BROWN ADIPOCYTE MODIFICATION
    5.
    发明申请
    BROWN ADIPOCYTE MODIFICATION 审中-公开
    棕色脂肪细胞修饰

    公开(公告)号:WO2012092049A2

    公开(公告)日:2012-07-05

    申请号:PCT/US2011/066358

    申请日:2011-12-21

    Abstract: Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.

    Abstract translation: 提供了通过增加棕色脂肪组织的活化来治疗代谢紊乱的方法和治疗剂。 通常,所述方法和治疗剂可以增加棕色脂肪组织的活化,以增加能量消耗并诱导体重减轻。 在一个实施方案中,用于增加棕色脂肪组织活化的方法包括修饰棕色脂肪细胞以表达激活棕色脂肪细胞的基因,例如解偶联蛋白1.在另一个实施方案中,用于增加棕色脂肪组织活化的方法包括增加褐色 脂肪细胞。 这可以通过诱导体内脂肪细胞增殖或体外扩增脂肪细胞,将脂肪细胞移植到棕色脂肪组织贮库或其它地方并诱导脂肪细胞祖细胞例如MSC,脂肪细胞祖细胞,前脂肪细胞和脂肪细胞前体细胞的分化来实现。

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