公开(公告)号：WO2010056426A1

公开(公告)日：2010-05-20

申请号：PCT/US2009/059151

申请日：2009-10-01

Applicant: MEDTRONIC, INC. ,  CHO, Yong, K. ,  SARKAR, Shantanu ,  HETTRICK, Douglas, A. ,  TAEPKE, Robert, T., II

Inventor： CHO, Yong, K. ,  SARKAR, Shantanu ,  HETTRICK, Douglas, A. ,  TAEPKE, Robert, T., II ,  BENNETT, Thomas, D.

IPC: A61B5/021 ,  A61B5/053

CPC classification number: A61B5/0452 ,  A61B5/0215 ,  A61B5/053 ,  A61B5/0538 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/36564

Abstract: Heart failure decompensation is detected by sensing at least one physiological signal. Values of at least two different heart failure variables are derived using one or more physiological signals and a threshold for the first heart failure variable is adjusted in response to the value of the second heart failure variable. The value of the first heart failure variable is compared to first threshold for detecting a heart failure condition.

Abstract translation: 通过感测至少一个生理信号来检测心力衰竭失代偿。 使用一个或多个生理信号导出至少两个不同的心力衰竭变量的值，并且响应于第二心力衰竭变量的值调整第一心力衰竭变量的阈值。 将第一心力衰竭变量的值与用于检测心力衰竭状况的第一阈值进行比较。

公开(公告)号：WO2009035596A1

公开(公告)日：2009-03-19

申请号：PCT/US2008010559

申请日：2008-09-10

Applicant: CARDIAC PACEMAKERS INC ,  HATLESTAD JOHN D ,  ROESKE CAL ,  MOON LOELL BOYCE ,  COOK JEFFREY P

Inventor： HATLESTAD JOHN D ,  ROESKE CAL ,  MOON LOELL BOYCE ,  COOK JEFFREY P

IPC: A61B5/00 ,  A61B5/053 ,  A61B5/08 ,  A61B5/085 ,  A61N1/08 ,  A61N1/36 ,  A61N1/372

CPC classification number: A61B5/053 ,  A61B5/0535 ,  A61B5/0537 ,  A61B5/08 ,  A61B5/0809 ,  A61B5/416 ,  A61B5/6846 ,  A61N1/36521

Abstract: Systems and methods for monitoring pulmonary edema or other thoracic fluid status in a subject use thoracic impedance histogram information. An internal or external processor circuit receives the thoracic impedance histogram information and uses it to compute and provide a lung fluid status indication. The thoracic impedance histogram information can include a count, mean or median of a histogram bin or subrange of bins within the histogram range.

Abstract translation: 用于监测受试者的肺水肿或其他胸腔液状态的系统和方法使用胸阻抗直方图信息。 内部或外部处理器电路接收胸部阻抗直方图信息并使用它来计算和提供肺液体状态指示。 胸廓阻抗直方图信息可以包括直方图区块的计数，平均值或中值或直方图范围内的区域的子范围。

公开(公告)号：WO2008143832A2

公开(公告)日：2008-11-27

申请号：PCT/US2008/006084

申请日：2008-05-13

Applicant: CARDIAC PACEMAKERS, INC. ,  ZHANG, Yunlong ,  BENTSEN, James G. ,  DALAL, Yousufali

Inventor： ZHANG, Yunlong ,  BENTSEN, James G. ,  DALAL, Yousufali

IPC: A61B5/029 ,  A61B5/053 ,  A61B5/03 ,  A61N1/36 ,  A61M25/10 ,  A61N1/365 ,  A61B5/00

CPC classification number: A61N1/36114 ,  A61B5/4035 ,  A61B5/4869 ,  A61B7/003 ,  A61B7/04 ,  A61M25/10 ,  A61M25/1002 ,  A61N1/36521 ,  A61N1/36528 ,  A61N1/3655 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36571

Abstract: A system delivers stimulation to volume receptors in the cardiovascular system to induce diuresis in a patient suffering volume overload. The system senses a volume signal indicative of a level of fluid retention in the patient's body and controls the delivery of the stimulation using the volume signal. In various embodiments, the stimulation includes one or more of electrical stimulation, which delivers electrical pulses to the volume receptors, and mechanical stimulation, which physically stretches the volume receptors.

Abstract translation: 系统向心血管系统中的体积受体提供刺激，以在患有体积过载的患者中诱发利尿。 该系统感测指示患者体内的液体保留水平的体积信号，并使用体积信号控制刺激的传送。 在各种实施例中，刺激包括将电脉冲传送到体积受体的电刺激和物理地拉伸体积受体的机械刺激中的一种或多种。

公开(公告)号：WO2008118349A1

公开(公告)日：2008-10-02

申请号：PCT/US2008/003720

申请日：2008-03-20

Applicant: CARDIAC PACEMAKERS, INC. ,  NI, Quan ,  HARTEMINK, Christopher ,  BELALCAZAR, Andres ,  SHUROS, Allan C. ,  MOON, Loell B.

Inventor： NI, Quan ,  HARTEMINK, Christopher ,  BELALCAZAR, Andres ,  SHUROS, Allan C. ,  MOON, Loell B.

IPC: A61N1/362 ,  A61N1/365

CPC classification number: A61N1/36521 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/11 ,  A61B5/686 ,  A61B5/6869 ,  A61N1/3627 ,  A61N1/3684

Abstract: An apparatus comprises a first impedance sensing circuit, a second sensing circuit, and an impedance-based cardiac dyssynchrony detector. The impedance sensing circuit senses an intracardiac local impedance signal that is indicative of a cardiac local wall motion of a first cardiac region from an implantable first bipolar pair of impedance sensing electrodes. The second sensing circuit is configured to produce a second sensor signal indicative of cardiovascular activity. The impedance-based cardiac dyssynchrony detector is configured for detecting cardiac dyssynchrony using a relationship between the first intracardiac local impedance signal and the second sensor signal. Other apparatuses and methods are disclosed.

Abstract translation: 一种装置包括第一阻抗感测电路，第二感测电路和基于阻抗的心脏不同步检测器。 阻抗感测电路感测指示来自可植入的第一双极对阻抗感测电极的第一心脏区域的心脏局部壁运动的心内局部阻抗信号。 第二感测电路被配置为产生指示心血管活动的第二传感器信号。 基于阻抗的心脏不同步检测器被配置为使用第一心内局部阻抗信号和第二传感器信号之间的关系来检测心脏不同步。 公开了其他装置和方法。

公开(公告)号：WO2008118041A1

公开(公告)日：2008-10-02

申请号：PCT/SE2007/000288

申请日：2007-03-23

Applicant: ST. JUDE MEDICAL AB ,  HOLMSTRÖM, Nils ,  ÖHLANDER, Malin ,  NOREN, Kjell ,  BLOMQVIST, Andreas ,  LJUNGSTRÖM, Karin

Inventor： HOLMSTRÖM, Nils ,  ÖHLANDER, Malin ,  NOREN, Kjell ,  BLOMQVIST, Andreas ,  LJUNGSTRÖM, Karin

IPC: A61N1/365 ,  A61N1/37

CPC classification number: A61N1/36521 ,  A61B5/0215 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/4035 ,  A61B5/4836 ,  A61B5/7257 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36592 ,  A61N1/3702

Abstract: An implantable cardiac device comprises a heart stimulator (10, 12) for electricly stimulating the heart of a patient, detecting means (2, 4) for measuring a physiologic parameter which is affected by the status of a cardiovascular disease associated with sympathetic activation, signal processing means (6) for determining at least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the measured parameter, and an analysor for analyzing the determined Mayer wave component in relation to a predetermined reference value to determine the status of the cardiovascular disease. The detecting means comprise measuring means (2) arranged to measure, as said physiologic parameter, a mechanical change in at least one of the four chambers of the heart. In a corresponding method for monitoring the status of a cardiovascular disease associated with sympathetic activation of a patient having an implantable electric heart stimulator (10, 12) a physiologic parameter affected by the cardiac disease is measured. At least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the parameter is determined, and the wave component is analysed in relation to a predetermined reference value to determine the status of the cardiovascular disease. A mechanical change in at least one of the four chambers of the heart is measured as the physiologic parameter.

Abstract translation: 可植入心脏装置包括用于电刺激患者心脏的心脏刺激器（10,12），用于测量受到与交感神经激活相关的心血管疾病状态影响的生理参数的检测装置（2,4），信号 用于确定所测量的参数中的低频，低频和极低频，伏尔伏特梅耶波分量中的至少一个的处理装置（6），以及用于相对于预定参考值分析所确定的梅尔波分量的分析器 以确定心血管疾病的状况。 检测装置包括测量装置（2），其被布置成根据所述生理参数测量心脏的四个腔室中的至少一个中的机械变化。 在用于监测与具有可植入电心脏刺激器（10,12）的患者的交感神经激活相关的心血管疾病的状态的相应方法中，测量受心脏病影响的生理参数。 确定参数中的低频，低频和极低频VLF，梅耶波分量中的至少一个，并且相对于预定参考值分析波分量以确定心血管疾病的状态。 测量心脏四个腔室中的至少一个的机械变化作为生理参数。

公开(公告)号：WO2008046090A3

公开(公告)日：2008-09-25

申请号：PCT/US2007081327

申请日：2007-10-13

Applicant: LIFESCIENCE SOLUTIONS LLC ,  RICHARDSON CHARLES

Inventor： RICHARDSON CHARLES

IPC: A61N1/00

CPC classification number: A61B19/2203 ,  A61B5/053 ,  A61B17/29 ,  A61B17/3468 ,  A61B34/30 ,  A61B34/37 ,  A61B34/71 ,  A61B34/72 ,  A61B2017/00221 ,  A61B2017/00243 ,  A61B2017/00734 ,  A61B2017/308 ,  A61B2034/302 ,  A61B2034/742 ,  A61N1/0587 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3684 ,  A61N1/3688

Abstract: A system for pacing a heart includes an implantable pulse generator configured to generate electrical impulses for stimulating contraction of cardiac tissue; first, second, third, and fourth leads configured to deliver the electrical impulses to activation sites within the cardiac tissue and to detect electrical activity of the activation sites; and a controller configured to control the delivery of the electrical impulses from each of the first, second, third, and fourth leads.

Abstract translation: 用于起搏心脏的系统包括：可植入脉冲发生器，其被配置为生成用于刺激心脏组织收缩的电脉冲; 第一引线，第二引线，第三引线和第四引线，所述第一引线，第二引线， 以及控制器，其被配置为控制来自第一，第二，第三和第四引线中的每一个的电脉冲的输送。

公开(公告)号：WO2008057302A9

公开(公告)日：2008-09-18

申请号：PCT/US2007022779

申请日：2007-10-29

Applicant: ACCESS CARDIOSYSTEMS INC ,  BOWERS KYLE R

Inventor： BOWERS KYLE R

IPC: A61N1/39

CPC classification number: A61N1/3943 ,  A61N1/36521 ,  A61N1/3906 ,  A61N1/3993

Abstract: An Automated External Defibrillator (AED) with wireless patient monitoring capability. The AED is used in conjunction with a monitoring chest strap that transmits the patient's ECG and other parameters over a wireless network to the AED. The AED is capable of monitoring several patients simultaneously for use in mass casualty incidents. The AED notifies and indicates to the operator when a patient requires defibrillation therapy. The device is ready to shock once the defibrillation electrodes are applied.

Abstract translation: 具有无线病人监测功能的自动外部除颤器（AED）。 AED与监测胸带一起使用，通过无线网络将患者的ECG和其他参数传输到AED。 AED能够同时监测多个患者用于大规模伤员事故。 当患者需要除颤治疗时，AED通知并向操作员指示。 一旦施加除颤电极，该装置就准备好休克。

公开(公告)号：WO2008109040A2

公开(公告)日：2008-09-12

申请号：PCT/US2008/002799

申请日：2008-03-03

Applicant: CARDIAC PACEMAKERS, INC. ,  PASTORE, Joseph, M. ,  BAYNHAM, Tamara, Colette ,  HOPPER, Donald, L. ,  SHUROS, Allan, C. ,  ARCOT-KRISHNAMURTHY, Shantha

Inventor： PASTORE, Joseph, M. ,  BAYNHAM, Tamara, Colette ,  HOPPER, Donald, L. ,  SHUROS, Allan, C. ,  ARCOT-KRISHNAMURTHY, Shantha

IPC: A61N1/362 ,  A61N1/365

CPC classification number: A61N1/3627 ,  A61N1/36514 ,  A61N1/36521 ,  A61N1/36585

Abstract: A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac pacing to create or augment regional stress in the heart. The cardiac pacing is delivered intermittently, such as on a periodic basis, according to a cardiac stress augmentation pacing sequence that includes alternating pacing and non-pacing periods. One or more physiological signals are monitored for closed-loop control of the cardiac pacing using baseline characteristics of the cardiac disorder, acute cardiac stress created by the cardiac pacing, and/or risk associated with the cardiac pacing.

Abstract translation: 心脏起搏系统通过递送心脏起搏来创建或增加心脏中的区域应力来控制心脏病症如心力衰竭的进展。 根据包括交替起搏和非起搏时间段的心脏应激增加起搏序列，间歇地递送心脏起搏，例如周期性地起搏。 使用心脏病症的基线特征，由心脏起搏产生的急性心脏压力和/或与心脏起搏相关的风险来监测一个或多个生理信号用于心脏起搏的闭环控制。

公开(公告)号：WO2008070818A9

公开(公告)日：2008-08-07

申请号：PCT/US2007086721

申请日：2007-12-07

Applicant: MEDTRONIC INC ,  STYLOS LEE

Inventor： STYLOS LEE

IPC: A61B5/053

CPC classification number: A61B5/0537 ,  A61B5/0538 ,  A61B5/07 ,  A61B5/076 ,  A61B5/4869 ,  A61B5/4878 ,  A61N1/36521 ,  A61N1/37258 ,  G16H10/60 ,  G16H10/65 ,  G16H50/20

Abstract: Adaptations to the OptiVol TM alert algorithm are disclosed which may reduce the number of false positive alerts while retaining the desired sensitivity. Some embodiments monitor fluid levels in patients. Some embodiments reset a cumulative index when a short-term impedance value is greater than a baseline impedance value minus a predetermined positive hysteresis value.

Abstract translation: 公开了对OptiVol ^{TM 警报算法的调整，可以减少错误警报的数量，同时保持所需的灵敏度。 一些实施例监测患者的液体水平。 当短期阻抗值大于基线阻抗值减去预定的正滞后值时，一些实施例重置累积指数。}

公开(公告)号：WO2008079370A1

公开(公告)日：2008-07-03

申请号：PCT/US2007/026235

申请日：2007-12-20

Applicant: CARDIAC PACEMAKERS, INC. ,  PASTORE, Joseph, M. ,  SALO, Rodney, W. ,  SPINELLI, Julio, C. ,  SHUROS, Allan, C. ,  BELALCAZAR, Andres

Inventor： PASTORE, Joseph, M. ,  SALO, Rodney, W. ,  SPINELLI, Julio, C. ,  SHUROS, Allan, C. ,  BELALCAZAR, Andres

IPC: A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC classification number: A61N1/3627 ,  A61N1/36521 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/3688

Abstract: An implantable pacing device for delivering ventricular pacing may be configured to intermittently reduce the AVD interval for beneficial effect in patients with compromised ventricular function (e.g., HF patients and post-MI patients). The AVD interval may be reduced in an AVD reduction mode, by shortening the AVD in an atrial triggered ventricular pacing mode or by switching to a non-atrial triggered ventricular pacing mode (e.g., VVI) and delivering paces at a rate above the intrinsic rate. The physiological effects of AVD reduction may be either positive or negative on cardiac output, depending upon the individual patient.

Abstract translation: 用于输送心室起搏的可植入起搏装置可以被配置为间歇性地减小AVD间隔，以在患有心室功能受损的患者（例如，HF患者和MI后患者）中产生有益效果。 通过在心房触发的心室起搏模式中缩短AVD或者通过切换到非心房触发的心室起搏模式（例如，VVI）并以高于内在速率的速率递送步进，AVD间期可以减小AVD减小模式 。 取决于个体患者，AVD减少的生理作用可能是心输出量的正或负。