公开(公告)号：WO2020165270A1

公开(公告)日：2020-08-20

申请号：PCT/EP2020/053631

申请日：2020-02-12

Applicant: THE UNIVERSITY OF SOUTHAMPTON

Inventor： FARRAND, Louise Diane ,  GOULDING, Mark John ,  OPOKU, Charles ,  ROSE, Nicholas ,  NEWTON, Marcus ,  HILL, Martyn

IPC: H01L41/18 ,  H01L41/113 ,  H02N2/18 ,  H01L41/35 ,  H01L51/42

Abstract: The present application relates to an electronic device comprising a piezoelectrically active composite layer as well as a method for producing such electronic device. The present application also relates to an electronic apparatus comprising such electronic device.

公开(公告)号：WO2019211628A1

公开(公告)日：2019-11-07

申请号：PCT/GB2019/051243

申请日：2019-05-03

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： PRODROMAKIS, Themistoklis ,  SERB, Alexantrou

IPC: H03F3/45 ,  A61B5/04

Abstract: A detector for detecting neural spike signals, the detector comprising a core amplifier. The core amplifier comprises two current paths, each current path integrating a current on a respective integrating node. Each current path comprises an input transistor receiving an analogue input signal, and a tunable load configured to tune an offset voltage of the core amplifier. The core amplifier further comprises a reset element configured to reset the integrating nodes periodically. The detector further comprises a read out element configured to process the integrated currents at the two integrating nodes.

公开(公告)号：WO2019158910A1

公开(公告)日：2019-08-22

申请号：PCT/GB2019/050375

申请日：2019-02-13

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： DREVINSKAS, Rokas ,  KAZANSKY, Peter ,  CERKAUSKAITE, Ausra

IPC: G02B1/00 ,  G02B5/30 ,  G02B27/28 ,  G11B7/00

Abstract: An optical element for modifying an incident laser beam propagated through the optical element from an input face to an output face via a geometric phase birefringent effect, the optical element comprising: a substrate of a transparent amorphous material with an input face and an opposite output face; and a structural modification in a volume of the substrate between the input face and output face comprising a plurality of randomly positioned nanostructures; wherein each nanostructure has a oblate spheroidal shape with an elliptical cross section in a plane parallel to the input face, the elliptical cross- section having a minor axis substantially not larger than 30 nm and a major axis greater than the minor axis, and each nanostructure having a length in a direction perpendicular to the input face which is substantially not larger than 100 nm.

公开(公告)号：WO2019053442A1

公开(公告)日：2019-03-21

申请号：PCT/GB2018/052612

申请日：2018-09-13

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： MORGAN, Hywel ,  MINGELS, Roel

IPC: G01N27/416 ,  A61B5/00 ,  G01N27/414

Abstract: A pH sensor for measuring pH levels within a measurement environment is described. T he sensor comprises a reference electrode, a pH sensitive electrode, and a controller, for measuring the potential difference between the pH sensitive electrode and the reference electrode, the measured potential difference being indicative of a pH level at the pH sensitive electrode. T he controller is operable to apply a voltage across first and second electrodes to control the p H level at the pH sensitive electrode, and to measure the potential difference between the p H sensitive electrode and the reference electrode following the application of the recalibration voltage. In this way, recalibration of the p H sensor is possible within the measurement environment.

公开(公告)号：WO2019034359A1

公开(公告)日：2019-02-21

申请号：PCT/EP2018/069597

申请日：2018-07-19

Applicant: UNIVERSITE DE STRASBOURG ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITY OF SOUTHAMPTON

Inventor： HEISER, M. Thomas ,  REGRETTIER, M. Thomas ,  KACZMAREK, Malgosia

IPC: G02F1/135

Abstract: The invention concerns a liquid crystal spatial light modulator (101) comprising: a liquid crystal layer (7); and on at least one side of the liquid crystal layer (7), at least one photovoltaic cell (456), each photovoltaic cell (456) comprising a photosensitive layer (5) comprising electron-donating (D) molecules and electron accepting (A) molecules, each photovoltaic cell (456) being arranged for spontaneous photovoltage under illumination. Electron-donating molecules and electron accepting molecules are preferably blended and form preferably an organic bulk heterojunction layer. The photosensitive layer (5) of each photovoltaic cell (456) is preferably comprised between: - an electron conducting layer (4) arranged for a transfer of an electron from its contacting photosensitive layer (5) easier than a transfer of an electron hole from its contacting photosensitive layer (5), and - an electron hole conducting layer (6) arranged for a transfer of an electron hole from its contacting photosensitive layer (5) easier than a transfer of an electron from its contacting photosensitive layer (5).

公开(公告)号：WO2019008352A1

公开(公告)日：2019-01-10

申请号：PCT/GB2018/051877

申请日：2018-07-04

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： WHEELER, Natalie ,  SHARDLOW, Peter ,  POLETTI, Francesco

IPC: C03B37/012 ,  C03B23/207 ,  G02B6/28

Abstract: A method of making an optical fibre preform comprising providing a hollow outer tube of glass, providing a hollow primary capillary tube of glass with an outer diameter smaller than an inner diameter of the outer tube, positioning the primary capillary tube inside the outer tube such that an outer surface of the primary capillary tube lies against an inner surface of the outer tube along a contact line parallel to the longitudinal axes of the primary capillary tube and the outer tube, and bonding the primary capillary tube into its position inside the outer tube by directing a laser beam onto a surface of the outer tube or the primary capillary at one or more locations aligned with the contact line.

公开(公告)号：WO2018234833A1

公开(公告)日：2018-12-27

申请号：PCT/GB2018/051770

申请日：2018-06-25

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： HOLDEN-DYE, Lindy ,  O'CONNOR, Vincent ,  URWIN, Peter

IPC: A01N43/38 ,  A01N61/00 ,  A01P5/00

Abstract: A method of inhibiting or preventing damage to plants or seeds by a PPN (Plant Parasitic Nematode). The method comprises applying an effective amount of a biogenic amine signalling pathway inhibitor to a plant or a seed. The biogenic amine signalling pathway inhibitor may be a serotonin signalling pathway inhibitor. In particular, the biogenic amine signalling pathway inhibitor may be reserpine or an active analogue or derivative thereof.

公开(公告)号：WO2018220370A1

公开(公告)日：2018-12-06

申请号：PCT/GB2018/051474

申请日：2018-05-31

Applicant: UNIVERSITY OF SOUTHAMPTON ,  ULTRA ELECTRONICS LIMITED

Inventor： STOTHERS, Ian ,  WATERS, Tim

IPC: B64D15/16

Abstract: We describe an ice protection system used for removing ice and/or other accretions from a structure. An actuator, coupled to a structure, is driven to generate vibrations in the structure. A controller drives the actuator using a signal that comprises a frequency chirp over a first period of time, and the controller controls the frequency chirp and the first period such that vibrations generated in the structure by the actuator propagate through the structure to coincide at a desired area of the structure remote from the actuator to remove ice and/or other accretions from the desired area of the structure.

公开(公告)号：WO2017129997A1

公开(公告)日：2017-08-03

申请号：PCT/GB2017/050220

申请日：2017-01-27

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： TAVASSOLI, Ali

IPC: C07K7/06 ,  C07K14/47 ,  G01N33/68

CPC classification number: C07K7/06 ,  C07K14/4702 ,  G01N33/6845 ,  G01N2500/02

Abstract: The present invention relates to inhibitors of HIF-1 and HIF-2 and uses thereof. The present invention further relates to the inhibitors for use in treatment of diseases. An isolated polypeptide is provided, that prevents dimerization of HIF-1 α with HIF-1 β and HIF-2α with HIF-1 β and/or inhibits the activity of HIF-1 and HIF-2, wherein the polypeptide comprises the amino acid sequence C-X1-X2-X3-Z-X4 (SEQ ID NO 1) and wherein XI, X2, X3 and X4 are any amino acid and wherein Z is leucine, valine of isoleucine or a non-natural derivative or leucine, valine or isoleucine. The isolated polypeptide prevents dimerization of HIF-1 α with HIF-1 β and HIF-2α with HIF-1 β and inhibits the activity of HIF-1 and HIF-2 by binding to HIF-1 α or HIF-1 β and/or HIF-2α or HIF-Ιβ.

Abstract translation: 本发明涉及HIF-1和HIF-2的抑制剂及其用途。 本发明进一步涉及用于治疗疾病的抑制剂。 提供了分离的多肽，其防止HIF-1α与HIF-1β和HIF-2α与HIF-1β的二聚化和/或抑制HIF-1和HIF-2的活性，其中多肽包含氨基酸 序列C-X1-X2-X3-Z-X4（SEQ ID NO1），并且其中X1，X2，X3和X4是任何氨基酸，并且其中Z是亮氨酸，异亮氨酸的缬氨酸或非天然衍生物或亮氨酸，缬氨酸 或异亮氨酸。 分离的多肽阻止HIF-1α与HIF-1β和HIF-2α与HIF-1β二聚化，并通过与HIF-1α或HIF-1β和/或HIF-1β结合而抑制HIF-1和HIF- 或HIF-2α或HIF-1β。

公开(公告)号：WO2017077307A1

公开(公告)日：2017-05-11

申请号：PCT/GB2016/053418

申请日：2016-11-03

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： GALE, Philip Alan ,  HOWE, Ethan Nam Wei ,  ROSSOM, Wim Van

IPC: C07D403/12 ,  C07F5/02 ,  C07F7/08 ,  A61K31/404 ,  A61P35/00

CPC classification number: C07D403/12

Abstract: A novel class of compounds called perenosins, and their use in the treatment and/or prevention of cancer or a neoplastic condition.

Abstract translation: 一种称为perenosins的新型化合物及其在治疗和/或预防癌症或肿瘤性疾病中的用途。