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    DELIVERY DEVICE AND METHOD
    41.
    发明申请
    DELIVERY DEVICE AND METHOD 审中-公开
    交付设备和方法

    公开(公告)号：WO2007093784A1

    公开(公告)日：2007-08-23

    申请号：PCT/GB2007/000505

    申请日：2007-02-14

    Applicant: OPTINOSE AS ,  DJUPESLAND, Per, Gisle ,  BODEN, Keith, McMurray

    Inventor： DJUPESLAND, Per, Gisle ,  BODEN, Keith, McMurray

    IPC: A61M11/08 ,  A61M15/00 ,  A61M15/08

    CPC classification number: A61M11/08 ,  A61M15/0065 ,  A61M15/0091 ,  A61M15/0095 ,  A61M15/0098 ,  A61M15/08 ,  A61M2016/0021 ,  A61M2016/0042 ,  A61M2202/04 ,  A61M2202/064 ,  A61M2205/276 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/75

    Abstract: A delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: at least one nosepiece unit (21) for insertion into one nasal cavity of a subject and comprising a nosepiece (25) for fitting to the respective nostril of the subject; and at least one delivery unit (23) which is operative to deliver a substance through the at least one nosepiece unit into the one nasal cavity of the subject, wherein the at least one delivery unit includes a substance supply unit (27) for delivering a substance and an actuation unit (29) which is operable to actuate the substance supply unit, either automatically or manually, in response to nasal exhalation or at least attempted nasal exhalation by the subject.

    Abstract translation: 一种用于将物质输送到被检体的鼻气道的输送装置和方法，所述输送装置包括：用于插入到受试者的一个鼻腔中的至少一个鼻梁单元（21），并且包括用于装配到所述鼻部的鼻梁 主题各自的鼻孔; 以及至少一个输送单元（23），其可操作以将物质通过所述至少一个鼻甲单元输送到所述受试者的一个鼻腔中，其中所述至少一个输送单元包括物质供应单元（27） 物质和致动单元（29），其可操作以响应于被呼吸的鼻呼气或至少尝试的鼻呼气自动或手动地致动物质供应单元。

    NASAL ADMINISTRATION
    42.
    发明申请
    NASAL ADMINISTRATION 审中-公开
    NASAL行政管理

    公开(公告)号：WO2007083073A1

    公开(公告)日：2007-07-26

    申请号：PCT/GB2006/000182

    申请日：2006-01-19

    Applicant: OPTINOSE AS ,  DJUPESLAND, Per, Gisle ,  HAFNER, Roderick, Peter

    Inventor： DJUPESLAND, Per, Gisle ,  HAFNER, Roderick, Peter

    IPC: A61M15/08

    CPC classification number: A61M15/08 ,  A61K31/404 ,  A61M11/00 ,  A61M15/0021 ,  A61M15/0065 ,  A61M15/009 ,  A61M15/0091 ,  A61M15/0098 ,  A61M16/049 ,  A61M16/0493 ,  A61M16/20 ,  A61M2202/04 ,  A61M2202/064

    Abstract: A delivery device for and method of providing for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit (17) for insertion into a nasal airway (1) of a subject and comprising an outlet unit (21) which includes a nozzle (25) for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle: wherein the delivery device is configured such that at least 30 % of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance.

    Abstract translation: 用于提供物质输送到受试者的中枢神经系统（CNS）的递送装置和方法，所述递送装置包括：用于插入到受试者的鼻气道（1）中的鼻梁单元（17），并且包括 出口单元（21），其包括用于将物质输送到对象的鼻气道中的喷嘴（25）; 以及物质供应单元，其可操作以将剂量的物质输送到所述喷嘴：其中所述递送装置被配置为使得最初沉积在所述鼻气道中的剂量的至少30％沉积在所述鼻部的上后部区域中 从而提供物质的CNS浓度，从而提供CNS效应，其明显大于从物质的对应血浆浓度预测的CNS效应。

    DELIVERY DEVICES
    44.
    发明申请
    DELIVERY DEVICES 审中-公开
    递送设备

    公开(公告)号：WO2005021059A2

    公开(公告)日：2005-03-10

    申请号：PCT/IB2004/003004

    申请日：2004-08-29

    Applicant: OPTINOSE AS ,  DJUPESLAND, Per, Gisle

    Inventor： DJUPESLAND, Per, Gisle

    IPC: A61M

    CPC classification number: A61M15/0098 ,  A61M11/001 ,  A61M15/00 ,  A61M15/0013 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/0028 ,  A61M15/0031 ,  A61M15/0083 ,  A61M15/08 ,  A61M2202/30 ,  A61M2205/7518

    Abstract: A delivery device for and method of delivering substance, the delivery device comprising: an outlet member through which substance is in use delivered in an entraining gas flow; and a substance supply unit for supplying substance to be entrained by an entraining gas flow as one or both of a vapor or a fine aerosol mist, wherein the substance supply unit comprises a flow channel which is fluidly connected to the outlet member, and a substance supporting element for supporting substance, at least a surface of which is in use disposed in the flow channel.

    Abstract translation: 用于输送物质的输送装置和方法，所述输送装置包括：出口构件，通过所述出口构件使用物质在夹带气流中传送; 以及物质供给单元，其用于将由夹带气体夹带的物质作为气雾或细气雾气中的一种或两种供应，其中所述物质供应单元包括流体连接到所述出口构件的流动通道和物质 用于支撑物质的支撑元件，其至少其表面使用设置在流动通道中。

    DELIVERY DEVICE AND METHOD
    45.
    发明申请
    DELIVERY DEVICE AND METHOD 审中-公开
    交付设备和方法

    公开(公告)号：WO2004103447A3

    公开(公告)日：2005-02-17

    申请号：PCT/IB2004001974

    申请日：2004-05-20

    Applicant: OPTINOSE AS ,  DJUPESLAND PER GISLE

    Inventor： DJUPESLAND PER GISLE

    IPC: A61M15/00 ,  A61M15/08 ,  A61M16/04

    CPC classification number: A61M15/0098 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/0091 ,  A61M15/08 ,  A61M16/0434 ,  A61M16/0493 ,  A61M16/0495 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2202/064 ,  A61M2202/30 ,  A61M2210/065

    Abstract: A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit (10) to be gripped in the mouth of a subject, wherein the mouthpiece unit (10) is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit (14) including at least one outlet (30) from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.

    Abstract translation: 用于将物质特别是疫苗递送到受试者的口腔内的粘膜表面的递送装置和方法，所述装置包括：待夹持在受试者口腔中的接口单元（10），其中所述接口 单元（10）被构造成使得在被检体呼气或尝试呼气时，在口腔中产生压力以使得关闭对象的口咽膜; 和口腔出口单元（14），其包括至少一个出口（30），物质从该出口（30）被输送到受试者口腔内的粘膜表面。

    NASAL DEVICES
    47.
    发明申请
    NASAL DEVICES 审中-公开

    公开(公告)号：WO2003090812A3

    公开(公告)日：2003-11-06

    申请号：PCT/IB2003/002305

    申请日：2003-04-25

    Applicant: OPTINOSE AS ,  DJUPESLAND, Per, Gisle

    Inventor： DJUPESLAND, Per, Gisle

    IPC: A61M15/08

    Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject; a delivery unit comprising a substance supply unit and a nozzle unit including at least one nozzle fluidly connected to the substance supply unit for generating an aerosol spray for delivery to a nasal airway of the subject; and an aerosol interactor operable to interact with an aerosol spray as generated by the at least one nozzle.

    NASAL DEVICES
    48.
    发明申请
    NASAL DEVICES 审中-公开
    NASAL设备

    公开(公告)号：WO2003082393A1

    公开(公告)日：2003-10-09

    申请号：PCT/IB2003/001557

    申请日：2003-03-28

    Applicant: OPTINOSE AS ,  DJUPESLAND, Per, Gisle

    Inventor： DJUPESLAND, Per, Gisle

    IPC: A61M16/06

    CPC classification number: A61M16/0666 ,  A61M15/002 ,  A61M15/0065 ,  A61M15/009 ,  A61M15/0098 ,  A61M15/08 ,  A61M16/20 ,  A61M16/202 ,  A61M16/204 ,  A61M16/205 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2202/064

    Abstract: A nasal delivery device (11) for delivering substance to a nasal airway (1) of a subject, comprising: first and second nosepiece units (17, 19), each including a nosepiece (21, 23) for fitting to respective nostrils of a subject; at least one substance supply unit (13, 15) for supplying substance for delivery to the nasal airway (1) of the subject; and a valve unit (35, 37) for selectively fluidly connecting the at least one substance supply unit (13, 15) alternately to respective ones of the nosepiece units (17, 19).

    Abstract translation: 一种用于将物质输送到被检体的鼻气道（1）的鼻输送装置（11），包括：第一和第二喷嘴单元（17,19），每个包括用于装配到鼻孔的相应鼻孔的鼻梁（21,23） 学科; 至少一个物质供应单元（13,15），用于供应物质以输送到所述对象的鼻气道（1）; 以及用于选择性地将所述至少一个物质供应单元（13,15）流体连接到所述喷嘴单元（17,19）中的各个单元的阀单元（35,37）。

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