公开(公告)号：WO2017003746A1

公开(公告)日：2017-01-05

申请号：PCT/US2016/038418

申请日：2016-06-20

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： PACETTI, Stephen D. ,  SHEEHY, Alexander J. ,  ABUNASSAR, Chad J.

IPC: A61L31/06 ,  A61L31/10 ,  A61L31/16

CPC classification number: A61F2/915 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/04

Abstract: Stents including a poly(D,L-lactide)(PDLLA)-based scaffold and PDLLA based therapeutic layer are disclosed. The PDLLA based scaffold may be amorphous and may include a primer layer. Methods of applying the PDLLA-based coating to the scaffold are disclosed with solvent processing methods using a solvent blend are also disclosed. Methods of removing residual solvent from a PDLLA-base coating that also condition the scaffold are disclosed. Methods of treating restenosis that release drugs to prevent restenosis without interfering with the natural positive remodeling of a vessel are disclosed.

Abstract translation: 公开了包含基于聚（D，L-丙交酯）（PDLLA）的支架和基于PDLLA的治疗层的支架。 基于PDLLA的支架可以是无定形的，并且可以包括底漆层。 公开了使用溶剂共混物的溶剂处理方法将基于PDLLA的涂层施用于支架的方法。 公开了从处于支架状态的PDLLA基底涂层除去残余溶剂的方法。 公开了治疗释放药物以预防再狭窄而不干扰血管的天然阳性重塑的再狭窄的方法。

公开(公告)号：WO2015195794A2

公开(公告)日：2015-12-23

申请号：PCT/US2015/036216

申请日：2015-06-17

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： MA, Xiao ,  KOSSUTH, Mary, Beth ,  OBERHAUSER, James ,  PACETTI, Stephen, D. ,  GADA, Manish

IPC: A61L31/04

CPC classification number: A61F2/90 ,  A61F2/91 ,  A61L31/041 ,  A61L31/06 ,  A61L31/148

Abstract: Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having thin struts in a selected range and sufficient radial strength to support a vessel upon deployment are disclosed. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.

Abstract translation: 公开了由具有选定范围的薄支柱的聚丙交酯和聚己内酯的组合制成的生物再吸收聚合物血管支架，并具有足够的径向强度以在展开时支撑血管。 支架具有有助于血管愈合的分子量，径向强度和质量的降解行为，包括向容器提供通畅性，降低径向强度，分解和再吸收以允许血管返回到自然状态。

公开(公告)号：WO2013052184A1

公开(公告)日：2013-04-11

申请号：PCT/US2012/043497

申请日：2012-06-21

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  PAPP, John E. ,  TROLLSAS, Mikael ,  DAVALIAN, Dariush ,  WANG, Yunbing ,  HOSSAINY, Syed Faiyaz Ahmed

Inventor： PAPP, John E. ,  TROLLSAS, Mikael ,  DAVALIAN, Dariush ,  WANG, Yunbing ,  HOSSAINY, Syed Faiyaz Ahmed

IPC: A61F2/915

CPC classification number: A61F2/89 ,  A61F2/915 ,  A61F2002/825 ,  A61F2002/828 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2220/005 ,  A61F2230/0013 ,  A61F2230/0054

Abstract: Stent scaffolds that include a polymeric structure or structures bonded to the scaffold and extending along their length are disclosed. The polymeric structure extends across some or all of the gaps in struts along the length of the scaffold. Segmented scaffolds are also disclosed that include two or more axial segments arranged end to end not connected by link sruts.

Abstract translation: 公开了包括结合到支架上并沿其长度延伸的聚合物结构或结构的支架。 聚合物结构沿着支架的长度延伸穿过支柱中的一些或全部间隙。 还公开了分段支架，其包括端对端布置的两个或更多个轴向段，其不被连接部分连接。

公开(公告)号：WO2012051195A1

公开(公告)日：2012-04-19

申请号：PCT/US2011/055792

申请日：2011-10-11

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  OBERHAUSER, James

Inventor： WANG, Yunbing ,  OBERHAUSER, James

IPC: A61L31/06 ,  A61L31/14

CPC classification number: A61F2/82 ,  A61F2/958 ,  A61F2002/9583 ,  A61L31/06 ,  A61L31/148 ,  H01J2237/31 ,  C08L67/04

Abstract: Methods of fabricating an implantable medical devices such as stents made from biodegradable polymers are disclosed that reduce or minimize chain scission and monomer generation during processing steps. The method includes processing a poly(L-lactide) resin having an number average molecular weight between 150 to 200 kD in an extruder in a molten state. A poly(L-lactide) tube is formed from the processed resin and a stent is fabricated from the tube. The number average molecular weight of the poly(L-lactide) of the stent after sterilization is 70 to 100 kD.

Abstract translation: 公开了制造可植入医疗装置的方法，例如由可生物降解的聚合物制成的支架，其可减少或最小化加工步骤期间的链断裂和单体产生。 该方法包括在熔融状态的挤出机中加工数均分子量为150〜200kD的聚（L-丙交酯）树脂。 由处理后的树脂形成聚（L-丙交酯）管，由管制造支架。 灭菌后支架的聚（L-丙交酯）的数均分子量为70〜100kD。

公开(公告)号：WO2011156449A1

公开(公告)日：2011-12-15

申请号：PCT/US2011/039556

申请日：2011-06-08

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  HARRINGTON, Joel ,  VAUGHAN, Ryan ,  JOW, Kevin ,  PIPPEY, William ,  CHEN, Yung-Ming

Inventor： HARRINGTON, Joel ,  VAUGHAN, Ryan ,  JOW, Kevin ,  PIPPEY, William ,  CHEN, Yung-Ming

IPC: B23K26/40 ,  B23K26/06 ,  A61F2/90

CPC classification number: B23K26/402 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2240/001 ,  B23K26/0624 ,  B23K2203/42 ,  B23K2203/50

Abstract: The present invention involves laser machining polymer substrates to form a stent with laser parameters that minimize damage to the substrate in a surface region adjacent to the machined edge surface. The wavelength and pulse width are selected for this unique application and they can be controlled to minimize the surface modifications (such as voids, cracks which are induced by the laser-material interaction) which contribute to the variation in mechanical properties with distance from the edge surface, bulk mechanical properties, or a combination thereof.

Abstract translation: 本发明涉及激光加工聚合物基底以形成具有最小化与邻近加工边缘表面的表面区域中对基底的损伤的激光参数的支架。 选择波长和脉冲宽度用于这种独特的应用，并且它们可以被控制以最小化表面修饰（例如空隙，由激光 - 材料相互作用引起的裂纹），这有助于机械性能随距离边缘的距离的变化 表面，体积机械性能或其组合。

公开(公告)号：WO2011031872A2

公开(公告)日：2011-03-17

申请号：PCT/US2010/048287

申请日：2010-09-09

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  GLAUSER, Thierry ,  GUERIGUIAN, Vincent J. ,  STEICHEN, Bethany ,  OBERHAUSER, James ,  GADA, Manish ,  KLEINER, Lothar

Inventor： GLAUSER, Thierry ,  GUERIGUIAN, Vincent J. ,  STEICHEN, Bethany ,  OBERHAUSER, James ,  GADA, Manish ,  KLEINER, Lothar

IPC: B29C49/08

CPC classification number: B29D22/00 ,  A61F2/91 ,  B29C49/0005 ,  B29C49/02 ,  B29C49/04 ,  B29C49/08 ,  B29C49/78 ,  B29C55/26 ,  B29C2793/009 ,  B29K2995/004 ,  B29K2995/0041 ,  B29K2995/0046 ,  B29K2995/0056 ,  B29K2995/006 ,  B29K2995/0077 ,  B29K2995/0089 ,  B29L2031/7542

Abstract: Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stent manufacture and fabrication of a stent therefrom are disclosed.

Abstract translation: 公开了扩展聚合物管的方法，其具有用于支架制造和制造支架的所需或最佳形态和机械性能。

公开(公告)号：WO2010120532A1

公开(公告)日：2010-10-21

申请号：PCT/US2010/029442

申请日：2010-03-31

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing

Inventor： WANG, Yunbing

IPC: A61F2/92 ,  B29C53/40 ,  B29C55/02 ,  B29C35/16

CPC classification number: B29D23/001 ,  A61F2/92 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2250/0031 ,  B23K2203/42 ,  B23K2203/50 ,  B29C53/40 ,  B29C55/04 ,  B29C2035/1658 ,  B29K2105/24 ,  B29K2995/006 ,  B29L2023/007

Abstract: Methods of fabricating a polymeric stent from a polymer sheet with improved strength, modulus and fracture toughness are disclosed. The methods include stretching the polymer sheet along one or more axes to increase the strength, fracture toughness, and modulus of the polymer along the axis of stretching. The methods further include forming a tubular stent from the stretched sheet. The stent can include a slide-and-lock mechanism that permits the stent to move from a collapsed diameter to an expanded diameter and inhibiting radial recoil from the expanded diameter.

Abstract translation: 公开了从具有改进的强度，模量和断裂韧性的聚合物片制造聚合物支架的方法。 所述方法包括沿着一个或多个轴拉伸聚合物片材以提高聚合物沿着拉伸轴的强度，断裂韧性和模量。 所述方法还包括从拉伸的片材形成管状支架。 支架可以包括滑动和锁定机构，其允许支架从塌缩直径移动到扩张直径并且抑制从扩张直径的径向反冲。

公开(公告)号：WO2009123824A2

公开(公告)日：2009-10-08

申请号：PCT/US2009/036291

申请日：2009-03-06

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing

Inventor： WANG, Yunbing

IPC: A61L31/04

CPC classification number: A61L31/041 ,  A61L31/06 ,  Y10S623/90 ,  C08L67/04

Abstract: The use of nucleating agents to manufacture polymeric stents is disclosed. The resulting stents may have increased crystallinity, decreased crystal size, increased mechanical properties, and faster degradation times.

Abstract translation: 公开了使用成核剂制造聚合物支架。 所得的支架可能具有增加的结晶度，减小的晶体尺寸，增加的机械性能和更快的降解时间。

公开(公告)号：WO2008151299A3

公开(公告)日：2008-12-11

申请号：PCT/US2008/065981

申请日：2008-06-05

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  KRAMER-BROWN, Pamela, A. ,  GALE, David, C. ,  KLEINER, Lothar, Walter ,  ASTAFIEVA, Irina ,  CHIU, Jessica ,  LUDWIG, Florian, N.

Inventor： KRAMER-BROWN, Pamela, A. ,  GALE, David, C. ,  KLEINER, Lothar, Walter ,  ASTAFIEVA, Irina ,  CHIU, Jessica ,  LUDWIG, Florian, N.

IPC: A61L31/02 ,  A61L31/16 ,  A61L31/14

Abstract: Implantable medical devices adapted to erodibly release delivery media for local and regional treatment are disclosed.

公开(公告)号：WO2008076847A3

公开(公告)日：2008-06-26

申请号：PCT/US2007/087487

申请日：2007-12-13

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  PACETTI, Stephen, D. ,  CONSIGNY, Paul ,  HEIL, Ronald, W. ,  LUDWIG, Florian, N. ,  DAVALIAN, Dariush ,  ZHAO, Li ,  ASTAFIEVA, Irina ,  WAN, Jinping ,  EL-NOUNOU, Fozan ,  MURASE, Katsuyuki ,  HOSSAINY, Syed, Faiyaz Ahmed ,  BRIGHT, Rachel ,  ELLIS, Jeffrey

Inventor： PACETTI, Stephen, D. ,  CONSIGNY, Paul ,  HEIL, Ronald, W. ,  LUDWIG, Florian, N. ,  DAVALIAN, Dariush ,  ZHAO, Li ,  ASTAFIEVA, Irina ,  WAN, Jinping ,  EL-NOUNOU, Fozan ,  MURASE, Katsuyuki ,  HOSSAINY, Syed, Faiyaz Ahmed ,  BRIGHT, Rachel ,  ELLIS, Jeffrey

IPC: A61M29/02 ,  A61F2/84 ,  A61F2/82

Abstract: The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.