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    MOLECULAR METHOD FOR DIAGNOSIS OF COLON CANCER
    74.
    发明申请
    MOLECULAR METHOD FOR DIAGNOSIS OF COLON CANCER 审中-公开
    用于诊断结肠癌的分子方法

    公开(公告)号：WO2008022432A1

    公开(公告)日：2008-02-28

    申请号：PCT/CA2007/001408

    申请日：2007-08-15

    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA ,  BELACEL, Nabil ,  CUPERLOVIC-CULF, Miroslava ,  OUELLETTE, Rodney

    Inventor： BELACEL, Nabil ,  CUPERLOVIC-CULF, Miroslava ,  OUELLETTE, Rodney

    IPC: C12Q1/68 ,  C12Q1/00 ,  C40B30/00 ,  C40B30/04 ,  A61B10/02

    CPC classification number: C12Q1/6886 ,  A61B10/0233 ,  C12Q2600/158 ,  G01N33/57419

    Abstract: Methods for diagnosing or detecting cancerous colon tissue. A panel of 21 specific marker genes are provided with GeneBank Accession Numbers as follows: M77836, X63468, H20426, L18960, U30872, X81438, H67367, Dl 3645, R33367, T94834, L20852, R39540, H86039, T78477, T84082, X05610, R39130, T49397, T94350, L42611 and M33653. The overexpression of some of these marker genes compared to their expression in normal colon tissue and the underexpression of the rest of these marker genes are indicative of cancerous colon tissue. By using these 21 marker genes as a diagnostic tool, smaller tissue samples, such as those obtained by core needle biopsies and from patient stool samples, can be used.

    Abstract translation: 诊断或检测癌性结肠组织的方法。 具有21个特异性标记基因的一组具有如下基因库登录号：M77836，X63468，H20426，L18960，U30872，X81438，H67367，D3645，R33367，T94834，L20852，R39540，H86039，T78477，T84082，X05610，R39130 ，T49397，T94350，L42611和M33653。 与其在正常结肠组织中的表达相比，这些标记基因中的一些的过表达和这些标记基因的其余部分的低表达指示癌性结肠组织。 通过使用这21种标记基因作为诊断工具，可以使用较小的组织样品，例如通过芯针活组织检查和从患者粪便样品获得的样本。

    METHOD AND SYSTEM FOR DESIGNING A COMBINATORIAL LIBRARY OF SAMPLES
    75.
    发明申请
    METHOD AND SYSTEM FOR DESIGNING A COMBINATORIAL LIBRARY OF SAMPLES 审中-公开
    用于设计样本组合图书馆的方法和系统

    公开(公告)号：WO2007143906A1

    公开(公告)日：2007-12-21

    申请号：PCT/CN2007/001723

    申请日：2007-05-29

    Applicant: ACCELERGY SHANGHAI R & D CENTER CO., LTD. ,  ACCELERGY CORPORATION ,  FENG, Xichen ,  GAO, Zi ,  HUA, Xinlei ,  HUANG, Fuxin ,  LIU, Zhifu ,  WANG, Zhuo

    Inventor： FENG, Xichen ,  GAO, Zi ,  HUA, Xinlei ,  HUANG, Fuxin ,  LIU, Zhifu ,  WANG, Zhuo

    IPC: G06F19/00 ,  C40B30/00

    CPC classification number: C40B50/02

    Abstract: A method for designing a combinatorial library of samples comprises:(l) providing an abstract formula, wherein the abstract formula comprises at least one member and variable corresponding to each member;(2) providing at least one selectable component for each member; (3) providing at least one selectable value for each variable; (4) providing at least one constraint for the variable;(5) generating at least one combination of variables by determining the value of each variable in the abstract formula;(6) identifying at least one combination which meets the constraint; and (7) associating variables in the combination which meets the constraint with corresponding members.

    Abstract translation: 一种用于设计样本的组合库的方法包括：（l）提供抽象公式，其中抽象公式包括对应于每个成员的至少一个成员和变量;（2）为每个成员提供至少一个可选择的组件; （3）为每个变量提供至少一个可选择的值; （4）为变量提供至少一个约束;（5）通过确定抽象公式中每个变量的值来生成变量的至少一个组合;（6）识别符合约束的至少一个组合; 和（7）将符合约束的组合中的变量与对应的成员相关联。

    IDENTIFICATION OF BIOMOLECULES THROUGH EXPRESSION PATTERNS IN MASS SPECTROMETRY
    77.
    发明申请
    IDENTIFICATION OF BIOMOLECULES THROUGH EXPRESSION PATTERNS IN MASS SPECTROMETRY 审中-公开
    通过质谱分析中的表达模式识别生物分子

    公开(公告)号：WO2007104160A1

    公开(公告)日：2007-09-20

    申请号：PCT/CA2007/000418

    申请日：2007-03-14

    Applicant: CAPRION PHARMACEUTICALS INC. ,  KEARNEY, Paul, Edward

    Inventor： KEARNEY, Paul, Edward

    IPC: G01N33/48 ,  C40B20/08 ,  C40B30/00 ,  G01N33/483 ,  G01N33/68 ,  G01N37/00 ,  G06F19/00 ,  H01J49/26 ,  G01N30/72

    CPC classification number: G01N33/6848 ,  G01N30/7233 ,  G01N30/8675 ,  G06F19/24 ,  G06F19/28

    Abstract: Systems, methods, apparatus, and computer programming useful in identifying proteins, peptides, carbohydrates, and other biomolecules, or for a validation of an identification of proteins, peptides, carbohydrates, and other biomolecules, is described. In particular, the invention provides systems, methods, apparatus, and programming useful for identifying proteins and other precursor biomolecules using expression patterns associated with peptides or other biomolecule fragments expressed from analyte samples, and data representing such expression patterns, and for determining and improving confidence levels associated with identification of precursor biomolecules using such methods, through the correlation of expression patterns for fragments associated with precursor biomolecules.

    Abstract translation: 描述了可用于鉴定蛋白质，肽，碳水化合物和其他生物分子的有用的系统，方法，装置和计算机程序，或用于蛋白质，肽，碳水化合物和其他生物分子鉴定的验证。 特别地，本发明提供用于鉴定蛋白质和其它前体生物分子的系统，方法，装置和程序，其使用与分析物样品表达的肽或其他生物分子片段相关的表达模式，以及表示这种表达模式的数据，以及用于确定和改善置信度 通过与前体生物分子相关的片段的表达模式的相关性，使用这种方法鉴定前体生物分子相关的水平。

    ULTRA HIGH THROUGHPUT CAPTURE LIFT SCREENING METHODS
    78.
    发明申请
    ULTRA HIGH THROUGHPUT CAPTURE LIFT SCREENING METHODS 审中-公开

    公开(公告)号：WO2006050346A3

    公开(公告)日：2006-05-11

    申请号：PCT/US2005/039436

    申请日：2005-10-31

    Applicant: MEDIMMUNE, INC. ,  WU, Herren ,  GAO, Changshou

    Inventor： WU, Herren ,  GAO, Changshou

    IPC: C40B30/00 ,  C12Q1/68

    Abstract: The present invention relates to a method for identification and isolation of binding molecules having a selective affinity for a ligand. More specifically, this invention provides a process for the ultra high throughput screening of binding molecules from expression libraries containing billions of independent clones without the biases and limitations of other high throughput screening methods such as panning. Additionally, the present invention provides a method for the production of expression libraries essentially free of clones encoding non-functional molecules.

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