公开(公告)号：WO1994007480A1

公开(公告)日：1994-04-14

申请号：PCT/US1993008517

申请日：1993-09-10

Applicant: MERRELL DOW PHARMACEUTICALS INC. ,  TYMS, A., Stanley ,  SNYDER, Ronald, D. ,  BOWLIN, Terry, L.

Inventor： MERRELL DOW PHARMACEUTICALS INC.

IPC: A61K31/13

CPC classification number: A61K31/13 ,  A61K31/135 ,  C07C211/14 ,  C07C211/27

Abstract: The present invention relates to treating CMV infections with polyamine compounds of formula (I) wherein Z is a saturated or branched chain (C2-C6) alkylene moiety; m is 7 or 8; each R group independently is hydrogen, a C1-C6 saturated or unsaturated hydrocarbyl, or -(CH2)x-(Ar)-X wherein Ar is phenyl or napthyl, X is H, C1-C6 alkoxy, halogen C1-C4 alkyl, wherein x is an integer 0, 1, or 2; with the proviso that both R groups cannot be hydrogen; or said compounds of formula (I) can be a pharmaceutically acceptable acid addition salt thereof.

Abstract translation: 本发明涉及用其中Z是饱和或支链（C 2 -C 6）亚烷基部分的式（I）的多胺化合物治疗CMV感染; m为7或8; 每个R基团独立地是氢，C1-C6饱和或不饱和烃基或 - （CH2）x-（Ar）-X，其中Ar是苯基或萘基，X是H，C1-C6烷氧基，卤素C1-C4烷基， 其中x是整数0,1或2; 条件是两个R基团不能是氢; 或所述式（I）的化合物可以是其药学上可接受的酸加成盐。

公开(公告)号：WO2012037119A3

公开(公告)日：2014-03-27

申请号：PCT/US2011051389

申请日：2011-09-13

Applicant: MICROBIOTIX INC ,  BASU ARNAB ,  MILLS DEBRA M ,  WILLIAMS JOHN D ,  LI BING ,  PEET NORTON P ,  BOWLIN TERRY L

Inventor： BASU ARNAB ,  MILLS DEBRA M ,  WILLIAMS JOHN D ,  LI BING ,  PEET NORTON P ,  BOWLIN TERRY L

IPC: A01N41/06 ,  A01N37/18 ,  A61K31/18

CPC classification number: C07C311/44 ,  A61K31/18

Abstract: The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.

Abstract translation: 本发明涉及抑制哺乳动物中病毒感染的化合物和方法的开发。 开发了一种假型病毒用于高通量测定，用于鉴定预防病毒进入宿主细胞的非肽小分子抑制剂。

公开(公告)号：WO2011022721A1

公开(公告)日：2011-02-24

申请号：PCT/US2010/046314

申请日：2010-08-23

Applicant: MICROBIOTIX, INC ,  BOWLIN, Terry, L. ,  PEET, Norton, P. ,  BUTLER, Michelle, M. ,  CARDINALE, Steven, C. ,  LI, Bing ,  PAI, Ramdas

Inventor： BOWLIN, Terry, L. ,  PEET, Norton, P. ,  BUTLER, Michelle, M. ,  CARDINALE, Steven, C. ,  LI, Bing ,  PAI, Ramdas

IPC: A61K31/425 ,  A61K31/42 ,  A61K31/415

CPC classification number: A61K31/415 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/425 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/519 ,  A61K31/536 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

Abstract: Organic compounds showing the ability to inhibit Botulinum neurotoxin activity are disclosed. The disclosed Botulinum neurotoxin inhibitor compounds are useful for treating, preventing, or reducing the intoxication of Botulinum neurotoxin, particularly Botulinum neurotoxin A and/or B.

Abstract translation: 公开了显示抑制肉毒杆菌神经毒素活性的有机化合物。 所公开的肉毒杆菌神经毒素抑制剂化合物可用于治疗，预防或减少肉毒神经毒素，特别是肉毒杆菌神经毒素A和/或B的中毒。

公开(公告)号：WO2012037119A2

公开(公告)日：2012-03-22

申请号：PCT/US2011/051389

申请日：2011-09-13

Applicant: MICROBIOTIX, INC. ,  BASU, Arnab ,  MILLS, Debra, M. ,  WILLIAMS, John, D. ,  LI, Bing ,  PEET, Norton, P. ,  BOWLIN, Terry, L.

Inventor： BASU, Arnab ,  MILLS, Debra, M. ,  WILLIAMS, John, D. ,  LI, Bing ,  PEET, Norton, P. ,  BOWLIN, Terry, L.

IPC: A61K31/44

CPC classification number: C07C311/44 ,  A61K31/18

Abstract: The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.

Abstract translation: 本发明涉及抑制哺乳动物中病毒感染的化合物和方法的开发。 开发了一种假型病毒用于高通量测定，用于鉴定预防病毒进入宿主细胞的非肽小分子抑制剂。