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    MICROCHANNEL POLYMERIZATION REACTOR
    72.
    发明申请
    MICROCHANNEL POLYMERIZATION REACTOR 审中-公开
    微通道聚合反应器

    公开(公告)号：WO2005084795A1

    公开(公告)日：2005-09-15

    申请号：PCT/US2005/007043

    申请日：2005-03-02

    申请人： VELOCYS, INC. ,  FITZGERALD, Sean, P. ,  HESSE, David, J. ,  TONKOVICH, Anna, Lee, Y. ,  SILVA, Laura, J.

    发明人： FITZGERALD, Sean, P. ,  HESSE, David, J. ,  TONKOVICH, Anna, Lee, Y. ,  SILVA, Laura, J.

    IPC分类号： B01J19/00

    CPC分类号： B01J19/0093 ,  B01F5/0475 ,  B01F5/0478 ,  B01F5/0619 ,  B01F5/0646 ,  B01F5/0653 ,  B01F5/0682 ,  B01F5/0688 ,  B01F13/0059 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00844 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907 ,  F28D7/00 ,  F28D9/00 ,  F28F2260/02 ,  Y10S526/918 ,  Y10T137/212

    摘要： A microchannel polymerization reactor comprising: (a) a first microchannel adapted to carry a reactant stream; (b) a fluid conduit adapted to carry a fluid in thermal communication with the first microchannel; and (c) a static mixer in fluid communication with the first microchannel adapted to provide a mixing zone operative to change the cross-sectional fluid flow profile at a predetermined point along the first microchannel without changing the primary direction of the reactant stream through the first microchannel. The present invention also includes a method of carrying out a polymerization reaction within a microchannel reactor comprising: (i) directing at least one of monomer, initiator, water, surfactant, coagulant, and solvent into a reactant stream and into contact with reactant flowing within a first microchannel to initiate a polymerization reaction occurring within a first microchannel; and (ii) mixing the reactant of the reactant stream by positioning at least one static mixer in series with the reactant stream, where the static mixer is adapted to change a cross-sectional fluid flow profile of the reactant stream flowing through the first microchannel without changing a primary direction of the reactant stream through the first microchannel.

    摘要翻译： 一种微通道聚合反应器，包括：（a）适于携带反应物流的第一微通道; （b）适于承载与第一微通道热连通的流体的流体导管; 和（c）与所述第一微通道流体连通的静态混合器，其适于提供混合区域，其可操作以沿着所述第一微通道改变在预定点处的横截面流体流动分布，而不改变所述反应物流的主要方向通过所述第一 微通道。 本发明还包括在微通道反应器内进行聚合反应的方法，包括：（i）将单体，引发剂，水，表面活性剂，凝结剂和溶剂中的至少一种引入反应物流中并与在其内流动的反应物接触 引发在第一微通道内发生聚合反应的第一微通道; 和（ii）通过将至少一个与反应物流串联的静态混合器定位来混合反应物流的反应物，其中静态混合器适于改变流过第一微通道的反应物流的横截面流体流动分布，而没有 改变反应物流通过第一微通道的主要方向。

    SYSTEM AND METHOD FOR HEATING, COOLING AND HEAT CYCLING ON MICROFLUIDIC DEVICE
    79.
    发明申请
    SYSTEM AND METHOD FOR HEATING, COOLING AND HEAT CYCLING ON MICROFLUIDIC DEVICE 审中-公开
    用于加热，冷却和热循环的微流控装置的系统和方法

    公开(公告)号：WO2004108287A1

    公开(公告)日：2004-12-16

    申请号：PCT/US2004/017943

    申请日：2004-06-07

    申请人： MICRONICS, INC. ,  BREIDFORD, Wayne ,  LANCASTER, Christy, A. ,  HAYENGA, Jon, Wallace ,  BARDELL, Ronald, L. ,  TONN, Jeffrey, F. ,  WEIGL, Bernhard, H.

    发明人： BREIDFORD, Wayne ,  LANCASTER, Christy, A. ,  HAYENGA, Jon, Wallace ,  BARDELL, Ronald, L. ,  TONN, Jeffrey, F. ,  WEIGL, Bernhard, H.

    IPC分类号： B01L3/00

    CPC分类号： B01L7/52 ,  B01J2219/00873 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/185 ,  B01L2300/1877 ,  B01L2400/0487 ,  Y10S435/809

    摘要： An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.

    摘要翻译： 微流控卡上集成的热交换系统。 根据本发明的一个方面，便携式微流控卡具有板上的加热，冷却和热循环系统，使得卡可以可移动地使用。 微流控卡包括一个或多个含有放热或吸热材料的储存器。 一旦储存器材料的化学过程被激活，储存器就向微流控卡的特定位置提供热量或冷却。 可以在单个卡上包括多个储存器以提供变化的温度。 测定化学品可以移动到各种储存器以产生可用于许多生物反应的热循环，例如聚合酶链式反应（PCR）或rtPCR。 根据本发明的另一方面，集成热交换器是包含独立加热或冷却的流体的相邻微流体回路，或者是放热或吸热材料，使得相邻回路中的流体将温度变化赋予 独立电路中的分析流体。 根据本发明的另一方面，热电冷却器（TEC）用于热循环一次性微流控卡的放大室。