASWAMY, Raghunathan

IPC: G06F17/50

CPC classification number: G06F17/5009 ,  G06F17/30294 ,  G06F17/3053 ,  G06F17/509 ,  G06F2217/16 ,  G06N3/086

Abstract: A computerized method for designing a discrete droplet microfluidic system: (a) provides an initial set of droplet based networks; (b) codes each droplet based network into a data structure such that all the data structures form a current set of data structures; (c) creates new data structures by performing one or more genetic operators on the current set of data structures; (d) adds new data structures to the current set of data structures; (e) creates a new set of data structures that satisfies one or more design parameters; (f) replaces the current set of data structures with the new set of data structures; (g) repeats steps (c), (d), (e) and (f) until the new set of data structures has been created a third number of times; and (h) displays/outputs the current set of data structures as possible designs for the discrete droplet microfluidic system to one or more output devices.

Abstract translation: 用于设计离散液滴微流体系统的计算机化方法：（a）提供初始的基于液滴的网络; （b）将每个基于液滴的网络编码成数据结构，使得所有数据结构形成当前的一组数据结构; （c）通过在当前数据结构集上执行一个或多个遗传算子来创建新的数据结构; （d）将新的数据结构添加到当前的数据结构集合中; （e）创建满足一个或多个设计参数的新的数据结构集合; （f）使用新的数据结构集替换当前数据结构集合; （g）重复步骤（c），（d），（e）和（f），直到新的数据结构集合被创建了第三次; 和（h）将当前数据结构集合显示/输出为离散液滴微流体系统到一个或多个输出装置的可能设计。

公开(公告)号：WO2014183014A2

公开(公告)日：2014-11-13

申请号：PCT/US2014/037466

申请日：2014-05-09

Applicant: AVIANTRONICS, LLC

Inventor： BOLEN, Pat, M.

IPC: A01M23/28 ,  G06T5/00

CPC classification number: A01M19/00 ,  A01M23/38 ,  A01M99/00 ,  G06T7/97 ,  H04N5/2257 ,  H04N5/23241

Abstract: The present invention includes an automated animal euthanization device for the destruction of an animal comprising: a housing having an housing opening to allow access to an interior cavity; a perch having a first perch end that extends into the interior cavity and a second perch end that extends through the housing opening and configured to accommodate the animal; a feed container position about the first perch end to provide food for the animal; an electrode set extending into the housing opening to contact the bird as it is positioned to eat the food; a camera position in the interior cavity to take a target image of the animal; a control unit connected to the camera to receive the target image and compare the target image to a set of reference images; a power supply connected to the control unit, the electrode set, and the camera to provide power for the operation thereof; and a container positioned below the perch to collect the animal falling from the perch.

Abstract translation: 本发明包括用于销毁动物的自动化动物安乐死装置，包括：壳体，具有允许进入内腔的外壳开口; 具有延伸到所述内部空腔中的第一海鲈尾和延伸穿过所述壳体开口并被构造成容纳所述动物的第二栖息端的导管; 饲料容器位置围绕第一栖息端为动物提供食物; 电极组，其延伸到所述壳体开口中以在所述鸟定位以接近所述食物时接触所述鸟; 在内腔中的相机位置拍摄动物的目标图像; 控制单元，连接到相机以接收目标图像，并将目标图像与一组参考图像进行比较; 连接到控制单元，电极组和照相机的电源，用于为其操作提供电力; 和一个位于鲈鱼下方的集装箱，用于收集从栖木鲈落下的动物。

公开(公告)号：WO2014158209A1

公开(公告)日：2014-10-02

申请号：PCT/US2013/054972

申请日：2013-08-14

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： AXELROD, Abram ,  JOHNSON, Trevor, C. ,  SIEGEL, Dionicio ,  CAMELIO, Andrew, M. ,  YUAN, Changxia ,  ELIASEN, Anders

IPC: C07F5/02 ,  C07F7/02 ,  C07D311/72 ,  C07D209/48 ,  C07D303/40 ,  C07B41/02 ,  C07C247/04 ,  C07C253/30 ,  C07D317/36 ,  C07C269/06 ,  C07C209/68 ,  C07C37/60 ,  C07C41/26 ,  C07C45/64 ,  C07C67/31

CPC classification number: C07D311/64 ,  C07B41/02 ,  C07C37/0555 ,  C07C37/60 ,  C07C41/26 ,  C07C45/64 ,  C07C51/367 ,  C07C67/00 ,  C07C67/29 ,  C07C67/31 ,  C07C209/68 ,  C07C247/04 ,  C07C253/30 ,  C07C269/06 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2603/26 ,  C07C2603/97 ,  C07D209/48 ,  C07D303/40 ,  C07D311/72 ,  C07D317/36 ,  C07C255/13 ,  C07C255/36 ,  C07C271/10 ,  C07C217/20 ,  C07C43/23 ,  C07C43/253 ,  C07C43/295 ,  C07C47/575 ,  C07C47/27 ,  C07C69/28 ,  C07C69/92 ,  C07C69/734 ,  C07C69/732 ,  C07C59/52 ,  C07C69/80 ,  C07C69/76 ,  C07C39/07 ,  C07C39/06 ,  C07C39/17 ,  C07C39/15 ,  C07C39/14 ,  C07C39/27 ,  C07C39/28 ,  C07C39/367 ,  C07C39/11 ,  C07C49/83 ,  C07C49/755 ,  C07C59/64 ,  C07C69/63

Abstract: The present invention provides a method for converting an aromatic hydrocarbon to a phenol by providing an aromatic hydrocarbon comprising one or more aromatic C-H bonds and one or more activated C-H bonds in a solvent; adding a phthaloyl peroxide to the solvent; converting the phthaloyl peroxide to a di-radical; contacting the di-radical with the one or more aromatic C-H bonds; oxidizing selectively one of the one or more aromatic C-H bonds in preference to the one or more activated C-H bonds; adding a hydroxyl group to the one of the one or more aromatic C-H bonds to form one or more phenols; and purifying the one or more phenols.

Abstract translation: 本发明提供一种通过在溶剂中提供包含一个或多个芳族C-H键和一个或多个活化C-H键的芳族烃来将芳族烃转化为苯酚的方法; 向溶剂中加入邻苯二甲酰过氧化物; 将过氧化二苯甲酰转化为二基; 使二基与一个或多个芳族C-H键接触; 优选选择性地一种或多种芳族C-H键中的一种，优选一种或多种活化的C-H键; 向所述一个或多个芳族C-H键中的一个添加羟基以形成一种或多种酚; 并纯化一种或多种酚类。

公开(公告)号：WO2014063057A1

公开(公告)日：2014-04-24

申请号：PCT/US2013/065694

申请日：2013-10-18

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： PEREZ, Ruth

IPC: A61K31/137 ,  A61K31/661 ,  A61K45/00 ,  A61P25/16

CPC classification number: A61K31/137 ,  A61K31/165 ,  A61K31/66 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides a method for treating, alleviating, reversing or delaying progression of at least one symptom of Parkinson's Disease in a subject in need thereof by administering to the subject an effective amount of a 2-amino-2-[2-(4-octylphenyl)ethyl]propane-l,3-diol composition or a derivative thereof to treat at least one symptom of Parkinson's Disease.

Abstract translation: 本发明提供了一种通过向受试者施用有效量的2-氨基-2- [2-（4（2-甲氧基苯基） - 辛基苯基）乙基]丙烷-1,3-二醇组合物或其衍生物，以治疗帕金森病的至少一种症状。