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    PROCESS FOR THE PRODUCTION OF POWDERED PULMONARY SURFACTANT PREPARATIONS
    2.
    发明申请
    PROCESS FOR THE PRODUCTION OF POWDERED PULMONARY SURFACTANT PREPARATIONS 审中-公开
    用于生产粉末肺表面活性剂制剂

    公开(公告)号：WO1997026863A1

    公开(公告)日：1997-07-31

    申请号：PCT/EP1997000230

    申请日：1997-01-18

    Applicant: BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH ,  EISTETTER, Klaus

    Inventor： BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH

    IPC: A61K09/14

    CPC classification number: A61K38/1709 ,  A61K9/0082 ,  A61K9/1688

    Abstract: The invention concerns a process for the production of a powdered pulmonary surfactant preparation containing a hydrophobic protein serving as a pulmonary surfactant characterized by the fact that an organic solution or suspension containing a hydrophobic protein serving as a pulmonary surfactant and possibly other components is subject to spray drying. Powder preparations are obtained that exhibit very good stability under storage, are easy to reconstitute and which are also suitable for administration by inhalation.

    Abstract translation: 它被描述包含疏水性肺表面活性蛋白，用于制备粉末状肺表面活性物质制剂，其特征在于，对含有疏水性的肺表面活性蛋白的有机溶液或悬浮液的方法，并且如果需要的话，另外的组分喷雾干燥。 这给出了一个非常好的货架稳定的，容易被复原粉末制剂也是适合于通过吸入给药。

    DEVICE FOR DOSING AND DRY NEBULIZATION
    4.
    发明申请
    DEVICE FOR DOSING AND DRY NEBULIZATION 审中-公开
    用于剂量和干燥性能的装置

    公开(公告)号：WO2006105980A8

    公开(公告)日：2008-01-10

    申请号：PCT/EP2006003172

    申请日：2006-04-07

    Applicant: NYCOMED GMBH ,  EISTETTER KLAUS ,  WURST WILHELM ,  POHLMANN GERHARD ,  WINDT HORST ,  NOLTE OLIVER ,  KOCH WOLFGANG

    Inventor： EISTETTER KLAUS ,  WURST WILHELM ,  POHLMANN GERHARD ,  WINDT HORST ,  NOLTE OLIVER ,  KOCH WOLFGANG

    IPC: A61M11/06 ,  A61M15/00 ,  A61M16/20 ,  B05B7/14 ,  B05B11/06

    CPC classification number: A61M11/06 ,  A61M11/065 ,  A61M15/0065 ,  A61M15/0086 ,  A61M16/14 ,  A61M16/202 ,  A61M2016/0027 ,  A61M2202/064 ,  B05B7/1404

    Abstract: The invention relates to a device (1) for dosing and dry nebulization of nebulizable material (12) chosen from the group comprising anti- infective agents and immunomodulators, comprising a nebulization channel (3), which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve (16) for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir (10) open only towards the nebulization channel, which contains the nebulizable material (12), is connected to the nebulizaton channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation (22) takes place in the nebulization channel and in the reservoir. The invention also relates to a method for dosing and dry nebulization of such a nebulizable material by means of such a device.

    Abstract translation: 本发明涉及一种用于定量和干燥可雾化材料（12）雾化的装置（1），该装置选自包含抗感染剂和免疫调节剂的组，包括雾化通道（3），其具有第一附接件和第二附件 以及经由阀（16）连接到第一附接件的压缩载气源，用于将载气压力脉冲发送到雾化通道中。 该装置的特征在于，在第一附接件和第二附接件之间并且在雾化通道上方，仅包含可雾化材料（12）的朝向雾化通道打开的储存器（10）连接到喷雾通道， 它相对于环境是气密的，并且当阀关闭时，在雾化通道和储存器中进行压力补偿（22）。 本发明还涉及通过这种装置对这种可喷雾材料进行计量和干燥雾化的方法。

    DEVICE FOR DOSING AND DRY NEBULIZATION
    7.
    发明申请
    DEVICE FOR DOSING AND DRY NEBULIZATION 审中-公开
    用于剂量和干燥性能的装置

    公开(公告)号：WO2006105980A1

    公开(公告)日：2006-10-12

    申请号：PCT/EP2006/003172

    申请日：2006-04-07

    Applicant: ALTANA PHARMA AG ,  EISTETTER, Klaus ,  WURST, Wilhelm ,  POHLMANN, Gerhard ,  WINDT, Horst ,  NOLTE, Oliver ,  KOCH, Wolfgang

    Inventor： EISTETTER, Klaus ,  WURST, Wilhelm ,  POHLMANN, Gerhard ,  WINDT, Horst ,  NOLTE, Oliver ,  KOCH, Wolfgang

    IPC: A61M11/06 ,  A61M15/00 ,  B05B11/06 ,  B05B7/14 ,  A61M16/20

    CPC classification number: A61M11/06 ,  A61M11/065 ,  A61M15/0065 ,  A61M15/0086 ,  A61M16/14 ,  A61M16/202 ,  A61M2016/0027 ,  A61M2202/064 ,  B05B7/1404

    Abstract: The invention relates to a device (1) for dosing and dry nebulization of nebulizable material (12) chosen from the group comprising anti-infective agents and immunomodulators, comprising a nebulization channel (3) , which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve (16) for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir (10) open only towards the nebulization channel, which contains the nebulizable material (12), is connected to the nebulizaton channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation (22) takes place in the nebulization channel and in the reservoir. The invention also relates to a method for dosing and dry nebulization of such a nebulizable material by means of such a device.

    Abstract translation: 本发明涉及一种用于对可分散的材料（12）进行定量和干燥雾化的装置（1），该装置选自包含抗感染剂和免疫调节剂的组，包括雾化通道（3），其具有第一附接件和第二附件 以及经由阀（16）连接到第一附接件的压缩载气源，用于将载气压力脉冲发送到雾化通道中。 该装置的特征在于，在第一附接件和第二附接件之间并且在雾化通道上方，仅包含可雾化材料（12）的朝向雾化通道打开的储存器（10）连接到喷雾通道， 它相对于环境是气密的，并且当阀关闭时，在雾化通道和储存器中进行压力补偿（22）。 本发明还涉及通过这种装置对这种可喷雾材料进行计量和干燥雾化的方法。

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