公开(公告)号：WO2005046658A2

公开(公告)日：2005-05-26

申请号：PCT/US2004037754

申请日：2004-11-12

Applicant: MCW RES FOUND INC ,  ROMAN RICHARD J ,  GREENE ANDREW ,  AMARAL SANDRA ,  SCICLI GUILLERMO ,  BROWN STEPHEN L ,  CHEN PING ,  GUO MENG

Inventor： ROMAN RICHARD J ,  GREENE ANDREW ,  AMARAL SANDRA ,  SCICLI GUILLERMO ,  BROWN STEPHEN L ,  CHEN PING ,  GUO MENG

IPC: A61K31/00 ,  A61K31/155 ,  A61K31/18 ,  A61K31/20 ,  A61K31/255 ,  A61K31/335 ,  A61K31/4174 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/537 ,  A61K31/5375

CPC classification number: A61K31/335 ,  A61K31/00 ,  A61K31/155 ,  A61K31/18 ,  A61K31/20 ,  A61K31/255 ,  A61K31/4174 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/537 ,  A61K31/5375

Abstract: Methods for regulating angiogenesis by modulating the activity of 20-HETE are disclosed. Further disclosed are methods of inhibiting cancer and tumor cell growth by exposing the cancer and tumor cells to 20-HETE inhibitors.

Abstract translation: 公开了通过调节20-HETE的活性来调节血管生成的方法。 进一步公开的是通过将癌症和肿瘤细胞暴露于20-HETE抑制剂来抑制癌症和肿瘤细胞生长的方法。

公开(公告)号：WO2004078714A2

公开(公告)日：2004-09-16

申请号：PCT/US2004006549

申请日：2004-03-03

Applicant: SQUIBB BRISTOL MYERS CO ,  CHEN BANG-CHI ,  SUNDEEN JOSEPH E ,  BEDNARZ MARK S ,  CHEN PING

Inventor： CHEN BANG-CHI ,  SUNDEEN JOSEPH E ,  BEDNARZ MARK S ,  CHEN PING

IPC: A61K31/498 ,  C07D20060101 ,  C07D241/36 ,  C07D487/14 ,  C07D

CPC classification number: C07D471/14 ,  C07D487/04

Abstract: Novel processes for the preparation of imidazoquinoxalinones, heterocyclic-substituted imidazopyrazinones, imidazoquinoxalines and heterocyclic-substituted imidazopyrazines are described.

Abstract translation: 描述了制备咪唑并喹喔啉酮，杂环取代的咪唑并吡嗪酮，咪唑并喹喔啉和杂环取代的咪唑并吡嗪的新方法。

公开(公告)号：WO2004011772A1

公开(公告)日：2004-02-05

申请号：PCT/GB2003/003339

申请日：2003-07-31

Applicant: CHAMPION TECHNOLOGIES, INC. ,  STATOIL, ASA ,  MONTGOMERIE, Harry, Trenouth, Russel ,  CHEN, Ping ,  HAGEN, Thomas ,  WAT, Rex, Man, Shing ,  SELLE, Olav, Martin ,  KOTLAR, Hans, Kristian

Inventor： MONTGOMERIE, Harry, Trenouth, Russel ,  CHEN, Ping ,  HAGEN, Thomas ,  WAT, Rex, Man, Shing ,  SELLE, Olav, Martin ,  KOTLAR, Hans, Kristian

IPC: E21B41/02

CPC classification number: E21B41/02 ,  C09K8/52

Abstract: The invention provides a method of increasing the retention of a scale inhibitor on a rock material comprising preconditioning the rock material with a positively charged bridging agent and contacting the rock material with said scale inhibitor.

Abstract translation: 本发明提供一种增加阻垢剂在岩石材料上的保留性的方法，包括用带正电荷的桥连剂预处理岩石材料并使岩石材料与所述阻垢剂接触。

公开(公告)号：WO2003059269A2

公开(公告)日：2003-07-24

申请号：PCT/US2002/041530

申请日：2002-12-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  IWANOWICZ, Edwin, J. ,  WATTERSON, Scott, H. ,  CHEN, Ping ,  DHAR, T., G., Murali ,  GU, Henry, H. ,  ZHAO, Yufen

Inventor： IWANOWICZ, Edwin, J. ,  WATTERSON, Scott, H. ,  CHEN, Ping ,  DHAR, T., G., Murali ,  GU, Henry, H. ,  ZHAO, Yufen

IPC: A61K

CPC classification number: C07D401/12 ,  C07D219/06 ,  C07D401/14 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds having formula (I), wherein R 3 is selected from H, OH and NH 2 ; R 30 is selected from =O and =S; W is -C(=O)-, -S(=O)-, or -S(O) 2 -; or W may be -CH 2 - if X is -C(=O)-; X is selected from -CH 2 -, -N(R 4 )-, and -O-, except that when W is -CH 2 -, X is -C(=O)-; Y is a bond or -C(R 40 )(R 45 )-; Q is a linker; Z is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; and R 1 , R 2 , R 24 and R 25 are as defined in the specification.

Abstract translation: 具有式（I）的化合物，其中R 3选自H，OH和NH 2; R 30选自= O和= S; W是-C（= O） - ， - S（= O） - 或-S（O）2 - ; 或者如果X是-C（= O） - ，则W可以是-CH 2 - ; X选自-CH 2 - ， - N（R 4） - 和-O-，但是当W是-CH 2 - 时，X是-C（= O） - ; Y是键或-C（R 40）（R 45） - ; Q是一个连接符; Z是任选取代的烷基，烯基，炔基，环烷基，芳基，杂芳基或杂环基; R 1，R 2，R 24和R 25如说明书中所定义。

公开(公告)号：WO2003055447A3

公开(公告)日：2003-07-10

申请号：PCT/US2002/041186

申请日：2002-12-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  CHEN, Ping ,  DHAR, T., G., Murali ,  IWANOWICZ, Edwin, J. ,  WATTERSON, Scott, H. ,  GU, Henry, H. ,  ZHAO, Yufen

Inventor： CHEN, Ping ,  DHAR, T., G., Murali ,  IWANOWICZ, Edwin, J. ,  WATTERSON, Scott, H. ,  GU, Henry, H. ,  ZHAO, Yufen

IPC: C07D471/04

Abstract: Compounds having the formula (I), wherein R 3 is selected from H, OH and NH 2 ; R 30 is selected from =O and =S; W is -C(=O)-, -S(=O)-, or -S(O) 2 -; or W may be -CH 2 - if X is -C(=O)-; X is selected from -CH 2 -, -N(R 4 )-, and -O-, except that when W is -CH 2 -, X is -C(=O)-; Y is a bond or -C(R 40 )(R 45 )-; Q is a linker; Z is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; and X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , X 8 , X 9 , X 10 and X 11 are selected such a tricyclic heteroaryl ring system is formed as further defined in the specification.

公开(公告)号：WO0121217A3

公开(公告)日：2001-08-09

申请号：PCT/US0026101

申请日：2000-09-22

Applicant: GENVEC INC ,  BRUDER JOSEPH T ,  KING C RICHTER ,  KIRKMAN WAYNE M ,  KOVESDI IMRE ,  WICKHAM THOMAS J ,  CHEN PING ,  RANSOM STEPHEN C

Inventor： BRUDER JOSEPH T ,  KING C RICHTER ,  KIRKMAN WAYNE M ,  KOVESDI IMRE ,  WICKHAM THOMAS J ,  CHEN PING ,  RANSOM STEPHEN C

IPC: A61K47/48 ,  C07K14/47 ,  C12N9/64 ,  A61B10/00 ,  A61K51/10 ,  C12N15/86

CPC classification number: C12N9/6475 ,  A61K47/6901 ,  C07K14/4747 ,  C12N2799/022

Abstract: The present invention provides methods of treating a mammal, such as a mammal suffering from benign prostate hyperplasia, prophylactically or therapeutically. The methods comprise administering a prophylactic or therapeutic nucleic acid operably linked to a promoter to a mammal in need of prophylactic or therapeutic treament of its prostate via transurethral injection, the use of a prostate-specific promoter and/or the use of a targeting moiety that preferentially binds to a prostate cell, instead of a non-prostate cell, whereupon the prophylactic or therapeutic nucleic acid is expressed in cells of the prostate of the mammal, thereby prophylactically or therapeutically treating the mammal.

Abstract translation: 本发明提供了治疗哺乳动物（例如患有良性前列腺增生的哺乳动物）的预防或治疗方法。 所述方法包括将需要通过经尿道注射的需要预防或治疗其前列腺的哺乳动物的启动子可操作地连接到启动子的预防或治疗核酸，使用前列腺特异性启动子和/或使用靶向部分， 优先地结合前列腺细胞而不是非前列腺细胞，于是预防或治疗性核酸在哺乳动物前列腺细胞中表达，从而预防或治疗哺乳动物。

公开(公告)号：WO1998024156A1

公开(公告)日：1998-06-04

申请号：PCT/US1997021505

申请日：1997-11-20

Applicant: THE WHITAKER CORPORATION ,  CHEN, Ping

Inventor： THE WHITAKER CORPORATION

IPC: H01R23/70

CPC classification number: H01R12/7047

Abstract: The present invention provides a circuit board connector which has a low profile and which occupies a small area on a circuit board without having any effect on the insertion of mating connectors even in cases where screws of which the length of the threaded section is greater than the combined total of the thickness of the lower wall of the housing and the thickness of the circuit board are used. The housing (10) of the connector (1) has latching surfaces on the inside of the upper wall (16) which forms the cavities (14) into which mating connectors are inserted. Furthermore, screw-attachment sections (26) which have holes (28) that accommodate screws (5) used to fasten the connector (1) to the circuit board are formed as integral parts of the housing (10) on the underside of the rear wall (12) of the housing (10). The front walls (30) which delineate the holes (28) are thicker than the opposite rear walls (32). When the screws (5) are screwed into the holes (28), the rear walls (32) expand slightly; accordingly the screws (5) move rearward so that there is no protrusion of the screws (5) into the interiors of the cavities (14).

Abstract translation: 本发明提供了一种电路板连接器，其具有低轮廓并且在电路板上占据小面积而不对配合连接器的插入产生任何影响，即使在螺纹部分的长度大于 使用壳体下壁厚度和电路板厚度的总和。 连接器（1）的壳体（10）在上壁（16）的内侧具有锁定表面，该锁定表面形成插入配合连接器的空腔（14）。 此外，具有用于将连接器（1）紧固到电路板上的螺钉（5）的孔（28）的螺钉附接部分（26）形成为在后部的下侧上的壳体（10）的一体部分 壳体（10）的壁（12）。 描绘孔（28）的前壁（30）比相对的后壁（32）厚。 当螺钉（5）拧入孔（28）时，后壁（32）稍微膨胀; 因此，螺钉（5）向后移动，使得螺钉（5）没有突出到空腔（14）的内部。

公开(公告)号：WO1997019492A1

公开(公告)日：1997-05-29

申请号：PCT/US1996018369

申请日：1996-11-15

Applicant: THE WHITAKER CORPORATION ,  CHEN, Ping

Inventor： THE WHITAKER CORPORATION

IPC: H01R13/115

CPC classification number: H01R13/113

Abstract: A receptacle contact in which the rigitidy of the spring-loaded contacting arms changes continuously. The receptacle contact (1) has a spring-loaded contact member (22) which is formed by bending backward a base wall (12) into a space (23) of a box-shaped contact section (10) and an extension (32) formed by bending back an inner end of the spring-loaded contact member (22) forward. Extension (32) has a flat section (36) which engages with the base wall (12) when spring-loaded contact member (22) is deformed; with the area of engagement or contact being changed gradually. In order to prevent excessive stress in bend (34), at a front end of extension (32), a projection (40) is made by bending the tip of the extension toward spring-loaded contact member (22). And in order to prevent excessive stress in bend (24), a projection (26) is made by bending a portion of base wall (12) upward in the area of bend (24).

Abstract translation: 弹簧加载的接触臂的连续性变化的插座触点。 插座触点（1）具有弹簧加载的接触构件（22），其通过将底壁（12）向后弯曲成盒形接触部分（10）和延伸部（32）的空间（23）而形成， 通过将弹簧加载的接触构件（22）的内端向前弯曲而形成。 当弹簧加载的接触构件（22）变形时，延伸部（32）具有与基壁（12）接合的平坦部分（36） 接触面积或接触面逐渐变化。 为了防止弯曲（34）中的过大应力，在延伸部（32）的前端，通过将延伸部的顶端朝向弹簧加载的接触构件（22）弯曲而制成突起（40）。 并且为了防止弯曲（24）中的过大的应力，通过在弯曲部分（24）的区域中向上弯曲基壁（12）的一部分而形成突起26。

公开(公告)号：WO2023016400A1

公开(公告)日：2023-02-16

申请号：PCT/CN2022/110840

申请日：2022-08-08

Applicant: TELEFONAKTIEBOLAGET LM ERICSSON (PUBL) ,  CHEN, Ping

Inventor： TAO, Jingrui ,  CHENG, Haiming ,  LIU, Qiang ,  LIANG, Tianmei ,  VAZQUEZ, Emiliano Merino

IPC: H04W8/18 ,  H04W60/04

Abstract: Embodiments of the present disclosure provide method and apparatus for session restoration. A method performed by a network node comprises receiving a first request for setting up a session with required quality of service (QoS) from an application node. The method further comprises sending a first response comprising error information and subscription information of an existing session including a subscription identifier to the application node.

公开(公告)号：WO2022109117A1

公开(公告)日：2022-05-27

申请号：PCT/US2021/059862

申请日：2021-11-18

Applicant: MERCK SHARP & DOHME CORP. ,  BOGEN, Stephane, L. ,  CHEN, Ping ,  CLAUSEN, Dane James ,  LIU, Jian ,  RUDD, Michael, T. ,  XIAO, Li ,  YANG, Dexi ,  LIN, Shishi

Inventor： BOGEN, Stephane, L. ,  CHEN, Ping ,  CLAUSEN, Dane James ,  LIU, Jian ,  RUDD, Michael, T. ,  XIAO, Li ,  YANG, Dexi ,  LIN, Shishi

IPC: C07D273/02 ,  C07D291/08 ,  C07D498/08

Abstract: The present invention is directed to 3-amino pyrrolidine and piperidine macrocyclic compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.