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    CROSS-LINKING OF FOAMS OF S-SULFONATED KERATIN
    71.
    发明申请
    CROSS-LINKING OF FOAMS OF S-SULFONATED KERATIN 审中-公开
    S-SULFONATED KERATIN的交叉关系

    公开(公告)号：WO2008040357A1

    公开(公告)日：2008-04-10

    申请号：PCT/DK2007/050134

    申请日：2007-10-02

    Applicant: COLOPLAST A/S ,  TRUELSEN, Jens Hoeg ,  NIELSEN, Pia

    Inventor： TRUELSEN, Jens Hoeg ,  NIELSEN, Pia

    IPC: C08J9/36 ,  C08J3/24 ,  C08H1/06

    CPC classification number: C08J9/36 ,  A61L27/227 ,  A61L27/56 ,  C08H1/06 ,  C08J3/24 ,  C08J2389/04

    Abstract: The present invention relates to a process for cross-linking of highly porous foams of S- sulfonated keratin, and to highly porous, cross-linked keratin foams (e.g. scaffolds) as such. Such scaffolds (foams) are particularly useful for wound care applications. Such porous keratin foams can be obtained through exchanging the aqueous solution of the reductant as the cross-linking media with an alcohol solution of the same reductant, and by exchanging the aqueous washing procedures with a similar alcohol washing procedure.

    Abstract translation: 本发明涉及S-磺化角蛋白的高度多孔泡沫交联和高度多孔的交联角蛋白泡沫（例如支架）的方法。 这种支架（泡沫）对伤口护理应用特别有用。 这种多孔角蛋白泡沫可以通过将还原剂的水溶液作为交联介质与相同的还原剂的醇溶液进行交换，并且通过用类似的醇洗涤方法更换含水洗涤程序来获得。

    FLOWABLE BIOMATERIAL COMPOSITION
    72.
    发明申请
    FLOWABLE BIOMATERIAL COMPOSITION 审中-公开
    流动性生物组合物

    公开(公告)号：WO2008016891A1

    公开(公告)日：2008-02-07

    申请号：PCT/US2007/074788

    申请日：2007-07-31

    Applicant: WARSAW ORTHOPEDIC, INC. ,  DRAPEAU, Susan J. ,  CHAMNESS, Kathy L.

    Inventor： DRAPEAU, Susan J. ,  CHAMNESS, Kathy L.

    IPC: C08H1/06 ,  A61L27/24

    CPC classification number: C08L5/04 ,  A61L27/46 ,  C08L5/00 ,  C08L89/06 ,  C08L2666/02

    Abstract: A putty form biomaterial composition made of a collagen scaffold and ceramic granule having improved flowable yet cohesive characteristics through the addition of, either individually or in some combination, polyhydroxy compounds, a liquid polyhydroxy compound ester, a liquid solution of solid polyhydroxy compound, a liquid solution of solid polyhydroxy compound ester to allow for use in surgical bone repair is presented. Specific polyhydroxy compounds, including polyethylene glycol polymers (PEG), PPO/PEO block co-polymers (i.e., a poloxamer NF grade), and the polysaccharides alginate and chitosan may be utilized.

    Abstract translation: 由胶原支架和陶瓷颗粒制成的油灰形式的生物材料组合物，通过单独地或以某种组合的方式加入多羟基化合物，液体多羟基化合物酯，固体多羟基化合物的液体溶液，液体 提出了固体多羟基化合物酯溶液用于手术骨修复。 可以使用特定的多羟基化合物，包括聚乙二醇聚合物（PEG），PPO / PEO嵌段共聚物（即泊洛沙姆NF级）和多糖藻酸盐和壳聚糖。

    EXTRACTION PROCESS OF HYDROLYZED COLLAGEN AND OF CHROME/COLLAGEN COMPLEX FROM CHROME TANNED LEATHER RESIDUES
    76.
    发明申请
    EXTRACTION PROCESS OF HYDROLYZED COLLAGEN AND OF CHROME/COLLAGEN COMPLEX FROM CHROME TANNED LEATHER RESIDUES 审中-公开
    水解胶原蛋白和铬/胶原复合物从铬皮革皮革残留物中的提取过程

    公开(公告)号：WO2006130936A2

    公开(公告)日：2006-12-14

    申请号：PCT/BR2005000191

    申请日：2005-09-19

    Applicant: RICARDO FRANZOI RENE ,  D ARC FELIX DE SOUZA JOANA

    Inventor： D ARC FELIX DE SOUZA JOANA

    IPC: A23J1/10 ,  C14C3/32 ,  A23J3/34 ,  A23K1/16 ,  C08H1/06 ,  C09H3/00

    CPC classification number: C09H3/00 ,  A23J1/10 ,  A23J3/342 ,  A23K20/147 ,  C08H1/06

    Abstract: This Invention Patent regards an Extraction Process of Hydrolyzed Collagen and of Chrome/Collagen Complex from Chrome Tanned Leather Residues from enzymes, where, in the first process, use is made of the JOANA FÉLIX-1H Enzyme and the JOANA FÉLIX-2H Enzyme, while in the second process the JOANA FÉLIX-1C Enzyme is used. The technique is based on the preparation of Liquid Hydrolyzed Collagen, Hydrolyzed Collagen in the form of Viscous Liquid, Dry Hydrolyzed Collagen, Solid Hydrolyzed Collagen, Chrome/Collagen Complex Paste, Dry Chrome/Collagen Complex and Solid Chrome/Collagen Complex. The Hydrolyzed Collagen can be used in the food, pharmaceutical, cosmetic, animal food, glue, adhesive, photograph, fertilizer, plastic, rubber, leather industries, industries of chemical products for tannery and in various segments of the chemical industries. The Chrome/Collagen Complex Paste can be used in various segments of the chemical industries.

    Abstract translation: 本发明专利涉及来自铬的鞣制皮革残留物的水解胶原蛋白和铬/胶原蛋白复合物的提取过程，其中在第一过程中使用JOANAFÉLIX-1H酶和JOANAFÉLIX-2H酶，而 在第二个过程中，使用JOANAFÉLIX-1C酶。 该技术基于液体水解胶原蛋白，粘性液体，干水解胶原蛋白，固体水解胶原蛋白，铬/胶原复合糊剂，干铬/胶原蛋白复合物和固体铬/胶原蛋白复合物形式的水解胶原蛋白的制备。 水解胶原蛋白可用于食品，制药，化妆品，动物食品，胶水，胶粘剂，照片，化肥，塑料，橡胶，皮革工业，制革用化工产品和化工行业各个行业。 铬/胶原复合糊可用于各行各业的化学工业。

    POLYAMIDE-BASED WATER-SOLUBLE BIODEGRADABLE COPOLYMERS AND THE USE THEREOF
    77.
    发明申请
    POLYAMIDE-BASED WATER-SOLUBLE BIODEGRADABLE COPOLYMERS AND THE USE THEREOF 审中-公开
    水溶性，可生物降解的聚酰胺基共聚物及其用途

    公开(公告)号：WO2004052960B1

    公开(公告)日：2004-08-05

    申请号：PCT/EP0314088

    申请日：2003-12-11

    Applicant: DEGUSSA CONSTRUCTION POLYMERS ,  SPINDLER CHRISTIAN ,  PLANK JOHANN

    Inventor： SPINDLER CHRISTIAN ,  PLANK JOHANN

    IPC: C04B24/28 ,  C08G69/48 ,  C08H1/00 ,  C08H1/02 ,  C08H1/04 ,  C08H1/06

    CPC classification number: C08G69/48 ,  C04B24/287 ,  C04B2103/0053 ,  C04B2103/0059 ,  C04B2103/0072 ,  C04B2103/0074 ,  C04B2103/30 ,  C04B2103/46 ,  C08H1/00 ,  C08H1/02 ,  C08H1/04 ,  C08H1/06

    Abstract: The invention relates to polyamide-based water-soluble biodegradable copolymers and containing at least one graft lateral chain consisting of aldehydes and sulphurous acids and the salts thereof and eventually of at least one of the following compounds: ketones, aromatic alcohols, (derivatives of) urea and amino-s-triazines. Used polyamide-type compounds are preferably embodied in the form of natural polyamides like caseins, gelatines, collagens, bone glue, serum albumins, and soybean proteins or the degradable products thereof, and synthetic polyamides such as aspargic acids or copolymers of aspartic and glutamic acids. The inventive copolymers are, in particular produced by graft polymerisation at a temperature ranging form 10 DEG C to 250 DEG C, preferably in the presence of a solvent like water, and by heat drying. Said copolymers are in particular used in the form of a solvent or a water-retaining agent for inorganic binders and pigments. Said copolymers are especially characterised in that they slightly delay setting when associated with hydraulic binding matters.

    Abstract translation: 描述了包含由醛和含硫的酸及其盐，和任选的至少一种化合物从系列酮基于聚酰胺的水溶性，生物可降解的共聚物，芳族醇，脲（衍生物）和氨基-s-三嗪，至少一种接枝侧链 ， 是天然的聚酰胺，像酪蛋白，明胶，胶原，骨胶，血白蛋白和大豆蛋白质或其降解产物和合成聚酰胺，如聚天冬氨酸或天冬氨酸与谷氨酸的共聚物，例如被用作优选的聚酰胺组分。 这些共聚物主要通过在-10和250℃之间的温度下，优选在溶剂存在下的接枝聚合来获得，例如， 但是接收到的水中，或通过加热干燥，并且特别被用作无机粘合剂和颜料，其中它们展开，与液压结合剂仅略微显abbindeverzögernde效果尤其在一起的超增塑剂或水Rentention剂。

    CROSS-LINKED COLLAGEN MATRICES AND METHODS FOR THEIR PREPARATION
    79.
    发明申请
    CROSS-LINKED COLLAGEN MATRICES AND METHODS FOR THEIR PREPARATION 审中-公开
    交联胶原蛋白及其制备方法

    公开(公告)号：WO0179342A3

    公开(公告)日：2002-05-02

    申请号：PCT/IL0100351

    申请日：2001-04-17

    Applicant: COLBAR R & D LTD ,  NOFF MATITIAU ,  SHAHAR PITARU

    Inventor： NOFF MATITIAU ,  SHAHAR PITARU

    IPC: A61L27/00 ,  C07K1/00 ,  C07K14/78 ,  C08H1/06 ,  A61K38/00 ,  A61K38/17 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

    CPC classification number: C08H1/06

    Abstract: A method for preparing cross-linked collagen, and cross-linked collagen products. The method includes incubating collagen in a solution including water, at least one polar solvent and at least one sugar, to form cross-linked collagen. The accompanying figure shows the effect of treatment with reducing sugar (D-ribose) and alcohol on particulate collagen degradation by bacterial collagenase. The solution may include a buffer having a suitable pH and ionic strength. The method may include removing excess unreacted sugar(s) and polar solvent(s) by washing the cross-linked collagen or by other methods. The method may also include dehydrating the cross-linked collagen, and may include subjecting the cross-linked collagen to critical point drying, or subjecting the collagen to drying or freeze-drying prior to cross-linking. The collagen may be prepared from atelopeptide collagen to reduce antigenicity, but may also be prepared from other suitable collagen types. The concentration and type of the polar solvent(s), the concentration and type of the reducing sugar(s), and the incubation duration may be varied to control the degree of cross-linking. The cross-linked collagen product may be in the form of a wet or dry matrix or membrane or may be suspended in a liquid in the form of an injectable preparation. The method may be applied to collagenous proteins and collagen-like peptides.

    Abstract translation: 制备交联胶原蛋白的方法和交联胶原蛋白产品。 该方法包括将胶原蛋白在包括水，至少一种极性溶剂和至少一种糖的溶液中孵育以形成交联的胶原蛋白。 附图显示用还原糖（D-核糖）和醇处理细菌胶原酶对胶原蛋白降解的影响。 溶液可以包括具有合适的pH和离子强度的缓冲液。 该方法可以包括通过洗涤交联的胶原蛋白或通过其它方法除去过量的未反应的糖和极性溶剂。 该方法还可以包括使交联的胶原脱水，并且可以包括使交联的胶原蛋白经历临界点干燥，或者在交联之前对胶原进行干燥或冷冻干燥。 胶原蛋白可以由阿曲肽胶原制备以降低抗原性，但也可以由其它合适的胶原类型制备。 可以改变极性溶剂的浓度和类型，还原糖的浓度和类型以及孵育时间以控制交联度。 交联胶原产品可以是湿的或干的基质或膜的形式，或者可以以可注射制剂的形式悬浮在液体中。 该方法可以应用于胶原蛋白和胶原样肽。

    SWELLING AND DESWELLING POLYMER BLENDS
    80.
    发明申请
    SWELLING AND DESWELLING POLYMER BLENDS 审中-公开
    溶胀和脱落聚合物混合物

    公开(公告)号：WO0134677A8

    公开(公告)日：2001-10-11

    申请号：PCT/US0030908

    申请日：2000-11-10

    Applicant: MACROMED INC

    Inventor： ZENTNER GAYLEN M ,  BARK JONG-SEOK ,  LIU FENG

    IPC: A61K47/32 ,  A61K9/20 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  C08J3/00 ,  C08J3/205 ,  C08L1/12 ,  C08L5/02 ,  C08L5/08 ,  C08L101/00 ,  C08G63/48 ,  C08G63/91 ,  C08H1/06 ,  C08J5/10

    CPC classification number: C08L1/12 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/205 ,  A61K9/2054 ,  C08J3/005 ,  C08L5/02 ,  C08L5/08 ,  C08L2666/02

    Abstract: A polymer blend is prepared by dissolving chitosan and a second polymer in an acidic aqueous solution to form an aqueous polymer blend, dehydrating said aqueous polymer blend, and recovering said polymer blend. The second polymer may be selected from the group consisting of polyether glycols including polyethylene glycols; cellulose esters including cellulose acetate; poloxamers; polysaccharides including dextran and guar; polyvinylpyrrolidones; polyvinyl alcohols; and mixtures or copolymers thereof. These polymer blends swell in an acidic environment and deswell in a more neutral or basic environment. This technology is valuable for the dispensing of biologically active material or drugs into a surrounding environment, especially the environment as is found in the gastrointestinal tract. Since the various polymer blends of the present invention are not covalently or ionically crosslinked, but are physically combined, each polymer in the physical blend maintains its original chemical structure, and therefore, is safe for oral or other routes of administration.

    Abstract translation: 通过将壳聚糖和第二聚合物溶解在酸性水溶液中以形成水性聚合物共混物，使所述水性聚合物共混物脱水并回收所述聚合物共混物来制备聚合物共混物。 第二聚合物可以选自包括聚乙二醇的聚醚二醇; 包括乙酸纤维素的纤维素酯 泊洛沙姆; 包括葡聚糖和瓜尔胶的多糖; 聚乙烯吡咯烷酮; 聚乙烯醇; 及其混合物或共聚物。 这些聚合物共混物在酸性环境中溶胀并在更中性或碱性环境中消除。 该技术对于将生物活性物质或药物分配到周围环境中是有价值的，尤其是在胃肠道中发现的环境。 由于本发明的各种聚合物共混物不是共价或离子交联的，而是物理结合的，物理共混物中的每种聚合物都保持其原始的化学结构，因此对于口服或其他给药途径是安全的。

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