公开(公告)号：WO2009144577A2

公开(公告)日：2009-12-03

申请号：PCT/IB2009005798

申请日：2009-06-01

Applicant: ADOCIA ,  SOULA REMI

Inventor： SOULA REMI

IPC: C08G69/10 ,  A61K38/00 ,  A61K47/34 ,  A61K47/48 ,  A61P43/00 ,  C08G69/08 ,  C08G69/48 ,  C08G73/10

CPC classification number: C08G69/48 ,  A61K47/645 ,  C08G69/10

Abstract: The invention relates to an anionic polyamide functionalized by at least one tryptophan unit, -Trp, said tryptophan unit being bonded to the polyamide by an amide function separated from the backbone by a linker arm L, the polyamide being a chain selected from the group consisting of the following polymers: Formulas (I), (II), (III), L being selected from the group consisting of a simple link, a -CH2- group, or a -CH2CH2- group, -Trp being a tryptophan residue, L and/or D, produced by the coupling of the amino of the tryptophan or a tryptophan derivative, selected from the group consisting of tryptophanol, tryptophanamide, and the alkaline cation salts thereof, and an acid carried by the polyamide. The present invention also relates to a pharmaceutical composition containing one of the polyamides according to the invention.

Abstract translation: 本发明涉及由至少一个色氨酸单元-Trp功能化的阴离子聚酰胺，所述色氨酸单元通过由主链与连接臂L分离的酰胺官能团键合到聚酰胺上，所述聚酰胺是选自以下的链： 的以下聚合物：式（I），（II），（III），L选自简单连接基团，-CH 2 - 基团或-CH 2 CH 2 - 基团，-Trp是色氨酸残基， 通过色氨酸的氨基或选自色氨酸，色氨酰胺及其碱性阳离子盐的色氨酸衍生物的偶联产生的L和/或D和由聚酰胺携带的酸。 本发明还涉及含有本发明的聚酰胺之一的药物组合物。

公开(公告)号：WO2007045010A1

公开(公告)日：2007-04-26

申请号：PCT/AU2006/000636

申请日：2006-05-15

Applicant: STARPHARMA PTY LIMITED ,  HENDERSON, Scott, Andrew ,  HOLAN, George ,  KRIPPNER, Guy, Yeoman ,  McCARTHY, Thomas, David

Inventor： HENDERSON, Scott, Andrew ,  HOLAN, George ,  KRIPPNER, Guy, Yeoman ,  McCARTHY, Thomas, David

IPC: A61K47/48 ,  A61K31/166 ,  A61K31/74 ,  A61K31/785 ,  C08G69/08 ,  C08G69/10 ,  C08G83/00 ,  C08L77/10

CPC classification number: A61K31/795 ,  A61K31/166 ,  A61K31/74 ,  A61K31/785 ,  A61K47/59 ,  A61K47/645 ,  C08L101/005

Abstract: The present invention provides an anionic dendrimer polymer of at least two generations. The present invention also provides for the production of these polymers and to their use in the inhibition of angiogenesis.

Abstract translation: 本发明提供了至少两代的阴离子树枝状聚合物聚合物。 本发明还提供这些聚合物的制备及其在抑制血管发生中的用途。

公开(公告)号：WO2005056636A2

公开(公告)日：2005-06-23

申请号：PCT/US2004040712

申请日：2004-12-03

Applicant: NEKTAR THERAPEUTICS AL CORP ,  MCMANUS SAMUEL P ,  KOZLOWSKI ANTONI ,  HUTCHISON TRACY L ,  BRAY BRIAN ,  SHEN XIAOMING

Inventor： MCMANUS SAMUEL P ,  KOZLOWSKI ANTONI ,  HUTCHISON TRACY L ,  BRAY BRIAN ,  SHEN XIAOMING

IPC: A61K47/48 ,  C08G65/333 ,  C08G69/08 ,  C08G65/00

CPC classification number: C07D403/12 ,  A61K47/60 ,  C08G65/33337 ,  C08G69/08

Abstract: Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.

Abstract translation: 提供了形成马来酰亚胺官能化聚合物的方法。 在一个这样的实施方案中，马来酰亚胺官能化聚合物在包括进行反向Diels-Alder反应的步骤的方法中制备。 还提供了可用于该方法的中间体以及制备中间体的方法。 还提供了聚合物试剂，使用聚合物试剂，化合物和共轭物的方法。

公开(公告)号：WO02057745A3

公开(公告)日：2003-03-13

申请号：PCT/US0200022

申请日：2002-01-08

Applicant: TROPIX INC

Inventor： SPARKS ALISON L

IPC: G01N33/53 ,  C08G69/08 ,  C08G73/04 ,  C12Q1/26 ,  C12Q1/34 ,  C12Q1/37 ,  C12Q1/44 ,  C12Q1/68 ,  G01N21/76 ,  G01N33/533 ,  G01N33/543 ,  G01N33/566 ,  G01N33/58 ,  G01N37/00 ,  C12Q1/00 ,  C12Q1/42 ,  C12Q1/66

CPC classification number: G01N33/533 ,  G01N33/543 ,  G01N33/582 ,  Y10S436/805

Abstract: Chemiluminescent substrate delivery systems comprising a conjugate a dendrimer and at least one chemiluminescent substrate are provided. The substrate delivery system can also include a chemiluminescence enhancer. The dendrimer/chemiluminescent substrate conjugates can be used in kits including an enzyme capable of activating the chemiluminescent substrate to produce a peroxygenated intermediate that decomposes to produce light. The dendrimer/chemiluminescent substrate conjugates can be used in assays to detect the presence of an analyte (e.g., an enzyme, an antibody, an antigen or a nucleic acid) in a sample. Figure (1A) shows a polyamidoamine (PAMAM) dendrimer with NH2 surface groups.

Abstract translation: 提供包含树枝状大分子和至少一种化学发光底物的共轭物的化学发光底物递送系统。 底物递送系统还可以包括化学发光增强剂。 树枝状聚合物/化学发光底物共轭物可以用于包括能够激活化学发光底物以产生分解产生光的过氧化中间体的酶的试剂盒中。 树枝状大分子/化学发光底物共轭物可用于检测样品中分析物（例如酶，抗体，抗原或核酸）的存在。 图（1A）显示了具有NH2表面基团的聚酰胺胺（PAMAM）树枝状聚合物。

公开(公告)号：WO01058863A1

公开(公告)日：2001-08-16

申请号：PCT/US2001/002655

申请日：2001-01-29

IPC: C08J5/00 ,  C07C309/17 ,  C08G63/688 ,  C08G69/26 ,  C08G69/48 ,  D01F6/80 ,  D01F6/84 ,  D06P3/24 ,  D06P3/52 ,  D06P5/22 ,  C08G63/183 ,  C08G69/08

CPC classification number: C07C309/17 ,  C08G63/6886 ,  C08G69/48 ,  D01F6/84 ,  Y10T428/2913

Abstract: A compound having the formula: R1OOC-(CH2)n-CH(CH2CH2SO3X)-(CH2)m-COOR2 where n is an integer from 1 to 10, m is an integer from 1 to 10, X is an alkali metal selected from the group consisting of lithium, sodium and potassium, and R1 and R2 are independently selected from hydrogen and alkyl groups having one to four carbon atoms is disclosed, and use thereof as a cationic dyeability modifier, e.g., for incorporation into polyesters and polyamides to increase their affinity for basic dyes.

Abstract translation: 具有下式的化合物：R1OOC-（CH2）n-CH（CH2CH2SO3X） - （CH2）m -COOR2其中n是1至10的整数，m是1至10的整数，X是选自 由锂，钠和钾组成的组，R1和R2独立地选自氢和具有1-4个碳原子的烷基，并且其用作阳离子染色性改性剂，例如用于掺入聚酯和聚酰胺以增加 它们对碱性染料的亲和力。

公开(公告)号：WO00029463A1

公开(公告)日：2000-05-25

申请号：PCT/US1999/026980

申请日：1999-11-15

IPC: C08J11/08 ,  C08G69/08 ,  C08F6/00 ,  C08G69/46 ,  C08G73/10 ,  C08J3/00

CPC classification number: C08J11/08 ,  C08J2377/00 ,  C08J2377/04 ,  Y02W30/701

Abstract: The invention comprises an improved recycling and recovery process for rugs, flooring, carpeting, carpeting materials, and other textiles particular from waste carpet containing at least some synthetic fiber backing materials, and at least some nylon as well, and more particularly for the separation and recovery of the nylon polymers in purified and reusable condition and also recovery of other polymeric fibers and materials which may be present and can be recycled and reused.

Abstract translation: 本发明包括改进的用于地毯，地板，地毯，地毯材料以及其它特别是含有至少一些合成纤维背衬材料的废地毯以及至少一些尼龙的织物的再循环和回收过程，更具体地说，用于分离和 在纯化和可重复使用的条件下回收尼龙聚合物，还可回收可能存在并可再循环使用的其它聚合物纤维和材料。

公开(公告)号：WO99038907A1

公开(公告)日：1999-08-05

申请号：PCT/EP1999/000653

申请日：1999-02-02

IPC: C08G69/04 ,  C08G69/08 ,  C08G69/16 ,  C08G69/18

CPC classification number: C08G69/08 ,  C08G69/04 ,  C08G69/16 ,  C08G69/18

Abstract: Aqueous monomer and oligomer extracts, which during the production of polyamides are obtained in the course of extraction of the polymerisate with water, are used for producing polyamides by direct reaction with aminonitriles.

Abstract translation: 与水的聚合物的萃取过程中聚酰胺的制备所得的水性单体和低聚物提取物被用于通过与氨基腈直接反应生产聚酰胺。

公开(公告)号：WO9808889A2

公开(公告)日：1998-03-05

申请号：PCT/EP9704640

申请日：1997-08-26

Applicant: BASF AG ,  WEISS ROBERT ,  KRAUSS DIETER ,  KELLER DIETER ,  PIPPER GUNTER ,  HARDER WOLFGANG ,  LUDWIG ALFONS ,  MOHRSCHLADT RALF

Inventor： WEISS ROBERT ,  KRAUSS DIETER ,  KELLER DIETER ,  PIPPER GUNTER ,  HARDER WOLFGANG ,  LUDWIG ALFONS ,  MOHRSCHLADT RALF

IPC: C08G69/00 ,  C08G69/04 ,  C08G69/08 ,  C08G69/28 ,  C08G69/36

CPC classification number: C08G69/04 ,  C08G69/08 ,  C08G69/28 ,  C08G69/36

Abstract: A process for producing a polyamide by reacting at least one aminonitrile with water has the following steps: (1) at least one aminonitrile is reacted with water at a temperature from 100 to 360 DEG C and pressure from 0.1 to 35.x 10 Pa, yielding a reaction mixture; (2) the reaction mixture is further reacted at a temperature from 150 to 400 DEG C and pressure lower than the pressure in step 1. The temperature and pressure are selected to yield a first gaseous phase and a first liquid or solid phase or a mixture of a first solid and a first liquid phase. The first gaseous phase is separated from the first liquid or solid phase or the mixture of a first liquid and a first solid phase is separated; and (3) the first liquid or solid phase or the mixture of a first liquid and first solid phase is mixed with a water-containing gaseous or liquid phase at a temperature from 150 to 360 DEG C and pressure from 0.1 to 30 x 10 Pa, yielding a product mixture. Also disclosed are other embodiments of this process and the thus produced polyamides.

Abstract translation: 一种用于通过至少一个氨基腈与水反应，包括下列步骤制备聚酰胺过程：（1）在100至360摄氏度的温度和0.1〜35×10的压力<至少一个氨基腈与水反应 6> Pa至获得得到的反应混合物，（2）进一步在150〜400℃和压力是比在步骤1中的压力更低的温度下的反应混合物反应，所述温度和压力被选择为使得 该第一气相和第一液体或第一固相或第一固体和第一液相的混合物获得，并从所述第一液体或第一固相或第一液体和第1固相的混合物中的第一气体相分离出 是，（3）将第一液体或第一固相或第一液体和第1固相的与气态或混合物 含有液体相包含水，在150〜360℃的温度和0.1〜30×10 <6> Pa的压力以获得产物混合物中获得，以及这样的方法的其它实施例中，将如此制备的 聚酰胺本身。

公开(公告)号：WO1994020563A1

公开(公告)日：1994-09-15

申请号：PCT/EP1994000511

申请日：1994-02-23

Applicant: BASF AKTIENGESELLSCHAFT ,  KRONER, Matthias ,  SCHORNICK, Gunnar ,  BOECKH, Dieter ,  BAUR, Richard ,  POTTHOFF-KARL, Birgit ,  SCHWENDEMANN, Volker ,  SCHADE, Christian ,  KUD, Alexander

Inventor： BASF AKTIENGESELLSCHAFT

IPC: C08G69/08

CPC classification number: C08G69/08 ,  C08G69/10 ,  C08G73/1092 ,  C11D3/3719

Abstract: A process is disclosed for preparing products from the reaction of polyasparaginic acid imides with aminoacids by reacting aminoacids with polyasparaginic acid imides in an aqueous medium at pH values at which at least 5 % of the amino groups of the aminoacids having a non-protonated form are in equilibrium with those having a protonated form. Also disclosed is the use of the thus obtained reaction products and of products from the reaction of polyasparaginic acid imides with alkanolamines or aminated C1-C30-fatty alcohol alkoxilates which contain up to 50 % by moles of polymerized ethylene and/or propylene oxide per mole of fatty alcohol. These products are useful as additives for washing and cleaning agents, as scale inhibitors and as dispersing agents.

公开(公告)号：WO1994015993A1

公开(公告)日：1994-07-21

申请号：PCT/EP1993003641

申请日：1993-12-21

Applicant: BASF AKTIENGESELLSCHAFT ,  KRONER, Matthias ,  HARTMANN, Heinrich ,  SCHORNICK, Gunnar ,  BAUR, Richard ,  POTTHOFF-KARL, Birgit ,  SCHWENDEMANN, Volker ,  KUD, Alexander

Inventor： BASF AKTIENGESELLSCHAFT

IPC: C08G69/08

CPC classification number: C11D3/3719 ,  B01F17/005 ,  C08G69/10 ,  C08G73/0611 ,  C08G73/1092 ,  C09B67/0085 ,  C09D17/00

Abstract: Described is a method of producing polymers of aspartic acid by reacting (a) maleic acid anhydride and (b) ammonia and/or primary or secondary amines essentially in the molar ratio (a):(b) of 1:0.1 to 1:3 to give half-amides of maleic acid or fumaric acid, or their ammonium salts, at temperatures of up to 100 DEG C and subsequently condensing the reaction products with each other, optionally also with compounds capable of condensing with them, at temperatures above 100 DEG C and optionally hydrolysing the condensation products. Also described is the use of the polymers thus produced as scale inhibitors, pigment dispersants and additives to washing and cleaning agents.