公开(公告)号：WO2014062839A1

公开(公告)日：2014-04-24

申请号：PCT/US2013/065297

申请日：2013-10-16

Applicant: SURMODICS, INC.

Inventor： FULLER, Shawn ,  CLASEMAN, Bryan, A. ,  SLAGER, Joram ,  MISSLING, Jeffrey, J. ,  MAHARAJ, Gary ,  OPPERMAN, Gary, W. ,  LOCKWOOD, Nathan ,  HERGENROTHER, Robert, W. ,  OLSON, Charles

IPC: A61L15/22 ,  A61L15/44 ,  A61L15/60 ,  A61L26/00

CPC classification number: A61F13/00068 ,  A61F13/00021 ,  A61F13/00029 ,  A61F13/8405 ,  A61F2013/00153 ,  A61F2013/00327 ,  A61F2013/00331 ,  A61F2013/00357 ,  A61F2013/00557 ,  A61L15/22 ,  A61L15/44 ,  A61L15/60 ,  A61L2300/102 ,  A61L2300/208

Abstract: Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements capable of absorbing exudate, wherein the surface of the spacing elements resist colonization by microorganisms. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.

Abstract translation: 本发明的实施例包括伤口包装装置及其制造和使用方法。 在一个实施方案中，本发明包括包含能够吸收渗出物的多个间隔元件的伤口包装装置，其中间隔元件的表面抵抗微生物的定居。 卷绕包装装置还可以包括将多个间隔元件彼此连接的连接器。 本文还包括其它实施例。

公开(公告)号：WO2012096787A1

公开(公告)日：2012-07-19

申请号：PCT/US2011/067722

申请日：2011-12-29

Applicant: SURMODICS, INC. ,  CHAPPA, Ralph, A.

Inventor： CHAPPA, Ralph, A.

IPC: A61M25/10 ,  A61L29/08

CPC classification number: A61M25/1011 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/00 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1086

Abstract: The present invention relates to a catheter assembly (10) that can deliver a therapeutic composition. The catheter assembly can include an outer balloon (30) with openings (36) for releasing the therapeutic composition. When the catheter assembly is in its contracted state, the openings are closed, and the assembly retains the therapeutic composition. When the catheter assembly is in its dilated state, the openings are open, and the therapeutic composition is released. The present invention also includes methods of making and using such a catheter assembly.

Abstract translation: 本发明涉及可递送治疗组合物的导管组件（10）。 导管组件可包括具有释放治疗组合物的开口（36）的外球囊（30）。 当导管组件处于收缩状态时，开口关闭，并且组件保持治疗组合物。 当导管组件处于其扩张状态时，开口是开放的，并且治疗组合物被释放。 本发明还包括制造和使用这种导管组件的方法。

公开(公告)号：WO2012058274A2

公开(公告)日：2012-05-03

申请号：PCT/US2011/057826

申请日：2011-10-26

Applicant: CHAPPA, Ralph, A. ,  BURKSTRAND, Michael, J. ,  BABCOCK, David, E. ,  SURMODICS, INC.

Inventor： CHAPPA, Ralph, A. ,  BURKSTRAND, Michael, J. ,  BABCOCK, David, E.

IPC: A61L27/34 ,  A61L31/10

CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L27/54 ,  A61L31/16 ,  A61L2420/02 ,  C08L31/04

Abstract: Embodiments of the invention include multi-layer coatings and methods for controlling the elution of hydrophilic active agents. In an embodiment, the invention includes a medical device including a substrate, a primer polymer layer disposed on the substrate, an expandable layer disposed on the primer polymer layer, and a hydrophilic active agent dispersed within the expandable layer. In an embodiment, the invention includes a method of forming a medical device including depositing a primer layer onto a substrate, the primer layer comprising a primer polymer. The method can further include depositing an expandable layer onto the primer layer, the expandable layer including an expandable polymer, and a hydrophilic active agent. The expandable layer can be deposited with a solvent that is effective to solvate both the expandable polymer and the primer polymer. Other embodiments are also included herein.

Abstract translation: 本发明的实施方案包括用于控制亲水性活性剂洗脱的多层涂层和方法。 在一个实施方案中，本发明包括医疗装置，其包括基底，设置在基底上的底漆聚合物层，设置在底漆聚合物层上的可膨胀层以及分散在可膨胀层内的亲水性活性剂。 在一个实施方案中，本发明包括一种形成医疗装置的方法，该方法包括将底漆层沉积到基底上，该底漆层包含底漆聚合物。 该方法可以进一步包括将可膨胀层沉积到底层上，可膨胀层包括可膨胀聚合物和亲水活性剂。 可膨胀层可以用有效溶解可膨胀聚合物和底层聚合物的溶剂沉积。 其他实施例也包括在本文中。

公开(公告)号：WO2011123651A3

公开(公告)日：2012-02-23

申请号：PCT/US2011030736

申请日：2011-03-31

Applicant: SURMODICS INC ,  ERICKSON SIGNE R ,  HAGEMEIER CHARLES J ,  WINCHESTER GARY A

Inventor： ERICKSON SIGNE R ,  HAGEMEIER CHARLES J ,  WINCHESTER GARY A

IPC: A61M5/178 ,  A61M5/28 ,  A61M5/31

CPC classification number: A61M5/24 ,  A61M5/2448 ,  A61M5/28 ,  A61M5/284

Abstract: Disclosed herein are systems and methods useful for delivery of suspensions and other microparticle compositions, and, in particular, for delivering microparticles at desired dosing levels and eliminating blockages within microparticle suspensions positioned within a delivery device.

Abstract translation: 本文公开了用于递送悬浮液和其它微粒组合物的系统和方法，特别是用于以期望的剂量水平递送微粒并消除位于递送装置内的微粒悬浮液内的阻塞物。

公开(公告)号：WO2012006135A2

公开(公告)日：2012-01-12

申请号：PCT/US2011042282

申请日：2011-06-29

Applicant: SURMODICS INC ,  ROLFES MEYERING EMILY R

Inventor： ROLFES MEYERING EMILY R

IPC: A61L27/34 ,  B32B3/00 ,  C08F220/22

CPC classification number: C08F226/10 ,  A61L27/16 ,  A61L29/085 ,  A61L31/10 ,  A61L2400/10 ,  A61M2025/0047 ,  C08F6/003 ,  C08F220/24 ,  C08F220/36 ,  C08F220/60 ,  Y10T428/1393 ,  Y10T428/265 ,  Y10T428/3154 ,  C08L27/12

Abstract: The invention provides fluorinated polymeric articles formed a composition including a fluoropolymer. The fluoropolymer is formed using a fluorinated monomer that provides the fluoropolymer with most or all of the fluorine atoms not directly covalently attached to an atom of the fluoropolymer backbone. The fluoropolymer can also include a non-fluorinated hydrophilic monomer in a weight amount greater than the fluorinated monomer. The fluoropolymer composition also includes an ultraviolet light (UV)-reactive group capable of covalent bonding to promotes formation of the fluorinated polymeric article. The fluorinated polymeric article can be in the form of a durable lubricious coating on the surface of an implantable medical device. Coatings of the invention exhibit excellent wet/dry lubricity, durability, and controlled swelling.

Abstract translation: 本发明提供形成包含含氟聚合物的组合物的氟化聚合物制品。 使用氟化单体形成含氟聚合物，所述氟化单体提供含氟聚合物，其中大部分或全部氟原子不直接共价连接到含氟聚合物主链的原子上。 含氟聚合物还可以包括重量比氟化单体重量的非氟化亲水性单体。 含氟聚合物组合物还包括能够共价键合以促进氟化聚合物制品的形成的紫外线（UV） - 反应性基团。 氟化聚合物制品可以是在可植入医疗装置的表面上的持久润滑涂层的形式。 本发明的涂料表现出优异的湿/干润滑性，耐久性和受控的溶胀。

公开(公告)号：WO2011143237A1

公开(公告)日：2011-11-17

申请号：PCT/US2011/035951

申请日：2011-05-10

Applicant: SURMODICS, INC. ,  MEYERING, Emily R. R.

Inventor： MEYERING, Emily R. R.

IPC: A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/00 ,  C08L67/00

Abstract: Embodiments of the invention include glycerol esters and use of the same for active agent delivery systems and methods. In an embodiment, the invention includes an active agent eluting device including a glycerol ester, an active agent dispersed within the glycerol ester, the active agent eluting device configured to elute the active agent from the glycerol ester in response to degradation of the glycerol ester. In an embodiment, the invention includes a composition including a glycerol ester; an active agent dispersed within the glycerol ester; the active agent eluting device configured to elute the active agent from the glycerol ester in response to degradation of the glycerol ester. Other embodiments are also included herein.

Abstract translation: 本发明的实施方案包括甘油酯和其用于活性剂递送系统和方法的用途。 在一个实施方案中，本发明包括活性剂洗脱装置，其包括甘油酯，分散在甘油酯内的活性剂，所述活性剂洗脱装置构造成响应于甘油酯的降解而从甘油酯中洗脱活性剂。 在一个实施方案中，本发明包括包含甘油酯的组合物; 分散在甘油酯内的活性剂; 活性剂洗脱装置构造成响应于甘油酯的降解而从甘油酯洗脱活性剂。 本文还包括其它实施例。

公开(公告)号：WO2010129328A2

公开(公告)日：2010-11-11

申请号：PCT/US2010/032741

申请日：2010-04-28

Applicant: SURMODICS, INC. ,  CHAPPA, Ralph A. ,  BACH, Andrew G.

Inventor： CHAPPA, Ralph A. ,  BACH, Andrew G.

IPC: A61L29/08

CPC classification number: A61L29/085 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/60

Abstract: Embodiments of the invention include bioactive agent eluting devices. In an embodiment the invention includes a bioactive agent delivery device including a substrate, a hydrophilic polymer disposed on the substrate, and a substantially amorphous bioactive agent disposed on the surface of the hydrophilic polymer. In an embodiment, the invention includes a method of making a bioactive agent delivery device including depositing a hydrophilic polymer on a substrate forming a hydrophilic surface and depositing a substantially amorphous bioactive agent on the hydrophilic surface. In an embodiment, the invention includes a bioactive agent-eluting catheter including a catheter shaft and an expandable balloon disposed on the catheter shaft. Other embodiments are included herein.

Abstract translation: 本发明的实施方案包括生物活性剂洗脱装置。 在一个实施方案中，本发明包括生物活性剂递送装置，其包括基底，设置在基底上的亲水性聚合物和设置在亲水性聚合物表面上的基本无定形的生物活性剂。 在一个实施方案中，本发明包括制备生物活性剂递送装置的方法，包括在形成亲水表面的基材上沉积亲水性聚合物，并在亲水表面上沉积基本无定形的生物活性剂。 在一个实施方案中，本发明包括生物活性剂洗脱导管，其包括导管轴和布置在导管轴上的可膨胀气囊。 其他实施例包括在本文中。

公开(公告)号：WO2009137689A2

公开(公告)日：2009-11-12

申请号：PCT/US2009043158

申请日：2009-05-07

Applicant: SURMODICS INC ,  SLAGER JORAM

Inventor： SLAGER JORAM

IPC: A61K9/16 ,  A61K48/00

CPC classification number: A61K9/1641 ,  A61K9/0024 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1658 ,  A61K47/543 ,  A61K47/58 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/61 ,  A61K47/6921 ,  A61K47/6923 ,  A61K47/6957 ,  A61K48/00 ,  C12N15/87

Abstract: Embodiments of the invention include particles with nucleic acid complexes, medical devices including the same and related methods. In an embodiment, the invention can include a method of making a medical device. The method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, adsorbing the nucleic acid complexes to porous particles to form nucleic acid complex containing particles, mixing the nucleic acid complex containing particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, combining the nucleic acid complexes with a material to form nucleic acid complex containing particles in situ, mixing the nucleic acid complex particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the invention can include an implantable medical device including a substrate, an elution control matrix disposed on the substrate; a plurality of particles disposed within the elution control matrix, and a plurality of nucleic acid complexes disposed within the particles, the nucleic acid complexes comprising a nucleic acid and a cationic carrier agent. Other embodiments are included herein.

Abstract translation: 本发明的实施方案包括具有核酸复合物的颗粒，包括相同方法的医疗装置。 在一个实施例中，本发明可以包括制造医疗装置的方法。 该方法可以包括使核酸与阳离子载体接触以形成核酸复合物，将核酸复合物吸附至多孔颗粒以形成含有核酸复合物的颗粒，将含有核酸复合物的颗粒与聚合物溶液混合以形成涂层混合物， 并将涂覆混合物施加到基底上。 在一个实施方案中，该方法可以包括使核酸与阳离子载体试剂接触以形成核酸复合物，将核酸复合物与材料组合以形成原位含有颗粒的核酸复合物，将核酸复合物颗粒与聚合物溶液混合 形成涂料混合物，并将涂料混合物施加到基材上。 在一个实施例中，本发明可以包括可植入医疗装置，其包括基底，设置在基底上的洗脱控制矩阵; 布置在洗脱控制基质内的多个颗粒，以及设置在颗粒内的多个核酸复合物，所述核酸复合物包含核酸和阳离子载体试剂。 本文还包括其它实施例。

公开(公告)号：WO2008130590A3

公开(公告)日：2009-11-05

申请号：PCT/US2008004949

申请日：2008-04-17

Applicant: SURMODICS INC ,  SWAN DALE G ,  KNOPKE JR WILLIAM B ,  REED PAMELA JO

Inventor： SWAN DALE G ,  KNOPKE JR WILLIAM B ,  CHUDZIK STEPHEN J

IPC: A61L27/16 ,  A61L27/18 ,  A61L27/52

CPC classification number: A61L27/58 ,  A61L24/08 ,  A61L27/20 ,  A61L27/34 ,  A61L31/042 ,  A61L31/148

Abstract: The invention provides biodegradable degradable matrix materials. The matrix materials of the invention are useful in a variety of applications such as to make implantable medical devices (e.g., implants, coatings, in-situ formed matrices, stents, tubes, aneurysm coils, and the like), in-situ delivery (e.g., cell delivery or bioactive agent delivery), and as tissue sealants. In many embodiments, the matrix materials of the invention are formed by reacting: (a) a first component comprising an aminated natural degradable polysaccharide with (b) a second component comprising an amine-reactive compound.

Abstract translation: 本发明提供可生物降解的可降解基质材料。 本发明的基质材料可用于各种应用，例如制造可植入的医疗装置（例如，植入物，涂层，原位形成的基质，支架，管，动脉瘤线圈等），原位递送（ 例如细胞递送或生物活性剂递送）和组织密封剂。 在许多实施方案中，本发明的基质材料通过使（a）包含胺化天然可降解多糖的第一组分与（b）包含胺反应性化合物的第二组分反应形成。

公开(公告)号：WO2009132214A1

公开(公告)日：2009-10-29

申请号：PCT/US2009/041575

申请日：2009-04-23

Applicant: SURMODICS, INC. ,  CHAPPA, Ralph, A. ,  ARPS, James

Inventor： CHAPPA, Ralph, A. ,  ARPS, James

IPC: B05B13/02

CPC classification number: A61F2/82 ,  A61F2240/001 ,  B05B13/0242 ,  B05B13/0442

Abstract: The invention relates to systems and methods for applying coatings to devices. In an embodiment, the invention includes a coating apparatus including a mandrel having a lengthwise axis and an exterior surface, the exterior surface of the mandrel defining a plurality of channels disposed parallel to the lengthwise axis, the mandrel configured to rotate around the lengthwise axis; and a spray head configured to direct a stream of material at the mandrel. In an embodiment the invention includes a method of applying a coating to a medical device. Other embodiments are also included herein.

Abstract translation: 本发明涉及将涂料涂覆到装置上的系统和方法。 在一个实施例中，本发明包括涂覆设备，其包括具有纵向轴线和外表面的心轴，心轴的外表面限定平行于纵向轴线设置的多个通道，心轴构造成围绕纵向轴线旋转; 以及喷头，其配置成在心轴处引导材料流。 在一个实施方案中，本发明包括将涂层施加到医疗装置的方法。 本文还包括其它实施例。