公开(公告)号：WO2009097380A1

公开(公告)日：2009-08-06

申请号：PCT/US2009/032326

申请日：2009-01-29

Applicant: INSIGHTRA MEDICAL, INC. ,  ADZICH, Vaso ,  BELL, Stephen Graham ,  AMATO, Giuseppe

Inventor： ADZICH, Vaso ,  BELL, Stephen Graham ,  AMATO, Giuseppe

IPC: A61F2/02

CPC classification number: A61F2/0063

Abstract: A mesh to repair a hole in a muscle wall includes a resilient mesh body (20) and fortifying structure (22) such as mesh portions of thicker weave than other portions, or strengthening members that can be engaged with the mesh and then removed from the mesh once the mesh is place over the hole. The same principles can be applied to a plug (204) that is engaged with the mesh for filling the hole.

Abstract translation: 用于修复肌肉壁中的孔的网格包括弹性网状体（20）和强化结构（22），例如比其他部分更厚的织物的网状部分，或者可以与网状物接合然后从 一旦网格放置在孔上方，网格就可以了。 相同的原理可以应用于与网孔接合以填充孔的插塞（204）。

公开(公告)号：WO2009047498A2

公开(公告)日：2009-04-16

申请号：PCT/GB2008/003407

申请日：2008-10-08

Applicant: ISIS INNOVATION LIMITED ,  WONG, Luet, Lok ,  BELL, Stephen, Graham ,  WHITEHOUSE, Christopher

Inventor： WONG, Luet, Lok ,  BELL, Stephen, Graham ,  WHITEHOUSE, Christopher

IPC: C12N9/02 ,  C12N15/53 ,  A01K67/027 ,  C12N5/10

CPC classification number: C12N9/0071 ,  C12P7/16 ,  C12P7/22 ,  C12P7/26 ,  C12P7/40 ,  C12Y114/14001

Abstract: This invention relates to mutant enzymes with enhanced properties and processes for oxidation of organic compound substrates using such enzymes.

Abstract translation: 本发明涉及具有增强特性的突变酶和使用这些酶氧化有机化合物底物的方法。

公开(公告)号：WO2008130750A1

公开(公告)日：2008-10-30

申请号：PCT/US2008/056779

申请日：2008-03-13

Applicant: MINOS MEDICAL ,  GASCHE, Christopher ,  BELL, Stephen Graham ,  NODA, Wayne A. ,  SHARP, Bradley J.

Inventor： GASCHE, Christopher ,  BELL, Stephen Graham ,  NODA, Wayne A. ,  SHARP, Bradley J.

IPC: A61B1/31

CPC classification number: A61B17/12013 ,  A61B1/00135 ,  A61B17/0057 ,  A61B17/0469 ,  A61B17/068 ,  A61B17/22031 ,  A61B17/32056 ,  A61B2017/00269 ,  A61B2017/00349 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00615 ,  A61B2017/00632 ,  A61B2017/00862 ,  A61B2017/0412 ,  A61B2017/0417 ,  A61B2017/0427 ,  A61B2017/0477 ,  A61B2017/12018 ,  A61B2017/306 ,  A61B2018/1407 ,  A61B2217/005 ,  A61B2217/007

Abstract: Systems and methods are disclosed for the inversion of gastro intestinal diverticula and repair of associated intestinal wall tissue by means of endoscopy through a natural orifice such as the mouth or anus without making incisions in the abdominal wall or opening the peritoneal cavity.

Abstract translation: 公开了用于胃肠憩室反转的系统和方法，并通过内窥镜检查通过诸如口或肛门的天然孔口修复相关的肠壁组织，而不会在腹壁中切开或打开腹膜腔。

公开(公告)号：WO0031273A3

公开(公告)日：2000-08-17

申请号：PCT/GB9903873

申请日：1999-11-19

Applicant: ISIS INNOVATION ,  WONG LUET LOK ,  BELL STEPHEN GRAHAM ,  CARMICHAEL ANGUS BISHOP

Inventor： WONG LUET LOK ,  BELL STEPHEN GRAHAM ,  CARMICHAEL ANGUS BISHOP

IPC: G01N33/50 ,  A61K31/045 ,  A61K31/336 ,  A61K45/00 ,  A61P31/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/02 ,  C12N15/01 ,  C12N15/09 ,  C12N15/53 ,  C12P7/02 ,  C12P17/02 ,  C12Q1/26 ,  C12R1/19 ,  C40B40/02 ,  C40B50/06 ,  G01N33/15

CPC classification number: C12N9/0077 ,  C07K2319/00 ,  C12P7/02

Abstract: A process for oxidising a substrate which is an acyclic or cyclic terpene, or a cycloalkene; or a substituted derivative thereof, which process comprises oxidising said compound with a mutant haem-containing enzyme, the mutant comprising the substitution of an amino acid in the active site by an amino acid with a less polar side-chain. The enzyme is typically P450cam or P450BM-3. Cells and libraries of cells in which the process can be carried out or which can be used to select advantageous mutant enzymes are also provided.

Abstract translation: 一种氧化无环或环状萜烯或环烯烃底物的方法; 或其取代的衍生物，该方法包括用突变体含血清酶氧化所述化合物，所述突变体包含活性位点中氨基酸被具有较小极性侧链的氨基酸取代。 该酶通常是P450cam或P450BM-3。 还提供了其中可以进行该过程或可以用于选择有利的突变酶的细胞和细胞文库。

公开(公告)号：WO2008066700A3

公开(公告)日：2008-08-28

申请号：PCT/US2007023878

申请日：2007-11-13

Applicant: MINOS MEDICAL ,  SHARP BRADLEY J ,  BELL STEPHEN GRAHAM ,  NODA WAYNE A ,  TZENG ELBERT T

Inventor： SHARP BRADLEY J ,  BELL STEPHEN GRAHAM ,  NODA WAYNE A ,  TZENG ELBERT T

IPC: A61M25/06

CPC classification number: A61B17/42 ,  A61B17/3421 ,  A61B17/3474 ,  A61B18/02 ,  A61B18/06 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/20 ,  A61B2017/003 ,  A61B2017/00889 ,  A61B2017/1142 ,  A61B2017/308 ,  A61B2017/320044 ,  A61B2017/3486 ,  A61B2017/4216 ,  A61B2018/00559 ,  A61B2018/1425

Abstract: A transuterine cannula (40, 100, 130, 172, 180, 200, 220, 226) through which an endoscope (46, 106, 132, 150, 252) can be advanced into the peritoneal space to provide visualization of tissue cutting in the peritoneal space pursuant to a vaginal hysterectomy.

Abstract translation: 一种可以通过其将内窥镜（46,106,132,150,252）推进到腹膜空间中的子宫套管（40,100,130,172,180,200,220,226），以提供可视化的组织切割 根据阴道子宫切除术的腹膜间隙。

公开(公告)号：WO2008066625A1

公开(公告)日：2008-06-05

申请号：PCT/US2007/022451

申请日：2007-10-23

Applicant: MINOS MEDICAL ,  BELL, Stephen, Graham

Inventor： BELL, Stephen, Graham

IPC: A61N1/30 ,  A61M29/00

CPC classification number: A61B18/04 ,  A61B18/042 ,  A61B2018/046 ,  A61N7/022

Abstract: Systems and methods for ablation of the gall bladder and appendix through a natural orifice.

Abstract translation: 通过自然孔切除胆囊和阑尾的系统和方法。

公开(公告)号：WO2009070522A1

公开(公告)日：2009-06-04

申请号：PCT/US2008/084492

申请日：2008-11-24

Applicant: MINOS MEDICAL ,  BELL, Stephen, Graham ,  NODA, Wayne, A.

Inventor： BELL, Stephen, Graham ,  NODA, Wayne, A.

IPC: A61F2/04

CPC classification number: A61B17/1285 ,  A61B2017/00827 ,  A61B2017/06176

Abstract: An arcuate nitinol splint (10, 40, 50) with a rounded cross-section has two ends facing each other and spaced from each other. The splint is advanced through the mouth into the esophagus by an introducer device. By means of the device the splint is implanted completely into the wall of the esophageal sphincter to strengthen the sphincter. Materials other than Nitinol may be used.

Abstract translation: 具有圆形横截面的弧形镍钛诺夹板（10,40,50）具有彼此面对并且彼此间隔开的两个端部。 夹板通过引导装置通过口进入食管。 通过该装置，夹板完全植入食管括约肌的壁以加强括约肌。 可以使用除镍钛诺以外的材料。

公开(公告)号：WO2009055300A1

公开(公告)日：2009-04-30

申请号：PCT/US2008/080134

申请日：2008-10-16

Applicant: MINOS MEDICAL ,  NODA, Wayne ,  BELL, Stephen, Graham

Inventor： NODA, Wayne ,  BELL, Stephen, Graham

IPC: A61B17/12

CPC classification number: A61B17/12013 ,  A61B2017/00296 ,  A61B2017/00349 ,  A61B2017/00893 ,  A61B2017/0641 ,  A61B2017/12018 ,  A61B2017/306 ,  Y10T29/53657

Abstract: A compression ring (28, 64, 74, 80, 88, 92, 96, 102, 108, 114, 120, 144, 152, 200, 210, 212, 228, 262) to grip and compress body structure such as diverticulum, hemorrhoids, and tissue adjacent a hole. A resilient ring-shaped body defines a compression channel, and one or more axially rigid elongated spikes (70, 78, 86, 94, 98, 104, 106. 112, 326, 206) extend from the body into the channel. The body defines a first axial segment (64a, 82) surrounding the compression channel and a second axiai segment (64b, 84) surrounding the compression channel, with the spike being engaged only with the second axial segment. The first axial segment more tightly compresses the body structure than the second axial segment.

Abstract translation: 压紧环（28,64,74,80,88,92,96,102,108,114,120,144,152,200,210,212,228,262）以夹持和压缩身体结构，例如憩室， 痔疮和邻近孔的组织。 弹性环形主体限定了压缩通道，并且一个或多个轴向刚性的细长尖钉（70,78,86,94,98,104,106,112,326,206）从主体延伸到通道中。 主体限定围绕压缩通道的第一轴向段（64a，82）和围绕压缩通道的第二轴向段（64b，84），其中，尖峰仅与第二轴向段接合。 第一轴向段比第二轴向段更紧密地压缩车体结构。

公开(公告)号：WO2008112850A3

公开(公告)日：2008-09-18

申请号：PCT/US2008/056785

申请日：2008-03-13

Applicant: MINOS MEDICAL ,  BELL, Stephen Graham ,  NODA, Wayne A.

Inventor： BELL, Stephen Graham ,  NODA, Wayne A.

IPC: A61B17/04

Abstract: To close a translumenal hole made in the stomach (or colon, etc.) pursuant to natural orifice surgical treatment of tissue in the peritoneal cavity, one or more guides (24) are engagd with the hole, and the guides (24) can be pulled to purse together tissue on opposite side of the hole. A closure device (12) is then advanced along the guides (24) over the pursed tissue to adhere the tissue together using heat, staples, sutures, etc.

公开(公告)号：WO2008112437A3

公开(公告)日：2008-09-18

申请号：PCT/US2008/055220

申请日：2008-02-28

Applicant: INSIGHTRA MEDICAL, INC. ,  AMATO, Giuseppe ,  BELL, Stephen Graham

Inventor： AMATO, Giuseppe ,  BELL, Stephen Graham

IPC: A61F2/02

Abstract: A space in a muscle wall such as the inguinal canal is dilated to break up fibrotic bands by divulsion. While the space is dilated a dynamic plug (100A-100G) is advanced into it, with the plug expanding and contracting with the space. Shields (28, 66) may be placed against opposite sides of the wall surrounding the space.