公开(公告)号：WO2010051376A2

公开(公告)日：2010-05-06

申请号：PCT/US2009/062582

申请日：2009-10-29

Applicant: WARSAW ORTHOPEDIC, INC. ,  TRIEU, Hai H. ,  HADDOCK, Sean M.

Inventor： TRIEU, Hai H. ,  HADDOCK, Sean M.

IPC: B01F5/04 ,  B01F7/16

CPC classification number: B01F15/0205 ,  B01F11/0082 ,  B01F13/002 ,  B01F13/0023 ,  B01F15/0201 ,  B01F15/0215 ,  B01F15/0224 ,  B01F15/0237 ,  B01F15/0279 ,  B01F2215/0027 ,  B01F2215/0029 ,  B01F2215/0034

Abstract: Mixing systems for storing and mixing multiple components of various medical compositions are provided. Generally, the instant mixing systems comprise a barrel, a plunger slidably disposed inside a barrel, and a pushing rod slidably disposed inside the plunger. The instant mixing system may further comprise multiple chambers for storing individual components or mixtures of components, with at least one chamber disposed in the barrel and at least one chamber disposed inside the plunger.

Abstract translation: 提供了用于储存和混合各种医药组合物的多种组分的混合系统。 通常，即时混合系统包括筒体，可滑动地设置在筒体内的柱塞以及可滑动地设置在柱塞内的推杆。 本混合系统还可以包括多个腔室，用于存储各个组分或组分的混合物，其中至少一个腔室设置在所述筒体中并且至少一个腔室设置在所述柱塞内部。

公开(公告)号：WO2008079864B1

公开(公告)日：2008-10-16

申请号：PCT/US2007088096

申请日：2007-12-19

Applicant: WARSAW ORTHOPEDIC INC ,  JUSTIS JEFF R ,  TRIEU HAI H ,  PROTOPSALTIS DIMITRI K ,  SHERMAN MICHAEL C

Inventor： JUSTIS JEFF R ,  TRIEU HAI H ,  PROTOPSALTIS DIMITRI K ,  SHERMAN MICHAEL C

IPC: A61B17/70 ,  A61B17/80 ,  A61B17/86 ,  A61F2/44

CPC classification number: A61B17/866 ,  A61B17/7013 ,  A61B17/7032 ,  A61B17/7049 ,  A61B17/80 ,  A61B17/8605 ,  A61B17/8625 ,  A61F2/441 ,  A61F2/4425 ,  A61F2/4455 ,  A61F2/4465 ,  A61F2/447 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/302 ,  A61F2002/30225 ,  A61F2002/30545 ,  A61F2002/30556 ,  A61F2002/30583 ,  A61F2002/30677 ,  A61F2002/30884 ,  A61F2002/3092 ,  A61F2002/444 ,  A61F2002/4495 ,  A61F2002/465 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2250/0009 ,  A61F2250/001

Abstract: An orthopedic implant device (100, 200, 300, 301, 320, 340, 400, 500, 600, 700', 720, 740, 760, 770, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500, 1600, 1700, 1800) is non-rigid, i.e., flexible and/or malleable, in a first form for insertion into a desired in vivo site, and then transformable into a rigid, or hardened, form for providing a load-bearing function or providing other structural and/or mechanical function after implantation. The device includes a biocompatible sheath (110) and a curable material (120) sealed within the sheath (110). The curable material (120) is provided in a first form that provides flexibility to the device and is structured to rigidize in a second form after insertion to an in vivo location at least one minute after application of a cure-initiating energy to the material (120) prior to insertion. Related methods and kits are also provided.

Abstract translation: 矫形外科植入装置（100,200,300,301,320,340,400,500,600,700,720,740,760,770,800,900,1000,1100,1200,1300,1400,1500等）中， 1600,1700,1800）是非刚性的，即柔性和/或可延展的第一形式，用于插入所需的体内部位，然后可转化成刚性或硬化的形式，以提供承载功能 或在植入后提供其它结构和/或机械功能。 该装置包括密封在护套（110）内的生物相容护套（110）和可固化材料（120）。 可固化材料（120）以提供对装置的柔性的第一形式提供，并且被构造成在向固体材料施加固化引发能量至少一分钟后将其插入至体内位置之后以第二形式固化（ 120）。 还提供了相关方法和试剂盒。

公开(公告)号：WO2007127548A3

公开(公告)日：2008-10-02

申请号：PCT/US2007064580

申请日：2007-03-22

Applicant: WARSAW ORTHOPEDIC INC ,  TRIEU HAI H

Inventor： TRIEU HAI H

IPC: A61M31/00 ,  A61F2/44

CPC classification number: A61M31/002 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/444 ,  A61F2002/4666 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61K9/0024 ,  A61M5/14276 ,  A61M5/16827 ,  A61M2005/14513 ,  A61M2210/02 ,  A61M2210/1003 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

Abstract: A device includes a sensor configured to determine a condition associated with a nucleus pulposus, a reservoir configured to include a first agent capable of affecting the condition associated with the nucleus pulposus, a control element configured to provide access to the reservoir, and a controller in communication with the sensor and the control element. The controller is configured to manipulate the control element to provide access to the reservoir in response to the condition determined by the sensor.

Abstract translation: 装置包括被配置为确定与髓核相关联的状况的传感器，被配置为包括能够影响与髓核相关联的状况的第一代理的储存器，被配置为提供对储存器的通路的控制元件，以及控制器， 与传感器和控制元件的通信。 控制器被配置为响应于由传感器确定的条件来操纵控制元件以提供对储存器的访问。

公开(公告)号：WO2008086354A3

公开(公告)日：2008-09-18

申请号：PCT/US2008050513

申请日：2008-01-08

Applicant: WARSAW ORTHOPEDIC INC ,  TRIEU HAI H

Inventor： TRIEU HAI H

IPC: A61F2/44 ,  A61B17/88 ,  A61F2/46

CPC classification number: A61F2/441 ,  A61B17/7097 ,  A61B2017/0256 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30062 ,  A61F2002/30133 ,  A61F2002/30146 ,  A61F2002/30156 ,  A61F2002/30163 ,  A61F2002/30179 ,  A61F2002/30299 ,  A61F2002/30583 ,  A61F2002/30677 ,  A61F2002/30841 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/448 ,  A61F2002/4495 ,  A61F2002/4627 ,  A61F2002/467 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61F2230/0015 ,  A61F2230/0017 ,  A61F2230/0023 ,  A61F2230/0028 ,  A61F2230/0058 ,  A61F2230/0093 ,  A61F2310/00365

Abstract: A system for treating an annular defect of an intervertebral disc is provided. The system comprises a cannula (34) for accessing a nucleus pulposus (24) of the intervertebral disc, an expandable spacing device, and a material delivery instrument (42). The expandable spacing device (40) has a first deflated position and a second inflated position. The spacing device is sized to pass through the cannula when in the first deflated position and the spacing device has a predetermined shape in the second inflated position. The material delivery instrument is adapted to inflate the spacing device from the first deflated position to the second inflated position by injecting a biocompatible material into the spacing device. In another aspect, a method of treating at least one annular defect of an intervertebral disc is provided.

Abstract translation: 提供一种用于治疗椎间盘的环状缺陷的系统。 该系统包括用于进入椎间盘的髓核（24）的插管（34），可扩张间隔装置和材料输送装置（42）。 可扩张间隔装置（40）具有第一放气位置和第二充气位置。 间隔装置的尺寸设置成当处于第一放气位置时穿过套管，并且间隔装置在第二充气位置具有预定形状。 材料输送工具适于通过将生物相容性材料注入到间隔装置中将间隔装置从第一收缩位置膨胀到第二充气位置。 另一方面，提供一种治疗椎间盘的至少一个环状缺陷的方法。

公开(公告)号：WO2008089117A2

公开(公告)日：2008-07-24

申请号：PCT/US2008/050957

申请日：2008-01-14

Applicant: WARSAW ORTHOPEDIC, INC. ,  TRIEU, Hai, H. ,  AGNIHOTRI, Aashiish

Inventor： TRIEU, Hai, H. ,  AGNIHOTRI, Aashiish

IPC: A61L27/50 ,  A61B17/88

CPC classification number: A61B17/8825 ,  A61B17/7095 ,  A61B17/8816 ,  A61B17/8822 ,  A61B17/8827 ,  A61B2017/00004 ,  A61F2/442 ,  A61F2/4455 ,  A61L27/50 ,  A61L2400/06 ,  A61L2430/02

Abstract: A method for treating a vertebral bone comprises providing a plurality of hollow microparticles and providing a flowable and settable bone filling material. The method further comprises mixing the plurality of hollow microparticles with the bone filling material to form a bone augmentation material. The method further comprises inserting an injection device into the vertebral bone and injecting the bone augmentation material from the injection device and into the vertebral bone.

Abstract translation: 一种治疗椎骨的方法包括提供多个中空微粒并提供可流动和可固定的骨填充材料。 该方法还包括将多个中空微粒与骨填充材料混合以形成骨增强材料。 该方法还包括将注射装置插入椎骨中，并将注射装置的注射装置注入到脊骨中。

公开(公告)号：WO2008086354A2

公开(公告)日：2008-07-17

申请号：PCT/US2008/050513

申请日：2008-01-08

Applicant: WARSAW ORTHOPEDIC, INC. ,  TRIEU, Hai H.

Inventor： TRIEU, Hai H.

IPC: A61F2/44

CPC classification number: A61F2/441 ,  A61B17/7097 ,  A61B2017/0256 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30062 ,  A61F2002/30133 ,  A61F2002/30146 ,  A61F2002/30156 ,  A61F2002/30163 ,  A61F2002/30179 ,  A61F2002/30299 ,  A61F2002/30583 ,  A61F2002/30677 ,  A61F2002/30841 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/448 ,  A61F2002/4495 ,  A61F2002/4627 ,  A61F2002/467 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61F2230/0015 ,  A61F2230/0017 ,  A61F2230/0023 ,  A61F2230/0028 ,  A61F2230/0058 ,  A61F2230/0093 ,  A61F2310/00365

Abstract: A system for treating an annular defect of an intervertebral disc is provided. The system comprises a cannula for accessing a nucleus pulposus of the intervertebral disc, an expandable spacing device, and a material delivery instrument. The expandable spacing device has a first deflated position and a second inflated position. The spacing device is sized to pass through the cannula when in the first deflated position and the spacing device has a predetermined shape in the second inflated position. The material delivery instrument is adapted to inflate the spacing device from the first deflated position to the second inflated position by injecting a biocompatible material into the spacing device. In another aspect, a method of treating at least one annular defect of an intervertebral disc is provided.

Abstract translation: 提供一种用于治疗椎间盘的环状缺陷的系统。 该系统包括用于进入椎间盘的髓核的套管，可扩张间隔装置和材料递送装置。 可扩张间隔装置具有第一放气位置和第二充气位置。 间隔装置的尺寸设置成当处于第一放气位置时穿过套管，并且间隔装置在第二充气位置具有预定形状。 材料输送仪器适于通过将生物相容性材料注射到间隔装置中来将间隔装置从第一放气位置膨胀到第二充气位置。 另一方面，提供一种治疗椎间盘的至少一个环状缺陷的方法。

公开(公告)号：WO2007140170A2

公开(公告)日：2007-12-06

申请号：PCT/US2007/069409

申请日：2007-05-22

Applicant: WARSAW ORTHOPEDIC, INC ,  ALLARD, Randall N. ,  LANGE, Eric C. ,  ANDERSON, Kent M. ,  TRIEU, Hai H. ,  BRUNEAU, Aurelien

Inventor： LANGE, Eric C. ,  ANDERSON, Kent M. ,  TRIEU, Hai H. ,  BRUNEAU, Aurelien

CPC classification number: A61B17/7067 ,  A61B17/7065 ,  A61B2017/00557 ,  A61F2/441 ,  A61F2/442 ,  A61F2002/4495

Abstract: An interspinous spacer for placement between adjacent spinous processes includes a flexible, fillable container (e.g., a bag or balloon) for containing a material that is compressible during end use, for example, silicone after curing. The container is impermeable to the material it will be filled with. A structural mesh, for example, made of PET fabric and interwoven shape-memory alloy wire, provides structure for and containment of the container, as well as shape control. The material can be injected into the container through an optional conduit, for example, a one-way valve.

Abstract translation: 用于放置在相邻棘突之间的棘突间间隔物包括用于容纳在最终使用期间可压缩的材料的柔性可填充容器（例如，袋或气囊），例如固化后的硅氧烷。 该容器对于将被填充的材料是不透水的。 例如由PET织物和交织形状记忆合金线制成的结构网格提供了容器的结构和容纳物以及形状控制。 该材料可以通过可选导管（例如单向阀）注入容器。

公开(公告)号：WO2007127734A2

公开(公告)日：2007-11-08

申请号：PCT/US2007/067305

申请日：2007-04-24

Applicant: WARSAW ORTHOPEDIC, INC. ,  TRIEU, Hai H. ,  CARLS, Thomas A. ,  LIM, Roy K. ,  LANGE, Eric C. ,  ANDERSON, Kent M. ,  BRUNEAU, Aurelien

Inventor： TRIEU, Hai H. ,  CARLS, Thomas A. ,  LIM, Roy K. ,  LANGE, Eric C. ,  ANDERSON, Kent M. ,  BRUNEAU, Aurelien

CPC classification number: A61B17/7065 ,  A61F2/441 ,  A61F2002/30581

Abstract: An implant is disclosed and can include a body and a plurality of pellets disposed within the body. The implant can be moved between an unmolded, relaxed configuration wherein the body is not conformed to a bone and a molded, relaxed configuration wherein the body is at least partially conformed to the bone.

Abstract translation: 公开了一种植入物，并且可以包括主体和设置在体内的多个小丸。 植入物可以在未模制的松弛构造之间移动，其中主体不符合骨骼和模制的松弛构造，其中主体至少部分地与骨骼相符。

公开(公告)号：WO2007127689A2

公开(公告)日：2007-11-08

申请号：PCT/US2007/067183

申请日：2007-04-23

Applicant: WARSAW ORTHOPEDIC, INC. ,  LIM, Roy K. ,  CARLS, Thomas A. ,  BRUNEAU, Aurelien ,  LANGE, Eric C. ,  ANDERSON, Kent M. ,  TRIEU, Hai H.

Inventor： LIM, Roy K. ,  CARLS, Thomas A. ,  BRUNEAU, Aurelien ,  LANGE, Eric C. ,  ANDERSON, Kent M. ,  TRIEU, Hai H.

IPC: A61B17/70

CPC classification number: A61B17/7062

Abstract: An adjustable interspinous process brace is disclosed and can include a superior component. The superior component can include a superior spinous process bracket that can engage a superior spinous process. Further, the adjustable interspinous process brace can include an inferior component. The inferior component can include an inferior spinous process bracket that can engage an inferior spinous process. Further, the inferior component can be movably engaged with the superior component from a retracted position to an extended position. In the extended position, a distance between the superior spinous process bracket and the inferior spinous process bracket can be increased.

Abstract translation: 公开了一种可调节棘突间过程支架，并且可以包括优异的部件。 优越的组件可以包括可以接合优良棘突的上级棘突支架。 此外，可调椎间过程支架可以包括下部构件。 下部组件可以包括可以接合下部棘突的下棘突支架。 此外，下部部件可以与上部部件从缩回位置可移动地接合到延伸位置。 在延伸位置，可以增加上棘部支架和下棘突支架之间的距离。

公开(公告)号：WO2007124253A2

公开(公告)日：2007-11-01

申请号：PCT/US2007/066015

申请日：2007-04-05

Applicant: WARSAW ORTHOPEDIC, INC ,  TRIEU, Hai H. ,  SERBOUSEK, Jon C. ,  VELDMAN, Michael S.

Inventor： TRIEU, Hai H. ,  SERBOUSEK, Jon C. ,  VELDMAN, Michael S.

CPC classification number: A61B17/864 ,  A61B17/7032 ,  A61B17/7059 ,  A61B17/7098 ,  A61B17/861 ,  A61B17/866 ,  A61B2017/00004

Abstract: The present application discloses various embodiments of surgical fasteners that combine mechanical and osteogenic means of fixation to maximize in vivo stability and long-term performance. The fastener generally includes a head and a shaft. The fastener is fenestrated and includes a channel that leads into one or more openings along the shaft. Bone void filling materials is delivered through the channel to the shaft to improve anchoring. In one embodiment, the osteogenic means comprise a coating applied to the fastener to improve bony apposition. The fastener with combined mechanical and osteogenic means provides initial, immediate anchoring and long term anchoring.

Abstract translation: 本申请公开了外科紧固件的各种实施例，其结合机械和成骨的固定方式以使体内稳定性和长期性能最大化。 紧固件通常包括头部和轴。 紧固件是开窗的，并且包括通向轴的一个或多个开口的通道。 骨空隙填充材料通过通道输送到轴以改善锚固。 在一个实施方案中，成骨装置包括施加到紧固件以改善骨性接合的涂层。 具有组合机械和成骨装置的紧固件提供初始的立即锚固和长期锚定。