公开(公告)号：WO2004099778A1

公开(公告)日：2004-11-18

申请号：PCT/US2004/013245

申请日：2004-04-28

Applicant: BECKMAN COULTER, INC. ,  BELL, Michael, L. ,  JAMES, Tony, D. ,  ARIMORI, Susumu

Inventor： BELL, Michael, L. ,  JAMES, Tony, D. ,  ARIMORI, Susumu

IPC: G01N33/543

CPC classification number: G01N33/54346 ,  G01N33/5308 ,  G01N33/533 ,  G01N33/66 ,  Y10T436/143333

Abstract: An analytical system for detecting a saccharide is provided. The analytical system includes a saccharide sensor attached to a solid substrate and a means for detecting at least one of saccharide that is bound to the sensor or saccharide that is not bound to the sensor. In one embodiment the saccharide sensor preferentially detects glucose. The invention further provides beads having the saccharide sensor attached thereto and methods of detecting glucose using the system.

Abstract translation: 提供了一种用于检测糖的分析系统。 分析系统包括连接到固体基底上的糖传感器和用于检测结合到传感器或与传感器结合的糖的至少一种糖的装置。 在一个实施方案中，糖传感器优先检测葡萄糖。 本发明还提供了附着有糖传感器的珠粒和使用该系统检测葡萄糖的方法。

公开(公告)号：WO2004027389A2

公开(公告)日：2004-04-01

申请号：PCT/US2003/030229

申请日：2003-09-23

Applicant: BECKMAN COULTER, INC. ,  BELL, Michael, L.

Inventor： BELL, Michael, L.

IPC: G01N

CPC classification number: G01N33/54313 ,  G01N33/582

Abstract: In cytometry and like procedures, the number of different types of identifiable particles (and, therefore, the number of detectable analytes) is increased by using the coding labels on some particles as signal labels on other particles, and by using the signal labels on some particles as coding labels on other particles. In one such procedure, the particles of a first class are coded with preselected amounts of a first pair of fluorochromes, and the particles of a second class of particles are coded with preselected amounts of a second pair of fluorochromes. The analytes which interact with the first class of particles are identified by a signal label selected from the second pair; and the analytes which interact with a second class of particles are identified by a signal label selected from the first pair.

Abstract translation: 在流式细胞术和类似程序中，通过使用某些颗粒上的编码标签作为其他颗粒上的信号标签来增加不同类型的可识别颗粒的数量（以及因此可检测分析物的数量） 并通过使用某些粒子上的信号标签作为其他粒子上的编码标签。 在一个这样的过程中，第一类颗粒用预选量的第一对荧光染料编码，第二类颗粒用预选量第二对荧光染料编码。 与第一类粒子相互作用的分析物由选自第二对的信号标签识别; 并且与第二类粒子相互作用的分析物通过从第一对中选择的信号标签来识别。

公开(公告)号：WO2005032719A1

公开(公告)日：2005-04-14

申请号：PCT/US2004/032298

申请日：2004-09-29

Applicant: BECKMAN COULTER, INC. ,  BELL, Michael, L.

Inventor： BELL, Michael, L.

IPC: B01L11/00

CPC classification number: G01N33/50 ,  B01L9/54 ,  B01L2200/027 ,  Y10T436/2575

Abstract: A system for analyzing samples having a portable analysis unit (12) and a base unit (10). The portable analysis unit (12) has a sample inlet (74), an analyzer (82), a reagent supply reservoir (56), a collection reservoir (68) for waste, a reagent inlet (58) for providing reagent to the supply reservoir (56), a waste outlet (72) for removing waste from the collection reservoir (68), a supply conduit from the reagent supply reservoir (56) to the analyzer (82), a waste conduit from the analyzer (82) to the collection reservoir (68), a power source, a data output element, and a pressure source for moving reagent and waste. The base unit (10) is connectable to the analyzer unit for providing reagent and receiving waste. The base unit (10) has a reagent storage reservoir (26), a waste storage reservoir, a waste inlet (70) for connection to the waste outlet (72); and an outlet for providing reagent from the reagent storage reservoir (26) to the reagent inlet (30).

Abstract translation: 一种用于分析具有便携式分析单元（12）和基本单元（10）的样本的系统。 便携式分析单元（12）具有样品入口（74），分析器（82），试剂供应储存器（56），用于废物的收集容器（68），用于向供应源提供试剂的试剂入口 储存器（56），用于从收集容器（68）去除废物的废物出口（72），从试剂供应储存器（56）到分析器（82）的供应管道，从分析器（82）到废物管道 收集储存器（68），电源，数据输出元件和用于移动试剂和废物的压力源。 基座单元（10）可连接到分析器单元，用于提供试剂和接收废物。 基座单元（10）具有试剂储存器（26），废物储存容器，用于连接到废物出口（72）的废物入口（70）。 以及用于将试剂从试剂储存容器（26）提供到试剂入口（30）的出口。

公开(公告)号：WO2004063716A3

公开(公告)日：2004-11-11

申请号：PCT/US2004000619

申请日：2004-01-09

Applicant: BECKMAN COULTER INC ,  BELL MICHAEL L

Inventor： BELL MICHAEL L

IPC: G01N15/14 ,  G01N21/64 ,  G01N33/58 ,  G01N33/533

CPC classification number: G01N15/1456 ,  G01N21/6428 ,  G01N2021/6421 ,  G01N2021/6441

Abstract: In cytometry and like procedures, the number of different types of identifiable particle (and, therefore, the number of detectable analytes) is increased by using the coding labels on some particles as signal labels on other particles, and by using the signal labels on some particles as coding labels on other particles. In one such procedure, the particles of a first class are coded with preselected amounts of a first pair of fluorochromes, and the particles of a second class of particles are coded with preselected amounts of a second pair of fluorochromes. The analytes which interact with the first class of particles are identified by a signal label selected from the second pair; and the analytes which interact with a second class of particles are identified by a signal label selected from the first pair.

Abstract translation: 在流式细胞仪和类似的程序中，通过使用某些颗粒上的编码标签作为其他颗粒上的信号标签，并通过使用某些颗粒上的信号标签，增加了不同类型的可识别颗粒的数量（以及因此可检测分析物的数量） 颗粒作为其他颗粒上的编码标签。 在一个这样的过程中，第一类颗粒用预选量的第一对荧光染料编码，第二类颗粒用预选量第二对荧光染料编码。 与第一类粒子相互作用的分析物由选自第二对的信号标签识别; 并且与第二类粒子相互作用的分析物由选自第一对的信号标签识别。

公开(公告)号：WO2006055318A3

公开(公告)日：2006-10-12

申请号：PCT/US2005040297

申请日：2005-11-04

Applicant: BECKMAN COULTER INC ,  BELL MICHAEL L

Inventor： BELL MICHAEL L

IPC: G01N35/00 ,  B04B1/16 ,  B04B5/04 ,  B04B7/08

CPC classification number: G01N35/00 ,  B04B1/16 ,  B04B5/04 ,  B04B5/0442 ,  B04B7/08 ,  B04B2011/046 ,  G01N1/34 ,  G01N2035/00495 ,  G01N2035/0449

Abstract: A laboratory apparatus that is readily adapted to execute a wide range of sample preparation protocols is a set forth. The laboratory apparatus comprises a plurality of tools that are adapted to execute one or more processes in preparing a sample for subsequent analysis and a hollow rotor that is mounted for rotation about a rotation axis. A septum divides the hollow rotor into first and second chambers. Both the first and second chambers are accessible to one or more of the plurality of tools. One or more valve mechanisms are disposed to control fluid communication between the first and second chambers based, at least in part, on the rotation rate imparted to the hollow rotor.

Abstract translation: 一种容易适用于执行各种样品制备方案的实验室设备是一个阐述。 该实验室设备包括多个工具，该多个工具适于执行一个或多个制备用于随后分析的样本的过程以及被安装用于围绕旋转轴线旋转的中空转子。 隔膜将空心转子分成第一和第二室。 第一和第二腔室都可由多个工具中的一个或多个工具访问。 一个或多个阀机构设置成至少部分地基于施加到中空转子的旋转速率来控制第一和第二腔室之间的流体连通。

公开(公告)号：WO2006083960A1

公开(公告)日：2006-08-10

申请号：PCT/US2006/003546

申请日：2006-01-31

Applicant: BECKMAN COULTER, INC. ,  BAKKER, Eric ,  XU, Chao ,  BELL, Michael L. ,  WYGLADACZ, Katarzyna ,  QIN, Yu ,  RETTER, Robert

Inventor： BAKKER, Eric ,  XU, Chao ,  BELL, Michael L. ,  WYGLADACZ, Katarzyna ,  QIN, Yu ,  RETTER, Robert

IPC: G01N21/64 ,  G01N31/22 ,  G01N33/84 ,  G01N15/14

CPC classification number: G01N33/54313 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00648 ,  B01J2219/00704 ,  G01N15/1459 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/7703 ,  G01N31/22 ,  G01N33/6872 ,  G01N33/84 ,  G01N2015/0092 ,  G01N2015/1486 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6484 ,  G01N2021/7759 ,  G01N2021/7786

Abstract: A sensor for determining the concentration of a target ion in a liquid sample having a particulate silica doped with: an ionophore capable of binding the target ion; and an indicator capable of producing a detectable signal in response to binding by the ionophore of the target ion. The detectable signal is related to the target ion concentration in the liquid sample.

Abstract translation: 一种用于确定具有掺杂有能够结合目标离子的离子载体的颗粒状二氧化硅的液体样品中的靶离子的浓度的传感器; 以及能够产生响应于靶离子的离子载体结合的可检测信号的指示剂。 可检测信号与液体样品中的目标离子浓度有关。

公开(公告)号：WO2006055318A2

公开(公告)日：2006-05-26

申请号：PCT/US2005/040297

申请日：2005-11-04

Applicant: BECKMAN COULTER, INC. ,  BELL, Michael, L.

Inventor： BELL, Michael, L.

IPC: G01N35/00 ,  B04B5/04 ,  B04B7/08 ,  B04B1/16

CPC classification number: G01N35/00 ,  B04B1/16 ,  B04B5/04 ,  B04B5/0442 ,  B04B7/08 ,  B04B2011/046 ,  G01N1/34 ,  G01N2035/00495 ,  G01N2035/0449

Abstract: A laboratory apparatus that is readily adapted to execute a wide range of sample preparation protocols is a set forth. The laboratory apparatus comprises a plurality of tools that are adapted to execute one or more processes in preparing a sample for subsequent analysis and a hollow rotor that is mounted for rotation about a rotation axis. A septum divides the hollow rotor into first and second chambers. Both the first and second chambers are accessible to one or more of the plurality of tools. One or more valve mechanisms are disposed to control fluid communication between the first and second chambers based, at least in part, on the rotation rate imparted to the hollow rotor.

Abstract translation: 阐述了容易适应于执行各种样品制备方案的实验室设备。 实验室设备包括多个工具，其适于在准备用于后续分析的样品中执行一个或多个过程，以及安装成围绕旋转轴线旋转的中空转子。 隔垫将中空转子分成第一和第二室。 第一和第二腔室都可以被多个工具中的一个或多个操作。 至少部分地基于施加到中空转子的转速来设置一个或多个阀机构以控制第一和第二室之间的流体连通。

公开(公告)号：WO2004063716A2

公开(公告)日：2004-07-29

申请号：PCT/US2004/000619

申请日：2004-01-09

Applicant: BECKMAN COULTER, INC. ,  BELL, Michael, L.

Inventor： BELL, Michael, L.

IPC: G01N

CPC classification number: G01N15/1456 ,  G01N21/6428 ,  G01N2021/6421 ,  G01N2021/6441

Abstract: In cytometry and like procedures, the number of different types of identifiable particle (and, therefore, the number of detectable analytes) is increased by using the coding labels on some particles as signal labels on other particles, and by using the signal labels on some particles as coding labels on other particles. In one such procedure, the particles of a first class are coded with preselected amounts of a first pair of fluorochromes, and the particles of a second class of particles are coded with preselected amounts of a second pair of fluorochromes. The analytes which interact with the first class of particles are identified by a signal label selected from the second pair; and the analytes which interact with a second class of particles are identified by a signal label selected from the first pair.

Abstract translation: 在细胞计数和类似程序中，通过使用某些颗粒上的编码标签作为其他颗粒上的信号标签，并通过使用一些信号标签来增加不同类型的可识别颗粒（以及因此可检测分析物的数量）的数量 颗粒作为其他颗粒上的编码标签。 在一个这样的过程中，第一类的颗粒用预选量的第一对荧光染料编码，第二类颗粒的颗粒用预选量的第二对荧光染料编码。 与第一类颗粒相互作用的分析物由选自第二对的信号标签识别; 并且与第二类颗粒相互作用的分析物由从第一对选择的信号标签识别。

公开(公告)号：WO2014151234A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/025254

申请日：2014-03-13

Applicant: BELL, Michael L.

Inventor： BELL, Michael L.

IPC: G01N1/28

CPC classification number: B01L99/00 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2300/0681 ,  B01L2300/0838 ,  B01L2300/0854 ,  B01L2300/161 ,  B01L2400/0644 ,  B01L2400/0694 ,  B01L2400/082 ,  G01N1/38 ,  G01N35/00871 ,  G01N2035/00099

Abstract: A point of use analyzer includes pump, valve, port, and storage channel. The storage channel may hold multiple assay packets composed of reagent aliquots separated by bounding slugs. The storage channel may define an elongated lumen having two ends with each of the ends coupled to the valve. A sampling device for use with the analyzer engages the port and may include a recurrent coaxial tube having a separation medium. A method of using the analyzer with the sampling device includes steps of pumping a fluid to displace a sample into the separation medium and out through the opposed connection.

Abstract translation: 使用点分析仪包括泵，阀，端口和存储通道。 存储通道可以保持多个测试分组，其由由边界分块分离的试剂等分试样组成。 存储通道可以限定具有两个端部的细长内腔，其中每个端部联接到阀门。 用于分析仪的采样装置接合端口并且可以包括具有分离介质的反复同轴管。 使用具有采样装置的分析器的方法包括以下步骤：泵送流体以将样品置于分离介质中并通过相对的连接排出。

公开(公告)号：WO2004027389A3

公开(公告)日：2004-05-27

申请号：PCT/US0330229

申请日：2003-09-23

Applicant: BECKMAN COULTER INC ,  BELL MICHAEL L

Inventor： BELL MICHAEL L

IPC: G01N33/543 ,  G01N33/58 ,  G01N33/553

CPC classification number: G01N33/54313 ,  G01N33/582

Abstract: In cytometry and like procedures, the number of different types of identifiable particles (and, therefore, the number of detectable analytes) is increased by using the coding labels on some particles as signal labels on other particles, and by using the signal labels on some particles as coding labels on other particles. In one such procedure, the particles of a first class are coded with preselected amounts of a first pair of fluorochromes, and the particles of a second class of particles are coded with preselected amounts of a second pair of fluorochromes. The analytes which interact with the first class of particles are identified by a signal label selected from the second pair; and the analytes which interact with a second class of particles are identified by a signal label selected from the first pair.

Abstract translation: 在细胞计数和类似程序中，通过使用某些颗粒上的编码标签作为其他颗粒上的信号标记，并通过使用一些信号标签来增加不同类型的可识别颗粒（以及因此可检测分析物的数量）的数量 颗粒作为其他颗粒上的编码标签。 在一个这样的过程中，第一类的颗粒用预选量的第一对荧光染料编码，并且第二类颗粒的颗粒用预选量的第二对荧光染料编码。 与第一类颗粒相互作用的分析物由选自第二对的信号标签识别; 并且与第二类颗粒相互作用的分析物由从第一对选择的信号标签识别。