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公开(公告)号：WO2005113832A2
公开(公告)日：2005-12-01
申请号：PCT/US2005017891
申请日：2005-05-20
Applicant: UNIV CALIFORNIA , ALBERTSON DONNA G , PINKEL DANIEL
Inventor： ALBERTSON DONNA G , PINKEL DANIEL
CPC classification number: G02B21/365 , C12M41/36 , G01N21/6452 , G01N2021/6463 , G02B21/08 , G02B27/0018 , G02B2207/113
Abstract: This invention provides an imaging system for high-accuracy quantitative analysis of a microarray. In certain embodiments, the system comprises a broad band excitation light source that provides Kohler illumination of said microarray at an incident angle that ranges from about 30 degrees to about 75 degrees from the normal to the microarray, and that has less than about ± 25 percent variation in intensity over the array at all wavelengths ranging from 400 to 800 nm; a support for holding a microarray; a detection lens system that is chromatically corrected so the apparent position of the microarray or a feature comprising the microarray varies by less than 10 µm as the detection wavelength varies from about 400 to about 800 nm; and a detection device for detecting and optionally recording an image produced by said detection lens system.
Abstract translation: 本发明提供了一种用于微阵列的高精度定量分析的成像系统。 在某些实施方案中，该系统包括宽带激发光源，其以距离微阵列的法线约30度至约75度的入射角度提供所述微阵列的科勒照明，并且具有小于约±25％ 在400至800 nm范围内的所有波长阵列上的强度变化; 支持持有微阵列; 检测透镜系统被校正为使得当检测波长从约400至约800nm变化时，微阵列的表观位置或包含微阵列的特征变化小于10μm; 以及用于检测和可选地记录由所述检测透镜系统产生的图像的检测装置。
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公开(公告)号：WO2003003277A2
公开(公告)日：2003-01-09
申请号：PCT/US2002/020766
申请日：2002-06-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PINKEL, Daniel , ALBERTSON, Donna, G. , GRAY, Joe, W. , HAMILTON, Greg , BROWN, Nils, W. , CLARK, Steven, M. , HANSON, John
Inventor： PINKEL, Daniel , ALBERTSON, Donna, G. , GRAY, Joe, W. , HAMILTON, Greg , BROWN, Nils, W. , CLARK, Steven, M. , HANSON, John
IPC: G06K
CPC classification number: B41J2/25 , B41J2/005 , C12Q1/6837 , Y10T436/119163 , Y10T436/143333 , Y10T436/2575 , C12Q2565/507
Abstract: This invention provides improved components (e.g. array "pins", print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries diposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direcion parallel to the long axis of the capillaries.
Abstract translation: 本发明提供了用于微阵列印刷装置的改进的部件（例如阵列“销”，印刷头，衬底台板，印刷头台板等）以及包含这些部件的微阵列印刷装置。 在一个实施方案中，本发明提供了一种微阵列印刷头，其包括放置在支撑物中的多个玻璃或石英点样毛细管，该毛细管保持点样毛细管之间的固定间距，并且允许点样毛细管沿着平行于 毛细血管。
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3.发明申请
公开(公告)号：WO0065092A3
公开(公告)日：2001-07-19
申请号：PCT/US0010873
申请日：2000-04-21
Applicant: SCIENCE & TECHNOLOGY CORP , UNIV NEW MEXICO , THOMPSON CURTIS T , SPIDLE JOSEPH A , ALBERTSON DONNA G , SEGRAVES RICK
Inventor： THOMPSON CURTIS T , SPIDLE JOSEPH A , ALBERTSON DONNA G , SEGRAVES RICK
CPC classification number: C12Q1/689 , C12Q1/6806 , G01N1/312 , C12Q2527/125
Abstract: This invention provides novel methods for detecting microorganisms is biological samples. The methods utilize in situ hybridization techniques. In one preferred embodiment, the methods involve blocking binding of nucleic acid probe(s) to granulocytes. The method typically involves contacting a biological sample with a nucleic acid probe that specifically hybridizes under stringent conditions to a nucleic acid of a microorganism and a blocking reagent that is a non-coding nucleic acid, washing the biological sample to remove probe that is not hybridized to a nucleic acid of the microorganism, and detecting the probe where the presence of remaining probe indicates the presence of the microorganism.
Abstract translation: 本发明提供了检测微生物的新方法是生物样品。 该方法利用原位杂交技术。 在一个优选的实施方案中，所述方法包括阻断核酸探针与粒细胞的结合。 该方法通常包括使生物样品与在严格条件下与微生物核酸和作为非编码核酸的封闭试剂特异性杂交的核酸探针接触，洗涤生物样品以除去未杂交的探针 涉及微生物的核酸，并检测其中存在的探针表明存在微生物的探针。
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4.发明申请MOLECULAR SUBTYPING OF ORAL SQUAMOUS CELL CARCINOMA TO DISTINGUISH A SUBTYPE THAT IS UNLIKELY TO METASTASIZE 审中-公开口腔鳞状细胞癌的分子分型鉴别子类型对于转移不敏感
公开(公告)号：WO2012018397A3
公开(公告)日：2012-04-26
申请号：PCT/US2011001377
申请日：2011-08-02
Applicant: UNIV CALIFORNIA , ALBERTSON DONNA G , SCHMIDT BRIAN L , BHATTACHARYA ADITI , OLSHEN ADAM B
Inventor： ALBERTSON DONNA G , SCHMIDT BRIAN L , BHATTACHARYA ADITI , OLSHEN ADAM B
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16
Abstract: The present invention provides methods of analyzing a sample from a subject having oral epithelial dysplasia or oral SCC or suspected of having oral epithelial dysplasia or oral SCC.
Abstract translation: 本发明提供了分析来自患有口腔上皮发育异常或口腔SCC或怀疑患有口腔上皮发育不良或口腔SCC的受试者的样品的方法。
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公开(公告)号：WO2005113832A3
公开(公告)日：2005-12-01
申请号：PCT/US2005/017891
申请日：2005-05-20
Inventor： ALBERTSON, Donna, G. , PINKEL, Daniel
Abstract: This invention provides an imaging system for high-accuracy quantitative analysis of a microarray. In certain embodiments, the system comprises a broad band excitation light source that provides Kohler illumination of said microarray at an incident angle that ranges from about 30 degrees to about 75 degrees from the normal to the microarray, and that has less than about ± 25 percent variation in intensity over the array at all wavelengths ranging from 400 to 800 nm; a support for holding a microarray; a detection lens system that is chromatically corrected so the apparent position of the microarray or a feature comprising the microarray varies by less than 10 µm as the detection wavelength varies from about 400 to about 800 nm; and a detection device for detecting and optionally recording an image produced by said detection lens system.
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Patent Agency Ranking6.发明申请
公开(公告)号：WO0065092A9
公开(公告)日：2001-09-20
申请号：PCT/US0010873
申请日：2000-04-21
Applicant: SCIENCE & TECHNOLOGY CORP , UNIV NEW MEXICO , THOMPSON CURTIS T , SPIDLE JOSEPH A , ALBERTSON DONNA G , SEGRAVES RICK
Inventor： THOMPSON CURTIS T , SPIDLE JOSEPH A , ALBERTSON DONNA G , SEGRAVES RICK
CPC classification number: C12Q1/689 , C12Q1/6806 , G01N1/312 , C12Q2527/125
Abstract: This invention provides novel methods for detecting microorganisms is biological samples. The methods utilize in situ hybridization techniques. In one preferred embodiment, the methods involve blocking binding of nucleic acid probe(s) to granulocytes. The method typically involves contacting a biological sample with a nucleic acid probe that specifically hybridizes under stringent conditions to a nucleic acid of a microorganism and a blocking reagent that is a non-coding nucleic acid, washing the biological sample to remove probe that is not hybridized to a nucleic acid of the microorganism, and detecting the probe where the presence of remaining probe indicates the presence of the microorganism.
Abstract translation: 本发明提供了检测微生物的新方法是生物样品。 这些方法利用原位杂交技术。 在一个优选的实施方案中，所述方法涉及阻断核酸探针与粒细胞的结合。 该方法通常包括使生物样品与在严格条件下与微生物的核酸和作为非编码核酸的封闭剂特异性杂交的核酸探针接触，洗涤生物样品以除去未杂交的探针 与微生物的核酸结合，并在剩余探针的存在表明存在微生物的情况下检测探针。
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7.发明申请MOLECULAR SUBTYPING OF ORAL SQUAMOUS CELL CARCINOMA TO DISTINGUISH A SUBTYPE THAT IS UNLIKELY TO METASTASIZE 审中-公开口腔鳞状细胞癌的分子分型鉴定为不能进行METASTASIZE的亚型
公开(公告)号：WO2012018397A2
公开(公告)日：2012-02-09
申请号：PCT/US2011/001377
申请日：2011-08-02
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ALBERTSON, Donna G. , SCHMIDT, Brian L. , BHATTACHARYA, Aditi , OLSHEN, Adam B.
Inventor： ALBERTSON, Donna G. , SCHMIDT, Brian L. , BHATTACHARYA, Aditi , OLSHEN, Adam B.
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16
Abstract: The present invention provides methods of analyzing a sample from a subject having oral epithelial dysplasia or oral SCC or suspected of having oral epithelial dysplasia or oral SCC.
Abstract translation: 本发明提供了分析来自具有口腔上皮发育异常或口服SCC或怀疑具有口腔上皮发育不良或口服SCC的受试者的样品的方法。
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8.发明申请DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES BY COMPARATIVE GENOMIC HYBRIDIZATION 审中-公开通过比较基因组杂交检测核酸序列差异
公开(公告)号：WO2005079474A3
公开(公告)日：2006-12-14
申请号：PCT/US2005005131
申请日：2005-02-17
Applicant: UNIV CALIFORNIA , ALBERTSON DONNA G , PINKEL DANIEL , FRIDYLAND JANE , HUEY BING , SNIJDERS ANTOINE
Inventor： ALBERTSON DONNA G , PINKEL DANIEL , FRIDYLAND JANE , HUEY BING , SNIJDERS ANTOINE
CPC classification number: C12Q1/6809
Abstract: The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to analyze the sequence differences between the samples. This method permits the identification of small sequence differences (e.g., sequence divergence of 1 % or less) in nucleic acid samples of high complexity (e.g., an entire genome).
Abstract translation: 本发明提供了检测两个核酸样品之间的核苷酸序列差异的方法。 该方法采用比较基因组杂交（CGH）技术分析样品间的序列差异。 该方法允许在高复杂度的核酸样品（例如，整个基因组）中鉴定小序列差异（例如，1％或更少的序列发散）。
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9.发明申请DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES BY COMPARATIVE GENOMIC HYBRIDIZATION 审中-公开通过比较基因组杂交检测核酸序列差异
公开(公告)号：WO2005079474A2
公开(公告)日：2005-09-01
申请号：PCT/US2005/005131
申请日：2005-02-17
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ALBERTSON, Donna, G. , PINKEL, Daniel , FRIDYLAND, Jane , HUEY, Bing , SNIJDERS, Antoine
Inventor： ALBERTSON, Donna, G. , PINKEL, Daniel , FRIDYLAND, Jane , HUEY, Bing , SNIJDERS, Antoine
IPC: C12Q1/68
CPC classification number: C12Q1/6809
Abstract: The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to analyze the sequence differences between the samples. This method permits the identification of small sequence differences (e.g., sequence divergence of 1 % or less) in nucleic acid samples of high complexity (e.g., an entire genome).
Abstract translation: 本发明提供了检测两个核酸样品之间的核苷酸序列差异的方法。 该方法采用比较基因组杂交（CGH）技术分析样品间的序列差异。 该方法允许在高复杂度的核酸样品（例如，整个基因组）中鉴定小序列差异（例如，1％或更少的序列差异）。
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公开(公告)号：WO03003277A3
公开(公告)日：2003-04-03
申请号：PCT/US0220766
申请日：2002-06-27
Applicant: UNIV CALIFORNIA , PINKEL DANIEL , ALBERTSON DONNA G , GRAY JOE W , HAMILTON GREG , BROWN NILS W , CLARK STEVEN M , HANSON JOHN
Inventor： PINKEL DANIEL , ALBERTSON DONNA G , GRAY JOE W , HAMILTON GREG , BROWN NILS W , CLARK STEVEN M , HANSON JOHN
CPC classification number: B41J2/25 , B41J2/005 , C12Q1/6837 , Y10T436/119163 , Y10T436/143333 , Y10T436/2575 , C12Q2565/507
Abstract: This invention provides improved components (e.g. array "pins", print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries diposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direcion parallel to the long axis of the capillaries.
Abstract translation: 本发明提供了用于微阵列打印装置的改进的组件（例如，阵列“针”，打印头，基板压板，打印头压板等）以及并入这些组件的微阵列打印装置。 在一个实施方案中，本发明提供了一种微阵列打印头，其包含多个玻璃或石英斑点毛细管，所述毛细管浸入到支撑体中，所述毛细管在所述点样毛细管之间保持固定的间隔，并允许所述毛细管点样平行于所述长轴 毛细血管
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