公开(公告)号：WO2012037119A2

公开(公告)日：2012-03-22

申请号：PCT/US2011/051389

申请日：2011-09-13

Applicant: MICROBIOTIX, INC. ,  BASU, Arnab ,  MILLS, Debra, M. ,  WILLIAMS, John, D. ,  LI, Bing ,  PEET, Norton, P. ,  BOWLIN, Terry, L.

Inventor： BASU, Arnab ,  MILLS, Debra, M. ,  WILLIAMS, John, D. ,  LI, Bing ,  PEET, Norton, P. ,  BOWLIN, Terry, L.

IPC: A61K31/44

CPC classification number: C07C311/44 ,  A61K31/18

Abstract: The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.

Abstract translation: 本发明涉及抑制哺乳动物中病毒感染的化合物和方法的开发。 开发了一种假型病毒用于高通量测定，用于鉴定预防病毒进入宿主细胞的非肽小分子抑制剂。

公开(公告)号：WO2011046646A2

公开(公告)日：2011-04-21

申请号：PCT/US2010041632

申请日：2010-07-10

Applicant: MICROBIOTIX INC ,  BASU ARNAB ,  MILLS DEBRA M ,  PEET NORTON P ,  WILLIAMS JOHN D

Inventor： BASU ARNAB ,  MILLS DEBRA M ,  PEET NORTON P ,  WILLIAMS JOHN D

IPC: A61K31/5513

CPC classification number: A61K31/5513 ,  A61K31/18 ,  C07D213/74 ,  C07D215/40 ,  C07D243/12 ,  C07D249/10 ,  C07D307/71 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D471/04 ,  C07D491/22 ,  A61K2300/00

Abstract: Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains.

Abstract translation: 公开了显示抑制病毒糖蛋白（GP）介导的病毒入宿主细胞的能力的有机化合物。 所公开的叶病毒入侵抑制剂化合物可用于治疗，预防或减少包括类型物种马尔堡病毒（MARV）和埃博拉病毒（EBOV）的病毒感染的扩散。 本发明优选的抑制剂提供用于对抗科特迪瓦海岸，苏丹，扎伊尔，Bundibugyo和Reston埃博拉病毒毒株的治疗剂。

公开(公告)号：WO2012037119A3

公开(公告)日：2014-03-27

申请号：PCT/US2011051389

申请日：2011-09-13

Applicant: MICROBIOTIX INC ,  BASU ARNAB ,  MILLS DEBRA M ,  WILLIAMS JOHN D ,  LI BING ,  PEET NORTON P ,  BOWLIN TERRY L

Inventor： BASU ARNAB ,  MILLS DEBRA M ,  WILLIAMS JOHN D ,  LI BING ,  PEET NORTON P ,  BOWLIN TERRY L

IPC: A01N41/06 ,  A01N37/18 ,  A61K31/18

CPC classification number: C07C311/44 ,  A61K31/18

Abstract: The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.

Abstract translation: 本发明涉及抑制哺乳动物中病毒感染的化合物和方法的开发。 开发了一种假型病毒用于高通量测定，用于鉴定预防病毒进入宿主细胞的非肽小分子抑制剂。

公开(公告)号：WO2011046646A3

公开(公告)日：2011-04-21

申请号：PCT/US2010/041632

申请日：2010-07-10

Applicant: MICROBIOTIX, INC. ,  BASU, Arnab ,  MILLS, Debra, M. ,  PEET, Norton, P. ,  WILLIAMS, John, D.

Inventor： BASU, Arnab ,  MILLS, Debra, M. ,  PEET, Norton, P. ,  WILLIAMS, John, D.

IPC: A01N43/62 ,  A61K31/55

Abstract: Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains.