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    FATTY ESTER-BASED PARTICLES AND METHODS OF PREPARATION AND USE THEREOF
    62.
    发明申请
    FATTY ESTER-BASED PARTICLES AND METHODS OF PREPARATION AND USE THEREOF 审中-公开
    基于脂肪酶的颗粒及其制备和使用方法

    公开(公告)号：WO2012109755A1

    公开(公告)日：2012-08-23

    申请号：PCT/CA2012/050090

    申请日：2012-02-16

    申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO ,  SHUHENDLER, Adam ,  WU, Xiao Yu

    发明人： SHUHENDLER, Adam ,  WU, Xiao Yu

    IPC分类号： A61K49/00 ,  A61K47/14 ,  A61K47/44

    CPC分类号： A61K49/0067 ,  A61K49/0056 ,  A61K49/0093

    摘要： Fluorescent particles and methods of preparation and use thereof are provided in which a fatty matrix comprising fatty ester is employed for the encapsulation of a fluorescent payload. The fluorescent payload may be a fluorescent nanoparticle or a fluorophore. In one embodiment, the fluorescent payload is a plurality of quantum dots, which may be incorporated without a passivation capping layer while preserving the quantum efficiency of the quantum dot. The compositions can be used in biological imaging in vitro, in vivo and ex vivo. Whole body imaging may be achieved by selecting a fluorescent payload (such as a PbSe quantum dots) that has an emission bandwidth that is suitable for imaging of a tissue.

    摘要翻译： 提供了荧光颗粒及其制备方法和使用方法，其中包含脂肪酸酯的脂肪基质用于封装荧光有效载荷。 荧光有效载荷可以是荧光纳米颗粒或荧光团。 在一个实施例中，荧光有效载荷是多个量子点，其可以并入没有钝化覆盖层，同时保持量子点的量子效率。 该组合物可用于体外，体内和离体的生物成像。 可以通过选择具有适合于组织成像的发射带宽的荧光有效载荷（例如PbSe量子点）来实现全身成像。

    METHOD FOR PRODUCING A STAMP FOR HOT EMBOSSING
    64.
    发明申请
    METHOD FOR PRODUCING A STAMP FOR HOT EMBOSSING 审中-公开
    用于生产热烫印花的方法

    公开(公告)号：WO2010088765A1

    公开(公告)日：2010-08-12

    申请号：PCT/CA2010/000144

    申请日：2010-02-03

    申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO ,  GREENER, Jesse ,  LI, Wei ,  KUMACHEVA, Eugenia

    发明人： GREENER, Jesse ,  LI, Wei ,  KUMACHEVA, Eugenia

    IPC分类号： B81C1/00 ,  G03F1/00

    CPC分类号： B81C99/009 ,  B01L3/502707 ,  B81B2201/051 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  G03F7/0017

    摘要： The present invention provides a process for producing a stamp for hot embossing (HE). The stamp can be constructed from any photo-resist epoxy that is stable at temperatures equal to the glass transition temperature (T g ) of the material to be stamped. The stamp can be used repeatedly without significant distortion of features. The stamp benefits from low relative cost, high fidelity of features in all three-dimensions and fast construction. The process for producing a stamp for hot embossing from a resist, comprising the steps of producing a seed layer L1 from a selected photoresist polymer material, soft baking the seed layer L1, exposing said seed layer L1 to initiate cross-linking and then post-exposure bake L1 to fully cross-link it, coating the cross-linked seed layer L1 with a second photoresist polymer layer L2; soft baking the second photoresist polymer layer L2; applying a mask to the top surface of the soft baked layer L2 and illuminating the unmasked portions of the soft baked layer L2 with UV radiation through the mask, wherein the exposed areas form the pattern of the embossing features, washing away un-exposed regions of the photoresist with a developer to leave behind a relief pattern formed in the second photoresist polymer layer L2, which relief pattern corresponds to a pattern in the mask.

    摘要翻译： 本发明提供一种用于生产热压花印花（HE）的印模的方法。 印模可以由任何光刻胶环氧树脂构成，其在等于要冲压的材料的玻璃化转变温度（Tg）的温度下是稳定的。 邮票可以重复使用，而不会有特征的明显变形。 邮票受益于相对成本低，三维特征的高保真度和快速建设。 用于从抗蚀剂制造用于热压花的印模的方法，包括以下步骤：从所选择的光致抗蚀剂聚合物材料制备种子层L1，软化种子层L1，暴露所述种子层L1以引发交联， 曝光烘烤L1使其完全交联，用第二光致抗蚀剂聚合物层L2涂覆交联的种子层L1; 软烘烤第二光致抗蚀剂聚合物层L2; 对软烘烤层L2的上表面施加掩模，并通过掩模用UV辐射照射软烘烤层L2的未遮蔽部分，其中暴露区域形成压纹特征的图案，冲洗未曝光区域 具有显影剂的光致抗蚀剂留下形成在第二光致抗蚀剂聚合物层L2中的浮雕图案，该凹凸图案对应于掩模中的图案。

    DIGITAL MICROFLUIDIC METHOD FOR PROTEIN EXTRACTION BY PRECIPITATION FROM HETEROGENEOUS MIXTURES
    65.
    发明申请
    DIGITAL MICROFLUIDIC METHOD FOR PROTEIN EXTRACTION BY PRECIPITATION FROM HETEROGENEOUS MIXTURES 审中-公开
    通过异源混合物降解蛋白质提取的数字微流化方法

    公开(公告)号：WO2010040214A1

    公开(公告)日：2010-04-15

    申请号：PCT/CA2009/001418

    申请日：2009-10-08

    申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO ,  WHEELER, Aaron, R. ,  JEBRAIL, Mais, J.

    发明人： WHEELER, Aaron, R. ,  JEBRAIL, Mais, J.

    IPC分类号： C07K1/30 ,  B81B7/00 ,  C07K1/14 ,  G01N33/68

    CPC分类号： C07K1/30 ,  Y10T436/105831 ,  Y10T436/255 ,  Y10T436/2575

    摘要： A method for extracting proteins from heterogeneous fluids by precipitation using microfluidics. The method uses a digital microfluidic device having an array of discrete actuating electrodes formed on a substrate surface, a hydrophobic working surface coating the substrate surface and array of discrete actuating electrodes, an actuating electrode controller for exciting or de-exciting discrete actuating electrodes for translating liquid droplets over the hydrophobic working surface. Droplets containing protein are dispensed onto positions on the hydrophobic working surface, and droplets containing a protein precipitant are deposited as well. All the drops are translated to one or more corresponding designated protein extraction positions on the hydrophobic working surface where they mix. The mixed drops are incubated at the extraction positions to precipitate the protein contained in the droplets to separate the precipitated protein from a drop of supernatant above the precipitate. Supernatant drops are removed and the precipitants are washed and then precipitants are dried. The method uses an automated protocol for precipitation of proteins onto surfaces, rinsing the precipitates to remove impurities, and resolubilization in buffer for further analysis. The method is compatible with proteins representing a range of different physicochemical properties, as well as with complex mixtures such as fetal bovine serum and cell lysate.

    摘要翻译： 一种使用微流体通过沉淀从异质流体中提取蛋白质的方法。 该方法使用数字微流体装置，其具有形成在衬底表面上的离散致动电极的阵列，涂覆衬底表面的疏水性工作表面和离散致动电极阵列，用于激发或去激励离散致动电极以用于平移的致动电极控制器 液滴在疏水工作表面上。 将含有蛋白质的液滴分配到疏水性工作表面上的位置，并且还沉积含有蛋白沉淀剂的液滴。 所有的液滴被翻译成疏水工作表面上的一个或多个相应的指定的蛋白质提取位置，在那里它们混合。 将混合的液滴在提取位置孵育以沉淀出液滴中的蛋白质，以将沉淀的蛋白质与沉淀物上方的一滴上清液分离。 去除上清液滴并洗涤沉淀剂，然后干燥沉淀剂。 该方法使用自动化方案将蛋白质沉淀到表面上，漂洗沉淀物以除去杂质，并在缓冲液中再溶解以进一步分析。 该方法与表示一系列不同物理化学性质的蛋白质以及复杂混合物如胎牛血清和细胞裂解物相容。

    TEMPLATE-DIRECTED SYNTHESIS OF POROUS MATERIALS USING DENDRIMER PRECURSORS
    67.
    发明申请
    TEMPLATE-DIRECTED SYNTHESIS OF POROUS MATERIALS USING DENDRIMER PRECURSORS 审中-公开
    使用DENDRIMER PRECURSORS的多孔材料的模板指导性合成

    公开(公告)号：WO2005049625A1

    公开(公告)日：2005-06-02

    申请号：PCT/CA2004/001990

    申请日：2004-11-19

    申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO ,  LANDSKRON, Kai Manfred Martin ,  HATTON, Benjamin David ,  PEROVIC, Doug Dragan ,  OZIN, Geoffrey, Alan

    发明人： LANDSKRON, Kai Manfred Martin ,  HATTON, Benjamin David ,  PEROVIC, Doug Dragan ,  OZIN, Geoffrey, Alan

    IPC分类号： C07F7/18

    CPC分类号： C07F7/1836 ,  C01B33/124 ,  C01B33/126 ,  C01B37/00 ,  C01B37/02 ,  C03C17/007 ,  C03C2217/213 ,  C03C2217/425 ,  C07F7/0841 ,  C08G77/50

    摘要： The present invention provides a template-directed self-assembly strategy to integrate the class of materials called dendrimers with periodic mesoporous and macroporous silica materials to create two totally new classes of organic/inorganic nanocomposite materials, which we call periodic mesoporous dendrisilicas (PMeDs) and periodic macroporous dendrisilicas (PMaDs). The unusual combination of inorganic silica and organic dendrimer chemical structures with these scales of porosity and surfaces suggests a myriad of uses for PMeDs and PMaDs, such as the controlled release and uptake of chemicals, chiral separations and catalysis, electronic printing and microelectronic packaging, biomaterial platforms, chromatography stationary phase, and photonic crystal applications. These applications target the synergistic relationship between the dendrimer and the meso- or macroporous structure within a single hierarchical nanostructured organic/inorganic hybrid material.

    摘要翻译： 本发明提供了一种模板定向的自组装策略，将称为树枝状聚合物的材料类与周期性介孔和大孔二氧化硅材料整合以产生两种全新的有机/无机纳米复合材料，我们称之为周期性介孔树状（PMeDs）和 周期性大孔树状（PMaDs）。 无机二氧化硅和有机树枝状大分子化学结构与这些孔隙度和表面尺度的不寻常组合表明了PMeDs和PMaD的无数用途，如化学品的控制释放和吸收，手性分离和催化，电子印刷和微电子封装，生物材料 平台，色谱固定相和光子晶体应用。 这些应用针对单层次纳米结构有机/无机混合材料中树枝状大分子与中等或大孔结构之间的协同关系。

    LOW LEAKAGE ASYMMETRIC SRAM CELL DEVICES
    68.
    发明申请
    LOW LEAKAGE ASYMMETRIC SRAM CELL DEVICES 审中-公开
    低泄漏非对称SRAM单元器件

    公开(公告)号：WO2004015711A2

    公开(公告)日：2004-02-19

    申请号：PCT/US2003/025084

    申请日：2003-08-08

    申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO ,  NAJM, Farid, N. ,  AZIZI, Navid ,  MOSHOVOS, Andreas

    发明人： NAJM, Farid, N. ,  AZIZI, Navid ,  MOSHOVOS, Andreas

    IPC分类号： G11C

    CPC分类号： G11C7/067 ,  G11C7/062 ,  G11C11/412

    摘要： Asymmetric SRAM cell designs exploiting data storage patterns found in ordinary software programs wherein most of the bits stored are zeroes for data and instruction streams. The asymmetric SRAM cell designs offer lower leakage power with little impact on latency. In asymmetric SRAM cells, selected transistors are "weakened" to reduce leakage current when the cell is storing a zero. Transistor weakening may be achieved by using higher voltage threshold transistors, by varying transistor geometries, or other means. In addition, a novel sense amplifier design is provided that leverages the asymmetric nature of the asymmetric SRAM cells to offer cell read times that are comparable with conventional symmetric SRAM cells. Lastly, cache memory designs are provided that are based on asymmetric SRAM cells offering leakage power reduction while maintaining high performance, comparable noise margins, and stability with respect to conventional cache memories.

    摘要翻译： 非对称SRAM单元设计利用在普通软件程序中找到的数据存储模式，其中存储的大部分位是数据和指令流的零。 非对称SRAM单元设计提供较低的泄漏功率，对延迟影响很小。 在不对称SRAM单元中，所选择的晶体管被​​“削弱” 当电池存储零点时减少泄漏电流。 可以通过使用更高电压阈值晶体管，通过改变晶体管几何形状或其他手段来实现晶体管弱化。 此外，还提供了一种新颖的读出放大器设计，利用非对称SRAM单元的非对称性提供与传统对称SRAM单元相当的单元读取时间。 最后，提供基于非对称SRAM单元的高速缓冲存储器设计，其提供泄漏功率减少，同时保持高性能，可比较的噪声容限以及相对于常规高速缓冲存储器的稳定性。

    IRON-BASED COMPLEXES FOR USE IN THE CATALYSIS OF HYDROSILYLATION REACTIONS
    70.
    发明申请
    IRON-BASED COMPLEXES FOR USE IN THE CATALYSIS OF HYDROSILYLATION REACTIONS 审中-公开

    公开(公告)号：WO2022266768A1

    公开(公告)日：2022-12-29

    申请号：PCT/CA2022/051014

    申请日：2022-06-23

    申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

    发明人： SONG, Datong ,  LIANG, Qiuming ,  JIMENEZ SANTIAGO, José Luis

    IPC分类号： C07F15/02 ,  B01J31/28 ,  B01J37/00 ,  C07F7/04

    摘要： There is provided an iron-based complex of formula (IA) or (IB) or a solvate thereof (IA) (IB). The iron-based complex can be used for catalyzing a hydrosilylation reaction, such as the hydrosilylation of a ketone or an aldehyde. Also provided is a method for preparing a silyl ether from a ketone or an aldehyde comprising the hydrosilylation of the ketone or aldehyde in the presence of the iron-based complex. Another method is provided for the synthesis of an alcohol from a ketone or an aldehyde comprising the hydrosilylation of the ketone or aldehyde in the presence of the iron-based complex to form a silyl ether, and then hydrolyzing the silyl ether to obtain the alcohol. A process for preparing the iron-based complex is further disclosed.