公开(公告)号：WO2022251089A1

公开(公告)日：2022-12-01

申请号：PCT/US2022/030472

申请日：2022-05-23

Applicant: TWENTY TWENTY THERAPEUTICS LLC

Inventor： TUMLINSON, Alexandre R. ,  KAPLAN, Ellen

IPC: A61B10/00 ,  A61B10/02 ,  A61M5/34 ,  A61F9/00 ,  B65D51/00 ,  A61B10/0045 ,  A61B10/0096 ,  A61B10/0283 ,  A61F9/0008 ,  A61J1/1406 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2096 ,  A61M2205/582 ,  A61M5/3146 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/345 ,  B65D51/002

Abstract: A sampling device includes a container having a body defining a chamber and an opening to the chamber. A septum is bonded to the container to cover the opening and hermetically seal the chamber. The septum has an adherent layer with a first thickness and including a material configured to adhere to a rim of the container to provide a hermetic seal with the container. A metallic foil layer having a second thickness is coupled to the adherent layer. An elastomeric layer having a third thickness is coupled to the metallic foil layer to position the metallic foil layer between the adherent layer and the elastomeric layer. The third thickness is greater than the sum of the first thickness and the second thickness.

公开(公告)号：WO2022225719A1

公开(公告)日：2022-10-27

申请号：PCT/US2022/023854

申请日：2022-04-07

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： FLEISCHMAN, Aaron

IPC: B06B1/02 ,  B06B1/06 ,  H01L41/193 ,  H01L41/333

Abstract: High-resolution intravascular ultrasound (H-IVUS) operates under a large acoustic bandwidth, provides high resolution while maintaining good depth penetration, and exhibits other favorable characteristics like focused imaging. A H-IVUS transducer assembly can be manufactured at a low cost using conventional methods commonly utilized in the microelectronics industry. The H-IVUS transducer assembly can include a printed circuit having one or more electrical signal conditioners. One or more convertors made of a polymer and configured to convert electrical energy to acoustic energy and acoustic energy to electrical energy can be formed in place away from the printed circuit. After construction, the one or more formed in place convertors are interfaced to the printed circuit with at least a conductive material.

公开(公告)号：WO2022056370A1

公开(公告)日：2022-03-17

申请号：PCT/US2021/050050

申请日：2021-09-13

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  THE GENERAL HOSPITAL CORPORATION

Inventor： SHAFIEE, Hadi ,  BORMANN, Charles ,  KANAKASABAPATHY, Manoj Kumar ,  THIRUMALARAJU, Prudhvi

IPC: A61B5/00

Abstract: Systems and methods are provided for determining a clinical parameter representing the location of interest within a reproductive cellular structure. An image of the reproductive cellular structure is obtained and provided to a neural network to generate the clinical parameter. The clinical parameter is stored on a non-transitory computer readable medium.

公开(公告)号：WO2022051476A1

公开(公告)日：2022-03-10

申请号：PCT/US2021/048839

申请日：2021-09-02

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  THE GENERAL HOSPITAL CORPORATION ,  KATHAROS LABORATORIES, LLC

Inventor： KARP, Jeffrey M. ,  HYUN, Chulho ,  SAMIR, Anthony Edward ,  YANG, Kisuk ,  GORDON, Steven

IPC: A41D13/11 ,  A61M16/06 ,  A62B23/02

Abstract: Provided herein is a face mask that has a flexible filter body that is configured to fit over at least the mouth and the nose of a wearer. The face mask includes a shape-preserving strip extending along the periphery of the filter body. The shape-preserving strip is integral with the filter body and is configured to sufficiently seal the face mask against the wearer's face to minimize or prevent entry and/or exit of airborne particulate matter.

公开(公告)号：WO2022046901A1

公开(公告)日：2022-03-03

申请号：PCT/US2021/047545

申请日：2021-08-25

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： CHIODO, Christopher P. ,  MICHALSKI, Max

IPC: A61B17/86

Abstract: A helical bone fixation screw is provided. The bone fixation device can be an intramedullary fixation device that can be used for bone fracture or osteotomy stabilization Specifically, the device can be used to stabilize and/or compress two or more bone fragments or segments. The helical bone fixation screw has a plurality of threads with a leading end and a trailing end. The pitch between the plurality of threads is non-uniform and the bone fixation screw lacks a central longitudinally extending shaft about which the plurality of threads is disposed.

公开(公告)号：WO2022035728A1

公开(公告)日：2022-02-17

申请号：PCT/US2021/045153

申请日：2021-08-09

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： NAVIA, Jose ,  KAPADIA, Samir ,  HOVEST, Torey ,  GEOFFRION, Richard ,  FARNAN, Robert

IPC: A61F2/24

Abstract: An apparatus for partially supporting a leaflet of a regurgitant heart valve includes at least one subvalvular device including a subvalvular supporting portion and an anchor portion. The subvalvular supporting portion and anchor portion are each at least partially formed from at least one of braided mesh strands of a first configuration, braided mesh strands of a second configuration, a balloon, a plurality of longitudinally extending struts, and a plurality of laterally extending struts. A connector neck is interposed longitudinally between, and is attached to both of, the subvalvular supporting portion and the anchor portion. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.

公开(公告)号：WO2022016132A1

公开(公告)日：2022-01-20

申请号：PCT/US2021/042114

申请日：2021-07-17

Applicant: JELLISEE OPHTHALMICS INC.

Inventor： ELLIS, Forrest J.

IPC: A61F2/16

Abstract: An intraocular lens (IOL) with a shape-changing optic is provided. The IOL includes an anterior face and/or a posterior face that is fabricated from a poly(dimethylsiloxane) elastomer having a durometer between about 30 Shore A to about 50 Shore A. A chamber is located between the anterior face and the posterior face and includes a silicone oil including diphenyl siloxane and dimethyl siloxane units. The silicone oil has a maximum viscosity of about 700 mm2/s at 25°C and has a mean molecular weight of less than about 3,000 Daltons. An IOL is also provided that includes an anterior face and/or posterior face that is fabricated from a polysiloxane that is at least 99% poly(dimethylsiloxane) elastomer.

公开(公告)号：WO2022011054A1

公开(公告)日：2022-01-13

申请号：PCT/US2021/040750

申请日：2021-07-07

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： VARADARAJAN, Kartik Mangudi ,  BORJALI, Alireza ,  ESFAHANI, Soheil Ashkani ,  LUBBERTS, Bart ,  WARYASZ, Gregory R. ,  DIGIOVANNI, Christopher W. ,  MURATOGLU, Orhun K. ,  GUSS, Daniel

IPC: A61B5/00

Abstract: Systems and methods are provided for evaluating a stability of a joint within the foot and ankle complex of a subject. The subject is instructed to assume a position in which the joint is bearing weight, and a three-dimensional medical image of the joint comprising a sequence of two-dimensional image slices is captured at a scanner. The sequence of two-dimensional image slices is provided to a predictive model, comprising an artificial neural network having at least one convolutional layer. A clinical parameter representing the stability of the joint at the predictive model is determined from at least the sequence of two-dimensional image slices.

公开(公告)号：WO2022010601A1

公开(公告)日：2022-01-13

申请号：PCT/US2021/035754

申请日：2021-06-03

Applicant: VANDERBILT UNIVERSITY

Inventor： HIGDON, Kent K. ,  BRAUN, Stephane A.

IPC: A61B17/11 ,  A61B17/064 ,  A61B17/115 ,  B23P11/00 ,  A61B2017/1107 ,  A61B2017/1132

Abstract: An apparatus for anastomosing a cut vessel is provided. The apparatus includes a first ring having an inner surface that defines inner lumen. The inner lumen is configured to receive a first vessel end of the cut vessel. The inner surface of the first ring has at least one spike configured to penetrate the first vessel end and secure the first ring to the first vessel end. A second ring has an inner surface defining an inner lumen configured to receive a second vessel end of the cut vessel. The inner surface of the second ring has at least one spike configured to penetrate the second vessel end and secure the second ring to the second vessel end. The first and second rings, after being secured to the first and second vessel ends, are configured to be joined together into direct engagement to anastomose the cut vessel.

公开(公告)号：WO2021183501A1

公开(公告)日：2021-09-16

申请号：PCT/US2021/021490

申请日：2021-03-09

Applicant: VANDERBILT UNIVERSITY ,  VIRTUOSO SURGICAL, INC.

Inventor： AMANOV, Ernar ,  ROPELLA, Dominick ,  NIMMAGADDA, Naren ,  KAVOUSSI, Nicholas ,  DILLON, Neal ,  HENDRICK, Richard ,  HERRELL, Stanley ,  WEBSTER, Robert

IPC: A61B17/00 ,  A61B17/04 ,  A61B17/32 ,  A61B1/00 ,  A61B1/04

Abstract: A surgical system, method, and apparatus for suturing a first anatomical structure to a second anatomical structure of a subject includes an endoscope tube for being advanced through a lumen of the first anatomical structure to a surgical site near the second anatomical structure. A manipulator arm extends through the endoscope tube to the surgical site, and includes a first concentric tube manipulator with an end effector configured to grasp and manipulate a suture at the surgical site. A needle arm extends through the endoscope tube to the surgical site, and includes a second concentric tube manipulator with a needle tip configured to pierce the tissue of the first and second anatomical structures. The needle arm is also configured to grasp the suture and to retract and pull the suture through the pierced tissue so that the suture extends through and forms stitching that stitches together the first and second anatomical structures.