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283 条记录 (耗时 0.016 秒)

    PROCESS FOR THE PREPARATION OF UNSATURATED KETONES
    31.
    发明申请
    PROCESS FOR THE PREPARATION OF UNSATURATED KETONES 审中-公开
    制备不饱和酮的方法

    公开(公告)号：WO2002088064A1

    公开(公告)日：2002-11-07

    申请号：PCT/EP2002/002243

    申请日：2002-03-01

    申请人： DEGUSSA AG

    发明人： SHI, Nongyuan ,  DRAPAL, Bernd ,  KRILL, Steffen ,  JULINO, Markus ,  HUTHMACHER, Klaus

    IPC分类号： C07C45/51

    CPC分类号： C07C45/513 ,  C07C45/62 ,  C07C49/203 ,  C07C49/04

    摘要： Process for the preparation of ß,Υ,Δ-unsaturated ketones and/or α,ß,Υ,Δ-unsaturated ketones by the reaction of an unsaturated alcohol with an enol ether or mixture of enol ethers, with formation of ketals as a by-product, at temperatures of from 50°C to 200°C, in the presence of an acid catalyst, whereby one or all of the reagents is/are heated to the reaction temperature of from 50°C to 200°C before the acid catalyst is added.

    摘要翻译： 通过不饱和醇与烯醇醚或烯醇醚的混合物的反应制备ss，UPSILON，Δ-不饱和酮和/或α，ss，UPSILON，Δ-不饱和酮的方法， - 产物，在50℃至200℃的温度下，在酸催化剂的存在下，在酸之前将一种或全部试剂加热至50℃至200℃的反应温度 加入催化剂。

    3,3-DIMETHYLCYCLOHEXANE DERIVATIVES
    33.
    发明申请
    3,3-DIMETHYLCYCLOHEXANE DERIVATIVES 审中-公开
    3,3-二甲基衍生物

    公开(公告)号：WO01090038A1

    公开(公告)日：2001-11-29

    申请号：PCT/EP2001/004820

    申请日：2001-04-28

    IPC分类号： C07C43/315 ,  C07C45/51 ,  C07C45/62 ,  C07C47/11 ,  C07C47/225 ,  C11B9/00

    CPC分类号： C11B9/0034 ,  C07C43/315 ,  C07C45/515 ,  C07C45/62 ,  C07C47/11 ,  C07C47/225 ,  C07C2601/14

    摘要： The invention relates to 3,3-dimethylcyclohexane derivatives of the general structure (I), wherein the broken line, which binds the carbon atoms that are in the alpha - and beta position in relation to the aldehyde group, represents a C-C single bond or a cis- or trans-configured C=C double bond. Said derivatives are characterized by interesting and original fragrance characteristics which diffuse extremely well and are suitable for use as perfumes, for example in cosmetic preparations, technical products or alcohol-based perfumery.

    摘要翻译： （I）的一般结构的3,3-二甲基环己烷衍生物，其中虚线连接到醛α - 链接和β-ständigen个碳原子，一个CC单键或顺式或反式配置的C = C双键 ，其特征在于通过以极大的光彩一个有趣的和原始的香味特性，且适合用作香料，例如，在化妆品制剂中，工业产品或醇的香料。

    CONTINUOUS METHOD FOR PRODUCTION OF CINNAMALDEHYDE AND DIHYDROCINNAMALDEHYDE DERIVATIVES
    34.
    发明申请
    CONTINUOUS METHOD FOR PRODUCTION OF CINNAMALDEHYDE AND DIHYDROCINNAMALDEHYDE DERIVATIVES 审中-公开
    连续工艺用于生产和肉桂dihydrocinnamaldehyde衍生品

    公开(公告)号：WO01027061A1

    公开(公告)日：2001-04-19

    申请号：PCT/EP2000/009918

    申请日：2000-10-10

    IPC分类号： C07B61/00 ,  C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C47/232 ,  C07C47/228

    CPC分类号： C07C45/74 ,  C07C45/62 ,  C07C45/73 ,  C07C47/228 ,  C07C47/232

    摘要： The invention relates to a continuous method for production of cinnamaldehyde or cinnamaldehyde derivatives comprising continuous reaction of benzaldehyde derivatives with alkanals in the presence of bases and, optionally, as the final step, continuous hydrogenation in a recirculating reactor in the presence of a suspended catalyst and hydrogen to give dihydrocinnamaldehyde derivatives.

    摘要翻译： 本发明涉及一种用于生产肉桂醛的肉桂醛衍生物或通过苯甲醛与在碱存在链烷醛连续反应，并且如果在悬浮催化剂和氢的存在下，循环反应器适当后续连续氢化，得到dihydrocinnamaldehyde衍生物的连续方法。

    PROCESSES FOR THE PREPARATION OF ALCOHOLS
    35.
    发明申请
    PROCESSES FOR THE PREPARATION OF ALCOHOLS 审中-公开
    制备酒精的方法

    公开(公告)号：WO00035845A1

    公开(公告)日：2000-06-22

    申请号：PCT/JP1999/007035

    申请日：1999-12-15

    IPC分类号： B01J31/22 ,  C07B61/00 ,  C07C29/145 ,  C07C31/10 ,  C07C33/20 ,  C07C33/22 ,  C07C33/30 ,  C07C35/08 ,  C07C45/62

    CPC分类号： C07C29/145 ,  C07B2200/09 ,  C07C45/62 ,  C07C2601/14 ,  C07C33/22 ,  C07C35/08 ,  C07C33/20

    摘要： Alcohols are prepared practically advantageously through hydrogenation of carbonyl compounds under mild conditions either by reacting a carbonyl compound with hydrogen in the presence of a bipyridyl derivative, a Group VIII transition metal complex and a base, or by reducing a carbonyl compound in the presence of a bipyridyl derivative, a Group VIII transition metal complex, a base and an alcoholic solvent.

    摘要翻译： 通过羰基化合物在联吡啶衍生物，VIII族过渡金属络合物和碱的存在下使羰基化合物与氢反应，或者在羰基化合物存在下还原羰基化合物， 联吡啶衍生物，VIII族过渡金属络合物，碱和醇溶剂。

    PRODUCTION OF NABUMETONE OR PRECURSORS THEREOF
    37.
    发明申请
    PRODUCTION OF NABUMETONE OR PRECURSORS THEREOF 审中-公开
    生产纳豆酮或其前体

    公开(公告)号：WO1998017616A1

    公开(公告)日：1998-04-30

    申请号：PCT/US1997018936

    申请日：1997-10-21

    申请人： ALBEMARLE CORPORATION

    发明人： ALBEMARLE CORPORATION ,  BECNEL, Brian, F. ,  SABAHI, Mahmood ,  THERIOT, Kevin, J.

    IPC分类号： C07C41/16

    CPC分类号： C07C49/255 ,  C07C37/00 ,  C07C41/16 ,  C07C41/34 ,  C07C41/40 ,  C07C41/42 ,  C07C45/004 ,  C07C45/512 ,  C07C45/62 ,  C07C45/68 ,  C07C45/74 ,  C07C47/575 ,  C07C43/225 ,  C07C39/38

    摘要： In producing nabumetone or precursors thereof, use is made of 2-bromo-6-methoxynaphthalene formed by: (a) methylating 6-bromo-2-naphthol with methyl bromide or methyl chloride, in a halogen-free liquid solvent comprising at least 40 % by weight of one or more compounds of the formula RZ where R is a hydrogen atom or an alkyl group, and Z is a hydroxyl group or a cyanide group with the proviso that if Z is a cyanide group, R is an alkyl group, and in the presence of at least one strong base; and (b) recovering and purifying 2-bromo-6-methoxynaphthalene so formed. The 6-bromo-2-naphthol in turn is preferably formed by reacting 1,6-dibromo-2-naphthol with hydrogen in a halogen-containing liquid solvent comprising at least 50 % by weight of: (A) at least one liquid organic halide solvent in which the halogen content has an atomic number of 35 or less, or (B) a mixture of water and at least one such liquid organic halide solvent, and in the presence of catalytic amounts of (i) a tungsten carbide-based catalyst, and (ii) at least one phase transfer catalyst, most preferably while purging HBr from the reaction mixture as it is formed. In this way, the quantities of by-products formed in the overall operation are reduced, the need for use of excess iron and/or dimethyl sulfate as reaction components is avoided, and the overall efficiency of plant operation is improved especially when conducted on a large scale.

    摘要翻译： 在制备萘布酮或其前体时，使用通过以下步骤形成的2-溴-6-甲氧基萘：（a）在无卤素的液体溶剂中将6-溴-2-萘酚与甲基溴或甲基氯进行甲基化，所述无卤液体溶剂包含至少40 重量％的一种或多种式RZ化合物，其中R是氢原子或烷基，Z是羟基或氰基，条件是如果Z是氰基，则R是烷基， 并且在至少一个强碱的存在下; 和（b）回收和纯化如此形成的2-溴-6-甲氧基萘。 优选6-溴-2-萘酚通过在含卤素的液体溶剂中使1,6-二溴-2-萘酚与氢反应形成，该溶剂包含至少50重量％的：（A）至少一种液体有机物 卤素溶剂，其中卤素含量为35或更小的原子序数，或（B）水和至少一种这样的液体有机卤化物溶剂的混合物，并且在催化量存在下，（i）碳化钨基 催化剂，和（ii）至少一种相转移催化剂，最优选当其形成时从反应混合物中吹扫HBr。 以这种方式，减少了在整个操作中形成的副产物的数量，避免了使用过量的铁和/或硫酸二甲酯作为反应组分的需要，并且特别是当在 大规模

    INDANE DIMER COMPOUNDS WITH SMOOTH MUSCLE RELAXING AND/OR MAST CELL STABILISING AND/OR ANTIINFLAMMATORY ACTIVITY
    38.
    发明申请
    INDANE DIMER COMPOUNDS WITH SMOOTH MUSCLE RELAXING AND/OR MAST CELL STABILISING AND/OR ANTIINFLAMMATORY ACTIVITY 审中-公开
    具有平滑肌松弛和/或MAST细胞稳定和/或抗炎活性的INDANE DIMER化合物

    公开(公告)号：WO1997020805A1

    公开(公告)日：1997-06-12

    申请号：PCT/IE1996000081

    申请日：1996-12-06

    申请人： VENANTIUS LIMITED ,  WALSH, John ,  FRANKISH, Neil ,  SHERIDAN, Helen ,  BYRNE, William

    发明人： VENANTIUS LIMITED

    IPC分类号： C07C225/20

    CPC分类号： C07C311/20 ,  C07C13/465 ,  C07C35/32 ,  C07C35/52 ,  C07C43/188 ,  C07C45/46 ,  C07C45/511 ,  C07C45/62 ,  C07C45/65 ,  C07C45/673 ,  C07C45/68 ,  C07C45/71 ,  C07C45/74 ,  C07C49/67 ,  C07C49/683 ,  C07C49/697 ,  C07C49/755 ,  C07C59/86 ,  C07C65/36 ,  C07C69/007 ,  C07C69/013 ,  C07C69/738 ,  C07C69/76 ,  C07C69/92 ,  C07C215/44 ,  C07C225/20 ,  C07C233/32 ,  C07C251/44 ,  C07C309/66 ,  C07C2602/08 ,  C07C49/80

    摘要： Indane dimer compounds of general formula 5, 6 or 9 and their pharmaceutical use, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or antiinflammatory activity are described, wherein in formulae 5 and 9, R and R to R , and in formula 6, R , R and R to R , are selected from one or more of the same or different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate, nitrite, nitroso groups, nitrile, heterocyclic groups containing one or more heteroatoms selected from N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms or cycloalkyl groups containing 3 to 8 carbon atoms which may be saturated or unsaturated, substituted alkyl or cycloalkyl groups which may be saturated or unsaturated. In formulae 5, 6 and 9, X is O, NR (wherein R is acyl, alkyl or sulphonate groups), S, SO or SO2. In formulae 5, 6 and 9, any one or more of R , R ; R , R ; R , R ; R , R ; R , R and R , R may together represent oxo.

    摘要翻译： 描述了通式5,6或9的吲哚二聚体化合物及其药物用途，特别是实现平滑肌松弛活性和/或肥大细胞稳定活性和/或抗炎活性，其中在式5和9中，R 1和 R 3至R 15，并且在式6中，R 1，R 2和R 4至R 15选自以下相同或不同的一个或多个：H， 卤素，羟基，烷氧基，芳氧基，乙酰氧基，羧基，烷基羰基，氢羰基，氨基，酰胺基，烷基氨基，羟基氨基，氧化胺基，偶氮基，氰基，肼基，酰肼基，腙基，酰亚胺基，亚氨基醚基， 芴基，肟基，硝基，硝酸根，亚硝酸根，亚硝基，腈，含有一个或多个选自N，O或S的杂原子的杂环基，芳烷基，单和多芳族芳基，取代的芳基，硫醇，硫脲基，苯硫醇基 磺酸基，亚砜基，砜基，含1-10个碳原子的烷基或 可以是饱和或不饱和的，可以是饱和或不饱和的取代的烷基或环烷基的含有3-8个碳原子的环烷基。 在式5,6和9中，X是O，NR（其中R是酰基，烷基或磺酸酯基），S，SO或SO 2。 在式5,6和9中，R 1，R 1，R 2， R 2，R 1，R 2， R 3，R 1，R 3， R 9，R 1，R 9， R 10，R 10和R 14，R 14可以一起代表氧代。

    PROCESS FOR PRODUCING TETRAHYDROISOALPHA ACIDS
    40.
    发明申请
    PROCESS FOR PRODUCING TETRAHYDROISOALPHA ACIDS 审中-公开
    生产四氢叶酸的方法

    公开(公告)号：WO1996031593A1

    公开(公告)日：1996-10-10

    申请号：PCT/US1996004706

    申请日：1996-04-05

    申请人： JOHN I. HAAS, INC.

    发明人： JOHN I. HAAS, INC. ,  POYNER, William, R. ,  SMITH, Geoffrey ,  WESTWOOD, Keith, Thomas ,  HYSERT, David, W.

    IPC分类号： C12C03/00

    CPC分类号： C12C5/026 ,  C07C45/62 ,  C12C3/08 ,  C12C3/12 ,  C12C9/025 ,  C07C49/743

    摘要： Tetrahydro-iso- alpha -acids ("THIAA") are prepared directly from iso- alpha -acids ("IAA") by hydrogenation. Free IAA are first dissolved in ethanol. The solution is then hydrogenated in the presence of a particular type of noble metal catalyst. Hydrogenation is controlled naturally by the reaction between the catalyst and the IAA so that the IAA will be selectively converted to THIAA without unacceptable perhydrogenation into other forms.

    摘要翻译： 通过氢化从异 - 酸（“IAA”）直接制备四氢异构α-酸（“THIAA”）。 首先将游离IAA溶解在乙醇中。 然后在特定类型的贵金属催化剂的存在下氢化该溶液。 通过催化剂和IAA之间的反应自然地控制氢化，使得IAA将选择性地转化为THIAA，而不会使其他形式的过氢化反应。