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    ALPHA-FETOPROTEIN PEPTIDES AND USES FOR IMAGING
    71.
    发明申请
    ALPHA-FETOPROTEIN PEPTIDES AND USES FOR IMAGING 审中-公开
    ALPHA-FETOPROTEIN胶囊和成像用途

    公开(公告)号：WO03044041A2

    公开(公告)日：2003-05-30

    申请号：PCT/US0237291

    申请日：2002-11-20

    Applicant: CLF MEDICAL TECHNOLOGY ACCELERATION PROGRAM INC ,  ANDERSEN THOMAS T ,  BENNETT JAMES A ,  JACOBSON HERBERT I ,  MESFIN FASSIL B

    Inventor： ANDERSEN THOMAS T ,  BENNETT JAMES A ,  JACOBSON HERBERT I ,  MESFIN FASSIL B

    IPC: A61K38/00 ,  C07K14/47 ,  G01N33/574 ,  C07K

    CPC classification number: A61K49/0002 ,  A61K38/00 ,  C07K14/4715 ,  C07K2319/00 ,  G01N33/57415

    Abstract: The invention provides diagnostic procedures wherein the presence or absence of a cell-proliferating disorder, e.g., a breast cancer, may be determined. The imaging agents of the invention include alpha-fetoprotein hydrophilic analogs which have been determined to target cancers, e.g., breast cancer, and are also anti-cell proliferating in nature. These modulators contain amino acid structures which are arranged as a hydrophilic analog of an alpha-fetoprotein. The modulator may be a peptide; a peptidomimetic; or may be in the form of a pharmaceutically acceptable scaffold, such as a polycyclic hydrocarbon to which is attached the necessary amino acid structures. The imaging agents of the invention further comprise an imaging moiety that allows for the imaging of the area targeted by the imaging agent.

    Abstract translation: 本发明提供诊断方法，其中可以确定细胞增殖性病症（例如乳腺癌）的存在或不存在。 本发明的成像剂包括已被确定为靶向癌症（例如乳腺癌）的甲胎蛋白亲水类似物，并且在本质上也是抗细胞增殖。 这些调节剂含有排列成甲胎蛋白的亲水类似物的氨基酸结构。 调节剂可以是肽; 一个拟人的 或者可以是药学上可接受的支架的形式，例如连接有必需的氨基酸结构的多环烃。 本发明的成像剂还包括成像部分，其允许对由成像剂靶向的区域进行成像。

    OVARIAN TUMOR ANTIGEN AND METHODS OF USE THEREFOR
    73.
    发明申请
    OVARIAN TUMOR ANTIGEN AND METHODS OF USE THEREFOR 审中-公开
    OVARIAN肿瘤抗原及其使用方法

    公开(公告)号：WO01021653A2

    公开(公告)日：2001-03-29

    申请号：PCT/US2000/026318

    申请日：2000-09-25

    IPC: A61K38/00 ,  A61K39/00 ,  C07H21/00 ,  C07K14/47 ,  C07K14/00

    CPC classification number: C07H21/00 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/5154 ,  C07K14/4715

    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise HPP14, an immunogenic portion or variant thereof or a polynucleotide that encodes such a polypeptide. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses HPP14 (or a portion or other variant thereof), or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Diagnostic methods based on the detection of HPP14 expression are also provided.

    Abstract translation: 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含编码这种多肽的HPP14，其免疫原性部分或其变体或多核苷酸。 或者，治疗组合物可以包含表达HPP14（或其一部分或其它变体）的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了基于检测HPP14表达的诊断方法。

    ALTERED PROTEIN EXPRESSION IN HYPOXIC TROPHOBLASTS
    75.
    发明申请
    ALTERED PROTEIN EXPRESSION IN HYPOXIC TROPHOBLASTS 审中-公开
    HYPOXIC TROPHOBLASTS中更换的蛋白质表达

    公开(公告)号：WO1996033214A2

    公开(公告)日：1996-10-24

    申请号：PCT/US1996005441

    申请日：1996-04-18

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  FISHER, Susan, J. ,  GENBACEV, Olga ,  FOULK, Russell ,  CLAUSER, Karl, R. ,  BURLINGAME, Alama, L.

    Inventor： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    IPC: C07K14/47

    CPC classification number: C07K14/47 ,  C07K14/4715 ,  C07K14/775 ,  C12N5/0605 ,  C12N2500/02 ,  G01N33/56966 ,  G01N33/689 ,  G01N2800/36

    Abstract: This invention is the discovery that hypoxic mammalian fetal trophoblast cells are a valid model of abnormal maternal plancental function and of other invasive cell types. The trophoblast cells differentially express a number of proteins when grown under hypoxic conditions. These proteins are useful for determining the health of the trophoblasts, the condition of a maternal placental interface and the invasive properties of metastatic and other invasive cell types. The hypoxic cytotrophoblast cells provide a convenient means to isolate these proteins and develope assay kits based upon the presence or absence of the proteins in a human test sample.

    Abstract translation: 本发明是缺氧哺乳动物胎儿滋养层细胞是母体平面功能异常和其他浸润细胞类型的有效模型的发现。 当在缺氧条件下生长时，滋养层细胞差异表达许多蛋白质。 这些蛋白质可用于确定滋养层的健康状况，母体胎盘界面的状况以及转移性和其他侵入性细胞类型的侵入性质。 缺氧细胞滋养层细胞提供了一种方便的手段来分离这些蛋白质，并且基于人类测试样品中存在或不存在蛋白质开发测定试剂盒。

    A METHOD OF DETECTING RUPTURE OF THE AMNIOTIC MEMBRANES IN PREGANT MAMMALS
    77.
    发明申请
    A METHOD OF DETECTING RUPTURE OF THE AMNIOTIC MEMBRANES IN PREGANT MAMMALS 审中-公开
    检测乳腺癌细胞膜破裂的方法

    公开(公告)号：WO1994021687A1

    公开(公告)日：1994-09-29

    申请号：PCT/AU1994000144

    申请日：1994-03-23

    Applicant: VOROTELIAK, Victor ,  COWLEY, David, Michael

    IPC: C07K15/06

    CPC classification number: C07K14/4715 ,  C07K16/18 ,  Y10S530/806 ,  Y10S530/851

    Abstract: The present invention relates to the method of detecting rupture of the amniotic membranes in pregnant mammals including humans using an immunoassay and reagents useful in such an assay. The method describes how to prepare a suitable protein antigen form amniotic fluid, gives criteria for the selection of this protein from the mixture of proteins present in amniotic fluid using the techniques of protein purification, gives criteria for assessing a sufficient degree of antigen purity for raising antibodies to the antigen and shows how the resultant antibodies can be used in immunoassays to detect the presence of amniotic fluid in the vagina and consequently to detect rupture of the amniotic membranes. The method also relates to the detection of amniotic fluid in other situations.

    Abstract translation: 本发明涉及使用免疫测定法检测包括人在内的怀孕哺乳动物的羊膜破裂的方法以及在这种测定中有用的试剂。 该方法描述了如何制备羊水中合适的蛋白质抗原，使用蛋白质纯化技术从存在于羊水中的蛋白质的混合物中选择该蛋白质的标准，给出评估提高足够程度的抗原纯度的标准 并且显示所得抗体如何可用于免疫测定中以检测阴道中羊水的存在并因此检测羊膜的破裂。 该方法还涉及在其他情况下检测羊水。

    EXPRESSION AND PURIFICATION OF CLONED HUMAN ALPHA-FETOPROTEIN
    78.
    发明申请
    EXPRESSION AND PURIFICATION OF CLONED HUMAN ALPHA-FETOPROTEIN 审中-公开
    克隆人ALPHA-FETOPROTEIN的表达和纯化

    公开(公告)号：WO1994010199A1

    公开(公告)日：1994-05-11

    申请号：PCT/US1992008317

    申请日：1992-10-30

    Applicant: McGILL UNIVERSITY ,  MURGITA, Robert, A.

    Inventor： McGILL UNIVERSITY

    IPC: C07K13/00

    CPC classification number: C07K14/4715 ,  A61K38/00

    Abstract: In general, the invention features a method for producing human alpha-fetoprotein in prokaryotic cells. The method includes: providing a transformed prokaryotic cell including a recombinant DNA molecule encoding human alpha-fetoprotein operably linked to sequence elements capable of directing expression of alpha-fetoprotein, and permitting the transformed cell to express human alpha-fetoprotein.

    Abstract translation: 通常，本发明的特征在于在原核细胞中产生人甲胎蛋白的方法。 该方法包括：提供转化的原核细胞，其包括编码人甲胎蛋白的重组DNA分子，其可操作地连接到能够引导甲胎蛋白表达的序列元件，并允许转化的细胞表达人甲胎蛋白。

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