公开(公告)号：WO2009126571A3

公开(公告)日：2010-02-11

申请号：PCT/US2009039652

申请日：2009-04-06

Applicant: UNIV CORNELL ,  TE ALEXIS E ,  BATT CARL A ,  REY DIEGO ARIEL

Inventor： TE ALEXIS E ,  BATT CARL A ,  REY DIEGO ARIEL

IPC: A61B18/18 ,  A61N5/02

CPC classification number: A61N5/02 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61K9/0009 ,  A61K9/5094 ,  A61N1/406 ,  A61N2005/1098

Abstract: A method is provided for using magnetic nanoparticles to enhance microwave therapies for treating cells and tissues. The nanoparticles are designed to transduce microwave radiation into heat and furthermore, the nanoparticles may include specific tissue targeting and other functionality for enhancing in situ effects. In one embodiment, nanoparticles are introduced into a tissue system and a microwave field is applied. The nanoparticles react to the microwave energy by releasing heat thus heating the tissue and inducing hyperthermia (below 50°C) or thermotherapy (above 50°C). The nanoparticles can be designed for optimal heat production response at specific microwave frequencies and/or ranges of microwave frequencies where these frequencies may span the entire microwave spectrum, namely 300 MHz (3108 Hz) to 300 GHz (31011 Hz).

Abstract translation: 提供了一种使用磁性纳米颗粒增强微波治疗以治疗细胞和组织的方法。 纳米颗粒被设计成将微波辐射转化成热，此外，纳米颗粒可以包括特定的组织靶向和用于增强原位效应的其它功能。 在一个实施方案中，将纳米颗粒引入组织系统并施加微波场。 纳米颗粒通过释放热而对微波能量进行反应，从而加热组织并诱导高热（低于50℃）或热疗（高于50℃）。 纳米颗粒可以设计用于在特定微波频率和/或微波频率范围内的最佳热产生响应，其中这些频率可以跨越整个微波频谱，即300MHz（3108Hz）至300GHz（31011Hz）。

公开(公告)号：WO2010120531A3

公开(公告)日：2011-01-13

申请号：PCT/US2010029438

申请日：2010-03-31

Applicant: UNIV CORNELL ,  STRICKLAND AARON D ,  HINESTROZA JUAN ,  BATT CARL A

Inventor： STRICKLAND AARON D ,  HINESTROZA JUAN ,  BATT CARL A

IPC: G01N21/01 ,  G01N37/00

CPC classification number: B82Y30/00 ,  B82Y15/00 ,  G01N21/648 ,  G01N21/658 ,  G01N33/54346 ,  G01N33/54393 ,  G01N33/587 ,  Y10T428/25 ,  Y10T442/20

Abstract: Textile fibers and other fibrous substrates functionalized with particles are provided for use in the detection of targets of interest by spectroscopic methods. In one embodiment, a substrate is provided that comprises a conformal coating on its surface, wherein the coating comprises a plurality of chemically functional particles that are spectroscopically enhancing. Methods for producing such functionalized textile fibers are also provided. These textiles can be used as platforms for spectroscopic detection, including surface-enhanced Raman scattering (SERS), surface-enhanced infrared absorption (SEIRA), and surface-enhanced fluorescence (SEF). Functionalized textile fibers for use in the signature detection methods are produced by performing layer-by-layer self-assembly of particles on natural and synthetic textile substrates.

Abstract translation: 提供用颗粒功能化的纺织纤维和其它纤维底物用于通过光谱方法检测目标靶。 在一个实施例中，提供了在其表面上包括保形涂层的基底，其中所述涂层包括光谱增强的多个化学功能性颗粒。 还提供了生产这种官能化纺织纤维的方法。 这些纺织品可用作光谱检测的平台，包括表面增强拉曼散射（SERS），表面增强红外吸收（SEIRA）和表面增强荧光（SEF）。 用于签名检测方法的功能性纺织纤维通过在天然和合成纺织品基材上进行颗粒的逐层自组装来制备。

公开(公告)号：WO2006085948A2

公开(公告)日：2006-08-17

申请号：PCT/US2005/021790

申请日：2005-06-22

Applicant: CORNELL RESEARCH FOUNDATION, INC. ,  CADY, Nathaniel, C. ,  BATT, Carl, A. ,  STELICK, Scott, J. ,  KUNNAVAKKAM, Madanagopal, V. ,  YANG, Xin

Inventor： CADY, Nathaniel, C. ,  BATT, Carl, A. ,  STELICK, Scott, J. ,  KUNNAVAKKAM, Madanagopal, V. ,  YANG, Xin

IPC: C12M1/34 ,  C12Q1/68

CPC classification number: B01L3/502707 ,  B01L7/52 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/1822 ,  B01L2400/0478

Abstract: A portable, fully-automated, microchip including a DNA purification region fluidly integrated with a PCR-based detection region is used to detect specific DNA sequences for the rapid detection of bacterial pathogens. Using an automated detection system with integrated microprocessor, pumps, valves, thermocycler and fluorescence detection modules, the microchip is able to purify and detect bacterial DNA by real-time PCR amplification using fluorescent dye. The fully automated detection system is completely portable, making the system ideal for the detection of bacterial pathogens in the field or other point-of-care environments.

Abstract translation: 使用包括与基于PCR的检测区域流体整合的DNA纯化区域的便携式，全自动化的微芯片来检测用于快速检测细菌病原体的特异性DNA序列。 使用具有集成微处理器，泵，阀，热循环仪和荧光检测模块的自动检测系统，微芯片能够通过使用荧光染料的实时PCR扩增来纯化和检测细菌DNA。 完全自动化的检测系统是完全便携式的，使该系统成为现场或其他护理环境中细菌病原体检测的理想选择。

公开(公告)号：WO2006085948A3

公开(公告)日：2006-11-23

申请号：PCT/US2005021790

申请日：2005-06-22

Applicant: CORNELL RES FOUNDATION INC ,  CADY NATHANIEL C ,  BATT CARL A ,  STELICK SCOTT J ,  KUNNAVAKKAM MADANAGOPAL V ,  YANG XIN

Inventor： CADY NATHANIEL C ,  BATT CARL A ,  STELICK SCOTT J ,  KUNNAVAKKAM MADANAGOPAL V ,  YANG XIN

IPC: C12M1/34 ,  C12M3/00

CPC classification number: B01L3/502707 ,  B01L7/52 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/1822 ,  B01L2400/0478

Abstract: A portable, fully-automated, microchip (2) including a DNA purification region (4) fluidly integrated with a PCR-based detection region (6) is used to detect specific DNA sequences for the rapid detection of bacterial pathogens. Using an automated detection system with integrated microprocessor, pumps, valves, thermocycler and fluorescence detection modules, the microchip is able to purify and detect bacterial DNA by real-time PCR amplification using fluorescent dye. The fully automated detection system is completely portable, making the system ideal for detection of bacterial pathogens in the field or other point-of-care environments.

Abstract translation: 使用包括与基于PCR的检测区域（6）流体集成的DNA纯化区域（4）的便携式，全自动化的微芯片（2）来检测用于快速检测细菌病原体的特异性DNA序列。 使用具有集成微处理器，泵，阀，热循环仪和荧光检测模块的自动检测系统，微芯片能够通过使用荧光染料的实时PCR扩增来纯化和检测细菌DNA。 完全自动化的检测系统是完全便携式的，使该系统成为现场或其他护理环境中细菌病原体检测的理想选择。

公开(公告)号：WO2010120531A2

公开(公告)日：2010-10-21

申请号：PCT/US2010/029438

申请日：2010-03-31

Applicant: CORNELL UNIVERSITY ,  STRICKLAND, Aaron D. ,  HINESTROZA, Juan ,  BATT, Carl A.

Inventor： STRICKLAND, Aaron D. ,  HINESTROZA, Juan ,  BATT, Carl A.

IPC: G01N21/01 ,  G01N37/00

CPC classification number: B82Y30/00 ,  B82Y15/00 ,  G01N21/648 ,  G01N21/658 ,  G01N33/54346 ,  G01N33/54393 ,  G01N33/587 ,  Y10T428/25 ,  Y10T442/20

Abstract: Textile fibers and other fibrous substrates functionalized with particles are provided for use in the detection of targets of interest by spectroscopic methods. In one embodiment, a substrate is provided that comprises a conformal coating on its surface, wherein the coating comprises a plurality of chemically functional particles that are spectroscopically enhancing. Methods for producing such functionalized textile fibers are also provided. These textiles can be used as platforms for spectroscopic detection, including surface-enhanced Raman scattering (SERS), surface-enhanced infrared absorption (SEIRA), and surface-enhanced fluorescence (SEF). Functionalized textile fibers for use in the signature detection methods are produced by performing layer-by-layer self-assembly of particles on natural and synthetic textile substrates.

Abstract translation: 提供用颗粒功能化的纺织纤维和其它纤维底物用于通过光谱方法检测目标靶。 在一个实施例中，提供了在其表面上包括保形涂层的基底，其中所述涂层包括多个化学功能性的颗粒，其是光谱增强的。 还提供了生产这种官能化纺织纤维的方法。 这些纺织品可以用作光谱检测的平台，包括表面增强拉曼散射（SERS），表面增强红外吸收（SEIRA）和表面增强荧光（SEF）。 用于签名检测方法的功能化纺织纤维通过在天然和合成纺织品基材上进行颗粒的逐层自组装来制备。

公开(公告)号：WO2010045357A2

公开(公告)日：2010-04-22

申请号：PCT/US2009/060675

申请日：2009-10-14

Applicant: CORNELL UNIVERSITY ,  ERICKSON, David ,  HUH, Yun Suk ,  BATT, Carl A. ,  LOWE, Adam Joseph

Inventor： ERICKSON, David ,  HUH, Yun Suk ,  BATT, Carl A. ,  LOWE, Adam Joseph

IPC: G01N33/483

CPC classification number: C12Q1/6827 ,  B01F13/0076 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0809 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0424 ,  C12Q1/6862 ,  C12Q2565/632 ,  G01N21/658 ,  C12Q2563/137 ,  C12Q2531/137

Abstract: A method for detecting target nucleic acids such as SNPs is provided. The method comprises performing a ligase detection reaction (LDR), performing surface enhanced Raman scattering (SERS) on the LDR, and analyzing the outcome of the LDR using analysis and/or quantification of the SERS by detecting an emitted Raman signature. The LDR-SERS method can be used for sensitive and specific detection of any nucleic acid sequence of interest. A microfluidic SERS detection device is also provided. The device comprises electrokinetically active microwells for mixing and concentrating analytes and in which analytes can be quantified. The device can be used for performing the LDR-SERS method in optofluidic chip format.

Abstract translation: 提供了检测目标核酸如SNP的方法。 该方法包括在LDR上进行连接酶检测反应（LDR），进行表面增强拉曼散射（SERS），并通过检测发射的拉曼特征来分析和/或定量SERS来分析LDR的结果。 LDR-SERS方法可用于感兴趣的任何核酸序列的敏感和特异性检测。 还提供了微流体SERS检测装置。 该装置包括用于混合和浓缩分析物的电动活性微孔，并且其中可分析物被量化。 该器件可用于以光流体芯片格式执行LDR-SERS方法。

公开(公告)号：WO2009126571A2

公开(公告)日：2009-10-15

申请号：PCT/US2009/039652

申请日：2009-04-06

Applicant: CORNELL UNIVERSITY ,  TE, Alexis, E. ,  BATT, Carl, A. ,  REY, Diego, Ariel

Inventor： TE, Alexis, E. ,  BATT, Carl, A. ,  REY, Diego, Ariel

IPC: A61B18/18 ,  A61N5/02

CPC classification number: A61N5/02 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61K9/0009 ,  A61K9/5094 ,  A61N1/406 ,  A61N2005/1098

Abstract: A method is provided for using magnetic nanoparticles to enhance microwave therapies for treating cells and tissues. The nanoparticles are designed to transduce microwave radiation into heat and furthermore, the nanoparticles may include specific tissue targeting and other functionality for enhancing in situ effects. In one embodiment, nanoparticles are introduced into a tissue system and a microwave field is applied. The nanoparticles react to the microwave energy by releasing heat thus heating the tissue and inducing hyperthermia (below 50°C) or thermotherapy (above 50°C). The nanoparticles can be designed for optimal heat production response at specific microwave frequencies and/or ranges of microwave frequencies where these frequencies may span the entire microwave spectrum, namely 300 MHz (310 8 Hz) to 300 GHz (310 11 Hz).

Abstract translation: 提供了一种使用磁性纳米粒子来增强用于治疗细胞和组织的微波疗法的方法。 纳米颗粒被设计成将微波辐射转化成热，此外，纳米颗粒可以包括特定的组织靶向和用于增强原位效应的其它功能。 在一个实施方案中，将纳米颗粒引入组织系统并施加微波场。 纳米颗粒通过释放热而对微波能量进行反应，从而加热组织并诱导高温（低于50℃）或热疗（高于50℃）。 纳米颗粒可以设计用于在特定微波频率和/或微波频率范围内的最佳热产生响应，其中这些频率可以跨越整个微波频谱，即300MHz（3108Hz）至300GHz（31011Hz）。

公开(公告)号：WO2010045357A3

公开(公告)日：2010-07-01

申请号：PCT/US2009060675

申请日：2009-10-14

Applicant: UNIV CORNELL ,  ERICKSON DAVID ,  HUH YUN SUK ,  BATT CARL A ,  LOWE ADAM JOSEPH

Inventor： ERICKSON DAVID ,  HUH YUN SUK ,  BATT CARL A ,  LOWE ADAM JOSEPH

IPC: G01N33/483

CPC classification number: C12Q1/6827 ,  B01F13/0076 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0809 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0424 ,  C12Q1/6862 ,  C12Q2565/632 ,  G01N21/658 ,  C12Q2563/137 ,  C12Q2531/137

Abstract: A method for detecting target nucleic acids such as SNPs is provided. The method comprises performing a ligase detection reaction (LDR), performing surface enhanced Raman scattering (SERS) on the LDR, and analyzing the outcome of the LDR using analysis and/or quantification of the SERS by detecting an emitted Raman signature. The LDR-SERS method can be used for sensitive and specific detection of any nucleic acid sequence of interest. A microfluidic SERS detection device is also provided. The device comprises electrokinetically active microwells for mixing and concentrating analytes and in which analytes can be quantified. The device can be used for performing the LDR-SERS method in optofluidic chip format.

Abstract translation: 提供了检测靶核酸如SNP的方法。 该方法包括执行连接酶检测反应（LDR），对LDR执行表面增强拉曼散射（SERS），并且通过检测发射的拉曼签名使用SERS的分析和/或定量分析LDR的结果。 LDR-SERS方法可用于敏感和特异性检测任何感兴趣的核酸序列。 还提供了微流体SERS检测装置。 该装置包含用于混合和浓缩分析物的电动活性微孔，并且可以量化分析物。 该器件可用于执行光流控芯片格式的LDR-SERS方法。