公开(公告)号：WO2018187628A1

公开(公告)日：2018-10-11

申请号：PCT/US2018/026335

申请日：2018-04-05

Applicant: ROAR HOLDING, LLC

Inventor： BROCIA, Robert

IPC: A23L2/38 ,  A23L33/105 ,  C12G3/08

Abstract: Improved compositions of reversible monoamine oxidase inhibitors are obtained by improved methods of alcohol removal from distillates of fermented agave extracts.

公开(公告)号：WO2017161174A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022791

申请日：2017-03-16

Applicant: PROLYNX LLC

Inventor： SCHNEIDER, Eric L. ,  HEARN, Brian ,  HENISE, Jeffrey C. ,  ASHLEY, Gary W. ,  SANTI, Daniel, V.

IPC: A61K38/00 ,  C07K14/605

Abstract: Extended-release conjugates of stabilized GLP-1 agonists balance agonist stability with release rates to provide long lasting administration to treat diabetes and related conditions on once-a-month or less frequent dosing schedules.

Abstract translation: 稳定的GLP-1激动剂的缓释结合物平衡激动剂稳定性与释放速率以提供长期持续施用，以每月一次或更少频率的给药方案治疗糖尿病和相关病症。

公开(公告)号：WO2016105499A1

公开(公告)日：2016-06-30

申请号：PCT/US2015/000229

申请日：2015-12-23

Applicant: INTELLECTUAL PROPERTY ASSOCIATES, LLC

Inventor： SAND, Bruce, J. ,  BEAL, Ryan, R. ,  BURNHAM, Philippe, H.

IPC: A61F13/00

CPC classification number: A61K47/24 ,  A61F13/00063 ,  A61F13/02 ,  A61K8/0291 ,  A61K8/042 ,  A61K8/34 ,  A61K8/36 ,  A61K8/37 ,  A61K8/42 ,  A61K8/4953 ,  A61K8/553 ,  A61K8/86 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1075 ,  A61K31/137 ,  A61K31/167 ,  A61K31/196 ,  A61K31/245 ,  A61K31/454 ,  A61K31/7004 ,  A61K33/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/28 ,  A61Q7/00 ,  A61Q19/08

Abstract: Improved formulations for topical treatment that ensure at least localized transdermal systemic delivery of an active agent through skin, nails or hair follicles are disclosed.

Abstract translation: 公开了用于局部治疗的改进的制剂，其通过皮肤，指甲或毛囊确保活性剂的至少局部透皮系统递送。

公开(公告)号：WO2015200823A1

公开(公告)日：2015-12-30

申请号：PCT/US2015/038043

申请日：2015-06-26

Applicant: INSTITUTE FOR SYSTEMS BIOLOGY

Inventor： GHOSH, Dhimankrishna ,  COBBS, Charles, S. ,  PRICE, Nathan, D. ,  HOOD, Leroy

IPC: G01N33/574

CPC classification number: G01N33/57407 ,  A61K39/00 ,  G01N33/57484 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

Abstract: A signature of proteins occurring in glioblastoma multiforme (GBM) tissue comprised of 33 cell surface proteins (GBMSig) that distinguish subjects with GBM from healthy controls with more than 98% accuracy is described. In addition, four of the members of this signature are particularly useful as blood-borne markers of GBM. Certain other members of the signature are indicators of the possible efficacy of the use of TGF-βΙ inhibitors in the treatment of this condition. Methods to treat and to stratify GBM based on GBMSig proteins are also disclosed.

Abstract translation: 描述了以多于98％准确度区分患者与健康对照组的患者与33个细胞表面蛋白（GBMSig）组成的胶质母细胞瘤多形性（GBM）组织中发生的蛋白质的特征。 此外，该签名的四名成员特别适用于GBM的血源标记。 签名的某些其他成员是使用TGF-β1抑制剂治疗这种病症的可能功效的指标。 还公开了基于GBMSig蛋白处理和分层GBM的方法。

公开(公告)号：WO2014144806A1

公开(公告)日：2014-09-18

申请号：PCT/US2014/029367

申请日：2014-03-14

Applicant: INSTITUTE FOR SYSTEMS BIOLOGY ,  BROGAARD, Kristin ,  LAUSTED, Christopher ,  HOOD, Leroy

Inventor： BROGAARD, Kristin ,  LAUSTED, Christopher ,  HOOD, Leroy

IPC: C07H21/04

CPC classification number: G01N33/58 ,  G01N33/5017

Abstract: The invention provides an efficient multiplex method for identifying binding partners of small molecules and proteins. The small molecules and proteins are tagged with a nucleic acid barcode that can be used to identify the protein or small molecule, and thereby its partner.

Abstract translation: 本发明提供了用于鉴定小分子和蛋白质的结合伴侣的有效多重方法。 小分子和蛋白质用可用于鉴定蛋白质或小分子的核酸条形码，从而标记其配偶体。

公开(公告)号：WO2014047363A1

公开(公告)日：2014-03-27

申请号：PCT/US2013/060740

申请日：2013-09-19

Applicant: RED LION CHEM TECH, LLC

Inventor： PRONOVOST, Allan, D. ,  HICKEY, Michael, E.

IPC: B01J20/18

CPC classification number: C05B17/00 ,  B01J20/0229 ,  B01J20/06 ,  B01J20/186 ,  B01J43/00 ,  C02F1/281 ,  C02F1/288 ,  C02F2101/105 ,  C02F2101/16 ,  C02F2103/327 ,  C05B7/00 ,  C05F7/00 ,  C05G3/0047 ,  Y02A40/213 ,  C05D9/00 ,  C05D9/02

Abstract: The invention employs composites of zeolite and ferric oxide hydroxide for removal of inorganic nitrogen and phosphorus wastes from animal environments. The invention relates to the field of remediation of agricultural and livestock waste. More specifically it relates to removal of ammonia and phosphate from various depositories and converting these into a form suitable for use as a continuous release fertilizer.

Abstract translation: 本发明采用沸石和氧化铁氢氧化物复合材料，从动物环境中去除无机氮磷废物。 本发明涉及农业和畜禽废物补救领域。 更具体地说，它涉及从各种保藏库中去除氨和磷酸盐并将其转化为适合用作连续释放肥料的形式。

公开(公告)号：WO2012027716A1

公开(公告)日：2012-03-01

申请号：PCT/US2011/049432

申请日：2011-08-26

Applicant: COLLABRX, INC. ,  LEHRER, Raphael ,  COOPERSMITH, Robert

Inventor： LEHRER, Raphael ,  COOPERSMITH, Robert

IPC: G01N33/574

CPC classification number: A61K31/44 ,  A61K31/404 ,  A61K31/506 ,  G01N33/5743 ,  G01N33/57484 ,  G01N2333/91215 ,  G01N2500/04

Abstract: Methods to treat cancer patients, especially melanoma patients, who have BRAF mutations and have become resistant to BRAF mutant kinase inhibitors employ inhibitors of multiple receptor tyrosine kinases. In addition, methods are described for identifying pharmaceutical compositions and drugs that will be successful in treating these patients.

Abstract translation: 治疗具有BRAF突变并且已经变得对BRAF突变体激酶抑制剂具有抗性的癌症患者，特别是黑素瘤患者的方法使用多受体酪氨酸激酶抑制剂。 此外，描述了用于鉴定将成功治疗这些患者的药物组合物和药物的方法。

公开(公告)号：WO2011159938A2

公开(公告)日：2011-12-22

申请号：PCT/US2011/040761

申请日：2011-06-16

Applicant: TRELLIS BIOSCIENCE, INC. ,  KAUVAR, Lawrence, M. ,  ELLSWORTH, Stote ,  USINGER, William ,  MCCUTCHEON, Krista, Maureen ,  JIANG, Ying-Ping ,  ZHANG, Fen ,  CHEN, Bo ,  SPERINDE, Gizette ,  PARK, Minha ,  FOORD, Orit

Inventor： KAUVAR, Lawrence, M. ,  ELLSWORTH, Stote ,  USINGER, William ,  MCCUTCHEON, Krista, Maureen ,  JIANG, Ying-Ping ,  ZHANG, Fen ,  CHEN, Bo ,  SPERINDE, Gizette ,  PARK, Minha ,  FOORD, Orit

IPC: A61K39/42 ,  C12N15/13 ,  C12N5/10 ,  C12N1/00 ,  C12P21/08 ,  C07K16/08 ,  A61P31/20

CPC classification number: C07K16/088 ,  A61K39/245 ,  A61K2039/505 ,  C07K16/08 ,  C07K16/468 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

Abstract translation: 已从人B细胞中分离出人巨细胞病毒（CMV）gB蛋白的抗体。 这些抗体的亲和力高于先前报道的最佳抗体。 由于高亲和力对于预防跨越胎盘的病毒转移至关重要，本发明的抗体可用作预防或改善对怀孕期间CMV感染胎儿的影响的治疗和预防剂。

公开(公告)号：WO2011140376A1

公开(公告)日：2011-11-10

申请号：PCT/US2011/035403

申请日：2011-05-05

Applicant: PROLYNX LLC ,  ASHLEY, Gary ,  SANTI, Daniel, V.

Inventor： ASHLEY, Gary ,  SANTI, Daniel, V.

IPC: A61K9/22 ,  A61K9/52

CPC classification number: A61K47/48315 ,  A61K38/2242 ,  A61K38/26 ,  A61K38/50 ,  A61K47/60 ,  A61K47/641 ,  A61K47/645 ,  C08G83/003 ,  C08G83/004

Abstract: The invention relates to compositions that comprise dendrimers useful in medical and veterinary applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the dendrimer through a linkage that releases the drug or a prodrug through controlled beta elimination.

Abstract translation: 本发明涉及包含用于医学和兽医学应用中的树枝状大分子的组合物，其提供药物（例如肽，核酸和小分子）的受控释放。 这些药物通过通过对照β消除释放药物或前药的连接共价偶联到树状聚合物上。

公开(公告)号：WO2011028548A1

公开(公告)日：2011-03-10

申请号：PCT/US2010/046537

申请日：2010-08-24

Applicant: NEURALSTEM, INC. ,  VENKATRAMAN, Sripathy ,  MAHMOOD, Syed ,  MOBELE, Bingidimi, I. ,  LAPINA, Olga ,  VERCOE, Kellie ,  LI, Ying ,  SALSBURY, Jonathan ,  MCLAWS, Mark

Inventor： VENKATRAMAN, Sripathy ,  MAHMOOD, Syed ,  MOBELE, Bingidimi, I. ,  LAPINA, Olga ,  VERCOE, Kellie ,  LI, Ying ,  SALSBURY, Jonathan ,  MCLAWS, Mark

IPC: A61K31/4965

CPC classification number: C07D213/74 ,  C07D213/82

Abstract: The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions.

Abstract translation: 本发明描述了用烟酸和苄基部分衍生的哌嗪的改进的合成。 产品化合物可用于治疗神经病症。