公开(公告)号：WO2006002306A2

公开(公告)日：2006-01-05

申请号：PCT/US2005/022236

申请日：2005-06-22

Applicant: SYNECOR, LLC ,  WILLIAMS, Michael, S.

Inventor： WILLIAMS, Michael, S.

IPC: A61N1/05 ,  A61F2/02

CPC classification number: A61N1/05 ,  A61N1/057 ,  A61N1/375

Abstract: A percutaneously implantable chamber for the treatment of a cardiac condition is disclosed herein, the chamber capable of delivery and maintenance of viable cells comprising a pacemaker gene or other genes intended to impart a specific function via a host cell An artificial sinoatrial node and artificial atrial ventricular node for the restoration of the pacemaker function of the heart of a subject comprises a chamber comprising cells expressing a pacemaker gene. Further, a chamber may be used for the implantation and maintenance of viable, responsive, immunoisolated cells to induce or enhance muscle contraction of a subject for the treatment of a disorder.

Abstract translation: 本文公开了一种用于治疗心脏病症的经皮植入室，该腔室能够递送和维持包含起搏器基因或其它旨在通过宿主细胞赋予特定功能的基因的活细胞人造窦房结和人造心房心室 用于恢复受试者心脏起搏器功能的节点包括包含表达起搏器基因的细胞的腔室。 此外，腔室可以用于植入和维持活的，响应性的免疫分泌的细胞，以诱导或增强受试者的肌肉收缩来治疗病症。

公开(公告)号：WO2005065771A1

公开(公告)日：2005-07-21

申请号：PCT/US2004/043691

申请日：2004-12-23

Applicant: CARDIAC PACEMAKERS, INC. ,  LIBBUS, Imad ,  HEIL, Ronald, W., Jr. ,  SCHEINER, Avram ,  KELLEY, Peter, T.

Inventor： LIBBUS, Imad ,  HEIL, Ronald, W., Jr. ,  SCHEINER, Avram ,  KELLEY, Peter, T.

IPC: A61N1/36

CPC classification number: A61N1/057 ,  A61N1/36117

Abstract: An apparatus includes a flexible lead body, an electrode coupled to the lead body, and an implantable pulse generator electrically coupled to the electrode. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode. The apparatus includes means for passively fixating the electrode within the pulmonary artery.

Abstract translation: 一种装置包括柔性引线体，耦合到引线本体的电极以及电耦合到电极的可植入脉冲发生器。 可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。 该装置包括用于被动地固定肺动脉内的电极的装置。

公开(公告)号：WO2005061047A1

公开(公告)日：2005-07-07

申请号：PCT/US2004/040261

申请日：2004-12-01

Applicant: MEDTRONIC, INC. ,  BROSTROM, Thomas, D. ,  SOMMER, John, L.

Inventor： BROSTROM, Thomas, D. ,  SOMMER, John, L.

IPC: A61N1/05

CPC classification number: A61N1/057 ,  A61N2001/0582

Abstract: An improved suture sleeve for a lead body includes an elongated tubular sleeve body formed of a compressible elastomeric material wherein a surface of the lumen has a relatively rough texture formed by a particulate or fibrous media embedded therein.

Abstract translation: 用于引线主体的改进的缝合套管包括由可压缩弹性体材料形成的细长管状套管主体，其中内腔的表面具有由嵌入其中的颗粒或纤维介质形成的相对粗糙的纹理。

公开(公告)号：WO2004028348A3

公开(公告)日：2004-06-17

申请号：PCT/US0330525

申请日：2003-09-26

Applicant: SAVACOR INC ,  WARDLE JOHN L ,  EIGLER NEAL L

Inventor： WARDLE JOHN L ,  EIGLER NEAL L

IPC: A61B20060101 ,  A61B5/00 ,  A61B5/0215 ,  A61B5/04 ,  A61B5/042 ,  A61B17/00 ,  A61B17/064 ,  A61K9/22 ,  A61N1/05 ,  A61N1/37

CPC classification number: A61B5/0215 ,  A61B5/042 ,  A61B5/145 ,  A61B5/6882 ,  A61B17/064 ,  A61B2017/00243 ,  A61N1/057

Abstract: An anchoring device and a delivery method thereof can effectively provide a means for securing an implant to a wall of an internal organ within a patient in a variety of clinical applications. In one embodiment, an anchoring device used to retain a cardiac pressure measurement device is provided. The device is implanted in the body by deforming it to a small cross section profile, sliding it through a low profile delivery device and ejecting from the delivery device at a targeted site. The anchoring mechanism, when ejected from the delivery device, reverts back to pre-formed configuration and engages opposite sides of an organ wall, thereby anchoring the implant in the organ wall.

Abstract translation: 锚定装置及其递送方法可以有效地提供用于在多种临床应用中将植入物固定到患者内部器官的壁的装置。 在一个实施例中，提供了用于保持心脏压力测量装置的锚定装置。 通过将其变形成小的横截面轮廓将装置植入体内，将其通过低轮廓输送装置滑动并从目标部位的输送装置排出。 当从输送装置弹出时，锚定机构回复到预先形成的构型并且接合器官壁的相对侧，从而将植入物固定在器官壁中。

公开(公告)号：WO2004011082A1

公开(公告)日：2004-02-05

申请号：PCT/US2003/023303

申请日：2003-07-25

Applicant: MYOMEND, INC. ,  SANTAMORE, William, P. ,  SPECTOR, Kenneth, A. ,  LESNIAK, Jeanne, M.

Inventor： SANTAMORE, William, P. ,  SPECTOR, Kenneth, A. ,  LESNIAK, Jeanne, M.

IPC: A61N1/05

CPC classification number: A61N1/0587 ,  A61N1/056 ,  A61N1/0568 ,  A61N1/057

Abstract: Medical device and therapeutic methods for use in the field of cardiology, cardiac rhythm management and interventional cardiology, and more specifically to catheter-based systems for implantation of pacing leads and electrodes, or intramural myocardial reinforcement devices, within the myocardial wall of the heart, such as the ventricles, to provide improved cardiac funtion.

Abstract translation: 用于心脏病学，心律管理和介入心脏病领域的医疗装置和治疗方法，更具体地涉及在心脏心脏壁内植入起搏引线和电极或壁内心肌增强装置的基于导管的系统， 例如心室，以提供改善的心脏功能。

公开(公告)号：WO02018006A3

公开(公告)日：2002-06-13

申请号：PCT/US2001/027022

申请日：2001-08-30

IPC: A61N1/05

CPC classification number: A61N1/056 ,  A61N1/057 ,  A61N2001/0585

Abstract: A lead (100) for monitoring or simulating cardiac activity is provided. The lead (100) is adapted for implantation on or about the heart within the coronary vasculature and for connection to a signal generator (140). The lead is constructed and arranged so that when it is implanted, the electrodes (122) are housed in the coronary vasculature and urged into intimate contact a vessel wall (128). The lead optionally includes a tapered, flexible lead body portion that is distal to a biased portion.

Abstract translation: 提供了用于监测或模拟心脏活动的导联（100）。 引线（100）适于植入在冠状脉管系统内或心脏周围，并用于连接到信号发生器（140）。 引线被构造和布置成使得当其被植入时，电极（122）容纳在冠状脉管系统中并被促使与血管壁（128）紧密接触。 导线可选地包括在偏压部分的远侧的锥形的柔性引线主体部分。

公开(公告)号：WO0218006A2

公开(公告)日：2002-03-07

申请号：PCT/US0127022

申请日：2001-08-30

Applicant: CARDIAC PACEMAKERS INC ,  WESTLUND RANDY ,  TOCKMAN BRUCE ,  WARREN JAY A ,  SCHEINER AVRAM ,  HAIL RONALD W JR ,  KELLEY PETER T ,  REPASKY CHRISTINA ,  BYE LYLE A ,  SOLTIS BRIAN D

Inventor： WESTLUND RANDY ,  TOCKMAN BRUCE ,  WARREN JAY A ,  SCHEINER AVRAM ,  HAIL RONALD W JR ,  KELLEY PETER T ,  REPASKY CHRISTINA ,  BYE LYLE A ,  SOLTIS BRIAN D

IPC: A61N1/05

CPC classification number: A61N1/056 ,  A61N1/057 ,  A61N2001/0585

Abstract: A lead (100) for monitoring or simulating cardiac activity is provided. The lead (100) is adapted for implantation on or about the heart within the coronary vasculature and for connection to a signal generator (140). The lead is constructed and arranged so that when it is implanted, the electrodes (122) are housed in the coronary vasculature and urged into intimate contact a vessel wall (128). The lead optionally includes a tapered, flexible lead body portion that is distal to a biased portion.

Abstract translation: 提供了用于监测或模拟心脏活动的导联（100）。 引线（100）适于植入在冠状脉管系统内或心脏周围，并用于连接到信号发生器（140）。 引线被构造和布置成使得当其被植入时，电极（122）容纳在冠状脉管系统中并被促使与血管壁（128）紧密接触。 导线可选地包括在偏压部分的远侧的锥形的柔性引线主体部分。

公开(公告)号：WO2001002053A1

公开(公告)日：2001-01-11

申请号：PCT/US2000/040327

申请日：2000-07-07

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： PARTRIDGE, Scott, M. ,  BARTIG, Jeffrey, T. ,  KENKNIGHT, Bruce, H. ,  KELLEY, Peter, T. ,  KRISHNAN, Mohan

IPC: A61N1/05

CPC classification number: A61N1/057 ,  A61N1/0573 ,  A61N2001/0585

Abstract: A lead (100) having a distal end electrode assembly (130) adapted for implantation on or about the heart or within a vein and for connection to a system for monitoring or stimulating cardiac activity. The electrode assembly includes conductive fixation features, such as conductive tines (320) or flexible members, in combination with non-conductive fixation features (340). The conductive fixation features also include tines coated with a conductive material. The fixation features further include conductive tines which are retractable. A defibrillation coil is optionally disposed at the distal end of the lead in combination with the conductive tines.

Abstract translation: 一种具有远端电极组件（130）的引线（100），其适于植入在心脏上或其周围或静脉内并且用于连接到用于监测或刺激心脏活动的系统。 电极组件包括与非导电固定特征（340）组合的导电固定特征，例如导电尖（320）或柔性构件。 导电固定特征还包括涂覆有导电材料的尖齿。 固定特征还包括可伸缩的导电尖齿。 除颤线圈可选地配置在导电尖端的前端，与导电齿结合。

公开(公告)号：WO99042170A1

公开(公告)日：1999-08-26

申请号：PCT/US1999/002891

申请日：1999-02-11

IPC: A61N1/05

CPC classification number: A61N1/057 ,  A61N2001/0585

Abstract: An intravenous lead for use with a cardiac device for implantation in the coronary venous system of the heart includes a lead body (10) that is adapted to be routed through the vascular system into the coronary sinus with the distal end portion of the lead placed in the great cardiac vein (12) or branch vein. The lead body (10) includes a preformed section disposed just proximal of its tip so that the lead body exhibits a two-dimensional wave having peaks (22), and valleys (24) for contacting the endothelial layer of the vein (12) at discrete, longitudinally spaced points to stabilize the electrode (20) against displacement.

Abstract translation: 用于心脏装置用于植入心脏的冠状静脉系统的静脉导管包括引线体（10），其适于通过血管系统被引导到冠状窦中，其中铅的远端部分置于 大心静脉（12）或分支静脉。 引线体（10）包括设置在其尖端附近的预成形部分，使得引线体呈现出具有峰（22）和谷（24）的二维波，用于使静脉（12）的内皮层与 离散的纵向间隔的点以稳定电极（20）以防止位移。

公开(公告)号：WO99006102A1

公开(公告)日：1999-02-11

申请号：PCT/US1998/015250

申请日：1998-07-21

IPC: A61N1/05

CPC classification number: A61N1/056 ,  A61N1/057 ,  A61N2001/058

Abstract: A lead assembly (10) adapted for endocardial fixation to a human heart is provided. The lead assembly includes a lead body (12) that has a proximal end provided with a connector (16) for electrical connection to a cardiac stimulator (18). The cardiac stimulator may be a pacemaker, a cardioverter/defibrillator, or a sensing instrument. The distal end of the lead body is connected to a tubular electrode housing (22). The lead body (12) consists of a noncoiled conductor cable (24) surrounded by a coextensive insulating sleeve (26). In contrast to conventional leads, the lead body of the present invention does not require coiled conductor wires or an internal lumen. Manipulation of the lead body is via an external guide tube. Lead body diameters of 0.25 mm or smaller are possible.

Abstract translation: 提供了一种适于心内膜固定在人心上的引线组件（10）。 引线组件包括引线本体（12），其具有设置有用于与心脏刺激器（18）电连接的连接器（16）的近端。 心脏刺激器可以是起搏器，心律转复器/除颤器或感测器械。 引线主体的远端连接到管状电极壳体（22）。 引线体（12）包括由共同延伸的绝缘套（26）围绕的非卷绕导体电缆（24）。 与传统的引线相比，本发明的引线体不需要线圈导线或内腔。 引线体的操作是通过外部引导管。 铅体直径可达0.25mm以下。