公开(公告)号：WO2018213809A1

公开(公告)日：2018-11-22

申请号：PCT/US2018/033546

申请日：2018-05-18

Applicant: PATCH, Sarah Kathryn

Inventor： PATCH, Sarah Kathryn

IPC: A61N5/10 ,  A61N5/01 ,  A61K9/10

CPC classification number: A61K9/0019 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1071 ,  A61N2005/1058 ,  A61N2005/1087 ,  A61N2005/1098

Abstract: A particle beam range verification method includes acquiring at least one ultrasound image of target tissue that has been exposed to a particle beam, and obtaining range information for the particle beam from a change in ultrasound contrast due to destruction, by the particle beam, of microbubbles deposited in the target tissue. A particle treatment method includes delivering microbubbles to target tissue, and exposing the target tissue to a particle beam to cause damage to the target tissue, including damage caused by destruction of microbubbles by the particle beam. A microbubble-enhanced ultrasound imaging method includes acquiring an ultrasound image series of target tissue during at least one of wash-in of microbubbles to the target tissue and wash-out of the microbubbles from the target tissue, and deriving therefrom at least one of a wash-in rate and a wash-out rate indicating response of target tissue to particle treatment.

公开(公告)号：WO2017137795A1

公开(公告)日：2017-08-17

申请号：PCT/IB2016/001613

申请日：2016-10-21

Applicant: ELEKTA LTD.

Inventor： LACHAINE, Martin, Emile

IPC: A61N5/01 ,  A61N5/10 ,  G06T7/20

CPC classification number: G06T7/254 ,  A61N5/1045 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1067 ,  A61N5/1068 ,  A61N5/107 ,  A61N2005/1055 ,  G06T2207/10016 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/30096

Abstract: Systems and methods for managing motions of an anatomical region of interest of a patient during image-guided radiotherapy are disclosed. An exemplary system may include an image acquisition device, a radiotherapy device, and a processor device. The processor device may be configured to determine a primary plane of motion of the anatomical region of interest and determine a plurality of 2D slices parallel to the primary plane. The plurality of 2D slices may define a 3D volume substantially enclosing the anatomical region of interest. The processor device may also be configured to control the image acquisition device to acquire a plurality of 2D images based on the plurality of 2D slices and determine a motion of the anatomical region of interest based on at least a subset of the acquired plurality of 2D images. The processor device may be further configured to control radiation delivery based on the determined motion.

Abstract translation: 公开了用于在图像引导放射治疗期间管理患者的感兴趣解剖区域的运动的系统和方法。 示例性系统可以包括图像采集设备，放射治疗设备和处理器设备。 处理器装置可以被配置成确定感兴趣的解剖区域的主运动平面并且确定平行于主平面的多个2D切片。 多个2D切片可以限定基本上包围感兴趣解剖区域的3D体积。 处理器设备还可以被配置成控制图像采集设备基于多个2D切片获取多个2D图像，并且基于获取的多个2D图像的至少一个子集来确定感兴趣解剖区域的运动 。 处理器设备可以进一步被配置为基于所确定的运动来控制辐射输送。

公开(公告)号：WO2017134582A1

公开(公告)日：2017-08-10

申请号：PCT/IB2017/050546

申请日：2017-02-01

Applicant: UNIVERSITY HOSPITAL OSTRAVA ,  E& H SERVICES, A.S.

Inventor： CVEK, Jakub ,  OCELKA, Tomás

IPC: A61N5/10 ,  G02C7/04 ,  G02C7/02

CPC classification number: A61N5/1067 ,  A61B2090/3908 ,  A61B2090/3966 ,  A61B2090/3983 ,  A61N5/1017 ,  A61N5/1049 ,  A61N5/1083 ,  A61N2005/1051 ,  A61N2005/1061 ,  G02C7/021 ,  G02C7/04

Abstract: Methods, devices, and systems can be used to improve accuracy and precision of stereotactic radiosurgery. For example, this document provides methods and materials for using a fiducial marker device for stereotactic radiosurgery of ocular disorders. The fiducial marker device of the invention enables positional tracking of the target tissue during the stereotactic radiosurgery procedure despite occasional movement of the eye being subjected to stereotactic radiosurgery.

Abstract translation: 可以使用方法，设备和系统来提高立体定向放射外科的准确度和精确度。 例如，该文献提供了使用用于立体定向放射外科眼科疾病的基准标记装置的方法和材料。 本发明的基准标记装置能够在立体定向放射外科手术过程中对目标组织进行位置追踪，尽管眼睛偶尔会经受立体定向放射外科手术。

公开(公告)号：WO2016200464A1

公开(公告)日：2016-12-15

申请号：PCT/US2016/023463

申请日：2016-03-21

Applicant: ACCURAY INCORPORATED

Inventor： CHAPPELOW, Jonathan Cecil ,  JORDAN, Petr ,  MAURER, Calvin ,  SINGH, Sarbjit ,  FITTING, Andrew W. ,  MYRONENKO, Andriy ,  GAO, Jian

IPC: A61N5/10 ,  G21K1/04

CPC classification number: A61N5/1048 ,  A61N5/1045 ,  A61N5/1067 ,  G06K9/6211 ,  G06T5/006 ,  G06T7/74 ,  G06T2207/20048 ,  G06T2207/30164 ,  G21K1/046 ,  H04N5/2252 ,  H04N5/2257

Abstract: A radiation delivery system includes a multi-leaf collimator (MLC) that includes a housing, a plurality of leaves disposed within the housing, and an image sensor disposed within the housing at a position that is offset from a beam axis. The plurality of leaves are movable to define an aperture for the MLC, and the image sensor is directed toward the plurality of leaves. The image sensor is to generate an oblique-view image of the aperture. The radiation delivery system additionally includes a processing device to receive the oblique-view image, transform the oblique-view image into a top-view image having a reference coordinate space, and determine whether the aperture for the MLC corresponds to a specified aperture based on the top-view image.

Abstract translation: 辐射传送系统包括多叶准直器（MLC），其包括壳体，设置在壳体内的多个叶片，以及设置在壳体内的偏离光束轴线的位置处的图像传感器。 多个叶片可移动以限定MLC的孔，并且图像传感器指向多个叶片。 图像传感器用于产生光圈的斜视图像。 放射线传送系统还包括接收斜视图像的处理装置，将斜视图像变换为具有参考坐标空间的顶视图像，并且基于以下方式确定MLC的孔径是否对应于指定的孔径 顶视图。

公开(公告)号：WO2016187319A1

公开(公告)日：2016-11-24

申请号：PCT/US2016/033104

申请日：2016-05-18

Applicant: VARIAN MEDICAL SYSTEMS, INC. ,  VARIAN MEDICAL SYSTEMS

Inventor： BACH, Markus ,  HUTH, Isabel ,  HEESE, Juergen ,  PISKULICH, Franko ,  DONG, Lei

IPC: A61N5/10

CPC classification number: A61N5/1081 ,  A61N5/1037 ,  A61N5/1044 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1068 ,  A61N2005/1087

Abstract: To overcome the difficulties inherent in conventional proton therapy systems, new techniques are described herein for synchronizing the application of proton radiation with the periodic movement of a target area. In an embodiment, a method is provided that combines multiple rescans of a spot scanning proton beam while monitoring the periodic motion of the target area, and aligning the applications of the proton beam with parameters of the periodic motion. For example, the direction(s) and frequency of the periodic motion may be monitored, and the timing, dose rate, and/or scanning direction and spot sequence of the beam can be adjusted to align with phases in the periodic motion.

Abstract translation: 为了克服常规质子治疗系统中固有的困难，本文描述了用于使质子辐射的应用与目标区域的周期性运动同步的新技术。 在一个实施例中，提供了一种组合点扫描质子束的多个重新扫描的方法，同时监视目标区域的周期性运动，并且将质子束的应用与周期性运动的参数对准。 例如，可以监视周期性运动的方向和频率，并且可以调整光束的定时，剂量率和/或扫描方向和点序列以与周期运动中的相位对准。

公开(公告)号：WO2016050709A1

公开(公告)日：2016-04-07

申请号：PCT/EP2015/072290

申请日：2015-09-28

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： FONTANAROSA, Davide

IPC: A61B8/08 ,  A61B8/00 ,  A61N5/10

CPC classification number: A61B8/085 ,  A61B8/4227 ,  A61B8/4236 ,  A61B8/4455 ,  A61B8/483 ,  A61B8/582 ,  A61N5/1049 ,  A61N5/1067 ,  A61N2005/1058

Abstract: An ultrasonic diagnostic imaging system has a thin two dimensional array transducer probe which is taped or belted to a patient to image a target region during radiotherapy. The radiotherapy procedure is conducted based upon planning done based on images of the target region acquired prior to the procedure. The array transducer is operated by an ultrasound system to produce three dimensional images of the target region by electronic beam steering, either during or between fractions of the treatment procedure. The ultrasound images are used to adjust the treatment plan in response to any movement or displacement of the target anatomy during the treatment procedure.

Abstract translation: 超声波诊断成像系统具有薄的二维阵列换能器探针，其在放射治疗期间被胶带或绑带到患者以对目标区域成像。 放射治疗程序是基于基于在手术前获得的目标区域的图像进行的规划进行的。 阵列换能器由超声系统操作，通过电子束转向，在处理过程的分数之间或之间产生目标区域的三维图像。 超声图像用于在治疗过程期间响应于目标解剖结构的任何运动或位移来调整治疗计划。

公开(公告)号：WO2016000777A1

公开(公告)日：2016-01-07

申请号：PCT/EP2014/064189

申请日：2014-07-03

Applicant: BRAINLAB AG

Inventor： FRÖHLICH, Stephan ,  BERLINGER, Kajetan ,  WOHLGEMUTH, Richard

IPC: A61B6/00 ,  A61N5/10

CPC classification number: A61N5/1049 ,  A61B6/486 ,  A61B6/5264 ,  A61B6/527 ,  A61B6/5288 ,  A61B2034/2055 ,  A61B2090/3937 ,  A61B2090/3945 ,  A61B2090/3966 ,  A61N5/1067 ,  A61N5/1068 ,  A61N2005/105 ,  A61N2005/1051 ,  A61N2005/1052 ,  A61N2005/1054 ,  A61N2005/1058 ,  A61N2005/1059 ,  A61N2005/1061 ,  G16H30/20

Abstract: A data processing method and device for correlating the position of a radiation beam with the position of a target to be irradiated and contained in a structure underlying a repetitive motion comprising a plurality of successive motion cycles, the method/device comprising/performing the following steps which are constituted to be executed by a computer: a) acquiring first external position data, second external position data and third external position data describing the position of at least one external feature of said structure, for one or more sections of at least one first motion cycle occurring during a first period of time, for one or more sections of at least one second motion cycle occurring during a second period of time, and for one or more sections of at least one third motion cycle occurring during said second period of time, respectively; b) acquiring first target position data and second target position data describing the position of said target for at least one of said sections of said at least one first motion cycle, and for said sections of said at least one second motion cycle, respectively; c) determining, based on said first external position data and said first target position data, correlation model data describing a positional correlation of said external position and said target position; d) determining, based on said correlation model data and said second external position data, second predicted target position data describing a predicted position of said target for one or more sections of said at least one second motion cycle; e) determining, based on said second target position data and said second predicted target position data, primary verification data describing whether the position of said target for said sections of said at least one second motion cycles is different from said predicted position; f) acquiring, in case said primary verification data indicates that the position of said target is not different from the predicted position of said target, auxiliary second target position data and auxiliary third target position data describing the position of said target for one or more sections of said at least one second motion cycle, and of said at least one third motion cycle, respectively; g) determining, based on said first and/or said second external position data, said auxiliary second target position data and said third external position data, third predicted target position data describing a predicted position of said target for said sections of said at least one third motion cycle; h) determining, based on said auxiliary third target position data and said third predicted target position data, secondary verification data describing whether the position of said target for said sections of said at least one third motion cycle is different from said predicted position.

Abstract translation: 一种数据处理方法和装置，用于将辐射束的位置与待照射和包含在包括多个连续运动周期的重复运动的结构中的目标的位置相关联，该方法/装置包括/执行以下步骤 其被构造为由计算机执行：a）获取第一外部位置数据，第二外部位置数据和描述所述结构的至少一个外部特征的位置的第三外部位置数据，用于至少一个第一外部位置数据的一个或多个部分 在第一时段期间发生的运动周期，对于在第二时间段期间发生的至少一个第二运动周期的一个或多个部分以及在所述第二时段期间发生的至少一个第三运动周期的一个或多个部分， ， 分别; b）获取第一目标位置数据和描述所述目标对于所述至少一个第一运动周期的所述部分中的至少一个以及所述至少一个第二运动周期的所述部分的位置的第二目标位置数据; c）基于所述第一外部位置数据和所述第一目标位置数据确定描述所述外部位置与所述目标位置的位置相关性的相关模型数据; d）基于所述相关模型数据和所述第二外部位置数据确定描述所述目标对所述至少一个第二运动周期的一个或多个部分的预测位置的第二预测目标位置数据; e）基于所述第二目标位置数据和所述第二预测目标位置数据确定主验证数据，其描述所述目标对所述至少一个第二运动周期的所述部分的位置是否不同于所述预测位置; f）在所述主验证数据指示所述目标的位置与所述目标的预测位置不相同的情况下获取，辅助第二目标位置数据和辅助第三目标位置数据，描述所述目标对于一个或多个部分的位置 的所述至少一个第二运动周期和所述至少一个第三运动周期; g）基于所述第一和/或所述第二外部位置数据确定所述辅助第二目标位置数据和所述第三外部位置数据，所述第三预测目标位置数据描述所述目标对所述至少一个的所述部分的预测位置 第三运动周期; h）基于所述辅助第三目标位置数据和所述第三预测目标位置数据确定二次验证数据，其描述所述目标对所述至少一个第三运动周期的所述部分的位置是否不同于所述预测位置。

公开(公告)号：WO2015118021A1

公开(公告)日：2015-08-13

申请号：PCT/EP2015/052322

申请日：2015-02-04

Applicant: ELEKTA AB (PUBL)

Inventor： CARLSSON, Per

IPC: A61N5/10

CPC classification number: A61N5/1082 ,  A61N5/103 ,  A61N5/1049 ,  A61N5/1067 ,  A61N2005/1061

Abstract: A table with 6 degrees of freedom is regarded as essential in order to adjust the patient position to correct for positioning errors and the like. However, this imposes a significant cost, has a redundant axis in a conventional linac treatment system, and adds to the volume of the table. We disclose a way of dealing with rotation of the patient in an axis about which the source has a limited range of rotation, without needing a rotational adjustment of the table. An apparatus comprises a radiotherapy delivery apparatus having a radiation source adapted to emit a beam of radiation and to rotate around at least one axis that intersects with the beam, the rotation being confined to a limited range of rotation, an associated imaging device, and a control means controlling both the source and the imaging device, together with a treatment planning computer that accepts an image of a patient and parameters defining the machine capabilities, and creates a treatment plan based on both, wherein the source is capable of rotation in that axis through a range of at least x degrees, and a parameter is passed to the treatment planning computer defining the source's available range as x-e where e>0 , and the control means is adapted to detect the patient position using the imaging device, determine a rotation r of the patient around the axis relative to the image used by the treatment planning computer, and if r compensate for the rotation by offsetting the source by a rotation equal to r . The limited range of rotation is typically less than 360 degrees although this need not necessarily be the case. An example of the type of radiotherapy apparatus to which this invention is applicable is shown in our earlier patent application WO2005/041774, but it can equally be applied to other types.

Abstract translation: 被认为是具有6个自由度的表以便调整患者位置以校正定位误差等。 然而，这带来了显着的成本，在常规线性加速器处理系统中具有冗余轴，并增加了表的体积。 我们公开了一种处理患者旋转轴的方式，围绕该轴旋转源具有有限的旋转范围，而不需要对该台的旋转调节。 一种装置包括放射治疗输送装置，其具有适于发射辐射束的辐射源，并围绕与光束相交的至少一个轴线旋转，旋转被限制在有限的旋转范围内，相关的成像装置和 控制装置同时控制源和成像装置，以及接受患者图像的治疗计划计算机和定义机器能力的参数，并且基于两者创建治疗计划，其中源能够在该轴上旋转 通过至少x度的范围，并且将参数传递到定义源的可用范围的治疗计划计算机作为xe，其中e> 0，并且控制装置适于使用成像装置检测患者位置，确定旋转 r相对于治疗计划计算机使用的图像在轴线周围，并且如果r

公开(公告)号：WO2015090555A1

公开(公告)日：2015-06-25

申请号：PCT/EP2014/003360

申请日：2014-12-15

Applicant: VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH

Inventor： TIMMER, Jan

IPC: A61N5/10 ,  H05H7/00

CPC classification number: A61N5/1082 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1081 ,  A61N2005/1087 ,  H01J37/08 ,  H05H7/001 ,  H05H2007/002 ,  H05H2277/11

Abstract: Irradiation device for irradiating an irradiation object with heavy charged particles, comprising a support for the irradiation object, and an irradiation nozzle irradiating a charged particle beam towards the irradiation object, wherein the beam is deflected within the irradiation nozzle. The support for the irradiation object is moveable at least horizontally, and the irradiation nozzle is moveable at least vertically and rotatable around a nozzle swivel axis along which the particle beam enters into the irradiation nozzle.

Abstract translation: 用于对包含用于照射物体的支撑体的重带电粒子照射被照射物体的照射装置和照射被照射物体的带电粒子束的照射喷嘴，其中，所述光束在所述照射喷嘴内偏转。 照射物体的支撑物至少可以水平移动，并且照射喷嘴可以至少垂直移动并且围绕喷嘴旋转轴线旋转，沿着该喷嘴旋转轴线，粒子束沿着该旋转轴线进入照射喷嘴。

公开(公告)号：WO2015075797A1

公开(公告)日：2015-05-28

申请号：PCT/JP2013/081386

申请日：2013-11-21

Applicant: 三菱電機株式会社

Inventor： 岩田　高明 ,  原田　久 ,  池田　昌広 ,  蒲　越虎

IPC: A61N5/10

CPC classification number: A61N5/1079 ,  A61N5/1067 ,  A61N5/1068 ,  A61N2005/1074 ,  A61N2005/1087

Abstract: 　本発明は、タイムシェアリングにより複数の治療室へあたかも同時にビームを輸送することができる粒子線治療装置を提供することを目的とする。　粒子線治療装置（５１）のビーム輸送系（５９）は、複数の粒子線照射装置（５８）のいずれか一つに荷電粒子ビーム（８１）を輸送するようにビーム経路を変更するビーム経路変更器（１６）を有し、治療管理装置（９５）は、同一治療時間帯に治療を行う複数の粒子線照射装置（５８）に対して、荷電粒子ビーム（８１）を割当時間毎に複数の粒子線照射装置（５８）のいずれか一つに輸送するように、加速器（５４）の出射器（６２）を制御する出射器制御信号（ｃｓｉｇａ）とビーム経路変更器（１６）を制御するビーム経路変更器制御信号（キッカー制御信号（ｃｓｉｇｂ））とを生成するビーム経路制御器（１８）を有する。

Abstract translation: 本发明的目的是提供一种粒子治疗装置，其能够将束传送到多个治疗室，就像通过时间共享同时运送束一样。 粒子治疗装置（51）的束传送系统（59）包括光束修改器（16），其修改光束路径，使得带电粒子束（81）被传送到多个粒子束照射装置 （58）。 治疗管理装置（95）包括光束路径控制器（18），其生成用于控制加速器（54）的发射器（62）的发射器控制信号（csiga）和光束路径修正器控制信号（激光控制信号（csigb ））以控制光束路径修正器（16），以便将每个分配时间的带电粒子束（81）传输到在相同处理时间段内执行处理的多个粒子束照射装置（58）中的任何一个 。