公开(公告)号：WO2016067063A3

公开(公告)日：2016-09-09

申请号：PCT/HU2015050014

申请日：2015-11-02

Applicant: BAY ZOLTÁN KÖZHASZNÚ NONPROFIT KFT

Inventor： TOLMACSOV PÉTER

IPC: G01N35/10 ,  G01N1/20

CPC classification number: G01N1/2035 ,  B01L3/569 ,  B01L2300/044 ,  G01N1/20 ,  G01N35/1079 ,  G01N2001/2071

Abstract: Sampling vessel, to be used preferably with automated sampling apparatuses with moving sampling head for sampling a flowing substance stream, wherein the sampling vessel comprises a body (12), an inlet (14) and an outlet (16) formed on the body (12), a channel (13) defining a continuous flow path extending between the inlet (14) and the outlet (16), as well as a sampling opening to perform sampling by the sampling needle, wherein the sampling opening communicates with the channel (13) and is sealed in a gastight manner by a closing means (24) penetrable for the sampling needle. In the sampling vessel, a sampling segment (17) is formed in the channel (13), the sampling opening communicates with the sampling segment (17) through a needle guiding channel (15), and the inlet (14) and the outlet (16) are arranged so as to provide a substance flow in said sampling segment (17) towards the sampling opening.

Abstract translation: 采样容器优选地具有用于采样流动物质流的移动采样头的自动采样装置，其中采样容器包括主体（12），形成在主体（12）上的入口（14）和出口（16） ），限定在入口（14）和出口（16）之间延伸的连续流动路径的通道（13），以及采样开口，用于执行采样针采样，其中采样开口与通道（13） ），并通过可针对采样针的封闭装置（24）以气密方式密封。 在采样容器中，在通道（13）中形成采样段（17），采样开口通过针引导通道（15）与采样段（17）连通，入口（14）和出口 16）布置成在所述采样段（17）中朝向采样开口提供物质流。

公开(公告)号：WO2015028833A3

公开(公告)日：2015-09-11

申请号：PCT/HU2014000081

申请日：2014-09-02

Applicant: BAY ZOLTÁN KÖZHASZNÚ NONPROFIT KFT

Inventor： TOLMACSOV PÉTER

IPC: B65D51/20 ,  B01L3/08 ,  C12M1/00 ,  C12M1/24 ,  G01N1/00 ,  G01N1/10

CPC classification number: B01L3/08 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/042 ,  B01L2300/044 ,  G01N2001/1037

Abstract: The present invention relates to a sample holder vessel (10), in particular for sampling operations to be performed by an automated sample feeder apparatus having a sampling needle. Said sample holder vessel has a body (11) defining an internal space and comprising a top portion and a lower section. The body is further provided with a first sampling port (12) with a geometric axis at the top portion and a second sampling port (14) in the lower section, said sampling ports being adapted for receiving closing elements (13, 15) that can be detachably connected with the sampling ports, enable more than one successive sampling operations from predetermined regions of the internal space and also close the internal space of the sample holder vessel in a leakproof manner. Moreover, the geometric axis of the first sampling port extends substantially parallel to the sampling needle when a sampling operation from the sample holder vessel is performed with said sampling needle through the first sampling port. Furthermore, a collar (16) is arranged on the external surface of the sample holder vessel in the region of the first sampling port. The collar defines a locating gap (17) in cooperation with the closing element (13) connected with the first sampling port, wherein said locating gap is engaged with a retaining element associated with the sample feeder apparatus so as to ensure immobility of the sample holder vessel relative to the sample feeder apparatus via a stationary fit between said sample holder vessel and said retaining element when sampling operations are performed through at least one of said sampling ports (12, 14).

Abstract translation: 本发明涉及样品保持器容器（10），特别是用于由具有取样针的自动取样给料装置进行的取样操作。 所述样品保持器容器具有限定内部空间并包括顶部和下部的主体（11）。 主体还设置有在顶部具有几何轴线的第一采样端口（12）和下部分中的第二采样端口（14），所述采样端口适于接收闭合元件（13,15） 与采样端口可拆卸地连接，使得能够从内部空间的预定区域进行多于一次的连续采样操作，并且以防漏的方式关闭样品保持器容器的内部空间。 而且，当利用所述采样针通过第一取样口进行来自样品保持容器的取样操作时，第一取样口的几何轴线基本平行于采样针延伸。 此外，在第一采样口的区域中，在样品保持器容器的外表面上设置有轴环（16）。 套环与与第一采样口连接的关闭元件（13）配合定位定位间隙（17），其中所述定位间隙与与样品供料装置相关联的保持元件接合，以便确保样品架不动 通过所述采样端口（12,14）中的至少一个进行采样操作时，通过所述样品保持器容器和所述保持元件之间的固定配合，相对于所述采样馈送装置的容器。

公开(公告)号：WO2015001366A2

公开(公告)日：2015-01-08

申请号：PCT/HU2014/000048

申请日：2014-05-27

Applicant: BAY ZOLTÁN KÖZHASZNÚ NONPROFIT KFT

Inventor： LAKATOSNÉ, Varsányi Magdolna ,  POZMAN, Tamás ,  FURKÓ, Mónika

IPC: A61L27/06

CPC classification number: A61L27/06 ,  A61L27/30 ,  A61L27/54 ,  A61L2300/404 ,  A61L2400/12 ,  A61L2420/02 ,  C25D3/46 ,  C25D5/16 ,  C25D5/18 ,  C25D5/34 ,  C25D5/36 ,  C25D5/38 ,  C25D5/40

Abstract: The invention relates, on the one hand, to a method for producing a medical metallic implant with the properties of antimicrobiality and biocompatibility and, on the other hand, to the metallic implant itself. According to the method, an antimicrobial coating is applied onto a metallic substrate of said metallic implant, the method comprising the steps of arranging said substrate as cathode against a counter electrode in an electrolytic solution containing at least a salt of the metal to be deposited to form the coating, and depositing the coating from the electrolytic solution onto the substrate surface by electrolysis. The essence of the present method is that after an initial pre-treatment of the substrate surface, the electrolysis is performed directly onto the substrate, and said coating is formed as a non-continuous nanostructured coating by pulse current series electrochemical deposition during the electrolysis. The medical metallic implant according to the invention comprises a metallic substrate and an antimicrobial coating, wherein the antimicrobial coating is bound in the form of a plurality of nanostructured microclusters directly to a substrate surface subjected to pre-treatment, and said microclusters are located on said substrate so as to form local galvanic cells when get into contact with an electrolyte.

Abstract translation: 本发明一方面涉及具有抗菌性和生物相容性的特性，另一方面涉及金属植入物本身的用于生产医用金属植入物的方法。 根据该方法，将抗微生物涂层施加到所述金属植入物的金属基底上，该方法包括以下步骤：将至少含有待沉积金属的盐的电解液中的相对电极排列成阴极， 形成涂层，并通过电解将涂层从电解溶液沉积到基材表面上。 本方法的本质是在基板表面初始预处理之后，电解直接进行到基板上，并且所述涂层在电解期间通过脉冲电流串联电化学沉积形成为非连续纳米结构涂层。 根据本发明的医用金属植入物包括金属基底和抗微生物涂层，其中所述抗微生物涂层直接结合到多个纳米结构的微团簇的形式到经过预处理的基底表面，并且所述微团簇位于所述 衬底，以便当与电解质接触时形成局部原电池。

公开(公告)号：WO2016067063A2

公开(公告)日：2016-05-06

申请号：PCT/HU2015/050014

申请日：2015-11-02

Applicant: BAY ZOLTÁN KÖZHASZNÚ NONPROFIT KFT

Inventor： TOLMACSOV, Péter

CPC classification number: G01N1/2035 ,  B01L3/569 ,  B01L2300/044 ,  G01N1/20 ,  G01N35/1079 ,  G01N2001/2071

Abstract: The invention relates to a sampling vessel, to be used preferably with automated sampling apparatuses with moving sampling head for sampling a flowing substance stream, wherein the sampling vessel comprises a body (12), an inlet (14) and an outlet (16) formed on the body (12), a channel (13) defining a continuous flow path extending between the inlet (14) and the outlet (16), as well as a sampling opening to perform sampling by the sampling needle, wherein the sampling opening communicates with the channel (13) and is sealed in a gastight manner by a closing means (24) penetrable for the sampling needle. In the sampling vessel according to the invention, a sampling segment (17) is formed in the channel (13), the sampling opening communicates with the sampling segment (17) through a needle guiding channel (15), and the inlet (14) and the outlet (16) are arranged so as to provide a substance flow in said sampling segment (17) towards the sampling opening.

Abstract translation: 本发明涉及采样容器，优选地具有用于采样流动物质流的移动采样头的自动取样装置，其中采样容器包括主体（12），入口（14）和形成的出口（16） 在所述主体（12）上，限定在所述入口（14）和所述出口（16）之间延伸的连续流动路径的通道（13）以及用于由所述采样针进行采样的采样开口，其中所述采样开口连通 与通道（13）通过用于采样针可穿透的关闭装置（24）以气密方式密封。 在根据本发明的采样容器中，在通道（13）中形成采样段（17），采样开口通过针引导通道（15）与采样段（17）连通，并且入口（14） 并且所述出口（16）被布置成在所述采样段（17）中朝向所述取样开口提供物质流。

公开(公告)号：WO2015001366A3

公开(公告)日：2015-03-05

申请号：PCT/HU2014000048

申请日：2014-05-27

Applicant: BAY ZOLTÁN KÖZHASZNÚ NONPROFIT KFT

Inventor： LAKATOSNÉ VARSÁNYI MAGDOLNA ,  POZMAN TAMÁS ,  FURKÓ MÓNIKA

IPC: A61L27/06 ,  A61L27/30 ,  A61L27/54 ,  C25D5/18

CPC classification number: A61L27/06 ,  A61L27/30 ,  A61L27/54 ,  A61L2300/404 ,  A61L2400/12 ,  A61L2420/02 ,  C25D3/46 ,  C25D5/16 ,  C25D5/18 ,  C25D5/34 ,  C25D5/36 ,  C25D5/38 ,  C25D5/40

Abstract: The invention relates, on the one hand, to a method for producing a medical metallic implant with the properties of antimicrobiality and biocompatibility and, on the other hand, to the metallic implant itself. According to the method, an antimicrobial coating is applied onto a metallic substrate of said metallic implant, the method comprising the steps of arranging said substrate as cathode against a counter electrode in an electrolytic solution containing at least a salt of the metal to be deposited to form the coating, and depositing the coating from the electrolytic solution onto the substrate surface by electrolysis. The essence of the present method is that after an initial pre-treatment of the substrate surface, the electrolysis is performed directly onto the substrate, and said coating is formed as a non-continuous nanostructured coating by pulse current series electrochemical deposition during the electrolysis. The medical metallic implant according to the invention comprises a metallic substrate and an antimicrobial coating, wherein the antimicrobial coating is bound in the form of a plurality of nanostructured microclusters directly to a substrate surface subjected to pre-treatment, and said microclusters are located on said substrate so as to form local galvanic cells when get into contact with an electrolyte.

Abstract translation: 本发明一方面涉及生产具有抗微生物性和生物相容性的医用金属植入物的方法，另一方面涉及金属植入物本身。 根据该方法，将抗微生物涂层施加到所述金属植入物的金属基底上，所述方法包括以下步骤：将所述基底作为阴极布置在包含待沉积的金属的至少一种盐的电解溶液中的对电极上， 形成涂层，并且通过电解将来自电解液的涂层沉积到基板表面上。 本发明方法的实质在于，在对基材表面进行初始预处理之后，将电解直接进行到基材上，并且在电解期间通过脉冲电流串联电化学沉积将所述涂层形成为不连续的纳米结构涂层。 根据本发明的医学金属植入物包括金属基底和抗微生物涂层，其中抗微生物涂层以多个纳米结构的微团簇的形式直接结合到经过预处理的基底表面，并且所述微团簇位于所述 当与电解质接触时形成局部原电池。

公开(公告)号：WO2015028833A2

公开(公告)日：2015-03-05

申请号：PCT/HU2014/000081

申请日：2014-09-02

Applicant: BAY ZOLTÁN KÖZHASZNÚ NONPROFIT KFT

Inventor： TOLMACSOV, Péter

CPC classification number: B01L3/08 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/042 ,  B01L2300/044 ,  G01N2001/1037

Abstract: The present invention relates to a sample holder vessel (10), in particular for sampling operations to be performed by an automated sample feeder apparatus having a sampling needle. Said sample holder vessel has a body (11) defining an internal space and comprising a top portion and a lower section. The body is further provided with a first sampling port (12) with a geometric axis at the top portion and a second sampling port (14) in the lower section, said sampling ports being adapted for receiving closing elements (13, 15) that can be detachably connected with the sampling ports, enable more than one successive sampling operations from predetermined regions of the internal space and also close the internal space of the sample holder vessel in a leakproof manner. Moreover, the geometric axis of the first sampling port extends substantially parallel to the sampling needle when a sampling operation from the sample holder vessel is performed with said sampling needle through the first sampling port. Furthermore, a collar (16) is arranged on the external surface of the sample holder vessel in the region of the first sampling port. The collar defines a locating gap (17) in cooperation with the closing element (13) connected with the first sampling port, wherein said locating gap is engaged with a retaining element associated with the sample feeder apparatus so as to ensure immobility of the sample holder vessel relative to the sample feeder apparatus via a stationary fit between said sample holder vessel and said retaining element when sampling operations are performed through at least one of said sampling ports (12, 14).

Abstract translation: 本发明涉及样本保持器容器（10），特别是用于由具有取样针的自动化样本进给器装置执行的取样操作。 所述样品容器容器具有限定内部空间并包括顶部和下部的主体（11）。 本体还设置有第一取样口（12）和第二取样口（14），所述第一取样口在顶部具有几何轴线，所述取样口适于接收封闭元件（13,15），所述封闭元件 与采样口可拆卸地连接，使得能够从内部空间的预定区域进行多于一次的连续采样操作，并且还以防漏的方式关闭样本保持器容器的内部空间。 此外，当通过第一采样口利用所述采样针执行来自样本保持器的采样操作时，第一采样端口的几何轴线基本上平行于采样针延伸。 此外，在第一取样口的区域中，样品保持器容器的外表面上布置颈圈（16）。 套环与与第一采样口连接的关闭元件（13）配合限定定位间隙（17），其中所述定位间隙与与样本进给器装置相关联的保持元件接合，以确保样本保持器 当通过所述采样口（12,14）中的至少一个采样口进行采样操作时，通过所述样品容器容器和所述保持元件之间的静止配合，相对于所述样品进料装置容纳所述容器。