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    NEW PIPERAZINE DERIVATIVES
    1.
    发明申请
    NEW PIPERAZINE DERIVATIVES 审中-公开
    新的哌嗪衍生物

    公开(公告)号：WO1986003748A1

    公开(公告)日：1986-07-03

    申请号：PCT/EP1985000708

    申请日：1985-12-16

    Applicant: BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ... ,  ULRICH, Wolf-Rüdiger ,  AMSCHLER, Herman

    Inventor： BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ... ,  EISTETTER, Klaus ,  ELTZE, Manfrid ,  FLOCKERZI, Dieter ,  KLEMM, Kurt ,  KOLASSA, Norbert ,  SANDERS, Karl ,  SCHUDT, Christian

    IPC: C07D211/90

    CPC classification number: C07D211/90 ,  C07D401/12

    Abstract: Piperazine derivatives have the general formula (I) wherein R1, R2 and R3 are the same or different and represent hydrogen, C1-C6-alkyl, C3-C7 alkoxy alkyl, aryl, aryl-C1-C6-alkyl or aryloxy-C1-C6-alkyl, R4 represents C1-C4-alkoxy substituted completely or for its major part with fluorine, R5 represents aryl, heteroaryl, aryl-C1-C4-alkyl, heteroaryl-C1-C4-alkyl, diaryl-C1-C4-alkyl, heteroaryl-aryl-C1-C4-alkyl or di-heteroaryl-C1-C4-alkyl. Said derivatives and salts thereof are new compositions for the treatment and prophylaxy of diseases due to circulation troubles.

    Abstract translation: 哌嗪衍生物具有通式（I），其中R 1，R 2和R 3相同或不同，表示氢，C 1 -C 6烷基，C 3 -C 7烷氧基烷基，芳基，芳基-C 1 -C 6烷基或芳氧基-C C6烷基，R4代表完全取代的C1-C4-烷氧基或其主要部分与氟，R5表示芳基，杂芳基，芳基-C1-C4-烷基，杂芳基-C1-C4-烷基，二芳基-C1-C4-烷基 ，杂芳基 - 芳基-C 1 -C 4 - 烷基或二 - 杂芳基-C 1 -C 4 - 烷基。 所述衍生物和其盐是用于治疗和预防由于循环障碍引起的疾病的新组合物。

    METAL COMPLEXES HAVING AN ANTINEOPLASTIC ACTION, AND MEDICAMENTS CONTAINING THESE COMPLEXES
    7.
    发明申请
    METAL COMPLEXES HAVING AN ANTINEOPLASTIC ACTION, AND MEDICAMENTS CONTAINING THESE COMPLEXES 审中-公开
    具有抗肿瘤作用的金属复合物，以及含有这些复合物的药物

    公开(公告)号：WO1983000868A1

    公开(公告)日：1983-03-17

    申请号：PCT/EP1982000184

    申请日：1982-08-28

    Applicant: BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ... ,  KELLER, Heimo, J. ,  KEPPLER, Bernhard ,  KRÜGER, Uwe ,  LINDER, Rudolf

    Inventor： BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ...

    IPC: C07F07/00

    CPC classification number: A61K31/28 ,  A61K9/145 ,  A61K9/146 ,  A61K31/74 ,  C07F7/003

    Abstract: Metal complexes of the general formula I wherein M denotes titanium, zirconium or hafnium, R denotes hydrogen, C1-C8-alkyl or phenyl, which can be monosubstituted or polysubstituted by fluorine, chlorine, bromine, nitro, C1-C4-alkyl, C1-C4-alkoxy of trifluoromethyl, R denotes C1-C8-alkyl, or phenyl, which can be monosubstituted or polysubstituted by fluorine, chlorine, bromine, nitro, C1-C4-alkyl, C1-C4-alkoxy or trifluoromethyl, R denotes hydrogen or phenyl, R denotes C1-C18-alkyl, which can be substituted by hydroxyl, C1-C3-alkylamino or alkali metal sulfonato groups, or denotes C5-C8-cycloalkyl, which can be substituted by C1-C5-alkyl groups, hydroxyl or alkali metal sulfonato groups, X denotes fluorine, chlorine or bromine, m denotes the number 0 or 1, but does not denote 0 if R denotes hydrogen, and n denotes the number 0 or 1, and, if a radical R contains an amino group, hydrohalides thereof, exhibit a very good cytostatic activity, coupled with low toxicity. They are suitable for the production of medicaments having an antineoplastic action.

    Abstract translation: 其中M表示钛，锆或铪，R 1表示氢，C 1 -C 8 - 烷基或苯基，其可以被氟，氯，溴，硝基，C1单取代或多取代 C 1-4 - 烷基，三氟甲基的C 1 -C 4 - 烷氧基，R 2表示C 1 -C 8 - 烷基或苯基，其可以被氟，氯，溴，硝基，C 1 -C 4 - 烷基，C 1 -C 4 - C4烷氧基或三氟甲基，R 3表示氢或苯基，R 4表示可被羟基，C 1 -C 3 - 烷基氨基或碱金属磺酸基取代的C 1 -C 18 - 烷基，或表示C 5 -C 8 - 环烷基，其可以被C 1 -C 5 - 烷基，羟基或碱金属磺酸基取代，X表示氟，氯或溴，m表示数字0或1，但如果R 1表示氢，则不表示0， 并且n表示数字0或1，并且如果基团R 4含有氨基，则其氢卤化物表现出非常好的细胞抑制活性，加上低毒 市。 它们适用于生产具有抗肿瘤作用的药物。

    SUPPOSITORY WITH INCORPORATED BUFFER WICK
    8.
    发明申请
    SUPPOSITORY WITH INCORPORATED BUFFER WICK 审中-公开
    配有缓冲垫的支架

    公开(公告)号：WO1983000621A1

    公开(公告)日：1983-03-03

    申请号：PCT/EP1982000177

    申请日：1982-08-23

    Applicant: BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ...

    Inventor： BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ... ,  KEINTZEL, Ernst

    IPC: A61J03/08

    CPC classification number: A61J3/08

    Abstract: The torpedo-shaped suppository (12) with incorporated buffer wick (13) is packed between two bands presenting deep deformations (1, 2). The back ends (5, 6) of the two welded bands (1, 2) are folded back at right angles in the area (3) of the reception cavities (9, 10) of the suppositories, and the surface formed by the two folded edges receives a closure sheet (8).

    Abstract translation: 带有并入的缓冲芯（13）的鱼雷形栓剂（12）被填充在呈现深度变形（1,2）的两个带之间。 两个焊接带（1,2）的后端（5,6）在栓剂的接收腔（9,10）的区域（3）中以直角折回，并且由两个 折叠边缘接收封闭片（8）。

    RUTHENIUM COMPOUNDS HAVING A TUMOR INHIBITING ACTIVITY
    10.
    发明申请
    RUTHENIUM COMPOUNDS HAVING A TUMOR INHIBITING ACTIVITY 审中-公开
    具有肿瘤抑制活性的RUMENIUM化合物

    公开(公告)号：WO1986000905A1

    公开(公告)日：1986-02-13

    申请号：PCT/EP1985000369

    申请日：1985-07-24

    Applicant: BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ... ,  KELLER, Heimo, J. ,  KEPPLER, Bernhard

    Inventor： BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT ...

    IPC: C07F15/00

    CPC classification number: C07F15/0053

    Abstract: Compounds having the general formula (I) (BHn)m[RuX3+nm-q-r(OH)r(BHp)3-nm+q]1+p+q wherein B is a mononucleous or polynucleous basic heterocycle containing one or a plurality of nitrogen atoms, X is chlorine or bromine, m is 1 or 2, n is 1 or 2, the sum of n + m not exceeding 3, p is 0 or 1, but not 1 if n is 1, q is 0 or 1 but not 1 if p is 1 and r is 0 or 1, presenting a tumor inhibiting activity and thus useable in chemiotherapy for the treatment of cancer.

    Abstract translation: 具有通式（I）（BHn）m [RuX3 + nm-qr（OH）r（BHp）3-nm + q] 1 + p + q的化合物其中B是含有一个或多个的单核或多核碱性杂环 的氮原子，X为氯或溴，m为1或2，n为1或2，n + m的和不超过3，p为0或1，如果n为1，则不为1，q为0或 1，但不是1，如果p是1，r是0或1，呈现肿瘤抑制活性，因此可用于化学疗法用于治疗癌症。

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