公开(公告)号：WO2014016816A2

公开(公告)日：2014-01-30

申请号：PCT/IB2013056218

申请日：2013-07-29

Applicant: ASS FOR THE ADVANCEMENT OF TISSUE ENGINEERING AND CELL BASED TECHNOLOGIES AND THERAPIES A4TEC

Inventor： PEREIRA MARTINS ALBINO MANUEL ,  SOUSA DIAS ALVES DA SILVA MARTA LUISA ,  GONCALVES DOS REIS RUI LUIS ,  MELEIRO ALVES DAS NEVES NUNO JOAO

IPC: A61L27/18

CPC classification number: A61L27/58 ,  A61L15/20 ,  A61L15/225 ,  A61L15/26 ,  A61L15/28 ,  A61L15/64 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/54 ,  A61L27/56 ,  A61L27/60 ,  A61L2300/406 ,  A61L2430/06 ,  A61L2430/10 ,  A61L2430/12 ,  A61L2430/22

Abstract: The present application describes a polymeric mesh for the repair and regeneration of tissues from an organism that comprises pores wherein at least 70% of the pores of the said mesh have a size smaller than the one required to confine the cells of the said tissues, and wherein at least 70% of the pores of the said mesh has a size superior than the one needed for the passage of interstitial fluids of the said tissues; the degradation time of the said polymeric mesh within the organism is at least 8 weeks; the said polymeric mesh has an apparent tensile strength superior than 1 MPa; the said polymeric mesh has an apparent elastic modulus superior than 0.1 MPa. The mesh described in this application allows that the "new tissue" formed presents very similar properties to the ones of the damaged tissue. Thus, the polymeric mesh for the repair and regeneration of tissues described in this application can be used in medicine in combination or not with surgical methods, namely in the treatment of diseases that involve the repair and regeneration of tissues, particularly when the tissue to treat is cartilage, periodontal ligament, esophagus or skin.

Abstract translation: 本申请描述了用于修复和再生来自包含孔的生物体的组织的聚合物网状物，其中所述网状物的至少70％的孔的尺寸小于限制所述组织的细胞所需的尺寸，并且 其中所述网的至少70％的孔的尺寸大于所述组织的间质流体通过所需的尺寸; 所述聚合物网状物在生物体内的降解时间为至少8周; 所述聚合物网的表观拉伸强度优于1MPa; 所述聚合物网的表观弹性模量优于0.1MPa。 本申请中描述的网状物允许形成的“新组织”呈现与受损组织的非常类似的性质。 因此，本申请中描述的用于修复和再生组织的聚合物网状物可以与药物组合使用或不与手术方法结合使用，即用于治疗涉及组织修复和再生的疾病，特别是当治疗组织 是软骨，牙周韧带，食道或皮肤。

公开(公告)号：WO2015177776A4

公开(公告)日：2016-01-14

申请号：PCT/IB2015053870

申请日：2015-05-25

Applicant: ASS FOR THE ADVANCEMENT OF TISSUE ENGINEERING AND CELL BASED TECHNOLOGIES AND THERAPIES A4TEC

Inventor： MARQUES DE OLIVEIRA SARA MARIA ,  GONÇALVES REIS RUI LUÍS ,  COLARDELLE DA LUZ MANO JOÃO FILIPE

IPC: A61K35/19 ,  A61K45/06 ,  A61K47/36 ,  A61P43/00 ,  B05D1/18

CPC classification number: A61K35/19 ,  A61K45/06 ,  A61K47/34 ,  A61K47/36 ,  A61L27/34 ,  A61L27/3891 ,  A61L2420/08 ,  A61K2300/00 ,  C08L5/08 ,  C08L5/10 ,  C08L5/04

Abstract: The present application presents cell-instructing compositions rich in platelets derivatives, prepared by layer-by-layer assembling. These cell-instructing compositions may be incorporated in medical devices and be applied in tissue engineering and regenerative medicine.

Abstract translation: 本申请提出了通过逐层组装制备的富含血小板衍生物的细胞指导组合物。 这些细胞指示组合物可以并入医疗装置中并用于组织工程和再生医学。

公开(公告)号：WO2011119059A4

公开(公告)日：2011-12-01

申请号：PCT/PT2011000010

申请日：2011-03-26

Applicant: ASS FOR THE ADVANCEMENT OF TISSUE ENGINEERING AND CELL BASED TECHNOLOGIES AND THERAPIES A4TEC ,  DA SILVA CORREIA JOANA CATARINA ,  ANTUNES DE OLIVEIRA JOAQUIM MIGUEL ,  TEIXEIRA DE OLIVEIRA JOAO MANUEL ,  AMANDI ROMERO DE SOUSA RUI PEDRO ,  GONCALVES DOS REIS RUI LUIS

Inventor： DA SILVA CORREIA JOANA CATARINA ,  ANTUNES DE OLIVEIRA JOAQUIM MIGUEL ,  TEIXEIRA DE OLIVEIRA JOAO MANUEL ,  AMANDI ROMERO DE SOUSA RUI PEDRO ,  GONCALVES DOS REIS RUI LUIS

IPC: A61K9/00 ,  A61K47/36 ,  A61L24/00 ,  A61L27/34

CPC classification number: C08B37/006 ,  A61L27/28 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/64 ,  A61L2400/06 ,  C08L5/00

Abstract: This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. Formulations of gellan gum with different degrees of acylation serve as precursor material for insertion of a polymerizable moiety. The materials are capable of free radical polymerization with a photo-initiator at mild temperatures and exposure to ultraviolet light, enabling control of reticulation and withstanding the encapsulation of human and animal cells and/or drugs, and any combination thereof. The physicochemical and biological properties can be adjusted by combining different formulations of gellan gum and reaction conditions. The matrix can be used either as an acellular or cellular system, dispensed manually or automatically by injection and crosslinked directly at the site of application, and can be processed using manual or automated systems in different types of scaffolds, such as hydrogels, fibres, 3D structures and micro- or nanoparticles.

Abstract translation: 本发明涉及基于结冷胶的光交联水凝胶材料，其适用于组织工程和再生医学应用或作为药物递送系统。 具有不同酰化度的结冷胶制剂用作插入可聚合部分的前体材料。 该材料能够在温和的温度下暴露于紫外线下与光引发剂进行自由基聚合，从而能够控制网状结构，并且能够承受人和动物细胞和/或药物以及它们的任何组合的包封。 物理化学和生物学性质可以通过结合不同配比的结冷胶和反应条件来调节。 基质可以作为无细胞或细胞系统使用，手动分配或自动分配注射并直接在应用部位交联，也可以使用手动或自动系统处理不同类型的支架，如水凝胶，纤维，3D 结构和微米或纳米颗粒。