公开(公告)号：WO99046577A1

公开(公告)日：1999-09-16

申请号：PCT/US1999/004180

申请日：1999-02-26

IPC: G01N15/02 ,  G01N21/39 ,  G01N21/53

CPC classification number: G01N15/0205 ,  G01N15/0211 ,  G01N2021/391

Abstract: A particle counter uses optical scattering with heterodyne detection to lower the particle size detection limit imposed by background scattering from the fluid carrier in which the particles are immersed. In one embodiment, particle counter (10) includes a diode laser-pumped, high intracavity power solid-state laser. Intracavity radiation scatters from particles injected into flow (14) by nozzle (16) and from background gases in laser resonator (20). Scattered light (24), including the Doppler broadened Rayleigh background, is collected by optics (26), transmitted via beam combiner (28), and imaged by condenser lens (30) onto a linear photodiode array (32). Each photodiode (40) detects scattered light from a small length (42) along intracavity beam (40) in view-volume (18). A small amount of light simultaneously exits left-hand resonator mirror (48), is collected by beam expander (50), and redirected by mirrors (58, 60) to beam combiner (28), whence it copropagates collinearly to lens (30), which focuses it onto the photodiode array.

Abstract translation: 颗粒计数器使用具有外差检测的光学散射来降低由颗粒浸入的流体载体的背景散射所引起的粒度检测极限。 在一个实施例中，粒子计数器（10）包括二极管激光泵浦的高腔内功率固态激光器。 腔内辐射从通过喷嘴（16）和从激光谐振器（20）中的背景气体喷射到流体（14）中的颗粒散射。 包括多普勒扩展的瑞利背景的散射光（24）由光学器件（26）收集，通过光束组合器（28）传输，并由聚光透镜（30）成像到线性光电二极管阵列（32）上。 每个光电二极管（40）沿视场容积（18）中的腔内光束（40）检测来自小长度（42）的散射光。 少量的光同时离开左侧谐振器镜48，由光束扩展器50收集，并由反射镜58,60重定向到光束组合器28，该光束组合器28共同地与透镜（30）共同传播， ，将其聚焦到光电二极管阵列上。

公开(公告)号：WO9642006A3

公开(公告)日：1997-01-30

申请号：PCT/US9610342

申请日：1996-06-13

Applicant: UNIV SOUTH FLORIDA

Inventor： GARCIA-RUBIO LUIS HUMBERTO

IPC: G01N15/02

CPC classification number: G01N15/0211

Abstract: A system and method are provided for the characterization of a sample containing a macromolecule in solution. A light source illuminates the sample, generally in the ultraviolet-visible wavelength range, and a plurality of sensors that are radially disposed about the sample at a plurality of observation angles simultaneously sense the light energy emerging from the sample. An intensity spectrum is calculated as a function of wavelength for each observation angle, from which is calculated a particle characteristic such as shape, conformational change, composition, and particle size distribution. Both scattering and absorption data are utilized to provide complementary information.

公开(公告)号：WO1996031764A1

公开(公告)日：1996-10-10

申请号：PCT/SE1996000424

申请日：1996-04-01

Applicant: ALFA LAVAL AGRI AB ,  KLEIN, Cornelis

Inventor： ALFA LAVAL AGRI AB

IPC: G01N15/06

CPC classification number: G01N33/04 ,  G01N15/0211

Abstract: The present invention comprises method and apparatus for the quantitative determination of particles in fluid. Apparatus of the invention comprises an emitter set of one or more light emitters, in combination with a detector set of one or more light detectors sensitive to the output of the emitters; during analysis of the sample, data from a plurality of signal paths between the emitter and detector sets are gathered. This information is subsequently evaluated by comparison with known data for different fluid particle contents. Some differentiation between different particles in a fluid sample are possible in many embodiments. Typical uses include analysis of milk and dairy fluids, blood samples, lubricants, suspensions of pigments, etc.

Abstract translation: 本发明包括用于定量测定流体中颗粒的方法和装置。 本发明的装置包括一个或多个光发射器的发射器组，与对发射器的输出敏感的一个或多个光检测器的检测器组合; 在分析样本期间，收集来自发射器和检测器组之间的多个信号路径的数据。 随后通过与不同流体颗粒含量的已知数据进行比较来评估该信息。 在许多实施例中，流体样品中的不同颗粒之间的一些分化是可能的。 典型用途包括牛奶和乳液，血液样品，润滑剂，颜料悬浮液等的分析

公开(公告)号：WO1996012962A1

公开(公告)日：1996-05-02

申请号：PCT/US1995013410

申请日：1995-10-19

Applicant: BIOCIRCUITS CORPORATION

Inventor： BIOCIRCUITS CORPORATION ,  RIBI, Hans, O. ,  LIU, Ben ,  BENVEGNU, Nic ,  CHOATE, Glenda, L. ,  GUION, Todd

IPC: G01N33/555

CPC classification number: G01N15/0211 ,  G01N33/54373

Abstract: Methods and apparatus are provided for detecting analyte in a sample using diffraction patterns. In the subject method, sample suspected of comprising analyte and particles if the analyte is not the particle, as well specific binding pair members, are combined in an assay medium with a solid surface transparent to a wavelength range of interest. In one embodiment, a cross-linking agent is included in the assay medium, where the particles cross-link in an amount proportional to the amount of analyte in the sample. As the particles interact with analyte and specific binding pair members, larger diffraction particles are formed which are randomly distributed in a single plane in the assay medium. The diffraction particles may remain mobile in solution or may settle on the solid surface. In an alternative embodiment, the solid surface comprises members of a specific binding pair which are randomly distributed, providing for specific binding of the diffraction particles to the surface. The diffraction particles are then irradiated with coherent light, where the light is diffracted into a diffraction pattern by the diffraction particles. The spacing and amplitude of the diffraction pattern is detected and measured. A logic means is used to relate the spacing and amplitude of the diffraction pattern to the presence of analyte in the sample.

Abstract translation: 提供了使用衍射图案检测样品中的分析物的方法和装置。 在本发明方法中，如果分析物不是颗粒以及特异性结合对成员，怀疑含有分析物和颗粒的样品在测定介质中与在感兴趣的波长范围内透明的固体表面组合。 在一个实施方案中，交联剂包含在测定介质中，其中颗粒以与样品中分析物的量成比例的量交联。 当颗粒与分析物和特异性结合对成员相互作用时，形成较大的衍射粒子，其随机分布在测定介质中的单个平面中。 衍射颗粒可以保持在溶液中可移动或可以沉降在固体表面上。 在替代实施方案中，固体表面包括随机分布的特异性结合对的成员，提供衍射颗粒与表面的特异性结合。 然后用相干光照射衍射颗粒，其中光被衍射颗粒衍射成衍射图案。 检测并测量衍射图案的间距和幅度。 使用逻辑手段将衍射图案的间距和幅度与样品中分析物的存在相关联。

公开(公告)号：WO1991010123A1

公开(公告)日：1991-07-11

申请号：PCT/SE1990000858

申请日：1990-12-20

Applicant: ABB STAL AB ,  LEONARDSSON, Lars ,  LÄNDIN, Åke ,  PARASNIS, Amalendu

Inventor： ABB STAL AB

IPC: G01N21/53

CPC classification number: G01N15/0205 ,  G01N15/0211 ,  G01N2015/0238 ,  G01N2021/4716

Abstract: A laser (1) is applied on the side of a channel which is traversed by a medium. The light beam from the laser (1) passes across the channel. Particles (5) in the medium within the measuring volume are hit by light and deflect this, thus creating forwardly-directed light cones. These light cones are refracted outside the channel by a lens (6) and thereafter hit a detector plate (8). The light which hits the detector plate (8) occurs in the form of light rings which have arisen by light diffraction. On the detector plate (8) at least two detector rings are arranged, consisting of light-sensitive elements adapted to measure the light power in those light rings which fall onto the light-sensitive elements. In an electronic differentiating unit (9) a difference is created between the measured light power values from two of these detector rings. This results in a difference signal which can be related to the size distribution of particles occurring in the flowing medium.

Abstract translation: 激光器（1）被施加在由介质穿过的通道的侧面上。 来自激光器（1）的光束穿过通道。 在测量体积内的介质中的颗粒（5）被光击中并使其偏转，从而产生向前定向的光锥。 这些光锥由透镜（6）折射到通道外部，然后击中检测器板（8）。 击中检测器板（8）的光以光衍射产生的光环的形式发生。 在检测器板（8）上，布置有至少两个检测器环，其由适于测量落在光敏元件上的那些光环中的光功率的光敏元件组成。 在电子差分单元（9）中，从这些检测器环中的两个测量的光功率值之间产生差异。 这导致差异信号，其可以与在流动介质中发生的颗粒的尺寸分布有关。

公开(公告)号：WO1990010215A1

公开(公告)日：1990-09-07

申请号：PCT/US1990001139

申请日：1990-03-01

Applicant: COULTER ELECTRONICS OF NEW ENGLAND, INC.

Inventor： COULTER ELECTRONICS OF NEW ENGLAND, INC. ,  BOTT, Steven, E. ,  HART, W., Howard

IPC: G01N15/02

CPC classification number: G01N15/0211 ,  G01N21/51 ,  G01N2021/4711 ,  G01N2021/4716 ,  G01N2021/4792

Abstract: In a particle size measuring system, particles suspended in a sample cell (8') are illuminated by interrogating light beams (212) including a first interrogating component having a polarization parallel to a scattering plane, and a second interrogating component having a polarization perpendicular to the scattering plane. A photodetector (214) generates first and second intensity signals representative of the intensity, at various scattering angles, of scattered light corresponding to the first and second interrogating components. A processor (126) generates a difference signal representative of the difference between the first and second intensity signals, and calculates a resultant signal representative of particle size, based on a selected arithmetic transformation of the difference signal.

Abstract translation: 在粒度测量系统中，悬浮在样品池（8'）中的颗粒通过询问光束（212）被照亮，所述光束包括具有平行于散射平面的偏振的第一询问部件和具有垂直于散射平面的偏振的第二询问部件 散射面。 光电检测器（214）产生代表对应于第一和第二询问部件的散射光在各种散射角度的强度的第一和第二强度信号。 处理器（126）基于所选择的差分信号的算术变换，生成表示第一和第二强度信号之间的差的差分信号，并计算代表粒子大小的合成信号。

公开(公告)号：WO2018069024A1

公开(公告)日：2018-04-19

申请号：PCT/EP2017/074094

申请日：2017-09-22

Applicant: MALVERN INSTRUMENTS LIMITED

Inventor： SCULLION, Richard ,  CORBETT, Jason

IPC: G01N15/02 ,  G01N15/14 ,  G01N21/51 ,  G01N21/49 ,  G01N21/47

CPC classification number: G01N15/0211 ,  G01N15/1434 ,  G01N15/1456 ,  G01N21/49 ,  G01N2015/0222 ,  G01N2015/1454 ,  G01N2021/4707 ,  G01N2021/4709 ,  G01N2201/063 ,  G01N2201/0635

Abstract: A particle characterisation instrument (200), comprising a light source (201), a sample cell (202), an optical element (204) between the light source (201) and sample cell (202) and a detector (203). The optical element (204) is configured to modify light from the light source (201) to create a modified beam (207), the modified beam (207): a) interfering with itself to create an effective beam (208) in the sample cell (202) along an illumination axis (206) and b) diverging in the far field to produce a dark region (209) along the illumination axis (206) that is substantially not illuminated at a distance from the sample cell (202). The detector (203) is at the distance from the sample cell (202), and is configured to detect light scattered from the effective beam (208) by a sample in the sample cell (202), the detector (203) positioned to detect forward or back scattered light along a scattering axis (306) that is at an angle of 0° to 10° from the illumination axis (206).

Abstract translation: （201），样品池（202），在光源（201）和样品池（202）之间的光学元件（204）的粒子表征仪器（200） 和检测器（203）。 所述光学元件（204）被配置为修改来自所述光源（201）的光以创建修改后的光束（207），所述修改后的光束（207）：a）自行干涉以在所述样本中创建有效光束 沿着照明轴线（206）照射单元（202），以及b）在远场内发散以产生沿着照明轴线（206）的暗区域（209），其在距样本单元（202）一定距离处基本上未被照射。 检测器（203）与样本单元（202）相距一定距离，并且被配置为检测由样本单元（202）中的样本从有效射束（208）散射的光，检测器（203）被定位成检测 沿着散射轴（306）的前向散射光或后向散射光，散射轴（306）处于0°的角度; 到10℃ 来自照明轴（206）。

公开(公告)号：WO2017129390A1

公开(公告)日：2017-08-03

申请号：PCT/EP2017/050376

申请日：2017-01-10

Applicant: PLAIR SA

Inventor： KISELEV, Denis

IPC: G01N15/02 ,  G01N15/14 ,  G01N15/10 ,  G01N21/47

CPC classification number: G01N15/0211 ,  G01N15/1459 ,  G01N2015/1075 ,  G01N2015/1497 ,  G01N2021/4714

Abstract: Measurement device for the detection and/or analysis of fluid-borne particles, the measurement device comprising means (1, 1') for producing a flow of fluid along a fluid flow path, a laser (2) positioned for emitting a beam (20) of laser light in a measurement volume of the fluid flow path; a lens set (3) for collecting laser light (23) scattered in the measurement volume by fluid-borne particles (9) contained in the flow of fluid, a photo-detector (4) positioned for the detection of scattered laser light (23) collected by the lens set (3), wherein the lens set (3) is configured for focusing the scattered light (23) in a line at a focal distance (f2) of the lens set (3), said line being perpendicular to a flow direction (y) of the flow of fluid in said measurement volume; and wherein the photo-detector (4) is a linear multipixel detector for capturing the laser light focused by the lens set (3), wherein said linear multipixel detector (4) is positioned at a distance from the focal distance (f2) of the lens set (3) and oriented with its longitudinal axis parallel to said line. Measurement method for the detection and/or analysis of fluid-borne particles, comprising the steps of producing a flow of fluid along a fluid flow path, said flow of fluid potentially containing fluid-borne particles (9) to be detected; emitting a beam (20) of laser light in a measurement volume of the fluid flow path; collecting laser light (23) scattered in the measurement volume by fluid-borne particles (9) contained in the flow of fluid and focusing said scattered light in a line at a focal distance (f2), said line being perpendicular to a flow direction (y) of the flow of fluid in said measurement volume; capturing the collected and focused scattered laser light (23) with a linear multipixel photo-detector (4) positioned at a distance from the focal distance (f2) and oriented with its longitudinal axis parallel to said line; repeating the steps of emitting, collecting and capturing a plurality of times during the time of crossing the measurement volume by an individual fluid-borne particle (9) of the smallest size measured by the measurement method.

Abstract translation: 用于检测和/或分析流体运载颗粒的测量装置，所述测量装置包括用于沿着流体流动路径产生流体流的装置（1,1'），激光器（2） ），其定位成用于在流体流动路径的测量体积中发射激光束（20）; 用于收集在流体流中包含的流体颗粒（9）在测量体积中散射的激光（23）的透镜组（3），设置用于检测散射激光（23）的光检测器（4） ），其中所述透镜组（3）被配置成用于将所述散射光（23）聚焦成所述透镜组（3）的焦距（f2）的直线，所述直线垂直于所述透镜组 所述测量体积中流体流动的流动方向（y）; 并且其中所述光检测器（4）是用于捕获由所述透镜组（3）聚焦的激光的线性多像素检测器，其中所述线性多像素检测器（4）定位在与所述透镜组（3）的焦距（f2） 透镜组（3）并且其纵向轴线平行于所述线定向。 用于检测和/或分析流体携带颗粒的测量方法，包括以下步骤：沿流体流动路径产生流体流，所述流体流可能包含待检测的流体携带颗粒（9）; 在流体流动路径的测量体积内发射激光束（20）; 收集在流体流中包含的流体传播颗粒（9）散射在测量体积中的激光（23），并将所述散射光聚焦成焦距（f2）处的线，所述线垂直于流动方向（ y）所述测量体积中的流体流量; 用线性多像素光电检测器（4）捕获收集并聚焦的散射激光（23），所述线性多像素光电检测器（4）定位在距焦距（f2）一定距离处并且其纵轴平行于所述线定向; 在通过由测量方法测量的最小尺寸的单个流体传播颗粒（9）越过测量容积的时间内重复发射，收集和捕获多次的步骤。

公开(公告)号：WO2017066487A1

公开(公告)日：2017-04-20

申请号：PCT/US2016/056909

申请日：2016-10-13

Applicant: MANTA INSTRUCTIONS, INC.

Inventor： TATARKIEWICZ, Jan, J. ,  KARR, Monette

IPC: G01N15/02

CPC classification number: G01N15/0211 ,  G01N2013/006 ,  G01N2015/0038 ,  G01N2015/0053

Abstract: A system for determining the growth/dissolution rate of colloidal particles is disclosed and includes multiple light sources and multiple sensors. A light source is constructed to emit a beam of electromagnetic radiation at a specimen chamber that holds the colloidal particles. The chamber allows a portion of the combined beam to scatter perpendicularly or at some other angle to the combined beam. The scattered portion of the beam is directed to a sensor that detects electromagnetic radiation. The sensor is connected to processor that activates the light source and obtains an image from the sensor. Multiple images are taken at a time interval and for each image taken, and a total image intensity level is calculated and normalized. A formula is then calculated that fits the normalized values over time and a slope is determined from the formula.

Abstract translation: 公开了一种用于确定胶体粒子的生长/溶解速率的系统，其包括多个光源和多个传感器。 光源构造成在容纳胶体颗粒的样品室处发射电磁辐射束。 腔室允许组合光束的一部分垂直或以某个其他角度向组合光束散射。 光束的散射部分被引导至检测电磁辐射的传感器。 传感器连接到激活光源并从传感器获取图像的处理器。 以一定时间间隔拍摄多张图像并拍摄每张图像，然后计算并归一化总图像强度等级。 然后计算出一个公式，该公式随时间拟合归一化​​值，斜率由公式确定。

公开(公告)号：WO2017052721A1

公开(公告)日：2017-03-30

申请号：PCT/US2016/042447

申请日：2016-07-15

Applicant: INTEL CORPORATION

Inventor： XU, Shengbo ,  ACIKALIN, Tolga

IPC: G02B27/09 ,  H01S3/10

CPC classification number: G02B27/0927 ,  G01N15/0211 ,  G01N2015/0046 ,  G02B3/04 ,  G02B3/06 ,  G02B19/0014 ,  G02B19/0052 ,  H01S5/005

Abstract: Systems and techniques are disclosed for flat-top intensity laser sheet beam generation. The system includes a source of light directed at a first optical component arranged to receive the light and generate spherical aberration (e.g., third order positive aberration) in the light rays. The spherical aberration results in positive aberrations in the light in a first plane and also results in the light being substantially collimated in a second plane perpendicular to the first plane. In some cases, the source of light is provided from a laser diode and the first optical component is one of an aspherical lens and a spherical lens. The system also includes a second optical component for focusing the light in the second plane. In some cases, the second optical component is a cylindrical lens.

Abstract translation: 公开了用于平顶强度激光片束生成的系统和技术。 该系统包括指向被布置为接收光并且在光线中产生球面像差（例如，三阶正像差）的第一光学部件的光源。 球面像差导致第一平面中的光中的正像差，并且还导致光在垂直于第一平面的第二平面中基本准直。 在一些情况下，光源由激光二极管提供，第一光学部件是非球面透镜和球面透镜之一。 该系统还包括用于将光聚焦在第二平面中的第二光学部件。 在一些情况下，第二光学部件是柱面透镜。