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    NANOPARTICLE PHARMACEUTICAL CARRIER
    52.
    发明申请
    NANOPARTICLE PHARMACEUTICAL CARRIER 审中-公开
    纳米脂肪药物载体

    公开(公告)号：WO2007132205A3

    公开(公告)日：2009-03-05

    申请号：PCT/GB2007001741

    申请日：2007-05-11

    Applicant: UNIV BELFAST ,  HIKMA PHARMACEUTICALS LTD ,  MCCARRON PAUL ,  MAROUF WALEED

    Inventor： MAROUF WALEED

    IPC: A61K47/48 ,  A61K9/51 ,  A61P43/00

    CPC classification number: A61K9/1647 ,  A61K9/5153 ,  A61K9/5192 ,  A61K47/6937 ,  B82Y5/00

    Abstract: A nanoparticle pharmaceutical carrier comprising a first polymer, or copolymer, having a plurality of terminal amino-carboxyl groups and a second polymer, or copolymer. Preferably, the second polymer or copolymer is branched or linear. Preferably, the second polymer or copolymer has a plurality of terminal alkyl groups.

    Abstract translation: 包含具有多个末端氨基 - 羧基和第二聚合物或共聚物的第一聚合物或共聚物的纳米颗粒药物载体。 优选地，第二聚合物或共聚物是支链或直链的。 优选地，第二聚合物或共聚物具有多个末端烷基。

    EVIDENTIAL SUPPORT SYSTEM AND METHOD
    53.
    发明申请
    EVIDENTIAL SUPPORT SYSTEM AND METHOD 审中-公开
    证据支持系统和方法

    公开(公告)号：WO2009007703A2

    公开(公告)日：2009-01-15

    申请号：PCT/GB2008002327

    申请日：2008-07-07

    Applicant: UNIV BELFAST ,  BELL DAVID ANDREW

    Inventor： BELL DAVID ANDREW

    IPC: G06N7/00

    CPC classification number: G06N7/02

    Abstract: An evidential support system for determining the strength of agreement between a plurality of sets of evidential data comprising an input port for receiving a plurality of sets of evidential data from at least one external source, a data storage device for storing interval data corresponding to a plurality of confidence intervals and correlation value data corresponding to possible values of combinations of pre-determined weighting values, a correlation unit for determining a correlation between entries in the at least two of the plurality of sets evidential data, a comparison unit for comparing the strength of correlations between said entries, the correlation unit being arranged to assign pre-determined weight data to each entry in a set of evidential data and being further arranged to determine intersections between entries the at least two of the plurality of sets of evidential data, the correlation unit being arranged to determine correlation value data based upon the pre-determined weight data assigned to intersecting entries in the at least two sets of the plurality of sets of evidential data, the comparison unit being arranged to receive the correlation value data from the correlation means and to access the interval data stored upon the data storage device and to assign each correlation value datum to a respective credible interval range associated with an interval datum, and the comparison unit being further arranged to compare interval data associated with respective correlation value data in order to determine identifier data indicative of relative belief strengths of the plurality of sets of evidential data.

    Abstract translation: 一种证据支持系统，用于确定多组证据数据之间的一致性的强度，包括用于从至少一个外部源接收多组证据数据的输入端口，用于存储对应于多个证据数据的间隔数据的数据存储装置 的置信区间和对应于预定加权值的组合的可能值的相关值数据，相关单元，用于确定多个集合证据数据中的至少两个中的条目之间的相关性;比较单元，用于比较 所述条目之间的相关性，所述相关单元被布置为将一组预先确定的加权数据分配给一组证据数据中的每个条目，并进一步被布置成确定所述多个证据数据集中的至少两个证据数据组之间的相交， 单元被布置成基于预定义来确定相关值数据 分配给所述多组证据数据的所述至少两组中的相交条目的权重数据，所述比较单元被布置为从所述相关装置接收所述相关值数据，并访问存储在所述数据存储装置上的间隔数据，以及 将每个相关值数据分配给与间隔数据相关联的相应的可信区间范围，并且所述比较单元进一步被布置为比较与各个相关值数据相关联的间隔数据，以便确定指示所述多个 证据数据集。

    IMPROVEMENTS RELATING TO THE MEASUREMENT OF VISCOSITY
    55.
    发明申请
    IMPROVEMENTS RELATING TO THE MEASUREMENT OF VISCOSITY 审中-公开
    与粘度测量有关的改进

    公开(公告)号：WO2008040943A3

    公开(公告)日：2008-12-24

    申请号：PCT/GB2007003691

    申请日：2007-09-28

    Applicant: UNIV BELFAST ,  THOMPSON STEPHEN ,  MCAFEE MARION

    Inventor： THOMPSON STEPHEN ,  MCAFEE MARION

    IPC: B29C47/92 ,  G01N11/00

    CPC classification number: B29C47/92 ,  B29C47/0014 ,  B29C47/0021 ,  B29C47/0023 ,  B29C2947/92019 ,  B29C2947/92038 ,  B29C2947/92047 ,  B29C2947/92095 ,  B29C2947/92209 ,  B29C2947/92695 ,  B29C2947/92885 ,  B29C2947/92895

    Abstract: A method of determining the viscosity of an extrudate material in an extrusion system, comprising the steps of (i) acquiring measurements (T, N) of one or more process conditions of the extrusion system, (ii) acquiring indications of throughput of the extrudate material through the extrusion system, (iii) acquiring pressure measurements (Pm) of the extrudate material at one or more locations of the extrusion system, (iv) using a first model (40) to generate an estimated viscosity (?) of the extrudate material using data relating to the material and one of the measurements of the or each process condition, (v) using a second model (42) to generate an estimated pressure (Pe) of the extrudate material using data relating to the extrusion system geometry, the estimated viscosity (?) of the extrudate material and one of the indications of the extrudate material throughput, (vi) comparing the estimated pressure (Pe) of the extrudate material with a pressure measurement (Pm) of the extrudate material to generate a pressure difference value (Pdif), (vii) using the pressure difference value (Pdif) to generate a viscosity correction value, (viii) feeding the viscosity correction value into the first model (40) and using the viscosity correction value in the generation of a next estimated viscosity of the extrudate material, and (ix) repeating steps (iii) to (viii) one or more times, each repetition using another of the measurements of the or each process condition and another of the indications of the extrudate material throughput, wherein the generated pressure difference values are driven towards a minimum value.

    Abstract translation: 一种确定挤出系统中挤出物材料的粘度的方法，包括以下步骤：（i）获取挤出系统的一个或多个工艺条件的测量值（T，N）;（ii）获取挤出物的通过量的指示 （iii）在所述挤出系统的一个或多个位置处获取所述挤出物材料的压力测量值（Pm），（iv）使用第一模型（40）来生成所述挤出物的估计粘度（η） （v）使用第二模型（42）以使用与挤出系统几何形状相关的数据来生成挤出物材料的估计压力（Pe），其中使用与材料有关的数据以及所述或每个工艺条件的测量之一， （vi）挤出物材料的估计粘度（η）和挤出物材料通过量的指示之一，（vi）将挤出物材料的估计压力（Pe）与挤出物的压力测量值（Pm） 用于产生压差值（Pdif）的材料，（vii）使用压差值（Pdif）产生粘度校正值，（viii）将粘度校正值馈送到第一模型（40）中，并使用粘度校正值 （ix）重复步骤（iii）至（viii）一次或多次，每次重复使用另一个所述或每个工艺条件的测量结果以及另一个 挤出物材料通过量，其中产生的压力差值被驱向最小值。

    PROCESS FOR REMOVING SULFUR-CONTAINING ACIDS FROM CRUDE OIL
    57.
    发明申请
    PROCESS FOR REMOVING SULFUR-CONTAINING ACIDS FROM CRUDE OIL 审中-公开
    从原油中除去含硫酸的方法

    公开(公告)号：WO2007138307A3

    公开(公告)日：2008-06-05

    申请号：PCT/GB2007001985

    申请日：2007-05-19

    Applicant: UNIV BELFAST ,  COLLINS IAN RALPH ,  PLECHKOVA NATALIA VLADIMIROVNA ,  ANDERSON KRIS

    Inventor： COLLINS IAN RALPH ,  PLECHKOVA NATALIA VLADIMIROVNA ,  ANDERSON KRIS

    IPC: C10G21/27 ,  C07C211/63 ,  C07D233/54 ,  C07D521/00

    CPC classification number: C10G21/27

    Abstract: A sulfur-containing acid removal process for deacidifying a crude oil and/or crude oil distillate containing sulfur-containing acids comprising the steps of: (a) contacting the crude oil and/or crude oil distillate containing sulfur-containing acids with a basic ionic liquid having a melting point of below 1500 °C, and extracting at least a portion of the sulfur-containing acids into the basic ionic liquid as an extract phase; and (b) separating a crude oil and/or crude oil distillate phase which is reduced in acidity from the basic ionic liquid extract phase.

    Abstract translation: 一种用于使含有含硫酸的原油和/或原油馏出物脱酸的含硫酸脱除方法，包括以下步骤：（a）使含有硫的酸的原油和/或原油馏出物与碱性离子 熔点低于1500℃的液体，并将至少一部分含硫酸提取为碱性离子液体作为萃取相; 和（b）从碱性离子液体萃取相分离酸性降低的原油和/或原油馏出物相。

    PREPARATION OF OLIGONUCLEOTIDES WITH PHOTOSWITCHABLE PROPERTIES
    58.
    发明申请
    PREPARATION OF OLIGONUCLEOTIDES WITH PHOTOSWITCHABLE PROPERTIES 审中-公开
    具有光电性质的寡核苷酸的制备

    公开(公告)号：WO2007107775A3

    公开(公告)日：2008-03-27

    申请号：PCT/GB2007001056

    申请日：2007-03-23

    Applicant: UNIV BELFAST ,  VYLE JOSEPH S ,  TUCKER JAMES ROBERT

    Inventor： VYLE JOSEPH S ,  TUCKER JAMES ROBERT

    IPC: C07H21/00 ,  C12N15/11 ,  C12N15/113 ,  C12Q1/68

    CPC classification number: C07H21/00 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/351 ,  C12N2320/50

    Abstract: Linkers which provide for the attachment of photoswitchable compounds to nucleic acid are provided. These linkers can be used to provide photo-modulatable compounds wherein the chemical and biological properties of polynucleic acid incorporating these photo-modulatable compounds can be modulated by light. Further, methods for modulation of hybridisation of polynucleic acid sequences and binding of factors, for example polymerases to polynucleic acid sequences incorporating said photo-modulatable compounds are provided.

    Abstract translation: 提供了将可开关化合物附着到核酸上的接头。 这些接头可用于提供可光调制的化合物，其中掺入这些光可调节化合物的多核酸的化学和生物学性质可以通过光调制。 此外，提供了用于调节多核酸序列的杂交和因子结合的方法，例如聚合酶与掺入所述光可调节化合物的多核酸序列的结合。

    FAULT DETECTION
    59.
    发明申请
    FAULT DETECTION 审中-公开
    故障检测

    公开(公告)号：WO2007113582A3

    公开(公告)日：2007-11-29

    申请号：PCT/GB2007001290

    申请日：2007-04-05

    Applicant: UNIV BELFAST ,  SEZER SAKIR ,  LAMB DAVID MARTIN ,  SCOTT COLM ,  MULHOLLAN LIAM ,  KAVANAGH GARRET DAVID ,  MCLOUGHLIIN GARRET MICHAEL ANT

    Inventor： SEZER SAKIR ,  LAMB DAVID MARTIN ,  SCOTT COLM ,  MULHOLLAN LIAM ,  KAVANAGH GARRET DAVID ,  MCLOUGHLIIN GARRET MICHAEL ANT

    IPC: G01R31/08 ,  H02H7/26

    CPC classification number: H02H1/0007 ,  G01R31/088 ,  H02H3/042

    Abstract: An electricity network fault detection system comprising at least two fault detectors which detect a signal comprising a sferic caused by a fault in the network, and a system processor which receives details of the detected sferic from each of the detectors, and determines the approximate location of generation of the sferic. When a fault occurs in an electricity network, a fault current is generated. These, in conjunction with a part of the network where the fault current has occurred which acts as an antenna, produce electromagnetic radiation in the form of atmospheric radio waves or sferics. It has been realised that these sferics may be used to detect a fault and to determine its approximate location.

    Abstract translation: 一种电网故障检测系统，包括至少两个故障检测器，所述故障检测器检测包括由网络中的故障引起的故障的信号，以及系统处理器，其从每个检测器接收检测到的故障的细节，并且确定 世代的生成。 当电网发生故障时，会产生故障电流。 这些与发生故障电流的作为天线的网络部分一起产生大气无线电波或频率的电磁辐射。 已经认识到，这些网络可用于检测故障并确定其大致位置。

    BRCA1 MARKERS
    60.
    发明申请
    BRCA1 MARKERS 审中-公开
    BRCA1标记

    公开(公告)号：WO2005121786A3

    公开(公告)日：2006-04-27

    申请号：PCT/GB2005002227

    申请日：2005-06-06

    Applicant: UNIV BELFAST ,  HARKIN PAUL

    Inventor： HARKIN PAUL

    IPC: G01N33/50 ,  G01N33/574

    CPC classification number: G01N33/5011 ,  G01N33/57415 ,  G01N33/57449 ,  G01N2800/52

    Abstract: A method of predicting the presence of a non-functional BRCA1 gene in a biological sample, comprises the step of assaying the sample for expression of at least one specific member of the S100 family of genes. The invention also describes a kit for predicting the presence of non-functional BRCA1, comprising means for assaying a sample for expression of at least one specific member of the S100 gene family. A method of detecting a genetic predisposition to cancer is also described, comprising the step of assaying a biological sample for expression of a specific member of the S100 family of genes. Also described is a method of determining a suitable chemotherapeutic agent for an individual.

    Abstract translation: 预测生物样品中非功能性BRCA1基因的存在的方法包括测定样品以表达S100家族基因的至少一个特定成员的步骤。 本发明还描述了一种用于预测非功能性BRCA1的存在的试剂盒，其包括用于测定样品以表达S100基因家族的至少一个特定成员的方法。 还描述了检测癌症的遗传易感性的方法，包括测定生物样品以表达S100家族基因的特定成员的步骤。 还描述了确定个体的合适的化学治疗剂的方法。

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