公开(公告)号：WO2022256637A2

公开(公告)日：2022-12-08

申请号：PCT/US2022/032138

申请日：2022-06-03

申请人： WEINER, David ,  BHOJNAGARWALA, Pratik ,  GARY, Ebony

发明人： WEINER, David ,  BHOJNAGARWALA, Pratik ,  GARY, Ebony

IPC分类号： A61K39/205 ,  C07K14/005 ,  A61K39/12 ,  A61K31/417

摘要： Disclosed herein is a composition comprising one or more viral antigen or a recombinant nucleic acid sequence that encodes one or more viral antigen with enhanced immunogenicity in vivo. Also disclosed herein is a method of generating an immune response in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating a viral infection in a subject using said composition and methods.

公开(公告)号：WO2023077061A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/078863

申请日：2022-10-28

申请人： WEINER, David ,  PURWAR, Mansi ,  KULKARNI, Abhijeet ,  PARK, Daniel ,  BORDOLOI, Devivasha ,  BHOJNAGARWALA, Pratik

发明人： WEINER, David ,  PURWAR, Mansi ,  KULKARNI, Abhijeet ,  PARK, Daniel ,  BORDOLOI, Devivasha ,  BHOJNAGARWALA, Pratik

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K47/68 ,  A61P37/02 ,  C07K16/10

摘要： An advance on monoclonal technology is the development of bispecific T cell engagers (BITE) which combine the specificity of monoclonal antibodies with the cytotoxic potential of T cells. Disclosed herein are compositions comprising a recombinant nucleic acid sequence encoding a bispecific anti-HIV natural killer engager, a fragment thereof, a variant thereof, or a combination thereof, and methods of use thereof.

公开(公告)号：WO2023060169A1

公开(公告)日：2023-04-13

申请号：PCT/US2022/077665

申请日：2022-10-06

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  WEINER, David ,  PERALES-PUCHALT, Alfredo ,  BORDOLOI, Devivasha ,  BHOJNAGARWALA, Pratik

发明人： WEINER, David ,  PERALES-PUCHALT, Alfredo ,  BORDOLOI, Devivasha ,  BHOJNAGARWALA, Pratik

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/30

摘要： Disclosed herein are compositions comprising a recombinant nucleic acid sequences encoding a bispecific anti-FSHR T cell engager as well as FSHR-specific CAR molecules, fragments thereof, variants thereof, combinations thereof, and methods of use thereof.

公开(公告)号：WO2023034828A1

公开(公告)日：2023-03-09

申请号：PCT/US2022/075703

申请日：2022-08-30

申请人： WEINER, David ,  ZHU, Xizhou

发明人： WEINER, David ,  ZHU, Xizhou

IPC分类号： A61K39/245 ,  A61P35/00 ,  C07K16/08

摘要： The present invention generally relates to immunogenic compositions (e.g., vaccines and immunotherapies) that induce an immune response against Epstein Barr Virus (EBV)-associated antigens. The present invention also relates to methods of use thereof for the treatment and prevention of EBV infection, EBV-associated cancer, or a combination thereof. In various embodiments, the EBV antigen comprises BamHI-A rightward frame 1 (BARF1).

公开(公告)号：WO2021252620A2

公开(公告)日：2021-12-16

申请号：PCT/US2021/036606

申请日：2021-06-09

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  WEINER, David ,  MUTHUMANI, Kar ,  PARZYCH, Elizabeth

发明人： WEINER, David ,  MUTHUMANI, Kar ,  PARZYCH, Elizabeth

IPC分类号： A61K39/12 ,  A61K39/215 ,  A61K39/395 ,  A61P31/14 ,  C12N15/86 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K39/42 ,  C07K16/10 ,  C07K2317/41 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2770/20034

摘要： Disclosed herein are antibodies to SARS-CoV-2 antigens and recombinant nucleic acid sequences that encode the SARS-CoV-2 antibodies. The disclosure also provides a method of preventing and/or treating a SARS-CoV-2 infection or disease or disorder associated with SARS-CoV-2 infection (e.g., COVID-19) in a subject using said compositions and methods.

公开(公告)号：WO2017193101A1

公开(公告)日：2017-11-09

申请号：PCT/US2017/031449

申请日：2017-05-05

申请人： WEINER, David ,  PATEL, Ami ,  YAN, Jian

发明人： WEINER, David ,  PATEL, Ami ,  YAN, Jian

IPC分类号： A61K39/40 ,  C07K16/00 ,  C07K16/12

摘要： Disclosed herein are mono and bispecific DNA antibodies (DMAbs) targeting Pseudomonas aeruginosa. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the DMAbs to the subject. The disclosure also provides a method of preventing and/or treating Pseudomonas aeruginosa infection in a subject using said composition and method of generation.

摘要翻译： 本文公开了靶向铜绿假单胞菌的单特异性和双特异性DNA抗体（DMAbs）。 本文还公开了通过将DMAb施用于受试者而在受试者中产生合成抗体的方法。 本公开还提供了使用所述组合物和产生方法预防和/或治疗受试者中的铜绿假单胞菌感染的方法。

公开(公告)号：WO2016123285A1

公开(公告)日：2016-08-04

申请号：PCT/US2016/015263

申请日：2016-01-28

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  INOVIO PHARMACEUTICALS, INC. ,  WEINER, David ,  MUTHUMANI, Karuppiah ,  SARDESAI, Niranjan

发明人： WEINER, David ,  MUTHUMANI, Karuppiah ,  SARDESAI, Niranjan

IPC分类号： A61K39/00 ,  A61K39/395

CPC分类号： A61K39/395 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/585 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/2827 ,  C07K2317/76 ,  C12N2710/20034 ,  Y02A50/412 ,  A61K2300/00

摘要： Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.

摘要翻译： 本文公开了包含抗原和检查点抑制剂的疫苗。 本文还公开了增强受试者的免疫应答的方法。 该方法可以包括向有需要的受试者施用疫苗。

公开(公告)号：WO2014152121A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/026974

申请日：2014-03-14

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  WEINER, David ,  SCOTT, Veronica ,  HUTNICK, Natalie

发明人： WEINER, David ,  SCOTT, Veronica ,  HUTNICK, Natalie

IPC分类号： A61K39/08 ,  A61K39/40 ,  C12N15/31

CPC分类号： C07K14/33 ,  A61K39/08 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/55527 ,  A61K2039/55538 ,  A61K2039/575 ,  A61M37/00 ,  A61M2037/0007 ,  Y02A50/469

摘要： Disclosed herein are compositions and methods for treating Clostridium botulinum neurotoxin intoxication and in particular, vaccines against the neurotoxin that provide protection again lethal challenge with neurotoxin from one or more serotypes of Clostridium botulinum.

摘要翻译： 本文公开了用于治疗肉毒杆菌神经毒素中毒的组合物和方法，特别是针对来自一种或多种肉毒杆菌血清型的神经毒素再次致死致死攻击的神经毒素的疫苗。

公开(公告)号：WO2014144885A2

公开(公告)日：2014-09-18

申请号：PCT/US2014/029479

申请日：2014-03-14

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  WEINER, David ,  MUTHUMANI, Karuppiah ,  WALTERS, Jewell ,  YAN, Jian

发明人： WEINER, David ,  MUTHUMANI, Karuppiah ,  WALTERS, Jewell ,  YAN, Jian

IPC分类号： A61K39/00

CPC分类号： A61K39/0011 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55522 ,  A61K2039/55527 ,  A61K2039/575 ,  C12N9/0071 ,  C12N2710/20034 ,  C12N2730/10111 ,  C12N2770/24234 ,  C12Y114/18001

摘要： Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.

摘要翻译： 本文公开了治疗癌症的组合物和方法，特别是治疗和提供针对肿瘤生长的保护的疫苗。

公开(公告)号：WO2013062507A1

公开(公告)日：2013-05-02

申请号：PCT/US2011/057182

申请日：2011-10-24

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  INOVIO PHARMACEUTICALS, INC. ,  WEINER, David ,  LANG, Krystle ,  YAN, Jian ,  DRAGHIA-AKLI, Ruxandra ,  KHAN, Amir

发明人： WEINER, David ,  LANG, Krystle ,  YAN, Jian ,  DRAGHIA-AKLI, Ruxandra ,  KHAN, Amir

IPC分类号： A61K48/00 ,  C07H21/04

CPC分类号： A61K39/12 ,  A61K2039/53 ,  C07K14/005 ,  C12N2770/24222 ,  C12N2770/24234

摘要： Improved anti-HCV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HCV genotype 1a, including for example, NS4B, NS5A and NS5B. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HCV are disclosed.

摘要翻译： 公开了改进的抗HCV免疫原和编码它们的核酸分子。 所公开的免疫原包括那些具有共有HCV基因型1a的那些，包括例如NS4B，NS5A和NS5B。 公开了药物组合物，包含减毒活疫苗和减毒活疫苗的重组疫苗，并公开了针对HCV个体诱导免疫应答的方法。