公开(公告)号：WO98057666A1

公开(公告)日：1998-12-23

申请号：PCT/GB1998/001438

申请日：1998-05-19

IPC: A61K49/00 ,  A61K49/22

CPC classification number: A61K49/0043 ,  A61K49/0002 ,  A61K49/0013 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0041 ,  A61K49/0065 ,  A61K49/0078 ,  A61K49/0084 ,  A61K49/0093 ,  A61K49/0438 ,  A61K49/0466 ,  A61K49/22 ,  A61K49/223 ,  A61K49/227

Abstract: The invention relates inter alia to a method of generating information from an animate human or non-human animal body which method comprises: administering to said body a physiologically tolerable material capable of absorbing, scattering or emitting light at a wavelength in the range 300 to 1300 nm; subjecting at least a portion of said body to ultrasound irradiation; detecting light in the wavelength range 300 to 1300 nm from said portion of said body; and manipulating the detected light to generate said information.

Abstract translation: 本发明特别涉及从动物人或非人动物体产生信息的方法，该方法包括：向所述身体施用能够吸收，散射或发射波长在300至1300范围内的光的生理上可耐受的材料 纳米; 对所述身体的至少一部分进行超声波照射; 从所述主体的所述部分检测在300至1300nm的波长范围内的光; 并操纵检测到的光以产生所述信息。

公开(公告)号：WO1998018500A2

公开(公告)日：1998-05-07

申请号：PCT/GB1997002953

申请日：1997-10-28

Applicant: MARSDEN, John, Christopher ,  NYCOMED IMAGING AS ,  KLAVENESS, Jo ,  RONGVED, Pål ,  HOGSET, Anders ,  TOLLESHAUG, Helge ,  CUTHBERTSON, Alan ,  GODAL, Aslak ,  HOFF, Lars ,  GOGSTAD, Geir ,  BRYN, Klaus ,  NÆVESTAD, Anne ,  LOVHAUG, Dagfinn ,  HELLEBUST, Halldis ,  SOLBAKKEN, Magne

Inventor： MARSDEN, John, Christopher ,  NYCOMED IMAGING AS

IPC: A61K51/08

CPC classification number: A61K49/0056 ,  A61K47/542 ,  A61K47/549 ,  A61K47/55 ,  A61K47/554 ,  A61K47/62 ,  A61K47/6925 ,  A61K49/0043 ,  A61K49/0054 ,  A61K49/0091 ,  A61K51/0497 ,  A61K51/088

Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

Abstract translation: 可靶向的诊断和/或治疗活性剂，例如 超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

公开(公告)号：WO1997035560A1

公开(公告)日：1997-10-02

申请号：PCT/US1997004939

申请日：1997-03-28

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  NORTHWESTERN UNIVERSITY ,  ONYUKSEL, Hayat ,  RUBINSTEIN, Israel ,  McPHERSON, David, D. ,  MURER, Sasha, E.

Inventor： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  NORTHWESTERN UNIVERSITY

IPC: A61K09/127

CPC classification number: A61K9/1278 ,  A61K9/1271 ,  A61K38/2278 ,  A61K49/0017 ,  A61K49/0043 ,  A61K49/0054 ,  A61K49/0084 ,  A61K49/1812 ,  A61K49/227

Abstract: Provided are methods for preparing improved diagnostic liposome products comprising a biologically active amphipathic compound in association with a liposome. Methods for producing the liposome products as well methods of using the liposome products in diagnostic techniques are also provided.

Abstract translation: 提供了制备包含与脂质体结合的生物活性两亲化合物的改进的诊断性脂质体产物的方法。 还提供了生产脂质体产物的方法以及在诊断技术中使用脂质体产物的方法。

公开(公告)号：WO1997029114A1

公开(公告)日：1997-08-14

申请号：PCT/US1997002560

申请日：1997-02-07

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF WASHINGTON

Inventor： BOARD OF REGENTS OF THE UNIVERSITY OF WASHINGTON ,  WILBUR, Scott, D. ,  PATHARE, Pradip, M. ,  WEERAWARNA, S., Ananda ,  HAMLIN, Donald, K.

IPC: C07H15/00

CPC classification number: C07D495/04 ,  A61K41/0095 ,  A61K47/557 ,  A61K47/6893 ,  A61K49/0021 ,  A61K49/0043 ,  A61K49/0052 ,  B82Y5/00

Abstract: Water soluble biotin-containing compounds and biotinylation reagents incorporating soluble linker moieties are disclosed. The water soluble biotin-containing compounds and biotinylation reagents may additionally comprise one or more moieties that confers resistance to cleavage by biotinidase or that is cleavable in vitro or in vivo. Biotin-containing compounds and biotinylation reagents may include a reactive moiety that provides a site for reaction with yet another moiety, such as targeting, diagnostic or therapeutic functional moiety. Conjugates including functional moieties are disclosed. Biotin dimers, trimers and multimers comprising water soluble linker moieties which demonstrate enhanced water solubility are also disclosed. Methods for amplifying the number of sites for binding biotin-binding proteins at a selected target using biotin trimer compounds are disclosed. Methods for synthesizing the biotin-containing compounds and biotinylation reagents, and methods for using such compounds are described and an example of the invention, streptavidin cross-linking with biotin derivatives is shown in the figure.

Abstract translation: 公开了含有可溶性生物素的化合物和含有可溶性连接体部分的生物素化试剂。 含水溶性生物素的化合物和生物素化试剂可以另外包含赋予对生物素酶切割抗性或在体外或体内可切割的抗性的一个或多个部分。 含有生物素的化合物和生物素化试剂可以包括提供与另一部分例如靶向，诊断或治疗功能部分反应的位点的反应性部分。 公开了包括官能团的缀合物。 还公开了包含表现出增强的水溶性的水溶性连接体部分的生物素二聚体，三聚物和多聚体。 公开了使用生物素三聚体化合物扩增在选定靶标上结合生物素结合蛋白的位点数目的方法。 描述了用于合成含有生物素的化合物和生物素化试剂的方法，以及使用这些化合物的方法，本发明的实例与链霉亲和素与生物素衍生物的交联如图所示。

公开(公告)号：WO1997019938A1

公开(公告)日：1997-06-05

申请号：PCT/ES1996000231

申请日：1996-11-29

Applicant: CONSEJO SUPERIOR INVESTIGACIONES CIENTIFICAS ,  AMAT GUERRI, Francisco ,  SOUTO, Andre ,  ACUNA FERNANDEZ, Alberto Ulises ,  ANDREU MORALES, José Manuel ,  BARASOAIN BLASCO, Mª Isabel ,  ABAL, Miguel

Inventor： CONSEJO SUPERIOR INVESTIGACIONES CIENTIFICAS

IPC: C07D305/14

CPC classification number: C07D407/12 ,  A61K49/0039 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  C07D305/14

Abstract: Intensively fluorescent derivatives have been synthesized from a substance used at present as anticancer (chemotherapy) agent, against ovarian and mammal tumors, and other tumors. Said derivatives enable to visualize the cellular target of said drug, since the derivatization does not modify the biological activity. There is no existing compound which has the solubility, activity and fluorescence characteristics of the compounds disclosed in the present invention. Said derivatives may be used as fluorescence microscopy colorants specific to microtubules of the cytoskeleton in cells and other living organisms. Said derivatives have many applications in the analysis of the cell anatomy and in clinical diagnosis.

Abstract translation: 已经从目前用作抗癌（化疗）药物的物质，针对卵巢和哺乳动物肿瘤以及其它肿瘤合成了强烈荧光衍生物。 所述衍生物使得能够可视化所述药物的细胞靶标，因为衍生化不改变生物活性。 没有现有化合物具有本发明公开的化合物的溶解度，活性和荧光特性。 所述衍生物可用作细胞和其他生物体中细胞骨架微管特异性的荧光显微镜着色剂。 所述衍生物在细胞解剖学和临床诊断的分析中具有许多应用。

公开(公告)号：WO1997006833A1

公开(公告)日：1997-02-27

申请号：PCT/US1996013080

申请日：1996-08-09

Applicant: DENTRITECH, INC. ,  YIN, Rui ,  TOMALIA, Donald, A. ,  HEDSTRAND, David, M. ,  SWANSON, Douglas, R. ,  BAKER, James, R., Jr. ,  KUKOWSKA-LATALLO, Jolanta, F.

Inventor： DENTRITECH, INC.

IPC: A61K51/02

CPC classification number: A61Q13/00 ,  A61K8/90 ,  A61K47/56 ,  A61K47/58 ,  A61K47/59 ,  A61K47/593 ,  A61K47/595 ,  A61K47/61 ,  A61K47/641 ,  A61K47/6885 ,  A61K47/6949 ,  A61K48/00 ,  A61K49/0043 ,  A61K49/0054 ,  A61K2800/54 ,  A61K2800/57 ,  B82Y5/00 ,  C08G83/005 ,  C12N15/87 ,  Y10S424/16 ,  Y10S525/902

Abstract: A novel class of hyper comb-branched polymers conjugated with carried materials are disclosed.

Abstract translation: 公开了一种与携带材料共轭的新型超梳状支化聚合物。

公开(公告)号：WO1994023646A1

公开(公告)日：1994-10-27

申请号：PCT/US1994004267

申请日：1994-04-19

Applicant: MALLINCKRODT MEDICAL, INC.

Inventor： MALLINCKRODT MEDICAL, INC. ,  BEATY, Julie, A. ,  COOPER, Steven, R. ,  McLOUGHLIN, Margaret, A.

IPC: A61B05/00

CPC classification number: A61K49/0034 ,  A61K49/0021 ,  A61K49/0023 ,  A61K49/0043 ,  C09B67/0071

Abstract: The invention relates to stable aqueous solutions of voltage sensitive dyes. Particularly the invention relates to the proper formulation and storage conditions that provide marketable aqueous solutions of voltage sensitive dyes for use as optical imaging contrast agents.

Abstract translation: 本发明涉及稳定的电压敏感染料水溶液。 特别地，本发明涉及提供可用作光学成像造影剂的电压敏感染料的市售水溶液的适当配制和储存条件。

公开(公告)号：WO1993002192A1

公开(公告)日：1993-02-04

申请号：PCT/US1992005903

申请日：1992-07-15

Applicant: REPLIGEN CORPORATION

Inventor： REPLIGEN CORPORATION ,  MAIONE, Theodore, E.

IPC: C12N15/19

CPC classification number: A61K49/0056 ,  A61K38/00 ,  A61K47/60 ,  A61K47/643 ,  A61K47/6811 ,  A61K49/0043 ,  C07K14/522

Abstract: The subject invention pertains to the use of modified PF4 and recombinant PF4 (rPF4) as well as modified analogs (mutants) of PF4, and peptide fragments thereof, to inhibit angiogenesis. The modified PF4, analogs, and certain fragments are shown to have utility for treating angiogenic diseases and for the inhibition of endothelial cell proliferation. Also, the subject invention concerns modifications of PF4 which extend the half-life and facilitate the targeting of the biological activity of PF4 to specific locations.

Abstract translation: 本发明涉及修饰的PF4和重组PF4（rPF4）以及PF4的修饰类似物（突变体）及其肽片段用于抑制血管发生的用途。 修饰的PF4，类似物和某些片段显示具有治疗血管生成疾病和抑制内皮细胞增殖的效用。 此外，本发明涉及PF4的修饰，其延长了半衰期，并且有助于将PF4的生物活性靶向到特定位置。

公开(公告)号：WO1992001478A1

公开(公告)日：1992-02-06

申请号：PCT/GB1991001190

申请日：1991-07-18

Applicant: CHARWELL PHARMACEUTICALS LIMITED ,  JOLLIFEE, Stephen, Ronald ,  WEAVER, Lawrence, Trevelyan

Inventor： CHARWELL PHARMACEUTICALS LIMITED

IPC: A61K49/00

CPC classification number: A61K49/0043 ,  A61K49/0076 ,  A61K49/222

Abstract: Fluorescein dilaurate is dissolved in coconut oil and converted into an oil-in-water emulsion in the presence of a mannitol. The composition is administered orally. Fluorescein and mannitol are excreted in the urine. The ratio of recovered fluorescein and mannitol allows for the detection of pancreatic insufficiency without the need for control experiments.

Abstract translation: 将荧光素二月桂酸酯溶于椰子油中，并在甘露醇存在下转化成水包油乳液。 组合物口服给药。 荧光素和甘露醇在尿液中排泄。 回收的荧光素和甘露醇的比例允许检测胰腺功能不全，而不需要对照实验。

公开(公告)号：WO2017084645A1

公开(公告)日：2017-05-26

申请号：PCT/CZ2016/050043

申请日：2016-11-18

Applicant: UNIVERZITA KARLOVA

Inventor： DAVID, Tomas ,  HERMANN, Petr ,  KUBICEK, Vojtech

IPC: C07F9/30 ,  C07F9/38 ,  A61K49/06 ,  A61B5/00

CPC classification number: C07F9/94 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  A61K51/0402 ,  A61K51/0453 ,  A61K51/0459 ,  A61K51/0482 ,  A61K51/0489 ,  A61K51/0497 ,  A61K51/065 ,  A61K51/08 ,  A61K51/088 ,  A61K51/1027 ,  A61K51/1093 ,  C07F9/6524 ,  C07F9/65583 ,  C07F9/6561

Abstract: Cyclam based compounds, their conjugates, co-ordination compounds, pharmaceutical composition containing thereof, method of preparation and use thereof The present invention relates to cyclam based compounds of the general formula (I), conjugates of such compounds with conjugation groups, their coordination compounds, targeting conjugates, method of preparation of cyclam based compounds, intermediate products for the preparation of cyclam based compounds, a pharmaceutical preparation containing them, and the use thereof.

Abstract translation: 基于Cyclam的化合物，它们的缀合物，配位化合物，含有其的药物组合物，其制备方法和用途本发明涉及通式（I）的基于cyclam的化合物，这样的缀合物 具有缀合基团的化合物，它们的配位化合物，靶向缀合物，制备基于cyclam的化合物的方法，用于制备基于cyclam的化合物的中间产物，包含它们的药物制剂及其用途。