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    DEVICES AND METHODS FOR IMPLANTING A PLURALITY OF DRUG DEPOTS HAVING ONE OR MORE ANCHORING MEMBERS
    31.
    发明申请
    DEVICES AND METHODS FOR IMPLANTING A PLURALITY OF DRUG DEPOTS HAVING ONE OR MORE ANCHORING MEMBERS 审中-公开
    用于植入具有一个或多个锚定成员的多种药物组合物的装置和方法

    公开(公告)号：WO2011053375A1

    公开(公告)日：2011-05-05

    申请号：PCT/US2010/030703

    申请日：2010-04-12

    Applicant: WARSAW ORTHOPEDIC, INC. ,  MCKAY, William, F.

    Inventor： MCKAY, William, F.

    IPC: A61L17/00 ,  A61B17/06 ,  A61B17/00 ,  A61B17/04

    CPC classification number: A61B17/06 ,  A61B17/0487 ,  A61B17/06114 ,  A61B17/06166 ,  A61B2017/00893 ,  A61B2017/0472 ,  A61L17/005 ,  A61L2300/402 ,  A61L2300/41 ,  A61L2300/604

    Abstract: The present invention is directed to a device for implanting a plurality of drug depots at or near a target tissue site beneath the skin of a patient. The device comprises at least three or more drug depots, wherein each of the at least three or more drug depots has a first surface adapted to receive one or more anchoring members so as to limit movement of the at least three or more drug depots at or near the target tissue site, and wherein at least two of the at least three or more drug depots comprise a second surface adapted to receive the anchoring member after the anchoring member contacts the target tissue site. Each drug depot is capable of releasing a therapeutically effective amount of a drug over a period of at least one day.

    Abstract translation: 本发明涉及一种用于在患者皮肤下方的靶组织部位处或附近植入多个药物贮库的装置。 该装置包括至少三个或更多个药物贮库，其中至少三个或更多个药物贮库中的每一个具有适于接收一个或多个锚固构件的第一表面，以便限制至少三个或更多个药物贮库在 并且其中所述至少三个或更多个药物贮库中的至少两个包含适于在所述锚定构件接触所述靶组织部位之后接收所述锚定构件的第二表面。 每个药物贮库能够在至少一天的时间内释放治疗有效量的药物。

    OSTEOGENIC COMPOSITIONS CONTAINING A COLORING AGENT
    33.
    发明申请
    OSTEOGENIC COMPOSITIONS CONTAINING A COLORING AGENT 审中-公开
    含有着色剂的成骨组合物

    公开(公告)号：WO2010021823A4

    公开(公告)日：2010-06-03

    申请号：PCT/US2009052360

    申请日：2009-07-31

    Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F

    Inventor： MCKAY WILLIAM F

    IPC: A61L27/50 ,  A61F2/00 ,  A61L27/22 ,  A61L27/24 ,  A61L27/26

    CPC classification number: A61K38/1875 ,  A61L27/24 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/442 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2430/02

    Abstract: An osteogenic composition is provided for implantation at or near a target tissue site beneath the skin, the osteogenic composition comprising a growth factor and a coloring agent, wherein the coloring agent imparts color to the growth factor to allow the user to see the growth factor at or near the target tissue site. In some embodiments, a method is provided for accelerating bone repair, the method comprising mixing bone morphogenic protein-2 and a coloring agent to form a mixture; applying the mixture to a surface of a porous collagen matrix, wherein the coloring agent allows the user to see bone morphogenic protein-2 distribution on or in the porous collagen matrix; and implanting the porous collagen matrix at or near a target tissue site in need of bone repair.

    Abstract translation: 提供成骨组合物用于植入皮肤下方的目标组织部位处或附近，所述成骨组合物包含生长因子和着色剂，其中着色剂赋予生长因子颜色以允许使用者在 或靠近目标组织部位。 在一些实施方案中，提供了用于加速骨修复的方法，所述方法包括混合骨形态发生蛋白-2和着色剂以形成混合物; 将混合物施加到多孔胶原基质的表面，其中着色剂允许使用者看到多孔胶原基质上或其中的骨形态发生蛋白-2分布; 以及将多孔胶原基质植入需要骨修复的靶组织部位处或附近。

    A DEVICE AND METHOD FOR DELIVERY OF A DRUG DEPOT
    34.
    发明申请
    A DEVICE AND METHOD FOR DELIVERY OF A DRUG DEPOT 审中-公开
    一种用于递送药物库的设备和方法

    公开(公告)号：WO2010051383A2

    公开(公告)日：2010-05-06

    申请号：PCT/US2009/062612

    申请日：2009-10-29

    Applicant: WARSAW ORTHOPEDIC, INC. ,  SIMONTON, Thomas A. ,  MCKAY, William F. ,  HADDOCK, Sean M. ,  ZANELLA, John Myers

    Inventor： SIMONTON, Thomas A. ,  MCKAY, William F. ,  HADDOCK, Sean M. ,  ZANELLA, John Myers

    IPC: A61M5/178 ,  A61M5/00

    CPC classification number: A61M25/00 ,  A61B5/04001 ,  A61B5/4893 ,  A61M25/007 ,  A61M25/0084

    Abstract: Drug depot delivery devices and methods are provided for delivering one or more drug depots to one or more sites beneath the skin of a patient with or without repositioning the cannula. The device has a cannula capable of insertion to the site beneath the skin of the patient and one or more side port openings for delivering a drug depot. The side port openings are spaced a distance from the blunt tip, which will allow the user to implant at a set distance from a nerve. The device may also include an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot at or near the nerve.

    Abstract translation: 提供了药物贮库递送装置和方法，用于在将套管重新定位或不重新定位的情况下将一个或多个药物贮库递送至患者皮肤下方的一个或多个部位。 该装置具有能够插入患者皮肤下方部位的套管和用于输送药物仓库的一个或多个侧口开口。 侧端口开口与钝头间隔开一定距离，这将允许使用者在离神经设定的距离处植入。 该装置还可以包括用于检测套管的尖端与神经的接近程度的电子监视器。 在一些实施方案中，递送药物长效制剂的方法通过检测神经并将药物长效制剂递送到神经处或神经附近来提供。

    METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING CLONIDINE
    37.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING CLONIDINE 审中-公开
    用于治疗术后疼痛的方法和组合

    公开(公告)号：WO2009129437A2

    公开(公告)日：2009-10-22

    申请号：PCT/US2009040910

    申请日：2009-04-17

    Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  MCKAY WILLIAM F ,  WOHABREBBI AMIRA ,  MCDONALD PHILLIP EDWARD ,  CARTER TROY

    Inventor： KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  MCKAY WILLIAM F ,  WOHABREBBI AMIRA ,  MCDONALD PHILLIP EDWARD ,  CARTER TROY

    IPC: A61K9/00 ,  A61K31/4162

    CPC classification number: A61L31/16 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/4162 ,  A61K31/4168 ,  A61K47/34 ,  A61L31/06 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/604

    Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

    Abstract translation: 本发明涉及可用于减少，预防或治疗需要这种治疗的患者的手术后疼痛的可植入药物贮存库，所述可植入药物储库包含治疗有效量的可乐定或其药学上可接受的盐和聚合物; 其中所述贮存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述贮库能够释放（i）约5％至约45％的可乐定或其药学上可接受的盐相对于 在最多48小时的第一时间内装载在药物贮库中的可乐定或其药学上可接受的盐的总量和（ii）可乐定或其药学上可接受的盐的约55％至约95％相对于 至少3天的随后期间，将可乐定或其药学上可接受的盐装载在药物贮库中。

    RIGID BONE GRAFT SUBSTITUTE
    40.
    发明申请
    RIGID BONE GRAFT SUBSTITUTE 审中-公开

    公开(公告)号：WO2009129000A2

    公开(公告)日：2009-10-22

    申请号：PCT/US2009/036801

    申请日：2009-03-11

    Applicant: MEDTRONIC, INC. ,  WARSAW ORTHOPEDIC, INC. ,  MCKAY, William, F.

    Inventor： MCKAY, William, F.

    IPC: A61L27/24 ,  A61L27/54 ,  A61L27/56

    CPC classification number: A61L27/56 ,  A61F2/2803 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/3092 ,  A61F2002/3096 ,  A61F2210/0004 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61L27/40 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/02

    Abstract: A bone graft substitute includes a porous matrix at least partially covered by a reinforcing outer layer. The porous matrix may be a collagen-ceramic composite, and the reinforcing outer layer may be formed from highly cross-linked collagen. The implant may also include one or more reinforcement ribs, which may be made from calcium phosphate or dense collagen. In addition, the bone graft substitute preferably includes an effective amount of a bioactive agent, such as BMP-2, rhBMP-2, or functional fragments thereof. The bioactive agent is preferably disposed within the porous matrix.

    Abstract translation: 骨移植物替代物包括至少部分被增强外层覆盖的多孔基质。 多孔基质可以是胶原 - 陶瓷复合物，并且增强外层可以由高度交联的胶原形成。 植入物还可以包括一个或多个加强肋，其可由磷酸钙或致密胶原制成。 此外，骨移植物替代物优选包含有效量的生物活性剂，例如BMP-2，rhBMP-2或其功能片段。 生物活性剂优选设置在多孔基质内。

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