公开(公告)号：WO2022167455A1

公开(公告)日：2022-08-11

申请号：PCT/EP2022/052412

申请日：2022-02-02

Applicant: ELEKTA AB (PUBL)

Inventor： SJOLUND, Jens Olof

IPC: A61N5/10

Abstract: Techniques for generating a radiotherapy treatment plan are provided. The techniques include receiving a radiotherapy optimization problem, the radiotherapy problem comprising a plurality of parameters; processing the radiotherapy optimization problem to instantiate a first set of candidate parameters; converting the first set of candidate parameters into an adapted representation; defining an adapted radiotherapy optimization problem as a function of the adapted representation such that a given solution to the adapted optimization problem estimates a solution to the radiotherapy optimization problem; processing the adapted radiotherapy optimization problem to estimate a function of the solution to the adapted radiotherapy optimization problem; and processing the estimated function of the solution to the adapted optimization problem to generate a deliverable radiotherapy treatment plan.

公开(公告)号：WO2021009058A1

公开(公告)日：2021-01-21

申请号：PCT/EP2020/069588

申请日：2020-07-10

Applicant: ELEKTA AB (PUBL)

Inventor： SJÖLUND, Jens

IPC: A61N5/10

Abstract: Techniques for solving a radiotherapy treatment plan optimization problem are provided. The techniques include receiving a first radiotherapy treatment plan optimization problem having a first set of parameters; processing the first set of parameters to estimate a second set of parameters of a second radiotherapy treatment plan optimization problem; generating a solution to the second radiotherapy treatment plan optimization problem based on the estimated second set of parameters; and generating a radiotherapy treatment plan based on the solution to the second radiotherapy treatment plan optimization problem.

公开(公告)号：WO2016128255A1

公开(公告)日：2016-08-18

申请号：PCT/EP2016/052178

申请日：2016-02-02

Applicant: ELEKTA AB (PUBL)

Inventor： BERGFJORD, Per Harald

IPC: A61N5/10

CPC classification number: A61N5/1082 ,  A61B6/4435 ,  A61N5/1049 ,  A61N2005/1061

Abstract: A radiotherapy apparatus is disclosed, comprising a fixed support and a gantry comprising a chassis part and a source part, the chassis part being rotateably attached to the fixed support to allow rotation thereof about a generally horizontal axis, and the source part being connected to the chassis part via a rotateable connection allowing the source part to rotate relative to the chassis part around a transverse axis, being aligned transverse to and intersecting with the horizontal axis; the source part comprising a source of therapeutic radiation directed towards the intersection of the transverse axis and the horizontal axis; the chassis part and the source part together defining an annular ring that encircles the horizontal axis. In this way, the radiotherapy apparatus can provide the full usual range of treatments, but can also adapt itself to adopt a non-coplanar geometry when required, for example to treat difficult locations in the head and neck. The chassis part can comprise a source of diagnostic radiation and a detector for the imaging radiation, to allow the patient to be monitored prior to, during, and/or after treatment. The source of diagnostic radiation preferably emits a beam in a direction transverse to the direction of the therapeutic radiation so as to prevent scattering from the structure of the therapeutic source and to this end, the diagnostic beam can be emitted along the transverse axis. The detector can be moveable between a first position lying within the diagnostic beam and a second position that lies within the therapeutic beam in at least one relative position of the chassis part and source part; this permits the same detector to be used for either beam.

Abstract translation: 公开了一种放射治疗装置，其包括固定支撑件和包括底盘部分和源部分的台架，底架部分可旋转地附接到固定支撑件，以允许围绕大致水平的轴线旋转，并且源部件连接到 底座部分经由可旋转的连接，允许源部分围绕横向轴线相对于底盘部分旋转，横向于并与横轴相交; 所述源部分包括指向所述横向轴线和所述水平轴线的相交处的治疗辐射源; 底盘部分和源部分一起限定环绕水平轴线的环形圈。 以这种方式，放射治疗装置可以提供完全通常的治疗范围，但也可以在需要时适应自身采用非共面几何形状，例如治疗头颈部的困难部位。 底架部分可以包括诊断辐射源和用于成像辐射的检测器，以允许在治疗之前，期间和/或之后对患者进行监测。 诊断辐射源优选沿横向于治疗辐射方向的方向发射光束，以防止从治疗源的结构散射，并且为此，可以沿着横轴发射诊断光束。 检测器可以在位于诊断光束内的第一位置与位于治疗光束内的位于底座部分和源部分的至少一个相对位置的第二位置之间移动; 这允许将相同的检测器用于任一光束。

公开(公告)号：WO2015091748A1

公开(公告)日：2015-06-25

申请号：PCT/EP2014/078394

申请日：2014-12-18

Applicant: ELEKTA AB (PUBL) ,  UNIVERSITY HEALTH NETWORK

Inventor： HENNIX, Marcus ,  NORDSTROM, Hakan ,  ERIKSSON, Markus ,  ADLER, Jonas ,  JAFFRAY, David ,  BOOTSMA, Gregory ,  VERHAEGEN, Frank ,  NUTTI, Bjorn

IPC: A61B6/03 ,  A61B6/00 ,  G06T11/00 ,  G06T5/00

CPC classification number: G06T7/0012 ,  A61B6/032 ,  A61B6/5205 ,  A61B6/5282 ,  G06K9/52 ,  G06K9/6215 ,  G06T5/00 ,  G06T5/002 ,  G06T5/50 ,  G06T7/10 ,  G06T7/20 ,  G06T11/003 ,  G06T11/005 ,  G06T11/008 ,  G06T2207/10081 ,  G06T2207/10116 ,  G06T2207/20076 ,  G06T2207/20112 ,  G06T2207/20182 ,  G06T2207/20224 ,  G06T2207/30004

Abstract: Scatter correction of the projection images used to reconstruct volume CT images is a computationally intensive process that cannot at present be done in real time. We note, however, that although scatter is non-uniform, it varies smoothly - i.e. with a low spatial frequency. Existing Monte-Carlo estimation methods need to run over a large number of iterations in order to eliminate the mainly high-frequency artefacts that are present initially, but this process can be cut short and a low-pass filter applied instead thereby substantially reducing the computational load. By applying the same principle in the spatial domain and interpolating some scatter images from adjacent and surrounding scatter images, the computational load can be reduced still further. Applying these techniques in an iterative process on graphics-processor-quality computational hardware enables real-time scatter correction and reconstruction of CT volume images.

Abstract translation: 用于重建体积CT图像的投影图像的散射校正是目前无法实时完成的计算密集型过程。 然而，我们注意到，尽管散射是不均匀的，但其变化平滑 - 即具有低的空间频率。 现有的蒙特卡罗估计方法需要运行大量迭代，以消除最初存在的主要高频伪像，但是该过程可以被缩短，并且应用低通滤波器，从而显着地减少计算 加载。 通过在空间域中应用相同的原理，并从相邻和周围的散射图像内插一些散射图像，可以进一步降低计算量。 在图形处理器质量计算硬件的迭代过程中应用这些技术可实现CT体积图像的实时散射校正和重建。

公开(公告)号：WO2014140262A1

公开(公告)日：2014-09-18

申请号：PCT/EP2014/055085

申请日：2014-03-14

Applicant: ELEKTA AB (PUBL)

Inventor： LIDSTRÖM, Mattias ,  WILLIAMS, Malcolm ,  GORKA, Bartosz ,  CHEN, Rui ,  ARN, Thomas

IPC: A61N5/10

CPC classification number: A61N5/1049 ,  A61B2090/3945 ,  A61N5/1067 ,  A61N2005/1051 ,  A61N2005/1059 ,  A61N2005/1097

Abstract: The present invention relates to the field of radiation therapy. In particular, the invention concerns systems and methods for monitoring intra-fraction motions of patients in connection with treatment cancer in radiation therapy system. A patient marker is attached on the nose of the patient and images of the patient marker and reference markers of a reference tool is captured at predetermined time intervals, wherein the reference tool comprises The reference markers are arranged in a defined positions relative to a patient fixation arrangement for fixation of the patient during treatment. A position of the patient marker relative the reference markers is determined based on images captured by an optical tracking system, wherein changes in the position provide information if the patient or a part of the patient has moved.

Abstract translation: 本发明涉及放射治疗领域。 特别地，本发明涉及用于监测与辐射治疗系统中的治疗癌症相关的患者的部分内运动的系统和方法。 患者标记被附接在患者的鼻子上，并且以预定的时间间隔捕获患者标记和参考工具的参考标记的图像，其中参考工具包括参考标记布置在相对于患者固定件的限定位置 治疗期间患者固定的安排。 基于由光学跟踪系统拍摄的图像确定患者标记物相对于参考标记的位置，其中，如果患者或患者的一部分已经移动，则位置的改变提供信息。

公开(公告)号：WO2012119649A1

公开(公告)日：2012-09-13

申请号：PCT/EP2011/053529

申请日：2011-03-09

Applicant: ELEKTA AB (publ) ,  FRÖBERG, Peter ,  CHEN, Rui

Inventor： FRÖBERG, Peter ,  CHEN, Rui

IPC: A61N5/10

CPC classification number: A61N5/1049 ,  A61B34/20 ,  A61B2090/364 ,  A61B2090/502 ,  A61N2005/1059

Abstract: The present invention relates to the field of radiation therapy. In particular, the invention relates to systems and methods for image guided therapy, such as radiotherapy. According to the invention, the therapeutic apparatus and the image recording device are tracked and a relative position data for the therapeutic apparatus relative the image recording device is determined. The patient position data of the anatomy of said patient is extracted and a three-dimensional reference image of the patient is created. Further, images of said therapeutic apparatus are continuously using an image recording device. The three-dimensional reference image is super- positioned the recorded images and are displayed, wherein a user is provided with guidance when positioning a patient relative said therapeutic apparatus for treatment session.

Abstract translation: 本发明涉及放射治疗领域。 特别地，本发明涉及用于图像引导治疗（例如放射治疗）的系统和方法。 根据本发明，跟踪治疗装置和图像记录装置，并且确定治疗装置相对于图像记录装置的相对位置数据。 提取患者的解剖结构的患者位置数据，并创建患者的三维参考图像。 此外，所述治疗装置的图像连续地使用图像记录装置。 所述三维参考图像超过所记录的图像并被显示，其中当将患者相对于所述用于治疗会话的治疗仪器定位时，向用户提供指导。

公开(公告)号：WO2010066265A1

公开(公告)日：2010-06-17

申请号：PCT/EP2008/010396

申请日：2008-12-08

Applicant: ELEKTA AB (publ) ,  BROWN, Kevin

Inventor： BROWN, Kevin

IPC: A61B5/08 ,  A61B5/113 ,  A61B6/03

CPC classification number: A61B6/032 ,  A61B5/113

Abstract: The present invention therefore provides a method for the analysis of radiographic images, comprising the steps of acquiring a plurality of projection images of a patient, acquiring a surrogate signal indicative of the location of a target structure in the patient, reconstructing a plurality of volumetric images of the patient from the projection images, each volumetric image being reconstructed from projection images having a like breathing phase, identifying the position of the target structure such as a tumour in each volumetric image, associating a surrogate signal with each of the projection images, and determining a relationship between the surrogate signal and the position of the target structure. Multiple projection images having a like breathing phase can be grouped for reconstruction, to provide sufficient numbers for reconstruction. The analysis of the multiple values of the surrogate associated with each breathing phase can be used to determine the mean surrogate value and its variation. Multiple values of the surrogate signal associated with the same nominal breathing phase can be used to determine a mean value of the surrogate signal for the target position associated with that phase and a variation of the value of the surrogate signal for the target position associated with that phase. The breathing phase of specific projection images can be obtained by analysis of one or more features in the images, such as the method we described in US (7,356,112), or otherwise.

Abstract translation: 因此，本发明提供了一种用于分析放射线图像的方法，包括以下步骤：获取患者的多个投影图像，获取指示患者中目标结构的位置的替代信号，重建多个体积图像 从投影图像的患者的每个体积图像中，从具有相似呼吸相位的投影图像重建每个体积图像，识别每个体积图像中的诸如肿瘤的目标结构的位置，将替代信号与每个投影图像相关联，以及 确定替代信号与目标结构的位置之间的关系。 具有类似呼吸相位的多个投影图像可以被分组以进行重建，以提供足够数量的重建。 可以使用与每个呼吸阶段相关联的替代物的多个值的分析来确定平均替代值及其变化。 可以使用与相同标称呼吸相位相关联的替代信号的多个值来确定与该相位相关联的目标位置的替代信号的平均值，以及与该相位相关联的目标位置的替代信号的值的变化 相。 特定投影图像的呼吸阶段可以通过分析图像中的一个或多个特征来获得，例如我们在US（7,356,112）中描述的方法，或以其它方式。

公开(公告)号：WO2010006630A1

公开(公告)日：2010-01-21

申请号：PCT/EP2008/005912

申请日：2008-07-18

Applicant: ELEKTA AB (publ) ,  SADLER, Philip ,  HARRISON, David ,  MCCANN, Neil

Inventor： SADLER, Philip ,  HARRISON, David ,  MCCANN, Neil

IPC: H05H9/00

CPC classification number: H05H9/00

Abstract: We propose that during the factory testing of the linac, rather than simply confirming that the beam falls within the permissible ranges set out in the standard, the beam is in fact adjusted towards a standard signature. A new (or existing) linac could then be paired to a new linac, or to an existing linac, such as one that it is to operate alongside or one that it is to replace. Treatment plans would then be transferable between such pairs of linacs. In addition, the standard signature to which the linacs were approximated could be placed towards the centre of the permitted ranges, to produce linacs that were more reliable over the very long term. This requires a linac that has automatically adjustable parameters, so that a suitable programmed computer is able to monitor the output of the linac and adjust its operating parameters. We therefore provide a radiation source comprising a linear accelerator, beam control circuitry for the linear accelerator, an electronic control apparatus for the control circuitry arranged to adjust properties thereof, and a monitor for detecting properties of the radiation beam produced by the linear accelerator, wherein the control apparatus is adapted to retain a set of beam properties and periodically activate the accelerator, measure the current beam properties via the monitor, compare the measured beam properties to the retained beam properties, and potentially adjust the control circuitry properties to align the beam properties towards the retained beam properties. The beam properties that are measured may include at least one of beam flatness and beam width. The retained beam properties can be the properties of the beam produced by the linear accelerator when new, or the properties of a standard beam. The control apparatus is preferably arranged to send a message if the difference between the measured beam properties and the retained beam properties exceeds a threshold. It may also send a message to a remote location if the difference between the measured beam properties and the retained beam properties exceeds a second threshold.

Abstract translation: 我们建议在直线加速器的工厂测试期间，而不是简单地确认光束落在标准中规定的允许范围内，实际上该光束已经按照标准标记进行了调整。 一个新的（或现有的）线性加速器然后可以配对一个新的直线加速器，或者一个现有的直线加速器，比如一个或多个直线加速器，或者一个代替。 然后，治疗计划可以在这种直线加速器之间转移。 此外，线性加速器近似的标准签名可以放置在允许范围的中心，以生产在长期内更可靠的线性加速器。 这需要具有自动可调参数的直线加速器，以便合适的编程计算机能够监视直线加速器的输出并调整其操作参数。 因此，我们提供一种辐射源，其包括线性加速器，用于线性加速器的波束控制电路，用于调整其特性的控制电路的电子控制装置，以及用于检测由线性加速器产生的辐射束的特性的监视器，其中 控制装置适于保持一组光束特性并周期性地启动加速器，经由监视器测量当前的光束特性，将所测量的光束特性与所保留的光束特性进行比较，并且潜在地调整控制电路特性以对准光束特性 朝向保留梁的性质。 测量的光束特性可以包括光束平坦度和光束宽度中的至少一个。 保留的光束特性可以是当新的线性加速器或标准光束的特性时产生的光束的特性。 控制装置优选地布置成如果所测量的光束特性和所保留的光束特性之间的差超过阈值，则发送消息。 如果所测量的光束特性和所保留的光束特性之间的差异超过第二阈值，它也可以向远程位置发送消息。

公开(公告)号：WO2009129816A1

公开(公告)日：2009-10-29

申请号：PCT/EP2008/003179

申请日：2008-04-21

Applicant: ELEKTA AB (PUBL) ,  FURTH, Mark, Alexander ,  SMITH, Adrian, Maxwell

Inventor： FURTH, Mark, Alexander ,  SMITH, Adrian, Maxwell

IPC: A61N5/10 ,  G21K1/04

CPC classification number: G21K1/04 ,  A61N5/1042 ,  G21K1/046

Abstract: A multi-leaf collimator for a radiotherapy apparatus comprises a plurality of elongate leaves mounted in a carriage, the carriage being mounted on a substrate, wherein the leaves are independently moveable relative to the carriage in a longitudinal direction, and the carriage is moveable in that direction relative to the substrate, and a control apparatus arranged to receive a signal representing leaf positions relative to the substrate and being arranged to control the leaf positions relative to the carriage and the carriage positions relative to the substrate so as to achieve those leaf positions relative to the substrate. By allowing the carriage to be driven concurrently with the leaves, the speed of movement of the carriage can be added to that of the leaves. In this way, where leaves are required to make a long traverse they can do so more quickly. Most MLCs have a means for sensing the current positions of the leaves relative to the substrate, such as an optical or mechanical positional feedback system. The control apparatus can therefore compare the current leaf positions to the signalled leaf positions, and move the leaves and the carriage accordingly. Each leaf can be moved according to a difference between the current leaf position and the signalled leaf position, and the carriage can be moved according to an average difference between the current leaf positions and the signalled leaf positions. A corresponding method is also disclosed.

Abstract translation: 用于放射治疗装置的多叶准直器包括安装在托架中的多个细长叶片，滑架安装在基底上，其中叶片可相对于滑架在纵向方向上独立地移动，并且滑架可移动 方向相对于基板，以及控制装置，其布置成接收表示相对于基板的叶位置的信号，并被布置成相对于托架控制叶位置和相对于基板的托架位置，以便实现相对于基板的叶位置 到基底。 通过允许托架与叶片同时驱动，托架的运动速度可以加到叶片的运动速度。 以这种方式，需要叶子做长距离运动，他们可以更快地做到这一点。 大多数MLC具有用于感测叶片相对于基底的当前位置的装置，例如光学或机械位置反馈系统。 因此，控制装置可以将当前叶位置与信号叶位置进行比较，并相应地移动叶片和托架。 每个叶片可以根据当前叶位置和信号叶位置之间的差异来移动，并且可以根据当前叶位置和信号叶位置之间的平均差来移动滑架。 还公开了相应的方法。

公开(公告)号：WO2009056151A1

公开(公告)日：2009-05-07

申请号：PCT/EP2007/009404

申请日：2007-10-30

Applicant: ELEKTA AB (publ) ,  BROWN, Kevin ,  STREAMER, Ralph ,  BOURNE, Duncan

Inventor： BROWN, Kevin ,  STREAMER, Ralph ,  BOURNE, Duncan

IPC: A61N5/10

CPC classification number: A61N5/1049 ,  A61N5/1042 ,  A61N5/1067 ,  A61N2005/1061

Abstract: Realtime beam shape adjustment in response to (for example) online CT scanning of a patient during treatment is assisted by the radiotherapy apparatus comprising a source adapted to emit a beam of therapeutic radiation, a collimator for delimiting the radiation beam, the collimator comprising a plurality of leaves arranged alongside each other and be moveable longitudinally so that the tips of the leaves define a variable edge of the collimator, the leaves being mounted on a support that is moveable laterally with respect to the leaves. In this way, movements of the tumour that are perpendicular to the direction of leaf motion can be accommodated by simply moving the collimator bodily so as to accommodate this. It is preferred that the apparatus also includes a control means adapted to receive information as to the location of the target volume, and, on the basis of that information, control the longitudinal positions of the leaves and the lateral position of the support. It is also preferred that the support tilts as it moves laterally along a path. This can be achieved, by example, by bearings that are moveable on suitable guides, or by mounting the support on a plurality of pivot arms of unequal lengths. The lengths of such pivot arms can be adjusted as necessary.

Abstract translation: 响应于（例如）治疗期间患者的在线CT扫描的实时波束形状调整由包括适于发射治疗辐射束的源的放射治疗装置辅助，用于限定辐射束的准直器，准直器包括多个 的叶片彼此并排设置并且可纵向移动，使得叶片的尖端限定准直器的可变边缘，叶片安装在相对于叶片横向移动的支撑件上。 以这种方式，垂直于叶片运动方向的肿瘤的运动可以通过简单地移动准直器以适应这种方式来适应。 优选地，该装置还包括适于接收关于目标体积的位置的信息的控制装置，并且基于该信息来控制叶片的纵向位置和支撑件的横向位置。 还优选的是，当支撑件沿着路径横向移动时，支撑件倾斜。 这可以通过例如通过在合适的导轨上可移动的轴承，或者通过将支撑件安装在不等长度的多个枢轴臂上来实现。 这种枢转臂的长度可以根据需要进行调节。