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    DISPERSION DEVICES FOR AGGREGATES
    64.
    发明申请
    DISPERSION DEVICES FOR AGGREGATES 审中-公开
    聚合物分散装置

    公开(公告)号：WO2008067044A2

    公开(公告)日：2008-06-05

    申请号：PCT/US2007/080958

    申请日：2007-10-10

    Applicant: MERIAL LIMITED ,  RIGAUT, Guillaume

    Inventor： RIGAUT, Guillaume

    IPC: C12M1/00 ,  C12N5/06

    CPC classification number: C12M43/02 ,  C12M47/06 ,  C12N5/0603 ,  C12N2531/00

    Abstract: The present invention encompasses a flow-through dispersion device for the dispersion of cell aggregates, the device comprising a first or upstream inlet obstacle and a second or downstream outlet obstacle, each obstacle having at least one traversing hole wherein no two holes align. Between the two obstacles is a turbulence chamber, such that when a cell suspension is passed through the inlet holes, into the chamber and then exits the second obstacle, the turbulence within the chamber disrupts and disperses cell aggregates. The device optionally may have more than two obstacles and turbulence chambers and multiple units may be placed in series to increase the amount of turbulence and time applied to a volume of cells. The invention further encompasses methods of using the device to disperse cell aggregates, and methods of culturing cells that involve seeding cultures and maintaining dispersed individual cells.

    Abstract translation: 本发明包括用于细胞团聚体分散的流通式分散装置，该装置包括第一或上游进口障碍物和第二或下游出口障碍物，每个障碍物具有至少一个横向孔 其中没有两个孔对齐。 在两个障碍物之间是湍流室，使得当细胞悬液通过入口孔进入室并随后离开第二障碍物时，室内的湍流扰乱并分散细胞聚集体。 该设备可选地可以具有多于两个的障碍物，并且湍流室和多个单元可以串联放置以增加施加到一定体积的细胞的湍流量和时间量。 本发明还包括使用该装置分散细胞聚集体的方法，以及培养包括接种培养物和维持分散的单个细胞的细胞的方法。

    CANINE LEISHMANIA VACCINE
    65.
    发明申请
    CANINE LEISHMANIA VACCINE 审中-公开

    公开(公告)号：WO2008064181A2

    公开(公告)日：2008-05-29

    申请号：PCT/US2007/085142

    申请日：2007-11-19

    Applicant: MERIAL LIMITED ,  FISCHER, Laurent, Bernard

    Inventor： FISCHER, Laurent, Bernard

    IPC: C07K16/00

    CPC classification number: A61K39/008 ,  A61K2039/53 ,  A61K2039/545 ,  Y02A50/41

    Abstract: The present invention provides vectors that contain and express in vivo Leishmania KMP11 or an epitope thereof that elicits an immune response in a dog against Leishmania, compositions comprising said vectors, methods of vaccination against Leishmania , and kits for use with such methods and compositions.

    Abstract translation: 本发明提供含有体内利什曼原虫KMP11或其表位的载体，其在狗中针对利什曼原虫引起免疫应答，包含所述载体的组合物，针对利什曼原虫接种的方法，以及用于此类方法和组合物的试剂盒。

    POLYMORPHISMS IN THE UROCORTIN 3 GENE AND THEIR ASSOCIATIONS WITH MARBLING AND SUBCUTANEOUS FAT DEPTH IN BEEF CATTLE
    66.
    发明申请
    POLYMORPHISMS IN THE UROCORTIN 3 GENE AND THEIR ASSOCIATIONS WITH MARBLING AND SUBCUTANEOUS FAT DEPTH IN BEEF CATTLE 审中-公开
    乌洛托品3基因多态性及其与啤酒花粉和少量脂肪深度的关系

    公开(公告)号：WO2008060602A2

    公开(公告)日：2008-05-22

    申请号：PCT/US2007/024014

    申请日：2007-11-15

    Applicant: WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION

    Inventor： JIANG, Zhihua ,  MICHAL, Jennifer, J. ,  WILLIAMS, Galen, A.

    IPC: C12Q1/68

    CPC classification number: C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172 ,  G06F19/18

    Abstract: Aspects of the present invention also provide methods based on novel UCN3 nucleotide polymorphisms selected from the group consisting of AAFC03043460.1 :g.8272- 8281AATAATAAAT>GGAGC, g.8208OT, g.8265OT, g.8287T>C, g.8412A>G, g,8426T>A, C.8786OT, g.9074T>C, C.12609OT, c.l2621T>C, c.l2667T>G and C.12669OA, which may provide novel markers for marbling and/or subcutaneous fat. Additional aspects provide for novel methods which may comprise marker-assisted selection or marker-assisted management to improve marbling and/or subcutaneous fat depth in cattle.

    Abstract translation: 本发明的方面还提供了基于新型UCN3核苷酸多态性的方法，所述多态性选自AAFC03043460.1：g.8272-8281AATAATAAAT> GGAGC，g.8208OT，g.8265OT，g.8287T> C，g.8412A> G，g，8426T> A，C.8786OT，g.9074T> C，C.12609OT，c.l2621T> C，c.26636T> G和C.12669OA，其可以为大理石花纹和/或皮下脂肪提供新的标记 。 另外的方面提供可以包括标记辅助选择或标记辅助管理以改善牛的大理石花纹和/或皮下脂肪深度的新方法。

    STABILIZED FORMULATION OF IVERMERCTIN FEED PREMIX
    70.
    发明申请
    STABILIZED FORMULATION OF IVERMERCTIN FEED PREMIX 审中-公开
    维生素饲料的稳定配方

    公开(公告)号：WO2005063015A1

    公开(公告)日：2005-07-14

    申请号：PCT/US2004/042519

    申请日：2004-12-17

    Applicant: MERIAL LIMITED ,  FREEHAUF, Keith, Allan

    IPC: A01N25/00

    CPC classification number: A23K50/30 ,  A23K20/121 ,  A23K50/20

    Abstract: The invention relates to a stabilized premix feed or feed-like formulation that has an extended shelf life due to a decrease of the degradates of the active ingredient by controlling the amount of an already existing stabilizer in the formulation. The feed premix is used in the treatment or prophylaxis of parasites in mammals, in particular swine and horses. The invention further relates to a method to extend the shelf life of a stable premix feed or feed-like formulation for the treatment or prophylaxis of parasite infestation in swine and horses comprising controlling the amount of an already existing antioxidant or stabilizer in the formulation to decrease or to prevent the formation of acid/base catalyzed decomposition of the active ingredient.

    Abstract translation: 本发明涉及稳定的预混合饲料或饲料状制剂，其通过控制制剂中已经存在的稳定剂的量，由于活性成分的降解而具有延长的保质期。 饲料预混物用于治疗或预防哺乳动物，特别是猪和马的寄生虫。 本发明还涉及一种延长稳定的预混合饲料或饲料样制剂的保质期的方法，用于治疗或预防猪和马中的寄生虫侵袭，包括控制制剂中已经存在的抗氧化剂或稳定剂的量减少 或防止活性成分的酸/碱催化分解的形成。

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