公开(公告)号：WO2022178420A1

公开(公告)日：2022-08-25

申请号：PCT/US2022/017312

申请日：2022-02-22

Applicant: GRAVITON BIOSCIENCE BV

Inventor： WAKSAL, Samuel D. ,  WU, Rui

IPC: A01K67/027 ,  A61K31/4409 ,  A61P3/04

Abstract: The disclosure provides compositions and methods comprising selective inhibitors of Rho-associated coiled-coil kinase 2 (ROCK2) for use in the treatment of viral infections, particularly coronavirus infections such as SARS-CoV-2, and in the treatment of sequelae resulting from the viral infection, including sequelae resulting from coronavirus infection.

公开(公告)号：WO2020118295A1

公开(公告)日：2020-06-11

申请号：PCT/US2019/065212

申请日：2019-12-09

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  SYNTOLOGIC PHARMACEUTICALS, INC.

Inventor： BLUMBERG, Richard S. ,  HUANG, Yu-Hwa ,  GANDHI, Amit ,  BERTAGNOLLI, Monica ,  YOON, Charles ,  HOLGATE, Robert George Edward ,  HEARN, Arron Robert ,  JONES, Susan Dana

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395

Abstract: Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer.

公开(公告)号：WO2019199860A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/026627

申请日：2019-04-09

Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Inventor： LIN, Richard

IPC: A61K31/6615 ,  A61K31/683 ,  A61K38/00

Abstract: The present invention relates to the field of cancer biology and immunology. More specifically, the present invention relates to the use of genetically modified immune cells in combination with certain chemotherapeutic agents for the treatment of cancer, wherein the genetically modified immune cells are resistant to said chemotherapeutic agents.

公开(公告)号：WO2017136608A2

公开(公告)日：2017-08-10

申请号：PCT/US2017/016303

申请日：2017-02-02

Applicant: MEIRAGTX UK II LIMITED ,  MEIRAGTX, LLC

Inventor： VOLLES, Michael, J. ,  DANOS, Olivier, F. ,  BOYNE, Alex, K. ,  ZENNOU, Veronique ,  GUO, Xuecui

IPC: A61K48/00 ,  C12N15/861

CPC classification number: C12N15/85 ,  C12N15/111 ,  C12N15/63 ,  C12N2310/121 ,  C12N2310/16 ,  C12N2310/3519 ,  C12N2830/50

Abstract: The invention provides polynucleotide constructs for the regulation of gene expression by aptamer-based modulation of self-cleaving ribozymes and methods of using the constructs to regulate gene expression in response to the presence or absence of a ligand that binds the aptamer. The invention further provides methods for making and using riboswitches that decrease target gene expression in response to an aptamer ligand as well as riboswitches that increase target gene expression in response to an aptamer ligand.

Abstract translation: 本发明提供了用于通过基于适体的自我剪切核酶的调节来调节基因表达的多核苷酸构建体，以及使用该构建体响应存在或不存在配体的基因表达的方法 绑定适配子。 本发明进一步提供制备和使用响应于适体配体而降低靶基因表达的核糖开关的方法以及响应于适体配体而增加靶基因表达的核糖开关的方法。

公开(公告)号：WO2017106609A2

公开(公告)日：2017-06-22

申请号：PCT/US2016/067115

申请日：2016-12-16

Applicant: KADMON CORPORATION, LLC.

Inventor： LU, Dan

CPC classification number: C07K16/2863 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/76

Abstract: Provided herein are antibody agents that bind to PDGFRβ. Provided herein are also isolated nucleic acids encoding antibody agents that bind to PDGFRβ, nucleic acid vectors and prokaryotic or eukaryotic host cells including such isolated nucleic acids, as well as compositions including and methods of using such antibody agents.

Abstract translation: 本文提供了结合PDGFRβ的抗体药物。 本文还提供了编码结合PDGFRβ的抗体物质的分离的核酸，核酸载体和包括此类分离的核酸的原核或真核宿主细胞，以及包括和使用此类抗体剂的方法的组合物。

公开(公告)号：WO2016154135A1

公开(公告)日：2016-09-29

申请号：PCT/US2016/023457

申请日：2016-03-21

Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Inventor： SAMPSON, Nicole, S. ,  TAN, Li ,  PARKER, Kathlyn

IPC: C08F232/04 ,  C08F232/08

CPC classification number: C08G61/08 ,  B01J31/2265 ,  C07C13/06 ,  C07C13/18 ,  C07C13/32 ,  C08F232/04 ,  C08G2261/124 ,  C08G2261/1426 ,  C08G2261/3323 ,  C08G2261/3325 ,  C08G2261/418 ,  C09D165/00

Abstract: This invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. Specifically, the present invention provides a polymer comprising rigorously alternating AB subunits and methods of formation of the AB alternating polymers. In the polymers and process of the invention, the A monomer is derived from a cyclobutene derivative, and the B monomer is derived from a cyclohexene derivative. The polymerization takes place in the presence of an olefin metathesis catalyst.

Abstract translation: 本发明涉及聚合物和烯烃聚合领域，更具体地涉及烯烃易位聚合。 具体地，本发明提供了包含严格交替的AB亚基的聚合物和AB交替聚合物的形成方法。 在本发明的聚合物和方法中，A单体衍生自环丁烯衍生物，B单体衍生自环己烯衍生物。 聚合在烯烃复分解催化剂存在下进行。

公开(公告)号：WO2016073901A1

公开(公告)日：2016-05-12

申请号：PCT/US2015/059548

申请日：2015-11-06

Applicant: WILSON, Tristan, Victor

Inventor： WILSON, Tristan, Victor

IPC: C02F3/32

CPC classification number: A01G33/00 ,  A01G7/045 ,  A01G31/02 ,  A01K63/006 ,  A01K63/06 ,  A01K63/065 ,  C12M21/02 ,  C12M23/38 ,  C12M31/10 ,  C12M41/18 ,  F21V15/01 ,  F21V29/51 ,  F21V29/58 ,  F21V29/89 ,  F21Y2101/00 ,  F21Y2103/00 ,  F21Y2103/10 ,  F21Y2103/30 ,  F21Y2115/10 ,  F28D15/02 ,  F28D15/04

Abstract: The invention features a bioreactor for the growth of macroalgae and methods for using the bioreactor to maintain optimal nutrient levels for the organisms in an aquarium or aquaculture system. The devices and methods of the invention provide for the bioremediation of excess nutrients in order to maintain nutrient balance in an aquarium or aquaculture system that facilitates growth and/or health of one or more of the organisms that reside therein.

Abstract translation: 本发明的特征在于用于大型藻类生长的生物反应器和使用生物反应器维持水族箱或水产养殖系统中生物体的最佳养分水平的方法。 本发明的装置和方法提供过量营养物质的生物修复，以便维持养鱼系统中的养分平衡，促进其中存在的一种或多种生物体的生长和/或健康。

公开(公告)号：WO2015157556A1

公开(公告)日：2015-10-15

申请号：PCT/US2015/025176

申请日：2015-04-09

Applicant: KADMON CORPORATION, LLC ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： ZANIN-ZHOROV, Alexandra ,  BLAZAR, Bruce, Robert ,  FLYNN, Ryan

IPC: A61P37/00 ,  C07D239/86 ,  A61K31/416

CPC classification number: A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  C07D239/30 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The invention relates to treatment of graft versus host disease (GVHD) using compounds that inhibit ROCK2. In preferred aspects, the present invention provides methods for the treatment of GVHD, including chronic GVHD ( cGVHD) using compounds having the formulae l-XXV, as set forth herein.

Abstract translation: 本发明涉及使用抑制ROCK2的化合物治疗移植物抗宿主病（GVHD）。 在优选方面，本发明提供使用如本文所述的具有式I-XXV的化合物治疗GVHD的方法，包括慢性GVHD（cGVHD）。

公开(公告)号：WO2014004409A2

公开(公告)日：2014-01-03

申请号：PCT/US2013/047435

申请日：2013-06-24

Applicant: NEOSTEM, INC ,  UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. ,  RATAJCZAK, Mariusz ,  RATAJCZAK, Janina ,  KUCIA, Magdalena

Inventor： RATAJCZAK, Mariusz ,  RATAJCZAK, Janina ,  KUCIA, Magdalena ,  RODGERSON, Denis

IPC: A61K35/12

CPC classification number: A61K35/48 ,  A61K35/28 ,  C12N5/0607 ,  C12N5/0669

Abstract: The invention provides adult pluripotent stem cells (PSC) for treatment or prophylaxis for radiological exposure. In an embodiment of the invention, the cells are very small embryonic like stem cells (VSELs). The VSELs can be used to rescue the hematopoietic and immune systems of individuals suffering from the delayed effects of acute radiation syndrome (ARS).

Abstract translation: 本发明提供用于治疗或预防放射性暴露的成人多能干细胞（PSC）。 在本发明的一个实施方案中，细胞是非常小的胚胎样干细胞（VSEL）。 VSEL​​可用于拯救患有急性放射综合征（ARS）延迟作用的个体的造血和免疫系统。

公开(公告)号：WO2010014113A1

公开(公告)日：2010-02-04

申请号：PCT/US2008/071995

申请日：2008-08-01

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  PILE-SPELLMAN, John ,  LIN, Erwin

Inventor： PILE-SPELLMAN, John ,  LIN, Erwin

IPC: A61B5/05

CPC classification number: A61B5/055 ,  A61B5/01 ,  A61B5/412

Abstract: A method and apparatus for determining a temperature differential at a portion of a patient's body utilizing temperature sensitive MRI measurements. A diagnostic fluid bolus is administered into a blood vessel of the patient, wherein the diagnostic fluid bolus has a diagnostic fluid bolus temperature waveform. MRI measurements are used to determine the thermodiluted temperature waveform of the diagnostic fluid bolus at a target site in the body spaced away from the administration site. The temperature differential may be used to determine a cardiovascular parameter.

Abstract translation: 一种用于使用温度敏感的MRI测量来确定患者身体的一部分的温度差的方法和装置。 将诊断性流体推注施用于患者的血管，其中所述诊断性流体推注具有诊断性流体推注温度波形。 使用MRI测量来确定身体远离给药部位的身体目标部位的诊断性液体药丸的热稀释温度波形。 温差可用于确定心血管参数。